Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice von Sacino, Amanda N., Brooks, Mieu, Thomas, Michael A., McKinney, Alex B., Lee, Sooyeon, Regenhardt, Robert W., McGarvey, Nicholas H., Ayers, Jacob I., Notterpek, Lucia, Borchelt, David R., Golde, Todd E., Giasson, Benoit I.

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Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways von Ayers, Jacob I., Fromholt, Susan E., O’Neal, Veronica M., Diamond, Jeffrey H., Borchelt, David R.

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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection von Crown, Anthony, McAlary, Luke, Fagerli, Eric, Brown, Hilda, Yerbury, Justin J., Galaleldeen, Ahmad, Cashman, Neil R., Borchelt, David R., Ayers, Jacob I.

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Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts von Ayers, Jacob I, Riffe, Cara J, Sorrentino, Zachary A, Diamond, Jeffrey, Fagerli, Eric, Brooks, Mieu, Galaleldeen, Ahmad, Hart, P John, Giasson, Benoit I

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Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS von Ayers, Jacob I., Diamond, Jeffrey, Sari, Adriana, Fromholt, Susan, Galaleldeen, Ahmad, Ostrow, Lyle W., Glass, Jonathan D., Hart, P. John, Borchelt, David R.

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Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice von Ayers, Jacob I, Xu, Guilian, Lu, Qing, Dillon, Kristy, Fromholt, Susan, Borchelt, David R

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The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease von Ayers, Jacob I, Schutt, Charles R, Shikiya, Ronald A, Aguzzi, Adriano, Kincaid, Anthony E, Bartz, Jason C

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Expanding spectrum of prion diseases von Ayers, Jacob I., Paras, Nick A., Prusiner, Stanley B.

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The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease von Ayers, Jacob I, Schutt, Charles R, Shikiya, Ronald A, Aguzzi, Adriano, Kincaid, Anthony E, Bartz, Jason C

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Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models von Crosby, Keith, Crown, Anthony M, Roberts, Brittany L, Brown, Hilda, Ayers, Jacob I, Borchelt, David R

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Coinfecting Prion Strains Compete for a Limiting Cellular Resource von Shikiya, Ronald A, Ayers, Jacob I, Schutt, Charles R, Kincaid, Anthony E, Bartz, Jason C

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Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence von Ayers, Jacob, Xu, Guilian, Dillon, Kristy, Lu, Qing, Chen, Zhijuan, Beckman, John, Moreno-Romero, Alma K., Zamora, Diana L., Galaleldeen, Ahmad, Borchelt, David R.

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Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis von Crown, Anthony M, Roberts, Brittany L, Crosby, Keith, Brown, Hilda, Ayers, Jacob I, Hart, P John, Borchelt, David R

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Prion-like Spreading in Tauopathies von Ayers, Jacob I, Giasson, Benoit I, Borchelt, David R

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Phenotypic diversity in ALS and the role of poly-conformational protein misfolding von Ayers, Jacob I., Borchelt, David R.

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Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy von Ayers, Jacob I, Lee, Joanne, Monteiro, Octovia, Woerman, Amanda L, Lazar, Ann A, Condello, Carlo, Paras, Nick A, Prusiner, Stanley B

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ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons von Osking, Zachary, Ayers, Jacob I., Hildebrandt, Ryan, Skruber, Kristen, Brown, Hilda, Ryu, Daniel, Eukovich, Amanda R., Golde, Todd E., Borchelt, David R., Read, Tracy-Ann, Vitriol, Eric A.

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Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases von Ayers, Jacob I, Xu, Guilian, Pletnikova, Olga, Troncoso, Juan C, Hart, P John, Borchelt, David R

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Prion Strain Targeting Independent of Strain-Specific Neuronal Tropism von AYERS, Jacob I, XINCAID, Anthony E, BARTZ, Jason C

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Prion protein — mediator of toxicity in multiple proteinopathies von Ayers, Jacob I., Prusiner, Stanley B.

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