Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors von Sommer, Anette, Kopitz, Charlotte, Schatz, Christoph A, Nising, Carl F, Mahlert, Christoph, Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Hammer, Stefanie, Greven, Simone, Schuhmacher, Joachim, Braun, Manuela, Zierz, Ruprecht, Wittemer-Rump, Sabine, Harrenga, Axel, Dittmer, Frank, Reetz, Frank, Apeler, Heiner, Jautelat, Rolf, Huynh, Hung, Ziegelbauer, Karl, Kreft, Bertolt

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Structure at 2.7 Å resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment von Ostermeier, C, Harrenga, A, Ermler, U, Michel, H

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Site-specific modification of ED-B-targeting antibody using intein-fusion technology von Möhlmann, Sina, Bringmann, Peter, Greven, Simone, Harrenga, Axel

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The Cytochrome c Oxidase from Paracoccus denitrificans Does Not Change the Metal Center Ligation upon Reduction von Harrenga, Axel, Michel, Hartmut

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Evaluation of human pancreatic RNase as effector molecule in a therapeutic antibody platform von Schirrmann, Thomas, Frenzel, André, Linden, Lars, Stelte-Ludwig, Beatrix, Willuda, Jörg, Harrenga, Axel, Dübel, Stefan, Müller-Tiemann, Beate, Trautwein, Mark

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Probing Protein-tyrosine Phosphatase Substrate Specificity Using a Phosphotyrosine-containing Phage Library von Wälchli, Sébastien, Espanel, Xavier, Harrenga, Axel, Rossi, Mario, Cesareni, Gianni, van Huijsduijnen, Rob Hooft

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Anetumab ravtansine: a novel mesothelin-targeting antibody-drug conjugate cures tumors with heterogeneous target expression favored by bystander effect von Golfier, Sven, Kopitz, Charlotte, Kahnert, Antje, Heisler, Iring, Schatz, Christoph A, Stelte-Ludwig, Beatrix, Mayer-Bartschmid, Anke, Unterschemmann, Kerstin, Bruder, Sandra, Linden, Lars, Harrenga, Axel, Hauff, Peter, Scholle, Frank-Detlef, Müller-Tiemann, Beate, Kreft, Bertolt, Ziegelbauer, Karl

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Mapping of Synergistic Components of Weakly Interacting Protein-Protein Motifs Using Arrays of Paired Peptides von Espanel, Xavier, Wälchli, Sébastien, Rückle, Thomas, Harrenga, Axel, Huguenin-Reggiani, Martine, Hooft van Huijsduijnen, Rob

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Unexpected Active-Site Flexibility in the Structure of Human Neutrophil Elastase in Complex with a New Dihydropyrimidone Inhibitor von Hansen, Guido, Gielen-Haertwig, Heike, Reinemer, Peter, Schomburg, Dietmar, Harrenga, Axel, Niefind, Karsten

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In vitro Sortagging of an Antibody Fab Fragment: Overcoming Unproductive Reactions of Sortase with Water and Lysine Side Chains von Möhlmann, Sina, Mahlert, Christoph, Greven, Simone, Scholz, Peter, Harrenga, Axel

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A Neutralizing Prolactin Receptor Antibody Whose In Vivo Application Mimics the Phenotype of Female Prolactin Receptor-Deficient Mice von Otto, Christiane, Särnefält, Anna, Ljungars, Anne, Wolf, Siegmund, Rohde-Schulz, Beate, Fuchs, Iris, Schkoldow, Jenny, Mattsson, Mikael, Vonk, Richardus, Harrenga, Axel, Freiberg, Christoph

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Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hyp... von von Nussbaum, Franz, Li, Volkhart M., Meibom, Daniel, Anlauf, Sonja, Bechem, Martin, Delbeck, Martina, Gerisch, Michael, Harrenga, Axel, Karthaus, Dagmar, Lang, Dieter, Lustig, Klemens, Mittendorf, Joachim, Schäfer, Martina, Schäfer, Stefan, Schamberger, Jens

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Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima von Hansen, Guido, Harrenga, Axel, Wieland, Bernd, Schomburg, Dietmar, Reinemer, Peter

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Abstract DDT02-01: In vitro and in vivo characterization of a novel anti-fibroblast growth factor receptor (FGFR) 2 antibody (BAY 1179470) for the treatment of gastric cancer von Kopitz, Charlotte, Sommer, Anette, Hammer, Stefanie, Harrenga, Axel, Stelte-Ludwig, Beatrix, Dittmer, Frank, Reetz, Frank, May, Ekkehard, Zierz, Ruprecht, Wittemer-Rump, Sabine, Schatz, Christoph, Huynh, H. T., Ziegelbauer, Karl, Kreft, Bertolt

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The X-Ray Structure of RANTES: Heparin-Derived Disaccharides Allows the Rational Design of Chemokine Inhibitors von Shaw, Jeffrey P., Johnson, Zoë, Borlat, Frédéric, Zwahlen, Catherine, Kungl, Andreas, Roulin, Karen, Harrenga, Axel, Wells, Timothy N.C., Proudfoot, Amanda E.I.

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Discovery of substituted N-phenylbenzenesulphonamides as a novel class of non-nucleoside hepatitis C virus polymerase inhibitors von May, Marina M., Brohm, Dirk, Harrenga, Axel, Marquardt, Tobias, Riedl, Bernd, Kreuter, Joerg, Zimmermann, Holger, Ruebsamen-Schaeff, Helga, Urban, Andreas

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Tracing the D-Pathway in Reconstituted Site-Directed Mutants of Cytochrome c Oxidase from Paracoccus denitrificans von Pfitzner, Ute, Hoffmeier, Klaus, Harrenga, Axel, Kannt, Aimo, Michel, Hartmut, Bamberg, Ernst, Richter, Oliver-M. H, Ludwig, Bernd

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Abstract 1754: Identification of BAY 94-9343, a mesothelin antibody-drug conjugate (ADC): Characterization and anti-tumor activity in mesothelin-positive preclinical tumor models von Golfier, Sven, Kahnert, Antje, Heisler, Iring, Kopitz, Charlotte, Berhörster, Kerstin, Stelte-Ludwig, Beatrix, Mayer-Bartschmid, Anke, Bruder, Sandra, Linden, Lars, Harrenga, Axel, Schatz, Christoph, Kreft, Bertolt, Müller-Tiemann, Beate, Ziegelbauer, Karl

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Protein tyrosine phosphatases as drug targets: PTP1B and beyond von Huijsduijnen, Rob Hooft van, Wälchli, Sébastien, Ibberson, Mark, Harrenga, Axel

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The X-Ray Structure of RANTES von Shaw, Jeffrey P., Johnson, Zoë, Borlat, Frédéric, Zwahlen, Catherine, Kungl, Andreas, Roulin, Karen, Harrenga, Axel, Wells, Timothy N.C., Proudfoot, Amanda E.I.

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