A Phase 1b Safety Study of SER-287, a Spore-Based Microbiome Therapeutic, for Active Mild to Moderate Ulcerative Colitis von Henn, Matthew R., O’Brien, Edward J., Diao, Liyang, Feagan, Brian G., Sandborn, William J., Huttenhower, Curtis, Wortman, Jennifer R., McGovern, Barbara H., Wang-Weigand, Sherry, Lichter, David I., Chafee, Meghan, Ford, Christopher B., Bernardo, Patricia, Zhao, Peng, Simmons, Sheri, Tomlinson, Amelia D., Cook, David N., Pomerantz, Roger J., Misra, Bharat K., Auninš, John G., Trucksis, Michele

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SER-109, an Investigational Microbiome Drug to Reduce Recurrence After Clostridioides difficile Infection: Lessons Learned From a Phase 2 Trial von McGovern, Barbara H, Ford, Christopher B, Henn, Matthew R, Pardi, Darrell S, Khanna, Sahil, Hohmann, Elizabeth L, O’Brien, Edward J, Desjardins, Christopher A, Bernardo, Patricia, Wortman, Jennifer R, Lombardo, Mary-Jane, Litcofsky, Kevin D, Winkler, Jonathan A, McChalicher, Christopher W J, Li, Sunny S, Tomlinson, Amelia D, Nandakumar, Madhumitha, Cook, David N, Pomerantz, Roger J, Auninš, John G, Trucksis, Michele

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SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection von Feuerstadt, Paul, Louie, Thomas J, Lashner, Bret, Wang, Elaine E.L, Diao, Liyang, Bryant, Jessica A, Sims, Matthew, Kraft, Colleen S, Cohen, Stuart H, Berenson, Charles S, Korman, Louis Y, Ford, Christopher B, Litcofsky, Kevin D, Lombardo, Mary-Jane, Wortman, Jennifer R, Wu, Henry, Auniņš, John G, McChalicher, Christopher W.J, Winkler, Jonathan A, McGovern, Barbara H, Trucksis, Michele, Henn, Matthew R, von Moltke, Lisa

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Drugging the microbiome and bacterial live biotherapeutic consortium production von McChalicher, Christopher WJ, Auniņš, John G

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Manufacturing Processes of a Purified Microbiome Therapeutic Reduce Risk of Transmission of Potential Bacterial Pathogens in Donor Stool von McChalicher, Christopher W J, Lombardo, Mary-Jane, Khanna, Sahil, McKenzie, Gregory J, Halvorsen, Elizabeth M, Almomani, Sanabel, Schuster, Brian, Hasson, Brooke R, McGovern, Barbara H, Ege, David S, Auniņš, John G

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A Novel Microbiome Therapeutic Increases Gut Microbial Diversity and Prevents Recurrent Clostridium difficile Infection von Khanna, Sahil, Pardi, Darrell S., Kelly, Colleen R., Kraft, Colleen S., Dhere, Tanvi, Henn, Matthew R., Lombardo, Mary-Jane, Vulic, Marin, Ohsumi, Toshiro, Winkler, Jonathan, Pindar, Christina, McGovern, Barbara H., Pomerantz, Roger J., Aunins, John G., Cook, David N., Hohmann, Elizabeth L.

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End-to-end donor screening and manufacturing controls: complementary quality-based strategies to minimize patient risk for donor-derived microbiome therapeutics von Goldsmith, Jason, Tomkovich, Sarah, Auniņš, John G., McGovern, Barbara H., Mahoney, Jennifer C., Hasson, Brooke R., McChalicher, Christopher W J, Ege, David S.

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Manufacturing Process of SER-109, a Purified Investigational Microbiome Therapeutic, Reduces Risk of Coronavirus Transmission From Donor Stool von McChalicher, Christopher, Abdulaziz, Ahmad, Zhou, S Steve, Lombardo, Mary-Jane, Hasson, Brooke, Auniņš, John G, McGovern, Barbara H, Ege, David S

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35 SER-287, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC, INDUCES IN VIVO AND IN VITRO METABOLOMIC CHANGES ASSOCIATED WITH CLINICAL REMISSION IN PATIENTS WITH ACTIVE MILD-TO-MODERATE... von OBrien, Edward, Diao, Liyang, Kieser, Karen, Balasubramanian, Divya, Nandakumar, Madhu, Pina, Ambar, Martinez, Asuncion, Ford, Christopher B., Wortman, Jennifer R., Auninš, John, Henn, Matthew R.

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Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures von Amanullah, Ashraf, Otero, Jose Manuel, Mikola, Mark, Hsu, Amy, Zhang, Jinyou, Aunins, John, Schreyer, H. Brett, Hope, James A, Russo, A. Peter

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Quantitative Studies of Cell-Bubble Interactions and Cell Damage at Different Pluronic F-68 and Cell Concentrations von Ma, Ningning, Chalmers, Jeffery J., Auniņš, John G., Zhou, Weichang, Xie, Liangzhi

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Characterization of changes in PER.C6™ cellular metabolism during growth and propagation of a replication-deficient adenovirus vector von Maranga, Luis, Auniņš, John G., Zhou, Weichang

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Vaccine Technology III: An ECI Conference held in Puerto Vallarta, Mexico from June 6–11, 2010 von Buckland, Barry C., PhD, Aunins, John G., PhD, Jansen, Kathrin, PhD, Alves, Paula Marquez, PhD, Weiner, David, PhD

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Establishment of Higher Passage PER.C6 Cells for Adenovirus Manufacture von Berdichevsky, Marina, Gentile, Marie-Pierre, Hughes, Benjamin, Meis, Peter, Peltier, Joseph, Blumentals, Ilse, Auniņš, John, Altaras, Nedim Emil

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Production and Formulation of Adenovirus Vectors von Altaras, Nedim E., Aunins, John G., Evans, Robert K., Kamen, Amine, Konz, John O., Wolf, Jayanthi J.

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Serum-free suspension cultivation of PER.C6® cells and recombinant adenovirus production under different pH conditions von Xie, Liangzhi, Pilbrough, Warren, Metallo, Christian, Zhong, Tanya, Pikus, Lana, Leung, John, Auniņš, John G., Zhou, Weichang

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Large-scale mammalian cell culture von Hu, Wei-Shou, Aunins, John G

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Large-scale propagation of a replication-defective adenovirus vector in stirred-tank bioreactor PER.C6™ cell culture under sparging conditions von Xie, Liangzhi, Metallo, Christian, Warren, James, Pilbrough, Warren, Peltier, Joseph, Zhong, Tanya, Pikus, Lana, Yancy, Amanda, Leung, John, Auniņš, John G., Zhou, Weichang

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P075 SER-287, AN INVESTIGATIONAL MICROBIOME THERAPEUTIC, INDUCES WIDESPREAD METABOLOMIC AND HOST TRANSCRIPTIONAL CHANGES RELATED TO CLINICAL REMISSION IN PATIENTS WITH ACTIVE MILD-... von Diao, Liyang, O'Brien, Edward, Ford, Christopher, Wortman, Jennifer, Aunins, John, Henn, Matthew

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293 cell cycle synchronisation adenovirus vector production von Ferreira, Tiago B., Perdigão, Ricardo, Silva, Ana C., Zhang, Changhe, Aunins, John G., Carrondo, Manuel J.T., Alves, Paula M.

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