An Analysis of TSCA Reform Provisions Pertinent to Industrial Biotechnology Stakeholders von Bergeson, Lynn L., Auer, Charles M.

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Creative Adaptation: Enhancing Oversight of Synthetic Biology Under the Toxic Substances Control Act von Bergeson, Lynn L, Auer, Charles M, Hernandez, Oscar

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Mode of Action and the Assessment of Chemical Hazards in the Presence of Limited Data: Use of Structure-Activity Relationships (SAR) under TSCA, Section 5 von Auer, Charles M., Nabholz, J. Vincent, Baetcke, Karl P.

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Nano Disclosures: Too Small to Matter or Too Big to Ignore? von Bergeson, Lynn L., Auer, Charles M.

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Structure-Metabolism Relationships SMR) for the Prediction of Health Hazards)y the Environmental Protection Agency. I. Background for the Practice of Predictive Toxicology von Di Carlo, Frederick J., Bickart, Paul, Auer, Charles M.

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Structure-Metabolism Relationships (SMR) for the Prediction of Health Hazards by the Environmental Protection Agency. II. Application to Teratogenicity and Other Toxic Effects Caus... von Di Carlo, Frederick J., Bickart, Paul, Auer, Charles M.

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Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data von Wainschtein, Pierrick, Jain, Deepti, Zheng, Zhili, Cupples, L. Adrienne, Shadyab, Aladdin H., McKnight, Barbara, Shoemaker, Benjamin M., Mitchell, Braxton D., Psaty, Bruce M., Kooperberg, Charles, Liu, Ching-Ti, Albert, Christine M., Roden, Dan, Chasman, Daniel I., Darbar, Dawood, Lloyd-Jones, Donald M., Arnett, Donna K., Regan, Elizabeth A., Boerwinkle, Eric, Rotter, Jerome I., O’Connell, Jeffrey R., Yanek, Lisa R., de Andrade, Mariza, Allison, Matthew A., McDonald, Merry-Lynn N., Chung, Mina K., Fornage, Myriam, Chami, Nathalie, Smith, Nicholas L., Ellinor, Patrick T., Vasan, Ramachandran S., Mathias, Rasika A., Loos, Ruth J. F., Rich, Stephen S., Lubitz, Steven A., Heckbert, Susan R., Redline, Susan, Guo, Xiuqing, Chen, Y. -D Ida, Laurie, Cecelia A., Hernandez, Ryan D., McGarvey, Stephen T., Goddard, Michael E., Laurie, Cathy C., North, Kari E., Lange, Leslie A., Weir, Bruce S., Yengo, Loic, Yang, Jian, Visscher, Peter M.

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Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture von Forgetta, Vincenzo, Estrada, Karol, Leo, Paul J., Dahia, Chitra L., Liu, Ching‐Ti, Uggla, Charlotta, Evans, Daniel S., Walter, Klaudia, Pettersson‐Kymmer, Ulrika, McCarthy, Shane, Kwan, Tony, Jhamai, Mila, Trajanoska, Katerina, Huang, Jie, Danecek, Petr, Wilmot, Beth, Li, Rui, Moayyeri, Alireza, Claussnitzer, Melina, Cheng, Chia‐Ho, Cheung, Warren, Ge, Bing, Chen, Shu‐Huang, Choi, Kwangbom, Oei, Ling, Fraser, James, Hibbs, Matthew A., Gregson, Celia L., Paquette, Denis, Wibom, Carl, Tranah, Gregory J., Marshall, Mhairi, Gardiner, Brooke B., Cremin, Katie, Auer, Paul, Hsu, Li, Thorleifsson, Gudmar, Enneman, Anke W., de Groot, Lisette C. P. G. M., Melin, Beatrice, Christiansen, Claus, Sayers, Adrian, Zhou, Yanhua, Calderari, Sophie, van Rooij, Jeroen, Carlson, Chris, Peters, Ulrike, Uitterlinden, Andre G., Williams, Stephen R., Farber, Charles, Grinberg, Daniel, Chasman, Daniel I., Giulianini, Franco, Ridker, Paul M., Eisman, John A., Nguyen, Tuan V., Center, Jacqueline R., Garcia‐Giralt, Natalia, Mellström, Dan, Vandenput, Liesbeth, Amin, Najaf, van Duijn, Cornelia M., Karlsson, Magnus K., Svensson, Olle, Rousseau, François, Bussière, Johanne, Koromani, Fjorda, Langdahl, Bente L., Jensen, Jens‐Erik B., Kaptoge, Stephen, Khaw, Kay‐Tee, Reeve, Jonathan, Xuereb‐Anastasi, Angela, Åkesson, Kristina, Olmos, Jose M., Zarrabeitia, Maria T., Riancho, Jose A., Alonso, Nerea, Jiang, Xi, Goltzman, David, Grundberg, Elin, Gauguier, Dominique, Orwoll, Eric S., Karasik, David, Davey‐Smith, George, Smith, Albert V., Harris, Tamara B., Carola Zillikens, M., Thorsteinsdottir, Unnur, Soranzo, Nicole, Durbin, Richard, Brown, Matthew A., Spector, Tim, Adrienne Cupples, L., Greenwood, Celia M. T., Jackson, Rebecca D., Rowe, David W., Loomis, Cynthia A., Ackert‐Bicknell, Cheryl L., Kiel, Douglas P.

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Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale von Li, Xihao, Li, Zilin, Zhou, Hufeng, Gaynor, Sheila M., Liu, Yaowu, Chen, Han, Sun, Ryan, Dey, Rounak, Arnett, Donna K., Aslibekyan, Stella, Ballantyne, Christie M., Bielak, Lawrence F., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Broome, Jai G., Conomos, Matthew P., Correa, Adolfo, Cupples, L. Adrienne, Curran, Joanne E., Freedman, Barry I., Guo, Xiuqing, Hindy, George, Irvin, Marguerite R., Kardia, Sharon L. R., Kathiresan, Sekar, Khan, Alyna T., Kooperberg, Charles L., Laurie, Cathy C., Liu, X. Shirley, Mahaney, Michael C., Manichaikul, Ani W., Martin, Lisa W., Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., Montasser, May E., Moore, Jill E., Morrison, Alanna C., O’Connell, Jeffrey R., Palmer, Nicholette D., Pampana, Akhil, Peralta, Juan M., Peyser, Patricia A., Psaty, Bruce M., Redline, Susan, Rice, Kenneth M., Rich, Stephen S., Smith, Jennifer A., Tiwari, Hemant K., Tsai, Michael Y., Vasan, Ramachandran S., Wang, Fei Fei, Weeks, Daniel E., Weng, Zhiping, Wilson, James G., Yanek, Lisa R., Neale, Benjamin M., Sunyaev, Shamil R., Abecasis, Gonçalo R., Rotter, Jerome I., Willer, Cristen J., Peloso, Gina M., Natarajan, Pradeep, Lin, Xihong

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Improving polygenic risk prediction in admixed populations by explicitly modeling ancestral-differential effects via GAUDI von Sun, Quan, Rowland, Bryce T., Chen, Jiawen, Mikhaylova, Anna V., Avery, Christy, Peters, Ulrike, Lundin, Jessica, Matise, Tara, Buyske, Steve, Tao, Ran, Mathias, Rasika A., Reiner, Alexander P., Auer, Paul L., Cox, Nancy J., Kooperberg, Charles, Thornton, Timothy A., Raffield, Laura M., Li, Yun

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Four Susceptibility Loci for Gallstone Disease Identified in a Meta-analysis of Genome-Wide Association Studies von Joshi, Amit D, Andersson, Charlotte, Buch, Stephan, Stender, Stefan, Noordam, Raymond, Weng, Lu-Chen, Weeke, Peter E, Auer, Paul L, Boehm, Bernhard, Chen, Constance, Choi, Hyon, Curhan, Gary, Denny, Joshua C, De Vivo, Immaculata, Eicher, John D, Ellinghaus, David, Folsom, Aaron R, Fuchs, Charles, Gala, Manish, Haessler, Jeffrey, Hofman, Albert, Hu, Frank, Hunter, David J, Janssen, Harry L.A, Kang, Jae H, Kooperberg, Charles, Kraft, Peter, Kratzer, Wolfgang, Lieb, Wolfgang, Lutsey, Pamela L, Darwish Murad, Sarwa, Nordestgaard, Børge G, Pasquale, Louis R, Reiner, Alex P, Ridker, Paul M, Rimm, Eric, Rose, Lynda M, Shaffer, Christian M, Schafmayer, Clemens, Tamimi, Rulla M, Uitterlinden, André G, Völker, Uwe, Völzke, Henry, Wakabayashi, Yoshiyuki, Wiggs, Janey L, Zhu, Jun, Roden, Dan M, Stricker, Bruno H, Tang, Weihong, Teumer, Alexander, Hampe, Jochen, Tybjærg-Hansen, Anne, Chasman, Daniel I, Chan, Andrew T, Johnson, Andrew D

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Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixe... von Kowalski, Madeline H, Qian, Huijun, Hou, Ziyi, Rosen, Jonathan D, Tapia, Amanda L, Shan, Yue, Jain, Deepti, Argos, Maria, Arnett, Donna K, Avery, Christy, Barnes, Kathleen C, Becker, Lewis C, Bien, Stephanie A, Bis, Joshua C, Blangero, John, Boerwinkle, Eric, Bowden, Donald W, Buyske, Steve, Cai, Jianwen, Cho, Michael H, Choi, Seung Hoan, Choquet, Hélène, Cupples, L Adrienne, Cushman, Mary, Daya, Michelle, de Vries, Paul S, Ellinor, Patrick T, Faraday, Nauder, Fornage, Myriam, Gabriel, Stacey, Ganesh, Santhi K, Graff, Misa, Gupta, Namrata, He, Jiang, Heckbert, Susan R, Hidalgo, Bertha, Hodonsky, Chani J, Irvin, Marguerite R, Johnson, Andrew D, Jorgenson, Eric, Kaplan, Robert, Kardia, Sharon L R, Kelly, Tanika N, Kooperberg, Charles, Lasky-Su, Jessica A, Loos, Ruth J F, Lubitz, Steven A, Mathias, Rasika A, McHugh, Caitlin P, Montgomery, Courtney, Moon, Jee-Young, Morrison, Alanna C, Palmer, Nicholette D, Pankratz, Nathan, Papanicolaou, George J, Peralta, Juan M, Peyser, Patricia A, Rich, Stephen S, Rotter, Jerome I, Silverman, Edwin K, Smith, Jennifer A, Smith, Nicholas L, Taylor, Kent D, Thornton, Timothy A, Tiwari, Hemant K, Tracy, Russell P, Wang, Tao, Weiss, Scott T, Weng, Lu-Chen, Wiggins, Kerri L, Wilson, James G, Yanek, Lisa R, Zöllner, Sebastian, North, Kari E, Auer, Paul L, Raffield, Laura M, Reiner, Alexander P, Li, Yun

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Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality von Hong, Yun Soo, Battle, Stephanie L., Shi, Wen, Puiu, Daniela, Pillalamarri, Vamsee, Xie, Jiaqi, Pankratz, Nathan, Lake, Nicole J., Lek, Monkol, Rotter, Jerome I., Rich, Stephen S., Kooperberg, Charles, Reiner, Alex P., Auer, Paul L., Heard-Costa, Nancy, Liu, Chunyu, Lai, Meng, Murabito, Joanne M., Levy, Daniel, Grove, Megan L., Alonso, Alvaro, Gibbs, Richard, Dugan-Perez, Shannon, Gondek, Lukasz P., Guallar, Eliseo, Arking, Dan E.

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Deep-coverage whole genome sequences and blood lipids among 16,324 individuals von Natarajan, Pradeep, Peloso, Gina M., Zekavat, Seyedeh Maryam, Montasser, May, Ganna, Andrea, Chaffin, Mark, Khera, Amit V., Zhou, Wei, Bloom, Jonathan M., Engreitz, Jesse M., Ernst, Jason, O’Connell, Jeffrey R., Ruotsalainen, Sanni E., Alver, Maris, Manichaikul, Ani, Johnson, W. Craig, Perry, James A., Poterba, Timothy, Seed, Cotton, Surakka, Ida L., Esko, Tonu, Ripatti, Samuli, Salomaa, Veikko, Correa, Adolfo, Vasan, Ramachandran S., Kellis, Manolis, Neale, Benjamin M., Lander, Eric S., Abecasis, Goncalo, Mitchell, Braxton, Rich, Stephen S., Wilson, James G., Cupples, L. Adrienne, Rotter, Jerome I., Willer, Cristen J., Kathiresan, Sekar

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A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response von Luo, Yang, Kanai, Masahiro, Choi, Wanson, Li, Xinyi, Sakaue, Saori, Yamamoto, Kenichi, Ogawa, Kotaro, Gutierrez-Arcelus, Maria, Gregersen, Peter K., Stuart, Philip E., Elder, James T., Forer, Lukas, Schönherr, Sebastian, Fuchsberger, Christian, Smith, Albert V., Fellay, Jacques, Carrington, Mary, Haas, David W., Guo, Xiuqing, Palmer, Nicholette D., Chen, Yii-Der Ida, Rotter, Jerome I., Taylor, Kent D., Rich, Stephen S., Correa, Adolfo, Wilson, James G., Kathiresan, Sekar, Cho, Michael H., Metspalu, Andres, Esko, Tonu, Okada, Yukinori, Han, Buhm, McLaren, Paul J., Raychaudhuri, Soumya

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Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study von Hu, Yao, Bien, Stephanie A, Nishimura, Katherine K, Haessler, Jeffrey, Hodonsky, Chani J, Baldassari, Antoine R, Highland, Heather M, Wang, Zhe, Preuss, Michael, Sitlani, Colleen M, Wojcik, Genevieve L, Tao, Ran, Graff, Mariaelisa, Huckins, Laura M, Sun, Quan, Chen, Ming-Huei, Mousas, Abdou, Auer, Paul L, Lettre, Guillaume, Tang, Weihong, Qi, Lihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A, Li, Yun, Lin, Danyu, Reiner, Alexander P, North, Kari E, Loos, Ruth J F, Raffield, Laura M, Peters, Ulrike, Avery, Christy L, Kooperberg, Charles

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Chromosomal instability determines taxane response von Swanton, Charles, Nicke, Barbara, Schuett, Marion, Eklund, Aron C, Ng, Charlotte, Li, Qiyuan, Hardcastle, Thomas, Lee, Alvin, Roy, Rajat, East, Philip, Kschischo, Maik, Endesfelder, David, Wylie, Paul, Kim, Se Nyun, Chen, Jie-Guang, Howell, Michael, Ried, Thomas, Habermann, Jens K, Auer, Gert, Brenton, James D, Szallasi, Zoltan, Downward, Julian

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Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries von Zekavat, Seyedeh M., Ruotsalainen, Sanni, Handsaker, Robert E., Alver, Maris, Bloom, Jonathan, Poterba, Timothy, Seed, Cotton, Ernst, Jason, Chaffin, Mark, Engreitz, Jesse, Peloso, Gina M., Manichaikul, Ani, Yang, Chaojie, Ryan, Kathleen A., Fu, Mao, Johnson, W. Craig, Tsai, Michael, Budoff, Matthew, Vasan, Ramachandran S., Cupples, L. Adrienne, Rotter, Jerome I., Rich, Stephen S., Post, Wendy, Mitchell, Braxton D., Correa, Adolfo, Metspalu, Andres, Wilson, James G., Salomaa, Veikko, Kellis, Manolis, Daly, Mark J., Neale, Benjamin M., McCarroll, Steven, Surakka, Ida, Esko, Tonu, Ganna, Andrea, Ripatti, Samuli, Kathiresan, Sekar, Natarajan, Pradeep

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Whole genome sequence analysis of blood lipid levels in >66,000 individuals von Selvaraj, Margaret Sunitha, Li, Xihao, Li, Zilin, Pampana, Akhil, Zhang, David Y., Park, Joseph, Aslibekyan, Stella, Bis, Joshua C., Brody, Jennifer A., Cade, Brian E., Chuang, Lee-Ming, Chung, Ren-Hua, Curran, Joanne E., de las Fuentes, Lisa, de Vries, Paul S., Duggirala, Ravindranath, Freedman, Barry I., Graff, Mariaelisa, Guo, Xiuqing, Heard-Costa, Nancy, Hidalgo, Bertha, Hwu, Chii-Min, Irvin, Marguerite R., Kelly, Tanika N., Kral, Brian G., Lange, Leslie, Li, Xiaohui, Lisa, Martin, Lubitz, Steven A., Manichaikul, Ani W., Michael, Preuss, Montasser, May E., Morrison, Alanna C., Naseri, Take, O’Connell, Jeffrey R., Palmer, Nicholette D., Peyser, Patricia A., Reupena, Muagututia S., Smith, Jennifer A., Sun, Xiao, Taylor, Kent D., Tracy, Russell P., Tsai, Michael Y., Wang, Zhe, Wang, Yuxuan, Bao, Wei, Wilkins, John T., Yanek, Lisa R., Zhao, Wei, Arnett, Donna K., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Chen, Yii-Der Ida, Correa, Adolfo, Cupples, L. Adrienne, Dutcher, Susan K., Ellinor, Patrick T., Fornage, Myriam, Gabriel, Stacey, Germer, Soren, Gibbs, Richard, He, Jiang, Kaplan, Robert C., Kardia, Sharon L. R., Kim, Ryan, Kooperberg, Charles, Loos, Ruth J. F., Viaud-Martinez, Karine A, Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., Nickerson, Deborah, North, Kari E., Psaty, Bruce M., Redline, Susan, Reiner, Alexander P., Vasan, Ramachandran S., Rich, Stephen S., Willer, Cristen, Rotter, Jerome I., Rader, Daniel J., Lin, Xihong, Peloso, Gina M., Natarajan, Pradeep

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An integrated encyclopedia of DNA elements in the human genome von Kundaje, Anshul, Collins, Patrick J, Davis, Carrie A, Khatun, Jainab, Lajoie, Bryan R, Landt, Stephen G, Safi, Alexias, Altshuler, Robert C, Cheng, Chao, Greven, Melissa, Hoffman, Michael M, Lassmann, Timo, Thurman, Robert E, Wu, Weisheng, Xi, Hualin S, Zhuang, Jiali, Gunter, Chris, Dekker, Job, Elnitski, Laura, Giddings, Morgan C, Margulies, Elliott H, Stamatoyannopoulos, John A, Wold, Barbara, Kuiper, Heather C, Dobin, Alex, Tanzer, Andrea, Xue, Chenghai, Zaleski, Chris, Roder, Maik, Baer, Michael T, Bell, Kimberly, Gordon, Assaf, Howald, Cedric, Johnson, Rory, Kingswood, Colin, Li, Guoliang, Luo, Oscar J, Robyr, Daniel, Ruan, Xiaoan, Skancke, Jorgen, Suzuki, Ana Maria, Takahashi, Hazuki, Tilgner, Hagen, Wang, Huaien, Hayashizaki, Yoshihide, Hannon, Gregory J, Malladi, Venkat S, Dreszer, Timothy R, Showers, Kimberly A, London, Darin, Zhang, Zhancheng, Keefe, Damian, Zheng, Meizhen, Vielmetter, Jost, Jain, Preti, Pusey, Barbara, Meadows, Sarah K, Absher, Devin M, Pennachio, Len A, Abyzov, Alexej, Barrell, Daniel, Bignell, Alexandra, Diekhans, Mark, Ezkurdia, Iakes, Frankish, Adam, Hunt, Toby, Jungreis, Irwin, Loveland, Jane, Manthravadi, Deepa, Pei, Baikang, Snow, Catherine, Zhang, Zhengdong, Alexander, Roger P, Balasubramanian, Suganthi, Bettinger, Keith, Cayting, Philip, Habegger, Lukas, Lamarre-Vincent, Nathan, Lindahl-Allen, Marianne, Monahan, Hannah, Patacsil, Dorrelyn, Struhl, Kevin, Ma, Lijia, Inoue, Daigo, Kellner, Tanja, Kirchmaier, Stephan, Bates, Daniel L, Canfield, Theresa K, Boatman, Lisa, Neph, Shane J, Roach, Vaughn, Sanchez, Minerva E, Shafer, Anthony O, Vernot, Benjamin, Weaver, Molly A, Akey, Joshua M, Bender, Michael, Navas, Patrick, Hussami, Nadine, Schaub, Marc A

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