Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)­amino)-2-methylpiperidin-1-yl)­prop-2-en-1-one (PF-06651600) Allowing for the I... von Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste

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Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors von Casimiro-Garcia, Agustin, Trujillo, John I, Vajdos, Felix, Juba, Brian, Banker, Mary Ellen, Aulabaugh, Ann, Balbo, Paul, Bauman, Jonathan, Chrencik, Jill, Coe, Jotham W, Czerwinski, Robert, Dowty, Martin, Knafels, John D, Kwon, Soojin, Leung, Louis, Liang, Sidney, Robinson, Ralph P, Telliez, Jean-Baptiste, Unwalla, Ray, Yang, Xin, Thorarensen, Atli

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Implementation of combined approaches to quantify plasma protein binding of bRo5 compounds von Li, Na, Taylor, Simon, Davoren, Jennifer, Diner, Colin, Wang, Yi, Han, Chunyan, Jiao, Xingjin, Xu, Mandy, Thorarensen, Atli

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Target the More Druggable Protein States in a Highly Dynamic Protein–Protein Interaction System von Guo, Zuojun, Thorarensen, Atli, Che, Jianwei, Xing, Li

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Structural basis for CCR6 modulation by allosteric antagonists von Wasilko, David Jonathan, Gerstenberger, Brian S., Farley, Kathleen A., Li, Wei, Alley, Jennifer, Schnute, Mark E., Unwalla, Ray J., Victorino, Jorge, Crouse, Kimberly K., Ding, Ru, Sahasrabudhe, Parag V., Vincent, Fabien, Frisbie, Richard K., Dermenci, Alpay, Flick, Andrew, Choi, Chulho, Chinigo, Gary, Mousseau, James J., Trujillo, John I., Nuhant, Philippe, Mondal, Prolay, Lombardo, Vincent, Lamb, Daniel, Hogan, Barbara J., Minhas, Gurdeep Singh, Segala, Elena, Oswald, Christine, Windsor, Ian W., Han, Seungil, Rappas, Mathieu, Cooke, Robert M., Calabrese, Matthew F., Berstein, Gabriel, Thorarensen, Atli, Wu, Huixian

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A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation von Gierse, James, Thorarensen, Atli, Beltey, Konstantine, Bradshaw-Pierce, Erica, Cortes-Burgos, Luz, Hall, Troii, Johnston, Amy, Murphy, Michael, Nemirovskiy, Olga, Ogawa, Shinji, Pegg, Lyle, Pelc, Matthew, Prinsen, Michael, Schnute, Mark, Wendling, Jay, Wene, Steve, Weinberg, Robin, Wittwer, Arthur, Zweifel, Ben, Masferrer, Jaime

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Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters von Trujillo, John I., Kiefer, James R., Huang, Wei, Day, Jacqueline E., Moon, Joseph, Jerome, Gina M., Bono, Christine P., Kornmeier, Christine M., Williams, Melanie L., Kuhn, Cyrille, Rennie, Glen R., Wynn, Thomas A., Carron, Christopher P., Thorarensen, Atli

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The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal ch... von Thorarensen, Atli, Balbo, Paul, Banker, Mary E., Czerwinski, Robert M., Kuhn, Max, Maurer, Tristan S., Telliez, Jean-Baptiste, Vincent, Fabien, Wittwer, Arthur J.

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Tandem [4 + 2]/[3 + 2] Cycloadditions of Nitroalkenes. 11. The Synthesis of (+)-Crotanecine von Denmark, Scott E, Thorarensen, Atli

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PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor von Xu, Hua, Jesson, Michael I, Seneviratne, Uthpala I, Lin, Tsung H, Sharif, M. Nusrat, Xue, Liang, Nguyen, Chuong, Everley, Robert A, Trujillo, John I, Johnson, Douglas S, Point, Gary R, Thorarensen, Atli, Kilty, Iain, Telliez, Jean-Baptiste

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From in silico to in Vitro to In Vivo : Increasing Megakaryocytes to Treat Thrombocytopenia von Macias, Alejandra, Cortes, Mauricio, An, Na, Li, Na, Fulton, Timothy, Simpson, Allison, Miller, Samuel, Sun, Sunny, Fu, Doris, Garcia, Juan, Medicherla, Satya, Steelman, Scott, Thorarensen, Atli, Goddeeris, Matthew, Krishnamoorthy, Sriram

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Human serum albumin binding assay based on displacement of a non selective fluorescent inhibitor von Thorarensen, Atli, Sarver, Ronald W., Tian, Fang, Ho, Andrea, Romero, Donna L., Marotti, Keith R.

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Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition von Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli

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Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS) von Carron, Chris P, Trujillo, John I, Olson, Kirk L, Huang, Wei, Hamper, Bruce C, Dice, Tom, Neal, Bradley E, Pelc, Matthew J, Day, Jacqueline E, Rohrer, Douglas C, Kiefer, James R, Moon, Joseph B, Schweitzer, Barbara A, Blake, Tanisha D, Turner, Steve R, Woerndle, Rhonda, Case, Brenda L, Bono, Christine P, Dilworth, Vickie M, Funckes-Shippy, Christie L, Hood, Becky L, Jerome, Gina M, Kornmeier, Christine M, Radabaugh, Melissa R, Williams, Melanie L, Davies, Michael S, Wegner, Craig D, Welsch, Dean J, Abraham, William M, Warren, Chad J, Dowty, Martin E, Hua, Fengmei, Zutshi, Anup, Yang, Jerry Z, Thorarensen, Atli

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Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms von Leung, Louis, Yang, Xin, Strelevitz, Timothy J, Montgomery, Justin, Brown, Matthew F, Zientek, Michael A, Banfield, Christopher, Gilbert, Adam M, Thorarensen, Atli, Dowty, Martin E

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A Novel C-C Chemoattractant Cytokine (Chemokine) Receptor 6 (CCR6) Antagonist (PF-07054894) Distinguishes between Homologous Chemokine Receptors, Increases Basal Circulating CCR6+... von Li, Wei, Crouse, Kimberly K, Alley, Jennifer, Frisbie, Richard K, Fish, Susan C, Andreyeva, Tatyana A, Reed, Lori A, Thorn, Mitchell, DiMaggio, Giovanni, Donovan, Carol B, Bennett, Donald, Garren, Jeonifer, Oziolor, Elias, Qian, Jesse, Newman, Leah, Vargas, Amanda P., Kumpf, Steven W., Steyn, Stefan J, Schnute, Mark E, Thorarensen, Atli, Hegen, Martin, Stevens, Erin, Collinge, Mark, Lanz, Thomas A, Vincent, Fabien, Vincent, Michael S, Berstein, Gabriel

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Tandem [4 + 2]/[3 + 2] Cycloadditions of Nitroalkenes. 9. Synthesis of (−)-Rosmarinecine von Denmark, Scott E, Thorarensen, Atli, Middleton, Donald S

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ATP-Mediated Kinome Selectivity: The Missing Link in Understanding the Contribution of Individual JAK Kinase Isoforms to Cellular Signaling von Thorarensen, Atli, Banker, Mary Ellen, Fensome, Andrew, Telliez, Jean-Baptiste, Juba, Brian, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin

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Chiral Benzoquinones as a New Class of Ligands for Asymmetric Catalysis:  Synthesis and Application to the Palladium(II)-Catalyzed 1,4-Dialkoxylation of 1,3-Dienes von Itami, Kenichiro, Palmgren, Andreas, Thorarensen, Atli, Bäckvall, Jan-E

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Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoi... von Schnute, Mark E, Wennerstål, Mattias, Alley, Jennifer, Bengtsson, Martin, Blinn, James R, Bolten, Charles W, Braden, Timothy, Bonn, Tomas, Carlsson, Bo, Caspers, Nicole, Chen, Ming, Choi, Chulho, Collis, Leon P, Crouse, Kimberly, Färnegårdh, Mathias, Fennell, Kimberly F, Fish, Susan, Flick, Andrew C, Goos-Nilsson, Annika, Gullberg, Hjalmar, Harris, Peter K, Heasley, Steven E, Hegen, Martin, Hromockyj, Alexander E, Hu, Xiao, Husman, Bolette, Janosik, Tomasz, Jones, Peter, Kaila, Neelu, Kallin, Elisabet, Kauppi, Björn, Kiefer, James R, Knafels, John, Koehler, Konrad, Kruger, Lars, Kurumbail, Ravi G, Kyne, Jr, Robert E, Li, Wei, Löfstedt, Joakim, Long, Scott A, Menard, Carol A, Mente, Scot, Messing, Dean, Meyers, Marvin J, Napierata, Lee, Nöteberg, Daniel, Nuhant, Philippe, Pelc, Matthew J, Prinsen, Michael J, Rhönnstad, Patrik, Backström-Rydin, Eva, Sandberg, Johnny, Sandström, Maria, Shah, Falgun, Sjöberg, Maria, Sundell, Aron, Taylor, Alexandria P, Thorarensen, Atli, Trujillo, John I, Trzupek, John D, Unwalla, Ray, Vajdos, Felix F, Weinberg, Robin A, Wood, David C, Xing, Li, Zamaratski, Edouard, Zapf, Christoph W, Zhao, Yajuan, Wilhelmsson, Anna, Berstein, Gabriel

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