Discovery and Optimization of Potent and Orally Available CTP Synthetase Inhibitors for Use in Treatment of Diseases Driven by Aberrant Immune Cell Proliferation von Novak, Andrew, Laughton, David, Lane, Rebecca, Blackham, Emma, Thomas, Jennifer, Chatzopoulou, Elli, Wrigglesworth, Joseph, Quddus, Abdul, Ahmed, Saleh, Cousin, David, Duffy, Lorna, Dubois, Nathalie, Unitt, John, Orban, Katalin, Browne, Edward, Ward, Michelle, Mycock, David, Ieva, Maria, Bland, Nicholas, George, Pascal, Bourne, Timothy, Asnagli, Hélène, Birch, Louise, Jones, Geraint

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Selective pharmacologic targeting of CTPS1 shows single-agent activity and synergizes with BCL2 inhibition in aggressive mantle cell lymphoma von Durand, Romane, Bellanger, Céline, Kervoëlen, Charlotte, Tessoulin, Benoit, Dousset, Christelle, Menoret, Emmanuelle, Asnagli, Hélène, Parker, Andrew, Beer, Philip, Pellat-Deceunynck, Catherine, Chiron, David

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Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice von Soudais, Claire, Schaus, Romane, Bachelet, Camille, Minet, Norbert, Mouasni, Sara, Garcin, Cécile, Souza, Caique Lopes, David, Pierre, Cousu, Clara, Asnagli, Hélène, Parker, Andrew, Palmquist-Gomes, Paul, Sepulveda, Fernando E., Storck, Sébastien, Meilhac, Sigolène M., Fischer, Alain, Martin, Emmanuel, Latour, Sylvain

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CTPS1 is a novel therapeutic target in multiple myeloma which synergizes with inhibition of CHEK1, ATR or WEE1 von Pfeiffer, Christina, Grandits, Alexander M., Asnagli, Hélène, Schneller, Anja, Huber, Julia, Zojer, Niklas, Schreder, Martin, Parker, Andrew E., Bolomsky, Arnold, Beer, Philip A., Ludwig, Heinz

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Differential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation von Minet, Norbert, Boschat, Anne-Claire, Lane, Rebecca, Laughton, David, Beer, Philip, Asnagli, Hélène, Soudais, Claire, Bourne, Tim, Fischer, Alain, Martin, Emmanuel, Latour, Sylvain

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CTP Synthase 1 Is a Novel Therapeutic Target in Lymphoma von Asnagli, Hélène, Minet, Norbert, Pfeiffer, Christina, Hoeben, Eef, Lane, Rebecca, Laughton, David, Birch, Louise, Jones, Geraint, Novak, Andrew, Parker, Andrew E., Ludwig, Heinz, Fischer, Alain, Latour, Sylvain, Beer, Philip A.

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Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis von Asnagli, Hélène, Martire, Delphine, Belmonte, Nathalie, Quentin, Julie, Bastian, Hervé, Boucard-Jourdin, Mathilde, Fall, Papa Babacar, Mausset-Bonnefont, Anne-Laure, Mantello-Moreau, Amélie, Rouquier, Sandrine, Marchetti, Irène, Jorgensen, Christian, Foussat, Arnaud, Louis-Plence, Pascale

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Combined inhibition of CTPS1 and ATR is a metabolic vulnerability in p53‐deficient myeloma cells von Durand, Romane, Bellanger, Céline, Descamps, Géraldine, Dousset, Christelle, Maïga, Sophie, Derrien, Jennifer, Thirouard, Laura, Bouard, Louise, Asnagli, Hélène, Beer, Philip, Parker, Andrew, Gomez‐Bougie, Patricia, Devilder, Marie‐Claire, Moreau, Philippe, Touzeau, Cyrille, Moreau‐Aubry, Agnès, Chiron, David, Pellat‐Deceunynck, Catherine

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Cutting Edge: Identification of an Alternative GATA-3 Promoter Directing Tissue-Specific Gene Expression in Mouse and Human von Asnagli, Helene, Afkarian, Maryam, Murphy, Kenneth M

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Regulatory T Cell Therapy for Uveitis: A New Promising Challenge von Foussat, Arnaud, Gregoire, Sylvie, Clerget-Chossat, Nathalie, Terrada, Celine, Asnagli, Hélène, Lemoine, François M, Klatzmann, David, LeHoang, Phuc, Forte, Miguel, Bodaghi, Bahram

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Inhibition of Noninfectious Uveitis Using Intravenous Administration of Collagen II-Specific Type 1 Regulatory T Cells von Asnagli, Hélène, Jacquin, Marie, Belmonte, Nathalie, Gertner-Dardenne, Julie, Hubert, Marie-Françoise, Sales, André, Fall, Papa Babacar, Ginet, Clémence, Marchetti, Irène, Ménard, Frédérique, Lara, Grégory, Bobak, Nicole, Foussat, Arnaud

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Signaling and Transcription in T Helper Development von Murphy, Kenneth M, Ouyang, Wenjun, Farrar, J. David, Yang, Jianfei, Ranganath, Sheila, Asnagli, Helene, Afkarian, Maryam, Murphy, Theresa L

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Injection of antigen-specific regulatory Tr1 lymphocytes protects mice from severe collagen-induced arthritis von Martire, Delphine, Quentin, Julie, Mausset-Bonnefont, Anne-Laure, Asnagli, Hélène, Belmonte, Nathalie, Foussat, Arnaud, Jorgensen, Christian, Louis-Plence, Pascale

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A Phase 1/2 Study of STP938, a First in Class Inhibitor of CTP Synthase 1, in Patients with Relapsed/Refractory B or T Cell Lymphoma von Beer, Philip, Higgins, Maureen, Asnagli, Hélène, Hoeben, Eef, Hubank, Michael, Parker, Andrew, Schwartz, Brian

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Inducible Treg cell populations as cell based-therapy for rheumatoid arthritis von Martire, Delphine, Quentin, Julie, Mausset-Bonnefont, Anne-Laure, Asnagli, Hélène, Belmonte, Nathalie, Foussat, Arnaud, Jorgensen, Christian, Louis-Plence, Pascale

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Selective pharmacologic targeting of CTPS1 shows singleagent activity and synergizes with BCL2 inhibition in aggressive mantle cell lymphoma von Durand, Romane, Bellanger, Céline, Kervoëlen, Charlotte, Tessoulin, Benoit, Dousset, Christelle, Menoret, Emmanuelle, Asnagli, Hélène, Parker, Andrew, Beer, Philip, Pellat-Deceunynck, Catherine, Chiron, David

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STP938, a Selective CTPS1 Inhibitor, Shows Single Agent Activity and Synergy with BCL2 Inhibition in Preclinical Models of Mantle Cell Lymphoma von Chiron, David, Menoret, Emmanuelle, Kervoelen, Charlotte, Maïga, Sophie, Bellanger, Celine, Tessoulin, Benoit, Touzeau, Cyrille, Asnagli, Hélène, Parker, Andy, Beer, Philip, Pellat-Deceunynck, Catherine

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CTPS1 Is a Novel Therapeutic Target in Multiple Myeloma That Synergizes with Inhibition of ATR, CHEK1 or WEE1 von Pfeiffer, Christina, Grandits, Alexander Michael, Asnagli, Hélène, Schneller, Anja, Huber, Julia, Zojer, Niklas, Schreder, Martin, Parker, Andrew, Bolomsky, Arnold, Beer, Philip, Ludwig, Heinz

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P-096: Tackling pyrimidine biosynthesis - CTP Synthase 1 is a novel target in the treatment of multiple myeloma von Pfeiffer, Christina, Bolomsky, Arnold, Zojer, Niklas, Schreder, Martin, Asnagli, Hélène, Parker, Andrew, Ludwig, Heinz

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Consequences of Intrathymic TCR Engagement by Partial Agonist on Selection Events and Peripheral T Cell Activation Program von Auphan, Nathalie, Simon, Anna Katharina, Asnagli, Helene, Phillips, Roderick J, Rincon, Mercedes, Ghosh, Sankar, Flavell, Richard A, Schmitt-Verhulst, Anne-Marie

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