OC-0236: DTP-006: a novel, orally bioavailable hypoxia-activated prodrug von Niemans, R, Yaromina, A, Theys, J, Ashoorzadeh, A, Anderson, R, Bull, M, Guise, C, Hsu, H.L, Abbattista, M, Mowday, A, Patterson, A.V, Smaill, J.B, Ackerley, D.F, Dubois, L, Lambin, P

Volltext

129 (PB117): Harnessing hypoxia: CP-506’s journey from bench to bedside in cancer therapy von Liu, E., Jackson-Patel, V., Ashoorzadeh, A., Lin, X., Fu, Z., Hermans, I., Lambin, P., Smaill, J., Patterson, A.

Volltext

OC-0562: Exploiting tumor DNA repair status and hypoxia with CP-506, a novel hypoxia-activated prodrug von Van der Wiel, A., Marcus, D., Niemans, R., Yaromina, A., Theys, J., Mowday, A., Ashoorzadeh, A., Anderson, R., Bull, M., Abbattista, M., Heyerick, A., Guise, C., Smaill, J., Patterson, A., Dubois, L., Lambin, P.

Volltext

A Convergent Enantioselective Synthesis of the Anti-Malarial Agent (+)-Febrifugine von Ashoorzadeh, Amir, Caprio, Vittorio

Volltext

OC-0591: Hypoxic cell killing by SN36506, a novel hypoxia-activated prodrug von Niemans, R., Yaromina, A., Theys, J., Ashoorzadeh, A., Anderson, R., Bull, M., Guise, C., Hsu, H.L., Abbattista, M., Mowday, A., Patterson, A.V., Smaill, J.B., Dubois, L., Lambin, P.

Volltext

EP-2327: Hypoxic cell killing by CP-506, a novel hypoxia-activated prodrug von Niemans, R., Yaromina, A., Theys, J., Marcus, D., Ashoorzadeh, A., Abbattista, M., Mowday, A., Biemans, R., Lieuwes, N., Deschoemaeker, S., Heyerick, A., Guise, C., Smaill, J.B., Patterson, A.V., Dubois, L., Lambin, P.

Volltext

305 POSTER Structure–activity relationships for lipophilic dinitrobenzamide mustards as prodrugs for Escherichia coli NfsB nitroreductase von Sydall, S, Ashoorzadeh, A, Atwell, G.A, Smaill, J.B, Wilson, W.R, Denny, W.A, Patterson, A.V

Volltext

The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia von Toscan, CE, McCalmont, H, Ashoorzadeh, A, Lin, X, Fu, Z, Doculara, L, Kosasih, HJ, Cadiz, R, Zhou, A, Williams, S, Evans, K, Khalili, F, Cai, R, Yeats, KL, Gifford, AJ, Pickford, R, Mayoh, C, Xie, J, Henderson, MJ, Trahair, TN, Patterson, AV, Smaill, JB, de Bock, CE, Lock, RB

Volltext bestellen

Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours von Mowday, Alexandra M., Dubois, Ludwig J., Kubiak, Aleksandra M., Chan-Hyams, Jasmine V. E., Guise, Christopher P., Ashoorzadeh, Amir, Lambin, Philippe, Ackerley, David F., Smaill, Jeff B., Minton, Nigel P., Theys, Jan, Patterson, Adam V.

Volltext

Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug von Rich, Michelle H., Sharrock, Abigail V., Ashoorzadeh, Amir, Patterson, Adam V., Smaill, Jeff B., Ackerley, David F.

Volltext

The dinitrobenzamide mustard prodrugs, PR-104A and SN27686, for use in a novel MNDEPT cancer prodrug therapy approach von Ball, Patrick, Thompson, Emma, Anderson, Simon, Gwenin, Vanessa, Ashoorzadeh, Amir, Smaill, Jeff, Gwenin, Chris

Volltext

Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling von Jackson-Patel, Victoria, Liu, Emily, Bull, Matthew R, Ashoorzadeh, Amir, Bogle, Gib, Wolfram, Anna, Hicks, Kevin O, Smaill, Jeff B, Patterson, Adam V

Volltext

The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia von Lock, Richard B., Toscan, Cara E, McCalmont, Hannah, Evans, Kathryn, Doculara, Louise, Kosasih, Hansen J, Gifford, Andrew J, Ashoorzadeh, Amir, Lin, Xiaojing, Trahair, Toby N, De Bock, Charles E, Patterson, Adam V, Smaill, Jeff B

Volltext

The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia von Toscan, Cara E., McCalmont, Hannah, Ashoorzadeh, Amir, Lin, Xiaojing, Fu, Zhe, Doculara, Louise, Kosasih, Hansen J., Cadiz, Roxanne, Zhou, Anthony, Williams, Sarah, Evans, Kathryn, Khalili, Faezeh, Cai, Ruilin, Yeats, Kristy L., Gifford, Andrew J., Pickford, Russell, Mayoh, Chelsea, Xie, Jinhan, Henderson, Michelle J., Trahair, Toby N., Patterson, Adam V., Smaill, Jeff B., de Bock, Charles E., Lock, Richard B.

Volltext

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy von Copp, Janine N., Mowday, Alexandra M., Williams, Elsie M., Guise, Christopher P., Ashoorzadeh, Amir, Sharrock, Abigail V., Flanagan, Jack U., Smaill, Jeff B., Patterson, Adam V., Ackerley, David F.

Volltext

Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3 von Abbattista, Maria R, Ashoorzadeh, Amir, Guise, Christopher P, Mowday, Alexandra M, Mittra, Rituparna, Silva, Shevan, Hicks, Kevin O, Bull, Matthew R, Jackson-Patel, Victoria, Lin, Xiaojing, Prosser, Gareth A, Lambie, Neil K, Dachs, Gabi U, Ackerley, David F, Smaill, Jeff B, Patterson, Adam V

Volltext

Effect of One-Way Blunt Testis on Sperm Parameters in Acute and Chronic Periods after Injury in Mice von Pourentezari, Majid, Dehghan, Maryam, Ashoorzadeh, Sare, Talebi, Ali Reza

Volltext

Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications von Ashoorzadeh, Amir, Mowday, Alexandra M, Guise, Christopher P, Silva, Shevan, Bull, Matthew R, Abbattista, Maria R, Copp, Janine N, Williams, Elsie M, Ackerley, David F, Patterson, Adam V, Smaill, Jeff B

Volltext

Synthetic evaluation of an enantiopure tetrahydropyridine N-oxide. Synthesis of (+)-febrifugine von Ashoorzadeh, Amir, Archibald, Glenn, Caprio, Vittorio

Volltext

Selectively Targeting Tumor Hypoxia With the Hypoxia-Activated Prodrug CP-506 von van der Wiel, Alexander M A, Jackson-Patel, Victoria, Niemans, Raymon, Yaromina, Ala, Liu, Emily, Marcus, Damiënne, Mowday, Alexandra M, Lieuwes, Natasja G, Biemans, Rianne, Lin, Xiaojing, Fu, Zhe, Kumara, Sisira, Jochems, Arthur, Ashoorzadeh, Amir, Anderson, Robert F, Hicks, Kevin O, Bull, Matthew R, Abbattista, Maria R, Guise, Christopher P, Deschoemaeker, Sofie, Thiolloy, Sophie, Heyerick, Arne, Solivio, Morwena J, Balbo, Silvia, Smaill, Jeff B, Theys, Jan, Dubois, Ludwig J, Patterson, Adam V, Lambin, Philippe

Volltext