Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 von Mills, Evanna L., Ryan, Dylan G., Prag, Hiran A., Dikovskaya, Dina, Menon, Deepthi, Zaslona, Zbigniew, Jedrychowski, Mark P., Costa, Ana S. H., Higgins, Maureen, Hams, Emily, Szpyt, John, Runtsch, Marah C., King, Martin S., McGouran, Joanna F., Fischer, Roman, Kessler, Benedikt M., McGettrick, Anne F., Hughes, Mark M., Carroll, Richard G., Booty, Lee M., Knatko, Elena V., Meakin, Paul J., Ashford, Michael L. J., Modis, Louise K., Brunori, Gino, Sévin, Daniel C., Fallon, Padraic G., Caldwell, Stuart T., Kunji, Edmund R. S., Chouchani, Edward T., Frezza, Christian, Dinkova-Kostova, Albena T., Hartley, Richard C., Murphy, Michael P., O’Neill, Luke A.

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AMPK: regulating energy balance at the cellular and whole body levels von Hardie, D Grahame, Ashford, Michael L J

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The beta secretase BACE1 regulates the expression of insulin receptor in the liver von Meakin, Paul J., Mezzapesa, Anna, Benabou, Eva, Haas, Mary E., Bonardo, Bernadette, Grino, Michel, Brunel, Jean-Michel, Desbois-Mouthon, Christèle, Biddinger, Sudha B., Govers, Roland, Ashford, Michael L. J., Peiretti, Franck

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Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemically induced ty... von McNeilly, Alison D., Gallagher, Jennifer R., Evans, Mark L., de Galan, Bastiaan E., Pedersen-Bjergaard, Ulrik, Thorens, Bernard, Dinkova-Kostova, Albena T., Huang, Jeffrey-T., Ashford, Michael L. J., McCrimmon, Rory J.

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Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling von Reilly, Louise, Howie, Jacqueline, Wypijewski, Krzysztof, Ashford, Michael L. J., Hilgemann, Donald W., Fuller, William

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Correction: Chronic hyperglycaemia increases the vulnerability of the hippocampus to oxidative damage induced during post-hypoglycaemic hyperglycaemia in a mouse model of chemicall... von McNeilly, Alison D., Gallagher, Jennifer R., Evans, Mark L., de Galan, Bastiaan E., Pedersen-Bjergaard, Ulrik, Thorens, Bernard, Dinkova-Kostova, Albena T., Huang, Jeffrey-T., Ashford, Michael L. J., McCrimmon, Rory J.

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The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection von Chen, Changwei, Gallagher, Jennifer R, Tarlton, Jamie, van Aalten, Lidy, Bray, Susan E, Ashford, Michael L J, McCrimmon, Rory J, Pearson, Ewan R, McNeilly, Alison D, Sutherland, Calum

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Substrate recognition by the cell surface palmitoyl transferase DHHC5 von Howie, Jacqueline, Reilly, Louise, Fraser, Niall J., Walker, Julia M. Vlachaki, Wypijewski, Krzysztof J., Ashford, Michael L. J., Calaghan, Sarah C., McClafferty, Heather, Tian, Lijun, Shipston, Michael J., Boguslavskyi, Andrii, Shattock, Michael J., Fuller, William

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Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation von McGuire, Victoria A., Ruiz-Zorrilla Diez, Tamara, Emmerich, Christoph H., Strickson, Sam, Ritorto, Maria Stella, Sutavani, Ruhcha V., Weiβ, Anne, Houslay, Kirsty F., Knebel, Axel, Meakin, Paul J., Phair, Iain R., Ashford, Michael L. J., Trost, Matthias, Arthur, J. Simon C.

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Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation von Meakin, Paul J, Morrison, Vicky L, Sneddon, Claire C, Savinko, Terhi, Uotila, Liisa, Jalicy, Susan M, Gabriel, Jennie L, Kang, Li, Ashford, Michael L J, Fagerholm, Susanna C

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Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes von Hamilton, D. Lee, Findlay, John A., Montagut, Gemma, Meakin, Paul J., Bestow, Dawn, Jalicy, Susan M., Ashford, Michael L. J.

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Nrf2-Mediated Neuroprotection Against Recurrent Hypoglycemia Is Insufficient to Prevent Cognitive Impairment in a Rodent Model of Type 1 Diabetes von McNeilly, Alison D, Gallagher, Jennifer R, Dinkova-Kostova, Albena T, Hayes, John D, Sharkey, John, Ashford, Michael L J, McCrimmon, Rory J

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The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis von Deldicque, Louise, Cani, Patrice D, Philp, Andrew, Raymackers, Jean-Marc, Meakin, Paul J, Ashford, Michael L J, Delzenne, Nathalie M, Francaux, Marc, Baar, Keith

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High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents von McNeilly, Alison D, Gallagher, Jennifer R, Huang, Jeffrey T-J, Ashford, Michael L J, McCrimmon, Rory J

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Identification of Caveolar Resident Proteins in Ventricular Myocytes Using a Quantitative Proteomic Approach: Dynamic Changes in Caveolar Composition Following Adrenoceptor Activat... von Wypijewski, Krzysztof J., Tinti, Michele, Chen, Wenzhang, Lamont, Douglas, Ashford, MichaelL.J., Calaghan, Sarah C., Fuller, William

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Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice von Meakin, Paul J., Jalicy, Susan M., Montagut, Gemma, Allsop, David J. P., Cavellini, Daniella L., Irvine, Stuart W., McGinley, Christopher, Liddell, Mary K., McNeilly, Alison D., Parmionova, Karolina, Liu, Yu-Ru, Bailey, Charlotte L. S., Dale, J. Kim, Heisler, Lora K., McCrimmon, Rory J., Ashford, Michael L. J.

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Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Resp... von Meakin, Paul J., Chowdhry, Sudhir, Sharma, Ritu S., Ashford, Fiona B., Walsh, Shaun V., McCrimmon, Rory J., Dinkova-Kostova, Albena T., Dillon, John F., Hayes, John D., Ashford, Michael L. J.

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Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP-independent control of ATP-sensitive K+ channels von Ainscow, Edward K., Mirshamsi, Shirin, Tang, Teresa, Ashford, Michael L. J., Rutter, Guy A.

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Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 von Bell, Karen F.S., Al-Mubarak, Bashayer, Martel, Marc-André, McKay, Sean, Wheelan, Nicola, Hasel, Philip, Márkus, Nóra M., Baxter, Paul, Deighton, Ruth F., Serio, Andrea, Bilican, Bilada, Chowdhry, Sudhir, Meakin, Paul J., Ashford, Michael L.J., Wyllie, David J.A., Scannevin, Robert H., Chandran, Siddharthan, Hayes, John D., Hardingham, Giles E.

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Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2) von Sharma, Ritu S, Harrison, David J, Kisielewski, Dorothy, Cassidy, Diane M, McNeilly, Alison D, Gallagher, Jennifer R, Walsh, Shaun V, Honda, Tadashi, McCrimmon, Rory J, Dinkova-Kostova, Albena T, Ashford, Michael L.J, Dillon, John F, Hayes, John D

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