KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance von Ash, Leonard J, Busia-Bourdain, Ottavia, Okpattah, Daniel, Kamel, Avrosina, Liberchuk, Ariel, Wolfe, Andrew L

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Spontaneous hydrolysis and spurious metabolic properties of α-ketoglutarate esters von Parker, Seth J., Encarnación-Rosado, Joel, Hollinshead, Kate E. R., Hollinshead, David M., Ash, Leonard J., Rossi, Juan A. K., Lin, Elaine Y., Sohn, Albert S. W., Philips, Mark R., Jones, Drew R., Kimmelman, Alec C.

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Destabilized 3'UTR elements therapeutically degrade ERBB2 mRNA in drug-resistant ERBB2+ cancer models von Awah, Chidiebere U, Glemaud, Yana, Levine, Fayola, Yang, Kiseok, Ansary, Afrin, Dong, Fu, Ash, Leonard, Zhang, Junfei, Ogunwobi, Olorunseun O

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Metabolomic Expression of Laryngeal and Hindlimb Muscles in Adult versus Senescent Rats von Shembel, Adrianna C., Siu, Yik, Lhakhang, Tenzin, Ash, Leonard, Jones, Drew, Johnson, Aaron M.

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Abstract 1788: Engineered destabilized AU rich elements on the 3UTR of HER2 degrades HER2, inhibits proliferation, and induces apoptosis in HER2 positive trastuzumab resistant brea... von Awah, Chidiebere U., Dong, Fu, Levine, Fayola, Ash, Leonard, Glemaud, Yana, Ogunwobi, Olorunseun

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Cement mixer with removable mixing blade von LEONARD JOHN ASH, PETER DENNIS

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Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS von Ash, Peter E.A., Bieniek, Kevin F., Gendron, Tania F., Caulfield, Thomas, Lin, Wen-Lang, DeJesus-Hernandez, Mariely, van Blitterswijk, Marka M., Jansen-West, Karen, Paul, Joseph W., Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

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Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS von Gendron, Tania F., Bieniek, Kevin F., Zhang, Yong-Jie, Jansen-West, Karen, Ash, Peter E. A., Caulfield, Thomas, Daughrity, Lillian, Dunmore, Judith H., Castanedes-Casey, Monica, Chew, Jeannie, Cosio, Danielle M., van Blitterswijk, Marka, Lee, Wing C., Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

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Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress von Zhang, Yong-Jie, Jansen-West, Karen, Xu, Ya-Fei, Gendron, Tania F., Bieniek, Kevin F., Lin, Wen-Lang, Sasaguri, Hiroki, Caulfield, Thomas, Hubbard, Jaime, Daughrity, Lillian, Chew, Jeannie, Belzil, Veronique V., Prudencio, Mercedes, Stankowski, Jeannette N., Castanedes-Casey, Monica, Whitelaw, Ena, Ash, Peter E. A., DeTure, Michael, Rademakers, Rosa, Boylan, Kevin B., Dickson, Dennis W., Petrucelli, Leonard

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Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity von Vanderweyde, Tara, Apicco, Daniel J., Youmans-Kidder, Katherine, Ash, Peter E.A., Cook, Casey, Lummertz da Rocha, Edroaldo, Jansen-West, Karen, Frame, Alissa A., Citro, Allison, Leszyk, John D., Ivanov, Pavel, Abisambra, Jose F., Steffen, Martin, Li, Hu, Petrucelli, Leonard, Wolozin, Benjamin

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TIA1 regulates the generation and response to toxic tau oligomers von Jiang, Lulu, Ash, Peter E. A., Maziuk, Brandon F., Ballance, Heather I., Boudeau, Samantha, Abdullatif, Ali Al, Orlando, Marcello, Petrucelli, Leonard, Ikezu, Tsuneya, Wolozin, Benjamin

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Neurotoxic effects of TDP-43 overexpression in C. elegans von Ash, Peter E.A., Zhang, Yong-Jie, Roberts, Christine M., Saldi, Tassa, Hutter, Harald, Buratti, Emanuele, Petrucelli, Leonard, Link, Christopher D.

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MAGNETIC ACTUATOR von LEONARD P. ASH, JOSEPH A. GARRATT

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TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans von Vaccaro, Alexandra, Tauffenberger, Arnaud, Ash, Peter E A, Carlomagno, Yari, Petrucelli, Leonard, Parker, J Alex

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TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau von Ash, Peter E. A., Lei, Shuwen, Shattuck, Jenifer, Boudeau, Samantha, Carlomagno, Yari, Medalla, Maria, Mashimo, Bryce L., Socorro, Guillermo, Al-Mohanna, Louloua F. A., Jiang, Lulu, Öztürk, Muhammet M., Knobel, Mark, Ivanov, Pavel, Petrucelli, Leonard, Wegmann, Susanne, Kanaan, Nicholas M., Wolozin, Benjamin

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TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA von Saldi, Tassa K, Ash, Peter EA, Wilson, Gavin, Gonzales, Patrick, Garrido-Lecca, Alfonso, Roberts, Christine M, Dostal, Vishantie, Gendron, Tania F, Stein, Lincoln D, Blumenthal, Thomas, Petrucelli, Leonard, Link, Christopher D

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Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis von Wu, Chi-Hong, Fallini, Claudia, Ticozzi, Nicola, Keagle, Pamela J., Sapp, Peter C., Piotrowska, Katarzyna, Lowe, Patrick, Koppers, Max, McKenna-Yasek, Diane, Baron, Desiree M., Kost, Jason E., Gonzalez-Perez, Paloma, Fox, Andrew D., Adams, Jenni, Taroni, Franco, Tiloca, Cinzia, Leclerc, Ashley Lyn, Chafe, Shawn C., Mangroo, Dev, Moore, Melissa J., Zitzewitz, Jill A., Xu, Zuo-Shang, van den Berg, Leonard H., Glass, Jonathan D., Siciliano, Gabriele, Cirulli, Elizabeth T., Goldstein, David B., Salachas, Francois, Meininger, Vincent, Rossoll, Wilfried, Ratti, Antonia, Gellera, Cinzia, Bosco, Daryl A., Bassell, Gary J., Silani, Vincenzo, Drory, Vivian E., Brown Jr, Robert H., Landers, John E.

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Interaction of tau with HNRNPA2B1 and N 6 -methyladenosine RNA mediates the progression of tauopathy von Jiang, Lulu, Lin, Weiwei, Zhang, Cheng, Ash, Peter E A, Verma, Mamta, Kwan, Julian, van Vliet, Emily, Yang, Zhuo, Cruz, Anna Lourdes, Boudeau, Samantha, Maziuk, Brandon F, Lei, Shuwen, Song, Jaehyup, Alvarez, Victor E, Hovde, Stacy, Abisambra, Jose F, Kuo, Min-Hao, Kanaan, Nicholas, Murray, Melissa E, Crary, John F, Zhao, Jian, Cheng, Ji-Xin, Petrucelli, Leonard, Li, Hu, Emili, Andrew, Wolozin, Benjamin

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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity von Zhang, Yong-Jie, Xu, Ya-Fei, Cook, Casey, Gendron, Tania F, Roettges, Paul, Link, Christopher D, Lin, Wen-Lang, Tong, Jimei, Castanedes-Casey, Monica, Ash, Peter, Gass, Jennifer, Rangachari, Vijayaraghavan, Buratti, Emanuele, Baralle, Francisco, Golde, Todd E, Dickson, Dennis W, Petrucelli, Leonard

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The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins von Dickey, Chad A, Kamal, Adeela, Lundgren, Karen, Klosak, Natalia, Bailey, Rachel M, Dunmore, Judith, Ash, Peter, Shoraka, Sareh, Zlatkovic, Jelena, Eckman, Christopher B, Patterson, Cam, Dickson, Dennis W, Nahman, Jr, N Stanley, Hutton, Michael, Burrows, Francis, Petrucelli, Leonard

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