Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents von Chackalamannil, Samuel, Xia, Yan, Greenlee, William J, Clasby, Martin, Doller, Darìo, Tsai, Hsingan, Asberom, Theodros, Czarniecki, Michael, Ahn, Ho-Sam, Boykow, George, Foster, Carolyn, Agans-Fantuzzi, Jacqueline, Bryant, Matthew, Lau, Janice, Chintala, Madhu

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Muscarinic agonists and antagonists in the treatment of Alzheimer's disease von Greenlee, W, Clader, J, Asberom, T, McCombie, S, Ford, J, Guzik, H, Kozlowski, J, Li, S, Liu, C, Lowe, D, Vice, S, Zhao, H, Zhou, G, Billard, W, Binch, H, Crosby, R, Duffy, R, Lachowicz, J, Coffin, V, Watkins, R, Ruperto, V, Strader, C, Taylor, L, Cox, K

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Total Synthesis of (+)-Himbacine and (+)-Himbeline von Chackalamannil, Samuel, Davies, Robert J, Wang, Yuguang, Asberom, Theodros, Doller, Darío, Wong, Jesse, Leone, Daria, McPhail, Andrew T

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A Highly Efficient Total Synthesis of (+)-Himbacine von Chackalamannil, Samuel, Davies, Robert J, Asberom, Theodros, Doller, Darío, Leone, Daria

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Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED von Boyle, Craig D., Xu, Ruo, Asberom, Theodros, Chackalamannil, Samuel, Clader, John W., Greenlee, William J., Guzik, Henry, Hu, Yuequing, Hu, Zhiyong, Lankin, Claire M., Pissarnitski, Dmitri A., Stamford, Andrew W., Wang, Yuguang, Skell, Jeffrey, Kurowski, Stanley, Vemulapalli, Subbarao, Palamanda, Jairam, Chintala, Madhu, Wu, Ping, Myers, Joyce, Wang, Peng

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In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects von Cohen-Williams, Mary E., Leach, Prescott T., Del Vecchio, Robert A., Zhang, Qi, Hyde, Lynn A., Chen, Lei, Wong, Gwendolyn T., McHugh, Nansie A., Chen, Joseph, Higgins, Guy A., Asberom, Theodros, Li, Wei, Pissarnitski, Dmitri, Levitan, Diane, Nomeir, Amin A., Clader, John W., Zhang, Lili, Parker, Eric M.

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SAR development of polycyclic guanine derivatives targeted to the discovery of a selective PDE5 inhibitor for treatment of erectile dysfunction von PISSARNITSKI, Dmitri A, ASBEROM, Theodros, PALAMANDA, Jairam, STAMFORD, Andrew W, VEMULAPALLI, Subbarao, YUGUANG WANG, PENG WANG, PING WU, RUO XU, BOYLE, Craig D, CHACKALAMANNIL, Samuel, CHINTALA, Madhu, CLADER, John W, GREENLEE, William J, YUEQING HU, KUROWSKI, Stanley, MYERS, Joyce

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Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors von Wang, Yuguang, Chackalamannil, Samuel, Hu, Zhiyong, Boyle, Craig D, Lankin, Claire M, Xia, Yan, Xu, Ruo, Asberom, Theodros, Pissarnitski, Dmitri, Stamford, Andrew W, Greenlee, William J, Skell, Jeffrey, Kurowski, Stanley, Vemulapalli, Subbarao, Palamanda, Jairam, Chintala, Madhu, Wu, Ping, Myers, Joyce, Wang, Peng

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Synthesis and structure–Activity relationships of M 2-Selective muscarinic receptor ligands in the 1-[4-(4-Arylsulfonyl)-phenylmethyl]-4-(4-piperidinyl)-piperazine family von McCombie, Stuart W, Lin, Sue-Ing, Tagat, Jayaram R, Nazareno, Dennis, Vice, Susan, Ford, Jennifer, Asberom, Theodros, Leone, Daria, Kozlowski, Joseph A, Zhou, Guowei, Ruperto, Vilma B, Duffy, Ruth A, Lachowicz, Jean E

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The chemistry of cyclic vinyl ethers. 6. Total synthesis of polyether ionophore antibiotics of the calcimycin (A-23187) class von Boeckman, Robert K, Charette, Andre B, Asberom, Theodros, Johnston, Brian H

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A convergent general synthetic protocol for construction of spirocyclic ketal ionophores: an application to the total synthesis of (-)-A-23187 (calcimycin) von Boeckman, Robert K, Charette, Andre B, Asberom, Theodros, Johnston, Brian H

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The chemistry of cyclic vinyl ethers. VI, Total synthesis of polyether ionophore antibiotics of the calcimycin (A-23187) class von BOECKMAN, R. K, CHARETTE, A. B, ASBEROM, T, JOHNSTON, B. H

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Thrombin receptor antagonists von Y. XIA, S. CHACKALAMANNIL, T. ASBEROM

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ChemInform Abstract: A Highly Efficient Total Synthesis of (+)-Himbacine von CHACKALAMANNIL, S., DAVIES, R. J., ASBEROM, T., DOLLER, D., LEONE, D.

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Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo von Sun, Zhong-Yue, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane, Chu, Inhou, Clader, John, Cohen-Williams, Mary, Cole, David, Czarniecki, Michael, Durkin, James, Gallo, Gioconda, Greenlee, William, Josien, Hubert, Huang, Xianhai, Hyde, Lynn, Jones, Nicholas, Kazakevich, Irina, Li, Hongmei, Liu, Xiaoxiang, Lee, Julie, MacCoss, Malcolm, Mandal, Mihir B, McCracken, Troy, Nomeir, Amin, Mazzola, Robert, Palani, Anandan, Parker, Eric M, Pissarnitski, Dmitri A, Qin, Jun, Song, Lixin, Terracina, Giuseppe, Vicarel, Monica, Voigt, Johannes, Xu, Ruo, Zhang, Lili, Zhang, Qi, Zhao, Zhiqiang, Zhu, Xiaohong, Zhu, Zhaoning

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Identification of Presenilin 1-Selective γ-Secretase Inhibitors with Reconstituted γ-Secretase Complexes von Lee, Julie, Song, Lixin, Terracina, Giuseppe, Bara, Thomas, Josien, Hubert, Asberom, Theodros, Sasikumar, Thavalakulamgar K, Burnett, Duane A, Clader, John, Parker, Eric M, Zhang, Lili

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Efficient synthesis and reaction pathway studies of novel fused morpholine oxadiazolines for use as gamma secretase modulators von Huang, Xianhai, Pissarnitski, Dmitri, Li, Hongmei, Asberom, Theodros, Josien, Hubert, Zhu, Xiaohong, Vicarel, Monica, Zhao, Zhiqiang, Rajagopalan, Murali, Palani, Anandan, Aslanian, Robert, Zhu, Zhaoning, Greenlee, William, Buevich, Alexei

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Structure activity relationship studies of tricyclic bispyran sulfone γ-secretase inhibitors von Wu, Wen-Lian, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane A., Clader, John, Domalski, Martin, Greenlee, William J., Josien, Hubert, McBriar, Mark, Rajagopalan, Murali, Vicarel, Monica, Xu, Ruo, Hyde, Lynn A., Del Vecchio, Robert A., Cohen-Williams, Mary E., Song, Lixin, Lee, Julie, Terracina, Giuseppe, Zhang, Qi, Nomeir, Amin, Parker, Eric M., Zhang, Lili

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Design and synthesis of tricyclic sulfones as γ-secretase inhibitors with greatly reduced Notch toxicity von Xu, Ruo, Cole, David, Asberom, Ted, Bara, Tom, Bennett, Chad, Burnett, Duane A., Clader, John, Domalski, Martin, Greenlee, William, Hyde, Lynn, Josien, Hubert, Li, Hongmei, McBriar, Mark, McKittrick, Brian, McPhail, Andrew T., Pissarnitski, Dmitri, Qiang, Li, Rajagopalan, Murali, Sasikumar, Thavalakulamgar, Su, Jing, Tang, Haiqun, Wu, Wen-Lian, Zhang, Lili, Zhao, Zhiqiang

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Structure activity relationship studies of tricyclic bispyran sulfone [gamma]-secretase inhibitors von Wu, Wen-Lian, Asberom, Theodros, Bara, Thomas, Bennett, Chad, Burnett, Duane A, Clader, John, Domalski, Martin, Greenlee, William J, Josien, Hubert, McBriar, Mark, Rajagopalan, Murali, Vicarel, Monica, Xu, Ruo, Hyde, Lynn A, Del Vecchio, Robert A, Cohen-Williams, Mary E, Song, Lixin, Lee, Julie, Terracina, Giuseppe, Zhang, Qi, Nomeir, Amin, Parker, Eric M, Zhang, Lili

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