VISTA is an acidic pH-selective ligand for PSGL-1 von Johnston, Robert J., Su, Linhui Julie, Pinckney, Jason, Critton, David, Boyer, Eric, Krishnakumar, Arathi, Corbett, Martin, Rankin, Andrew L., Dibella, Rose, Campbell, Lynne, Martin, Gaelle H., Lemar, Hadia, Cayton, Thomas, Huang, Richard Y.-C., Deng, Xiaodi, Nayeem, Akbar, Chen, Haibin, Ergel, Burce, Rizzo, Joseph M., Yamniuk, Aaron P., Dutta, Sanjib, Ngo, Justine, Shorts, Andrea Olga, Ramakrishnan, Radha, Kozhich, Alexander, Holloway, Jim, Fang, Hua, Wang, Ying-Kai, Yang, Zheng, Thiam, Kader, Rakestraw, Ginger, Rajpal, Arvind, Sheppard, Paul, Quigley, Michael, Bahjat, Keith S., Korman, Alan J.

Volltext

Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions von Wang, Feng, Chau, Bryant, West, Sean M., Kimberlin, Christopher R., Cao, Fei, Schwarz, Flavio, Aguilar, Barbara, Han, Minhua, Morishige, Winse, Bee, Christine, Dollinger, Gavin, Rajpal, Arvind, Strop, Pavel

Volltext

Molecular Basis of Valine-Citrulline-PABC Linker Instability in Site-Specific ADCs and Its Mitigation by Linker Design von Dorywalska, Magdalena, Dushin, Russell, Moine, Ludivine, Farias, Santiago E, Zhou, Dahui, Navaratnam, Thayalan, Lui, Victor, Hasa-Moreno, Adela, Casas, Meritxell Galindo, Tran, Thomas-Toan, Delaria, Kathy, Liu, Shu-Hui, Foletti, Davide, O'Donnell, Christopher J, Pons, Jaume, Shelton, David L, Rajpal, Arvind, Strop, Pavel

Volltext

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire von Glanville, Jacob, Zhai, Wenwu, Berka, Jan, Telman, Dilduz, Huerta, Gabriella, Mehta, Gautam R, Ni, Irene, Mei, Li, Sundar, Purnima D, Day, Giles M.R, Cox, David, Rajpal, Arvind, Pons, Jaume

Volltext

Humanization of a strategic CD3 epitope enables evaluation of clinical T-cell engagers in a fully immunocompetent in vivo model von Zorn, Julie A., Wheeler, Matthew L., Barnes, Ralston M., Kaberna, Jim, Morishige, Winse, Harris, Marek, Huang, Richard Y.-C., Lohre, Jack, Chang, Yu Ching, Chau, Bryant, Powers, Kathleen, Schindler, Ian, Neradugomma, Naveen, Thomas, Winston, Liao, Xiaoyun, Zhou, Yinhan, West, Sean M., Wang, Feng, Kotapati, Srikanth, Chen, Guodong, Yamazoe, Sayumi, Kosenko, Anastasia, Dollinger, Gavin, Sproul, Tim, Rajpal, Arvind, Strop, Pavel

Volltext

High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with... von Abdiche, Yasmina Noubia, Miles, Adam, Eckman, Josh, Foletti, Davide, Van Blarcom, Thomas J, Yeung, Yik Andy, Pons, Jaume, Rajpal, Arvind

Volltext

Tim-3 mediates T cell trogocytosis to limit antitumor immunity von Pagliano, Ornella, Morrison, Robert M, Chauvin, Joe-Marc, Banerjee, Hridesh, Davar, Diwakar, Ding, Quanquan, Tanegashima, Tokiyoshi, Gao, Wentao, Chakka, Saranya R, DeBlasio, Richelle, Lowin, Ava, Kara, Kevin, Ka, Mignane, Zidi, Bochra, Amin, Rada, Raphael, Itay, Zhang, Shuowen, Watkins, Simon C, Sander, Cindy, Kirkwood, John M, Bosenberg, Marcus, Anderson, Ana C, Kuchroo, Vijay K, Kane, Lawrence P, Korman, Alan J, Rajpal, Arvind, West, Sean M, Han, Minhua, Bee, Christine, Deng, Xiaodi, Schebye, Xiao Min, Strop, Pavel, Zarour, Hassane M

Volltext

Anti–IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function von Lee, Li-Fen, Logronio, Kathryn, Tu, Guang Huan, Zhai, Wenwu, Ni, Irene, Mei, Li, Dilley, Jeanette, Yu, Jessica, Rajpal, Arvind, Brown, Colleen, Appah, Charles, Chin, Sherman Michael, Han, Bora, Affolter, Timothy, Lin, John C

Volltext

Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation von Glanville, Jacob, Kuo, Tracy C., von Büdingen, H.-Christian, Guey, Lin, Berka, Jan, Sundar, Purnima D., Huerta, Gabriella, Mehta, Gautam R., Oksenberg, Jorge R., Hauser, Stephen L., Cox, David R., Rajpal, Arvind, Pons, Jaume

Volltext

Universal Affinity Capture Liquid Chromatography-Mass Spectrometry Assay for Evaluation of Biotransformation of Site-Specific Antibody Drug Conjugates in Preclinical Studies von Kotapati, Srikanth, Passmore, David, Yamazoe, Sayumi, Sanku, Rajesh Kishore Kumar, Cong, Qiang, Poudel, Yam B, Chowdari, Naidu S, Gangwar, Sanjeev, Rao, Chetana, Rangan, Vangipuram S, Cardarelli, Pina M, Deshpande, Shrikant, Strop, Pavel, Dollinger, Gavin, Rajpal, Arvind

Volltext

Engineered ipilimumab variants that bind human and mouse CTLA-4 von Robison, Brett, Diong, S J, Kumar, Anusha, Moon, Thomas M, Chang, Olin, Chau, Bryant, Bee, Christine, Barman, Ishita, Rajpal, Arvind, Korman, Alan J, West, Sean, Strop, Pavel, Lee, Peter S

Volltext

Biophysical characterization of PVR family interactions and therapeutic antibody recognition to TIGIT von Diong, SJ J., Jashnani, Aarti, Drake, Andrew W., Bee, Christine, Findeisen, Felix, Dollinger, Gavin, Wang, Feng, Rajpal, Arvind, Strop, Pavel, Lee, Peter S.

Volltext

Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair von Strop, Pavel, Ho, Wei-Hsien, Boustany, Leila M., Abdiche, Yasmina N., Lindquist, Kevin C., Farias, Santiago E., Rickert, Mathias, Appah, Charles Takeshi, Pascua, Edward, Radcliffe, Teresa, Sutton, Janette, Chaparro-Riggers, Javier, Chen, Wei, Casas, Meritxell Galindo, Chin, Sherman Michael, Wong, Oi Kwan, Liu, Shu-Hui, Vergara, German, Shelton, Dave, Rajpal, Arvind, Pons, Jaume

Volltext

Determining the binding affinity of therapeutic monoclonal antibodies towards their native unpurified antigens in human serum von Bee, Christine, Abdiche, Yasmina N, Pons, Jaume, Rajpal, Arvind

Volltext

Proprotein Convertase Substilisin/Kexin Type 9 Antagonism Reduces Low-Density Lipoprotein Cholesterol in Statin-Treated Hypercholesterolemic Nonhuman Primates von Liang, Hong, Chaparro-Riggers, Javier, Strop, Pavel, Geng, Tao, Sutton, Janette E., Tsai, Daniel, Bai, Lanfang, Abdiche, Yasmina, Dilley, Jeanette, Yu, Jessica, Wu, Si, Chin, S. Michael, Lee, Nicole A., Rossi, Andrea, Lin, John C., Rajpal, Arvind, Pons, Jaume, Shelton, David L.

Volltext

Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire von Yeung, Yik Andy, Foletti, Davide, Deng, Xiaodi, Abdiche, Yasmina, Strop, Pavel, Glanville, Jacob, Pitts, Steven, Lindquist, Kevin, Sundar, Purnima D., Sirota, Marina, Hasa-Moreno, Adela, Pham, Amber, Melton Witt, Jody, Ni, Irene, Pons, Jaume, Shelton, David, Rajpal, Arvind, Chaparro-Riggers, Javier

Volltext

Improved therapeutic index of an acidic pH-selective antibody von Lee, Peter S, MacDonald, Katherine G, Massi, Evan, Chew, Pamela V, Bee, Christine, Perkins, Padma, Chau, Bryant, Thudium, Kent, Lohre, Jack, Nandi, Pradyot, Deyanova, Ekaterina G, Barman, Ishita, Gudmundsson, Olafur, Dollinger, Gavin, Sproul, Tim, Engelhardt, John J, Strop, Pavel, Rajpal, Arvind

Volltext

Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy von Dorywalska, Magdalena, Strop, Pavel, Melton-Witt, Jody A, Hasa-Moreno, Adela, Farias, Santiago E, Galindo Casas, Meritxell, Delaria, Kathy, Lui, Victor, Poulsen, Kris, Sutton, Janette, Bolton, Gary, Zhou, Dahui, Moine, Ludivine, Dushin, Russell, Tran, Thomas-Toan, Liu, Shu-Hui, Rickert, Mathias, Foletti, Davide, Shelton, David L, Pons, Jaume, Rajpal, Arvind

Volltext

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies von Shcherbatko, Anatoly, Foletti, Davide, Poulsen, Kris, Strop, Pavel, Zhu, Guoyun, Hasa-Moreno, Adela, Melton Witt, Jody, Loo, Carole, Krimm, Stellanie, Pios, Ariel, Yu, Jessica, Brown, Colleen, Lee, John K., Stroud, Robert, Rajpal, Arvind, Shelton, David

Volltext

A method for integrative structure determination of protein-protein complexes von SCHNEIDMAN-DUHOVNY, Dina, ROSSI, Andrea, SOBHANIFAR, Solmaz, DÖTSCH, Volker, RAJPAL, Arvind, PONS, Jaume, AGARD, David A, YIFAN CHENG, SALI, Andrej, AVILA-SAKAR, Agustin, SEUNG JOONG KIM, VELAZQUEZ-MURIEL, Javier, STROP, Pavel, HONG LIANG, KRUKENBERG, Kristin A, MAOFU LIAO, HO MIN KIM

Volltext