Itaconate: the poster child of metabolic reprogramming in macrophage function von O’Neill, Luke A. J., Artyomov, Maxim N.

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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization von Jha, Abhishek K., Huang, Stanley Ching-Cheng, Sergushichev, Alexey, Lampropoulou, Vicky, Ivanova, Yulia, Loginicheva, Ekaterina, Chmielewski, Karina, Stewart, Kelly M., Ashall, Juliet, Everts, Bart, Pearce, Edward J., Driggers, Edward M., Artyomov, Maxim N.

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Tumor neoantigens: building a framework for personalized cancer immunotherapy von Gubin, Matthew M, Artyomov, Maxim N, Mardis, Elaine R, Schreiber, Robert D

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TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy von Molgora, Martina, Esaulova, Ekaterina, Vermi, William, Hou, Jinchao, Chen, Yun, Luo, Jingqin, Brioschi, Simone, Bugatti, Mattia, Omodei, Andrea Salvatore, Ricci, Biancamaria, Fronick, Catrina, Panda, Santosh K., Takeuchi, Yoshiko, Gubin, Matthew M., Faccio, Roberta, Cella, Marina, Gilfillan, Susan, Unanue, Emil R., Artyomov, Maxim N., Schreiber, Robert D., Colonna, Marco

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Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease von Zhou, Yingyue, Song, Wilbur M., Andhey, Prabhakar S., Swain, Amanda, Levy, Tyler, Miller, Kelly R., Poliani, Pietro L., Cominelli, Manuela, Grover, Shikha, Gilfillan, Susan, Cella, Marina, Ulland, Tyler K., Zaitsev, Konstantin, Miyashita, Akinori, Ikeuchi, Takeshi, Sainouchi, Makoto, Kakita, Akiyoshi, Bennett, David A., Schneider, Julie A., Nichols, Michael R., Beausoleil, Sean A., Ulrich, Jason D., Holtzman, David M., Artyomov, Maxim N., Colonna, Marco

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Complete deconvolution of cellular mixtures based on linearity of transcriptional signatures von Zaitsev, Konstantin, Bambouskova, Monika, Swain, Amanda, Artyomov, Maxim N.

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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation von Lampropoulou, Vicky, Sergushichev, Alexey, Bambouskova, Monika, Nair, Sharmila, Vincent, Emma E., Loginicheva, Ekaterina, Cervantes-Barragan, Luisa, Ma, Xiucui, Huang, Stanley Ching-Cheng, Griss, Takla, Weinheimer, Carla J., Khader, Shabaana, Randolph, Gwendalyn J., Pearce, Edward J., Jones, Russell G., Diwan, Abhinav, Diamond, Michael S., Artyomov, Maxim N.

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Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH von Daemen, Sabine, Gainullina, Anastasiia, Kalugotla, Gowri, He, Li, Chan, Mandy M., Beals, Joseph W., Liss, Kim H., Klein, Samuel, Feldstein, Ariel E., Finck, Brian N., Artyomov, Maxim N., Schilling, Joel D.

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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders von Brioschi, Simone, Wang, Wei-Le, Peng, Vincent, Wang, Meng, Shchukina, Irina, Greenberg, Zev J., Bando, Jennifer K., Jaeger, Natalia, Czepielewski, Rafael S., Swain, Amanda, Mogilenko, Denis A., Beatty, Wandy L., Bayguinov, Peter, Fitzpatrick, James A. J., Schuettpelz, Laura G., Fronick, Catrina C., Smirnov, Igor, Kipnis, Jonathan, Shapiro, Virginia S., Wu, Gregory F., Gilfillan, Susan, Cella, Marina, Artyomov, Maxim N., Kleinstein, Steven H., Colonna, Marco

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease von Ulland, Tyler K., Song, Wilbur M., Huang, Stanley Ching-Cheng, Ulrich, Jason D., Sergushichev, Alexey, Beatty, Wandy L., Loboda, Alexander A., Zhou, Yingyue, Cairns, Nigel J., Kambal, Amal, Loginicheva, Ekaterina, Gilfillan, Susan, Cella, Marina, Virgin, Herbert W., Unanue, Emil R., Wang, Yaming, Artyomov, Maxim N., Holtzman, David M., Colonna, Marco

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The microbial metabolite desaminotyrosine protects from influenza through type I interferon von Steed, Ashley L., Christophi, George P., Kaiko, Gerard E., Sun, Lulu, Goodwin, Victoria M., Jain, Umang, Esaulova, Ekaterina, Artyomov, Maxim N., Morales, David J., Holtzman, Michael J., Boon, Adrianus C. M., Lenschow, Deborah J., Stappenbeck, Thaddeus S.

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Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool von Jordan, Stefan, Tung, Navpreet, Casanova-Acebes, Maria, Chang, Christie, Cantoni, Claudia, Zhang, Dachuan, Wirtz, Theresa H., Naik, Shruti, Rose, Samuel A., Brocker, Chad N., Gainullina, Anastasiia, Hornburg, Daniel, Horng, Sam, Maier, Barbara B., Cravedi, Paolo, LeRoith, Derek, Gonzalez, Frank J., Meissner, Felix, Ochando, Jordi, Rahman, Adeeb, Chipuk, Jerry E., Artyomov, Maxim N., Frenette, Paul S., Piccio, Laura, Berres, Marie-Luise, Gallagher, Emily J., Merad, Miriam

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Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models von Kim, Kyeongdae, Shim, Dahee, Lee, Jun Seong, Zaitsev, Konstantin, Williams, Jesse W, Kim, Ki-Wook, Jang, Man-Young, Seok Jang, Hyung, Yun, Tae Jin, Lee, Seung Hyun, Yoon, Won Kee, Prat, Annik, Seidah, Nabil G, Choi, Jungsoon, Lee, Seung-Pyo, Yoon, Sang-Ho, Nam, Jin Wu, Seong, Je Kyung, Oh, Goo Taeg, Randolph, Gwendalyn J, Artyomov, Maxim N, Cheong, Cheolho, Choi, Jae-Hoon

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High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy von Gubin, Matthew M., Esaulova, Ekaterina, Ward, Jeffrey P., Malkova, Olga N., Runci, Daniele, Wong, Pamela, Noguchi, Takuro, Arthur, Cora D., Meng, Wei, Alspach, Elise, Medrano, Ruan F.V., Fronick, Catrina, Fehlings, Michael, Newell, Evan W., Fulton, Robert S., Sheehan, Kathleen C.F., Oh, Stephen T., Schreiber, Robert D., Artyomov, Maxim N.

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Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function von Wu, Duojiao, Sanin, David E., Everts, Bart, Chen, Qiongyu, Qiu, Jing, Buck, Michael D., Patterson, Annette, Smith, Amber M., Chang, Chih-Hao, Liu, Zhiping, Artyomov, Maxim N., Pearce, Erika L., Cella, Marina, Pearce, Edward J.

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Single-cell analyses of Crohn’s disease tissues reveal intestinal intraepithelial T cells heterogeneity and altered subset distributions von Jaeger, Natalia, Gamini, Ramya, Cella, Marina, Schettini, Jorge L., Bugatti, Mattia, Zhao, Shanrong, Rosadini, Charles V., Esaulova, Ekaterina, Di Luccia, Blanda, Kinnett, Baylee, Vermi, William, Artyomov, Maxim N., Wynn, Thomas A., Xavier, Ramnik J., Jelinsky, Scott A., Colonna, Marco

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Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages von Huang, Stanley Ching-Cheng, Everts, Bart, Ivanova, Yulia, O'Sullivan, David, Nascimento, Marcia, Smith, Amber M, Beatty, Wandy, Love-Gregory, Latisha, Lam, Wing Y, O'Neill, Christina M, Yan, Cong, Du, Hong, Abumrad, Nada A, Urban, Joseph F, Artyomov, Maxim N, Pearce, Erika L, Pearce, Edward J

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Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression von Williams, Jesse W., Zaitsev, Konstantin, Kim, Ki-Wook, Ivanov, Stoyan, Saunders, Brian T., Schrank, Patricia R., Kim, Kyeongdae, Elvington, Andrew, Kim, Seung Hyeon, Tucker, Christopher G., Wohltmann, Mary, Fife, Brian T., Epelman, Slava, Artyomov, Maxim N., Lavine, Kory J., Zinselmeyer, Bernd H., Choi, Jae-Hoon, Randolph, Gwendalyn J.

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Interferon lambda protects the female reproductive tract against Zika virus infection von Caine, Elizabeth A., Scheaffer, Suzanne M., Arora, Nitin, Zaitsev, Konstantin, Artyomov, Maxim N., Coyne, Carolyn B., Moley, Kelle H., Diamond, Michael S.

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Single-cell transcriptomics reveals cell-type-specific diversification in human heart failure von Koenig, Andrew L., Shchukina, Irina, Amrute, Junedh, Andhey, Prabhakar S., Zaitsev, Konstantin, Lai, Lulu, Bajpai, Geetika, Bredemeyer, Andrea, Smith, Gabriella, Jones, Cameran, Terrebonne, Emily, Rentschler, Stacey L., Artyomov, Maxim N., Lavine, Kory J.

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