Discovery of 2-Hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123):  A Potent, Orally Bioavailable CXCR2/CXCR1... von Dwyer, Michael P, Yu, Younong, Chao, Jianping, Aki, Cynthia, Chao, Jianhua, Biju, Purakkattle, Girijavallabhan, Viyyoor, Rindgen, Diane, Bond, Richard, Mayer-Ezel, Rosemary, Jakway, James, Hipkin, R. William, Fossetta, James, Gonsiorek, Waldemar, Bian, Hong, Fan, Xuedong, Terminelli, Carol, Fine, Jay, Lundell, Daniel, Merritt, J. Robert, Rokosz, Laura L, Kaiser, Bernd, Li, Ge, Wang, Wei, Stauffer, Tara, Ozgur, Lynne, Baldwin, John, Taveras, Arthur G

Volltext

Genotype–phenotype correlations in WHIM syndrome: a systematic characterization of CXCR4WHIM variants von Zmajkovicova, Katarina, Pawar, Sumit, Maier-Munsa, Sabine, Maierhofer, Barbara, Wiest, Ivana, Skerlj, Renato, Taveras, Arthur G., Badarau, Adriana

Volltext

Discovery and Evaluation of a Non-Zn Chelating, Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitor for Potential Intra-articular Treatment of Osteoarthritis von Gege, Christian, Bao, Bagna, Bluhm, Harald, Boer, Jürgen, Gallagher, Brian M, Korniski, Brian, Powers, Timothy S, Steeneck, Christoph, Taveras, Arthur G, Baragi, Vijaykumar M

Volltext

Synthesis and structure–activity relationships of new disubstituted phenyl-containing 3,4-diamino-3-cyclobutene-1,2-diones as CXCR2 receptor antagonists von Lai, Gaifa, Merritt, J. Robert, He, Zhenmin, Feng, Daming, Chao, Jianhua, Czarniecki, Michael F., Rokosz, Laura L., Stauffer, Tara M., Rindgen, Diane, Taveras, Arthur G.

Volltext

A novel transmembrane CXCR4 variant that expands the WHIM genotype-phenotype paradigm von Zmajkovicova, Katarina, Pawar, Sumit, Sharapova, Svetlana O., Geier, Christoph B., Wiest, Ivana, Nguyen, Chi, Monticelli, Halenya, Maier-Munsa, Sabine, Chen, Kelly, Sleasman, John W., Aleshkevich, Svetlana, Polyakova, Ekaterina, Sakovich, Inga, Warnatz, Klaus, Grimbacher, Bodo, Proietti, Michele, Sondheimer, Neal, Ujhazi, Boglarka, Gordon, Sumai, Ellison, Maryssa, Yilmaz, Melis, Walter, Jolan E., Badarau, Adriana, Taveras, Arthur G., Neff, Jadee L., Bledsoe, Jacob R., Tarrant, Teresa K.

Volltext

BIIB042, a novel γ-secretase modulator, reduces amyloidogenic Aβ isoforms in primates and rodents and plaque pathology in a mouse model of Alzheimer's disease von Scannevin, Robert H., Chollate, Sowmya, Brennan, Melanie S., Snodgrass-Belt, Pamela A., Peng, Hairuo, Xu, Lin, Jung, Mi-young, Bussiere, Thierry, Arastu, Mahin F., Talreja, Tina, Xin, Zhili, Dunstan, Robert W., Fahrer, Diana, Rohde, Ellen, Dunah, Anthone W., Wang, Joy, Kumaravel, Gnanasambandam, Taveras, Arthur G., Moore Arnold, H., Rhodes, Kenneth J.

Volltext

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach von Xin, Zhili, Peng, Hairuo, Zhang, Andrew, Talreja, Tina, Kumaravel, Gnanasambandam, Xu, Lin, Rohde, Ellen, Jung, Mi-yong, Shackett, Melanie N., Kocisko, David, Chollate, Sowmya, Dunah, Anthone W., Snodgrass-Belt, Pamela A., Moore Arnold, H., Taveras, Arthur G., Rhodes, Kenneth J., Scannevin, Robert H.

Volltext

C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists von Chao, Jianhua, Taveras, Arthur G., Chao, Jianping, Aki, Cynthia, Dwyer, Michael, Yu, Younong, Purakkattle, Biju, Rindgen, Diane, Jakway, James, Hipkin, William, Fosetta, James, Fan, Xuedong, Lundell, Daniel, Fine, Jay, Minnicozzi, Michael, Phillips, Jonathan, Merritt, J. Robert

Volltext

3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists von Biju, Purakkattle, Taveras, Arthur G., Yu, Younong, Zheng, Junying, Hipkin, R. William, Fossetta, James, Fan, Xuedong, Fine, Jay, Lundell, Daniel

Volltext

Comprehensive in Vitro Characterization of CXCR4WHIM variants to Decipher Genotype-Phenotype Correlations in WHIM Syndrome von Zmajkovicova, Katarina, Maier-Munsa, Sabine, Maierhofer, Barbara, Taveras, Arthur G., Badarau, Adriana

Volltext

The Farnesyl Transferase Inhibitor SCH 66336 Induces a G2 → M or G1 Pause in Sensitive Human Tumor Cell Lines von Ashar, Hena R., James, Linda, Gray, Kimberly, Carr, Donna, McGuirk, Marnie, Maxwell, Eugene, Black, Stuart, Armstrong, Lydia, Doll, Ronald J., Taveras, Arthur G., Bishop, W.Robert, Kirschmeier, Paul

Volltext

Mavorixafor for Patients with Chronic Neutropenic Disorders Treated with G-CSF: Preliminary Response Data and G-CSF Dose Reduction in an Ongoing Phase 2, Open-Label, Multicenter St... von Warren, Julia T., Dickerson, Kathryn E., Sharathkumar, Anjali A., Walter, Jolan E., Wilson, David B., Adell, Katrina P., Chen, Kelly, Dubuc, Susan, MacLeod, Rick, Peters, Katie, Stewart, Murray, Taveras, Arthur G., Walkovich, Kelly

Volltext

Oral Administration of Mavorixafor, a CXCR4 Antagonist, Increases Peripheral White Blood Cell Counts across Different Disease States von Dale, David C., Treon, Steven P., McDermott, David F., Cadavid, Diego, Luo, Xia, Garg, Varun, Tang, Weihua, Jiang, Honghua, Chen, Kelly, Taveras, Arthur G., Bhandari, Ashish, Donadieu, Jean

Volltext

Characterization of a Novel Missense CXCR4 Mutation in a Patient with WHIM-like Syndrome von Pawar, Sumit, Zmajkovicova, Katarina, Sharapova, Svetlana, Wiest, Ivana, Nguyen, Chi, Monticelli, Halenya, Maier-Munsa, Sabine, Geier, Christoph, Sondheimer, Neal, Ujhazi, Boglarka, Gordon, Sumai, Ellison, Maryssa, Walter, Jolan E., Taveras, Arthur G., Badarau, Adriana, Tarrant, Teresa

Volltext

Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S 1 ′ Subsite of Matrix Metalloproteinase 8 (MMP-8) von Pochetti, Giorgio, Montanari, Roberta, Gege, Christian, Chevrier, Carine, Taveras, Arthur G., Mazza, Fernando

Volltext

Abstract 5866: Mavorixafor enhances apoptosis of tumor cells treated with ibrutinib or venetoclax in diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and c... von Kruitwagen, Tom, Rebelo, Thalia Martins, Maierhofer, Barbara, Heller, Gerwin, Monticelli, Halenya, Taveras, Arthur G., Nguyen, Chi

Volltext

(+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]- pyridin-11(R)-yl)-1-piperidinyl]-2-oxo-ethyl]-1-piperidinecarboxamide (SCH-66336):  A Very Potent Fa... von Njoroge, F. George, Taveras, Arthur G, Kelly, Joseph, Remiszewski, Stacy, Mallams, Alan K, Wolin, Ronald, Afonso, Adriano, Cooper, Alan B, Rane, Dinananth F, Liu, Yi-Tsung, Wong, Jesse, Vibulbhan, Bancha, Pinto, Patrick, Deskus, Jeffrey, Alvarez, Carmen S, del Rosario, Joycelyn, Connolly, Michael, Wang, James, Desai, Jagdish, Rossman, Randall R, Bishop, W. Robert, Patton, Robert, Wang, Lynn, Kirschmeier, Paul, Bryant, Mathew S, Nomeir, Amin A, Lin, C.-C, Liu, Ming, McPhail, Andrew T, Doll, Ronald J, Girijavallabhan, Viyyoor M, Ganguly, Ashit K

Volltext

Solid-state photochemistry. Remarkable effects of the packing of molecules in crystals on the diastereoselectivity of the intramolecular 2 + 2 photocycloaddition of a 4-(3'-butenyl... von Schultz, Arthur G, Taveras, Arthur G, Taylor, Richard E, Tham, Fook S, Kullnig, Rudolph K

Volltext

Abstract 6093: Mavorixafor enhances efficacy of Bruton tyrosine kinase inhibitors by overcoming the protective effect of bone marrow stroma on tumor cells in Waldenström’s macroglo... von Nguyen, Chi, Monticelli, Halenya, Kruitwagen, Tom, Tardelli, Matteo, Maierhofer, Barbara, Rebelo, Thalia Martins, Maier-Munsa, Sabine, Zmajkovicova, Katarina, Dillinger, Lukas, Badarau, Adriana, Taveras, Arthur G.

Volltext

Intramolecular 2 + 2 photocycloadditions of 4-(3'-alkenyl)- and 4-(3'-pentynyl)-2,5-cyclohexadien-1-ones von Schultz, Arthur G, Plummer, Mark, Taveras, Arthur G, Kullnig, Rudolph K

Volltext