Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island von Arriola Apelo, Sebastian I, Lamming, Dudley W

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A novel rapamycin analog is highly selective for mTORC1 in vivo von Schreiber, Katherine H., Arriola Apelo, Sebastian I., Yu, Deyang, Brinkman, Jacqueline A., Velarde, Michael C., Syed, Faizan A., Liao, Chen-Yu, Baar, Emma L., Carbajal, Kathryn A., Sherman, Dawn S., Ortiz, Denise, Brunauer, Regina, Yang, Shany E., Tzannis, Stelios T., Kennedy, Brian K., Lamming, Dudley W.

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Intermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice von Arriola Apelo, Sebastian I, Pumper, Cassidy P, Baar, Emma L, Cummings, Nicole E, Lamming, Dudley W

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Restoration of metabolic health by decreased consumption of branched‐chain amino acids von Cummings, Nicole E., Williams, Elizabeth M., Kasza, Ildiko, Konon, Elizabeth N., Schaid, Michael D., Schmidt, Brian A., Poudel, Chetan, Sherman, Dawn S., Yu, Deyang, Arriola Apelo, Sebastian I., Cottrell, Sara E., Geiger, Gabriella, Barnes, Macy E., Wisinski, Jaclyn A., Fenske, Rachel J., Matkowskyj, Kristina A., Kimple, Michelle E., Alexander, Caroline M., Merrins, Matthew J., Lamming, Dudley W.

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Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health von Fontana, Luigi, Cummings, Nicole E., Arriola Apelo, Sebastian I., Neuman, Joshua C., Kasza, Ildiko, Schmidt, Brian A., Cava, Edda, Spelta, Francesco, Tosti, Valeria, Syed, Faizan A., Baar, Emma L., Veronese, Nicola, Cottrell, Sara E., Fenske, Rachel J., Bertozzi, Beatrice, Brar, Harpreet K., Pietka, Terri, Bullock, Arnold D., Figenshau, Robert S., Andriole, Gerald L., Merrins, Matthew J., Alexander, Caroline M., Kimple, Michelle E., Lamming, Dudley W.

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Intravenous infusion of 5-hydroxytryptophan to mid-lactation Holstein cows transiently affects milk production and circulating amino acid concentrations von Pszczolkowski, Virginia L., Connelly, Meghan K., Hoppman, August, Benn, Amara D., Laporta, Jimena, Hernandez, Laura L., Arriola Apelo, Sebastian I.

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Increased transport of acetyl‐CoA into the endoplasmic reticulum causes a progeria‐like phenotype von Peng, Yajing, Shapiro, Samantha L., Banduseela, Varuna C., Dieterich, Inca A., Hewitt, Kyle J., Bresnick, Emery H., Kong, Guangyao, Zhang, Jing, Schueler, Kathryn L., Keller, Mark P., Attie, Alan D., Hacker, Timothy A., Sullivan, Ruth, Kielar‐Grevstad, Elle, Arriola Apelo, Sebastian I., Lamming, Dudley W., Anderson, Rozalyn M., Puglielli, Luigi

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Transposition of the common carotid artery in standing cattle von Munsterman, Amelia S., Arriola Apelo, Sebastian I., Nelson, Kathryn M.

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Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging von Apelo, Sebastian I. Arriola, Lin, Amy, Brinkman, Jacqueline A., Meyer, Emma, Morrison, Mark, Tomasiewicz, Jay L., Pumper, Cassidy P., Baar, Emma L., Richardson, Nicole E., Alotaibi, Mohammed, Lamming, Dudley W.

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Dry Period Heat Stress Impacts Mammary Protein Metabolism in the Subsequent Lactation von Dado-Senn, Bethany, Skibiel, Amy L., Dahl, Geoffrey E., Apelo, Sebastian I. Arriola, Laporta, Jimena

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Near-infrared spectroscopy analysis of blood plasma for predicting nonesterified fatty acid concentrations in dairy cows von Menezes, Guilherme L., Bresolin, Tiago, Ferreira, Rafael, Holdorf, Henry T., Arriola Apelo, Sebastian I., White, Heather M., Dórea, JoaoR.R.

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Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system von Arriola Apelo, Sebastian I., Neuman, Joshua C., Baar, Emma L., Syed, Faizan A., Cummings, Nicole E., Brar, Harpreet K., Pumper, Cassidy P., Kimple, Michelle E., Lamming, Dudley W.

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Insulin potentiates essential amino acids effects on mechanistic target of rapamycin complex 1 signaling in MAC-T cells von Pszczolkowski, Virginia L., Zhang, Jun, Pignato, Kayleigh A., Meyer, Emma J., Kurth, Madison M., Lin, Amy, Arriola Apelo, Sebastian I.

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mTORC2 Puts Its Shoulder to Krebs’ Wheel von Arriola Apelo, Sebastian I., Lamming, Dudley W.

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Effects of methionine, leucine, and insulin on circulating concentrations and mammary extraction of energy substrates and amino acids in lactating dairy cows von Pszczolkowski, Virginia L., Hu, Haowen, Zhang, Jun, Connelly, Meghan K., Munsterman, Amelia S., Arriola Apelo, Sebastian I.

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Hypothalamic mTORC2 is essential for metabolic health and longevity von Chellappa, Karthikeyani, Brinkman, Jacqueline A., Mukherjee, Sarmistha, Morrison, Mark, Alotaibi, Mohammed I., Carbajal, Kathryn A., Alhadeff, Amber L., Perron, Isaac J., Yao, Rebecca, Purdy, Cole S., DeFelice, Denise M., Wakai, Matthew H., Tomasiewicz, Jay, Lin, Amy, Meyer, Emma, Peng, Yajing, Arriola Apelo, Sebastian I., Puglielli, Luigi, Betley, J. Nicholas, Paschos, Georgios K., Baur, Joseph A., Lamming, Dudley W.

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The market for amino acids: understanding supply and demand of substrate for more efficient milk protein synthesis von Pszczolkowski, Virginia L., Arriola Apelo, Sebastian I.

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Maternal Overnutrition During Gestation in Sheep Alters Autophagy Associated Pathways in Offspring Heart von Liu, Yang, Ding, Qiyue, Halderson, Steven J, Arriola Apelo, Sebastian I, Jones, Amanda K, Pillai, Sambhu M, Hoffman, Maria L, Reed, Sarah, Govoni, Kristen E, Zinn, Steven A, Guo, Wei

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Pharmacologic inhibition of mTORC1 mimics dietary protein restriction in a mouse model of lactation von Pszczolkowski, Virginia L., Halderson, Steven J., Meyer, Emma J., Lin, Amy, Arriola Apelo, Sebastian I.

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Quantification of bovine plasma amino acids via liquid chromatography–electrospray ionization-mass spectrometry: Comparison of underivatized and precolumn derivatized methods von Toledo, Mateus Z., Nienow, Caleb, Luchini, Daniel, Arriola Apelo, Sebastian I., Wiltbank, Milo C.

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