Discovery of XL413, a potent and selective CDC7 inhibitor von Koltun, Elena S., Tsuhako, Amy Lew, Brown, David S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Ferguson, Kim, Franzini, Maurizio, Galan, Adam, Holst, Charles R., Huang, Ping, Kane, Brian, Kim, Moon H., Li, Jia, Markby, David, Mohan, Manisha, Noson, Kevin, Plonowski, Arthur, Richards, Steven J., Robertson, Scott, Shaw, Kenneth, Stott, Gordon, Stout, Thomas J., Young, Jenny, Yu, Peiwen, Zaharia, Cristiana A., Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Xu, Wei, Kearney, Patrick C.

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Discovery of a Novel Class of Highly Potent, Selective, ATP-Competitive, and Orally Bioavailable Inhibitors of the Mammalian Target of Rapamycin (mTOR) von Takeuchi, Craig S, Kim, Byung Gyu, Blazey, Charles M, Ma, Sunghoon, Johnson, Henry W. B, Anand, Neel K, Arcalas, Arlyn, Baik, Tae Gon, Buhr, Chris A, Cannoy, Jonah, Epshteyn, Sergey, Joshi, Anagha, Lara, Katherine, Lee, Matthew S, Wang, Longcheng, Leahy, James W, Nuss, John M, Aay, Naing, Aoyama, Ron, Foster, Paul, Lee, Jae, Lehoux, Isabelle, Munagala, Narsimha, Plonowski, Arthur, Rajan, Sharmila, Woolfrey, John, Yamaguchi, Kyoko, Lamb, Peter, Miller, Nicole

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Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90 von Bussenius, Joerg, Blazey, Charles M., Aay, Naing, Anand, Neel K., Arcalas, Arlyn, Baik, TaeGon, Bowles, Owen J., Buhr, Chris A., Costanzo, Simona, Curtis, Jeffrey K., DeFina, Steven C., Dubenko, Larisa, Heuer, Timothy S., Huang, Ping, Jaeger, Christopher, Joshi, Anagha, Kennedy, Abigail R., Kim, Angie I., Lara, Katherine, Lee, Jae, Li, Jonathan, Lougheed, Julie C., Ma, Sunghoon, Malek, Shiva, Manalo, Jean-Claire L., Martini, Jean-Francois, McGrath, Garth, Nicoll, Monique, Nuss, John M., Pack, Michael, Peto, Csaba J., Tsang, Tsze H., Wang, Longcheng, Womble, Scott W., Yakes, Michael, Zhang, Wentao, Rice, Kenneth D.

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The design, synthesis, and biological evaluation of PIM kinase inhibitors von Tsuhako, Amy Lew, Brown, David S., Koltun, Elena S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Franzini, Maurizio, Galan, Adam, Huang, Ping, Johnston, Stuart, Kane, Brian, Kim, Moon H., Douglas Laird, A., Lin, Rui, Mock, Lillian, Ngan, Iris, Pack, Michael, Stott, Gordon, Stout, Thomas J., Yu, Peiwen, Zaharia, Cristiana, Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Kearney, Patrick C., Xu, Wei

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Discovery and Characterization of an Inhibitor of Glucosylceramide Synthase von Richards, Steven, Larson, Christopher J, Koltun, Elena S, Hanel, Art, Chan, Vicky, Nachtigall, Jason, Harrison, Amanda, Aay, Naing, Du, Hongwang, Arcalas, Arlyn, Galan, Adam, Zhang, Jeff, Zhang, Wentao, Won, Kwang-Ai, Tam, Danny, Qian, Fawn, Wang, Tao, Finn, Patricia, Ogilvie, Kathy, Rosen, Jon, Aoyama, Ron, Plonowski, Artur, Cancilla, Belinda, Bentzien, Frauke, Yakes, Michael, Mohan, Raju, Lamb, Peter, Nuss, John, Kearney, Patrick

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SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors von Forsyth, Timothy, Kearney, Patrick C., Kim, Byung Gyu, Johnson, Henry W.B., Aay, Naing, Arcalas, Arlyn, Brown, David S., Chan, Vicky, Chen, Jeff, Du, Hongwang, Epshteyn, Sergey, Galan, Adam A., Huynh, Tai P., Ibrahim, Mohamed A., Kane, Brian, Koltun, Elena S., Mann, Grace, Meyr, Lisa E., Lee, Matthew S., Lewis, Gary L., Noguchi, Robin T., Pack, Michael, Ridgway, Brian H., Shi, Xian, Takeuchi, Craig S., Zu, Peiwen, Leahy, James W., Nuss, John M., Aoyama, Ron, Engst, Stefan, Gendreau, Steven B., Kassees, Robert, Li, Jia, Lin, Shwu-Hwa, Martini, Jean-Francois, Stout, Thomas, Tong, Philip, Woolfrey, John, Zhang, Wentao, Yu, Peiwen

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Erratum to “Discovery of XL413, a potent and selective CDC7 inhibitor” [Bioorg. Med. Chem. Lett. 22 (2012) 3727–3731] von Koltun, Elena S., Tsuhako, Amy Lew, Brown, David S., Aay, Naing, Arcalas, Arlyn, Chan, Vicky, Du, Hongwang, Engst, Stefan, Ferguson, Kim, Franzini, Maurizio, Galan, Adam, Holst, Charles R., Huang, Ping, Kane, Brian, Kim, Moon H., Li, Jia, Markby, David, Mohan, Manisha, Noson, Kevin, Plonowski, Arthur, Richards, Steven J., Robertson, Scott, Shaw, Kenneth, Stott, Gordon, Stout, Thomas J., Young, Jenny, Yu, Peiwen, Zaharia, Cristiana A., Zhang, Wentao, Zhou, Peiwen, Nuss, John M., Xu, Wei, Kearney, Patrick C.

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benzoxazepinas como inibidores de pi3k/mtor e métodos de seus usos e fabricação von Arlyn Arcalas, Jeffry Kimo Curtis, Eileen Jackson-Ugueto, Tsze H. Tsang, Joerg Bussenius, Steven Charles Defina, Angie Inyoung Kim, Michael Pack, Naing Aay, Larisa Dubenko, Jean-Claire Limun Manalo, Csaba J. Peto, Jason R. Harris, Kenneth Rice

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PYRIDINYL SUBSTITUTED TROPANE COMPOUNDS AND USES THEREOF von BUSSENIUS, JOERG, KENNEDY, ABIGAIL R, MANALO, JEAN-CLAIRE LIMUN, WANG, LONGCHENG, LARA, KATHERINE, PETO, CSABA J, DUBENKO, LARISA, AAY, NAING, CURTIS, JEFFRY KIMO, BLAZEY, CHARLES M, COSTANZO, SIMONA, MA, SUNGHOON, BAIK, TAE-GON, BOWLES, OWEN JOSEPH, KIM, ANGIE INYOUNG, ARCALAS, ARLYN, RICE, KENNETH D, ANAND, NEEL KUMAR, BUHR, CHRIS A, TSANG, TSZE H, DEFINA, STEVEN CHARLES

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compostos de tropano, suas composições farmacêuticas, seus usos e método in vitro de inibição de hsp90 em uma célula von Catherine Lara, Neel Kumar Anand, Arlyn Arcalas, Longcheng Wang, Charles M. Blazey, Abigail R. Kennedy, Jeffry Kimo Curtis, Chris A. Buhr, Sunghoon MA, Tsze H. Tsang, Joerg Bussenius, Steven Charles Defina, Angie Inyoung Kim, Naing Aay, Simona Costanzo, Larisa Dubenko, Jean-Claire Limun Manalo, Kenneth D. Rice, Tae-Gon Baik, Owen Joseph Bowles, Csaba J. Peto

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compostos de tropano, suas composições farmacêuticas, seus usos e método in vitro de inibição de hsp90 em uma célula von Catherine Lara, Neel Kumar Anand, Arlyn Arcalas, Longcheng Wang, Charles M. Blazey, Abigail R. Kennedy, Jeffry Kimo Curtis, Chris A. Buhr, Sunghoon MA, Tsze H. Tsang, Joerg Bussenius, Steven Charles Defina, Angie Inyoung Kim, Naing Aay, Simona Costanzo, Larisa Dubenko, Jean-Claire Limun Manalo, Kenneth D. Rice, Tae-Gon Baik, Owen Joseph Bowles, Csaba J. Peto

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Compostos tropano von ARLYN ARCALAS, JOERG BUSSENIUS, CHARLES M. BLAZEY, JEAN-CLAIRE LIMUN MANALO, NEEL KUMAR ANAND, JEFFRY KIMO CURTIS, SIMONA COSTANZO, OWEN JOSEPH BOWLES, TSZE H. TSANG, CHRIS A. BUHR, ANGIE INYOUNG KIM, LARISA DUBENKO, CSABA J. PETO, CATHERINE LARA, ABIGAIL R. KENNEDY, NAING AAY, STEVEN CHARLES DEFINA, TAE-GON BAIK, KENNETH D. RICE, LONGCHENG WANG, SUNGHOON MA

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TROPANE COMPOUNDS von BUSSENIUS, JOERG, KENNEDY, ABIGAIL R, MANALO, JEAN-CLAIRE LIMUN, WANG, LONGCHENG, LARA, KATHERINE, PETO, CSABA J, DUBENKO, LARISA, AAY, NAING, CURTIS, JEFFRY KIMO, BLAZEY, CHARLES M, COSTANZO, SIMONA, MA, SUNGHOON, BAIK, TAE-GON, BOWLES, OWEN JOSEPH, KIM, ANGIE INYOUNG, ARCALAS, ARLYN, RICE, KENNETH D, ANAND, NEEL KUMAR, BUHR, CHRIS A, TSANG, TSZE H, DEFINA, STEVEN CHARLES

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TROPANE COMPOUNDS von ARLYN ARCALAS, JOERG BUSSENIUS, KIM ANGIE INYOUNG, WANG LONGCHENG, JEAN-CLAIRE LIMUN MANALO, NEEL KUMAR ANAND, BOWLES OWEN JOSEPH, CHARLES M BLAZEY, AAY NAING, COSTANZO SIMONA, ABIGAIL R KENNEDY, KATHERINE LARA, LARISA DUBENKO, BUHR CHRIS A, TSANG TSZE H, STEVEN CHARLES DEFINA, BAIK TAE-GON, RICE KENNETH D, CURTIS JEFFRY KIMO, PETO CSABA J, MA SUNGHOON

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Pyrimidinones as casein kinase II (CK2) modulators von Koltun, Elena S, Kearney, Patrick, Aay, Naing, Arcalas, Arlyn, Chan, Wai Ki Vicky, Curtis, Jeffry Kimo, Du, Hongwang, Huang, Ping, Kane, Brian, Kim, Moon Hwan, Pack, Michael, Tsuhako, Amy L, Xu, Wei, Zaharia, Cristiana A, Zhou, Peiwen

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Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture von DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, HARRIS JASON R, BOWLES OWEN JOSEPH, ARCALAS ARLYN, AAY NAING, JACKSON-UGUETO EILEEN E, MANALO JEAN-CLAIRE LIMUN, BUSSENIUS JOERG, TSANG TSZE H, CURTIS JEFFRY KIMO, PETO CSABA J, RICE KENNETH D, DUBENKO LARISA, PACK MICHAEL

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Pyrimidinones as Casein kinase II (CK2) modulators von KEARNEY, PATRICK, DU, HONGWANG, AAY, NAING, CURTIS, JEFFRY KIMO, TSUHAKO, AMY L, ZAHARIA, CRISTIANA A, HUANG, PING, XU, WEI, PACK, MICHAEL, KOLTUN, ELENA S, ZHOU, PEIWEN, KIM, MOON HWAN, ARCALAS, ARLYN, KANE, BRIAN, CHAN, WAI KI VICKY

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Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture von DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, HARRIS JASON R, BOWLES OWEN JOSEPH, ARCALAS ARLYN, AAY NAING, JACKSON-UGUETO EILEEN E, MANALO JEAN-CLAIRE LIMUN, BUSSENIUS JOERG, TSANG TSZE H, PETO CSABA J, RICE KENNETH D, CURTIS JEFFRY KIMO, DUBENKO LARISA, PACK MICHAEL

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Tropane compounds von BUSSENIUS, JOERG, KENNEDY, ABIGAIL R, WANG, LONGCHENG, MANALO, JEAN-CLAIRE LIMUN, LARA, KATHERINE, PETO, CSABA J, DUBENKO, LARISA, AAY, NAING, CURTIS, JEFFRY KIMO, BLAZEY, CHARLES M, COSTANZO, SIMONA, MA, SUNGHOON, BAIK, TAE-GON, BOWLES, OWEN JOSEPH, KIM, ANGIE INYOUNG, ARCALAS, ARLYN, ANAND, NEEL KUMAR, BUHR, CHRIS A, RICE, KENNETH D, TSANG, TSZE H, DEFINA, STEVEN CHARLES

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PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS von KEARNEY, PATRICK, DU, HONGWANG, AAY, NAING, CURTIS, JEFFRY KIMO, TSUHAKO, AMY L, ZAHARIA, CRISTIANA A, HUANG, PING, PACK, MICHAEL, XU, WEI, KOLTUN, ELENA S, ZHOU, PEIWEN, KIM, MOON HWAN, ARCALAS, ARLYN, KANE, BRIAN, CHAN, WAI KI VICKY

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