Identification of potent and selective inhibitors of PKR via virtual screening and traditional design von Cusack, K P, Argiriadi, M A, Gordon, T D, Harris, C M, Herold, J M, Hoemann, M Z, Yestrepsky, B D

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Detoxification of Environmental Mutagens and Carcinogens: Structure, Mechanism, and Evolution of Liver Epoxide Hydrolase von Argiriadi, Maria A., Morisseau, Christophe, Hammock, Bruce D., Christianson, David W.

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Binding of Alkylurea Inhibitors to Epoxide Hydrolase Implicates Active Site Tyrosines in Substrate Activation von Argiriadi, Maria A., Morisseau, Christophe, Goodrow, Marvin H., Dowdy, Deanna L., Hammock, Bruce D., Christianson, David W.

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Biochemical Evidence for the Involvement of Tyrosine in Epoxide Activation during the Catalytic Cycle of Epoxide Hydrolase von Yamada, Takashi, Morisseau, Christophe, Maxwell, Joseph E., Argiriadi, Maria A., Christianson, David W., Hammock, Bruce D.

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Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium von Argiriadi, Maria A, Goedken, Eric R, Bruck, Irina, O'Donnell, Mike, Kuriyan, John

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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages von Runtsch, Marah C., Angiari, Stefano, Hooftman, Alexander, Wadhwa, Ridhima, Zhang, Yanling, Zheng, Yunan, Spina, Joseph S., Ruzek, Melanie C., Argiriadi, Maria A., McGettrick, Anne F., Mendez, Rui Santalla, Zotta, Alessia, Peace, Christian G., Walsh, Aoife, Chirillo, Roberta, Hams, Emily, Fallon, Padraic G., Jayaraman, Ranjith, Dua, Kamal, Brown, Alexandra C., Kim, Richard Y., Horvat, Jay C., Hansbro, Philip M., Wang, Chu, O’Neill, Luke A.J.

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Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol von Goedken, Eric R., Argiriadi, Maria A., Banach, David L., Fiamengo, Bryan A., Foley, Sage E., Frank, Kristine E., George, Jonathan S., Harris, Christopher M., Hobson, Adrian D., Ihle, David C., Marcotte, Douglas, Merta, Philip J., Michalak, Mark E., Murdock, Sara E., Tomlinson, Medha J., Voss, Jeffrey W.

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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site von Goedken, Eric R., Argiriadi, Maria A., Dietrich, Justin D., Petros, Andrew M., Krishnan, Navasona, Panchal, Sanjay C., Qiu, Wei, Wu, Haihong, Zhu, Haizhong, Adams, Ashley M., Bodelle, Pierre M., Goguen, Lucas, Richardson, Paul L., Slivka, Peter F., Srikumaran, Myron, Upadhyay, Anup K., Wu, Bainan, Judge, Russell A., Vasudevan, Anil, Gopalakrishnan, Sujatha M., Cox, Philip B., Stoll, Vincent S., Sun, Chaohong

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In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494) von Parmentier, Julie M, Voss, Jeff, Graff, Candace, Schwartz, Annette, Argiriadi, Maria, Friedman, Michael, Camp, Heidi S, Padley, Robert J, George, Jonathan S, Hyland, Deborah, Rosebraugh, Matthew, Wishart, Neil, Olson, Lisa, Long, Andrew J

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Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis von Todorović, Viktor, Su, Zhi, Putman, C. Brent, Kakavas, Stevan J., Salte, Katherine M., McDonald, Heath A., Wetter, Joseph B., Paulsboe, Stephanie E., Sun, Qi, Gerstein, Clare E., Medina, Limary, Sielaff, Bernhard, Sadhukhan, Ramkrishna, Stockmann, Henning, Richardson, Paul L., Qiu, Wei, Argiriadi, Maria A., Henry, Rodger F., Herold, J. Martin, Shotwell, J. Brad, McGaraughty, Steve P., Honore, Prisca, Gopalakrishnan, Sujatha M., Sun, Chaohong C., Scott, Victoria E.

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1063 Small molecule antagonists of interleukin 17 offer an orthogonal approach to inhibit key inflammatory processes von Goedken, E.R., Argiriadi, M.A., Dietrich, J.D., Petros, A.M., Panchal, S.C., Qiu, W., Wu, H., Zhu, H., Srikumaran, M., Gopalakrishnan, S.M., Cox, P.B., Stoll, V.C., Sun, C.

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Optimized Protein Kinase Cθ (PKCθ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis von George, Dawn M., Breinlinger, Eric C., Argiriadi, Maria A., Zhang, Yang, Wang, Jianfei, Bansal-Pakala, Pratima, Duignan, David B., Honore, Prisca, Lang, QingYu, Mittelstadt, Scott, Rundell, Lian, Schwartz, Annette, Sun, Jiakang, Edmunds, Jeremy J.

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FDG-PET/MRI for the preoperative diagnosis and staging of peritoneal carcinomatosis: a prospective multireader pilot study von Vietti Violi, Naik, Gavane, Somali, Argiriadi, Pamela, Law, Amy, Heiba, Sherif, Bekhor, Eliahu Y., Babb, James S., Ghesani, Munir, Labow, Daniel M., Taouli, Bachir

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Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors von Friedman, Michael, Frank, Kristine E., Aguirre, Ana, Argiriadi, Maria A., Davis, Heather, Edmunds, Jeremy J., George, Dawn M., George, Jonathan S., Goedken, Eric, Fiamengo, Bryan, Hyland, Deborah, Li, Bin, Murtaza, Anwar, Morytko, Michael, Somal, Gagandeep, Stewart, Kent, Tarcsa, Edit, Van Epps, Stacy, Voss, Jeffrey, Wang, Lu, Woller, Kevin, Wishart, Neil

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Higher Growth Rate of Branch Duct Intraductal Papillary Mucinous Neoplasms Associates With Worrisome Features von Kolb, Jennifer M., Argiriadi, Pamela, Lee, Karen, Liu, Xiaoyu, Bagiella, Emilia, Gupta, Shivani, Lucas, Aimee L., Kim, Michelle Kang, Kumta, Nikhil A., Nagula, Satish, Sarpel, Umut, DiMaio, Christopher J.

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Creation of a S1P Lyase bacterial surrogate for structure-based drug design von Argiriadi, Maria A., Banach, David, Radziejewska, Elzbieta, Marchie, Susan, DiMauro, Jennifer, Dinges, Jurgen, Dominguez, Eric, Hutchins, Charles, Judge, Russell A., Queeney, Kara, Wallace, Grier, Harris, Christopher M.

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Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors von Dinges, Jurgen, Harris, Christopher M., Wallace, Grier A., Argiriadi, Maria A., Queeney, Kara L., Perron, Denise C., Dominguez, Eric, Kebede, Tegest, Desino, Kelly E., Patel, Hetal, Vasudevan, Anil

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Discovery of Selective and Orally Bioavailable Protein Kinase Cθ (PKCθ) Inhibitors from a Fragment Hit von George, Dawn M., Breinlinger, Eric C., Friedman, Michael, Zhang, Yang, Wang, Jianfei, Argiriadi, Maria, Bansal-Pakala, Pratima, Barth, Martine, Duignan, David B., Honore, Prisca, Lang, QingYu, Mittelstadt, Scott, Potin, Dominique, Rundell, Lian, Edmunds, Jeremy J.

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THU0127 Pharmacodynamics of A Novel JAK1 Selective Inhibitor in Rat Arthritis and Anemia Models and in Healthy Human Subjects von Voss, J., Graff, C., Schwartz, A., Hyland, D., Argiriadi, M., Camp, H., Dowding, L., Friedman, M., Frank, K., George, J., Goedken, E., Lo Schiavo, G., Morytko, M., O'Brien, R., Padley, R., Rozema, M., Rosebraugh, M., Stewart, K., Wallace, G., Wishart, N., Murtaza, A., Olson, L.

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Are Clinical Guidelines for the Management of Intraductal Papillary Mucinous Neoplasms Followed?: A Single-Center Analysis von Tabrizian, Parissa, Berger, Yaniv, Pierobon, Elisa Sefora, Aycart, Samantha, Argiriadi, Pamela, Fei, Kezhen, Carrasco-Avino, Gonzalo, Labow, Daniel M, Sarpel, Umut

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