Spatiotemporal analysis of glioma heterogeneity reveals COL1A1 as an actionable target to disrupt tumor progression von Comba, Andrea, Faisal, Syed M., Dunn, Patrick J., Argento, Anna E., Hollon, Todd C., Al-Holou, Wajd N., Varela, Maria Luisa, Zamler, Daniel B., Quass, Gunnar L., Apostolides, Pierre F., Abel, Clifford, Brown, Christine E., Kish, Phillip E., Kahana, Alon, Kleer, Celina G., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.

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The complex interactions between the cellular and non-cellular components of the brain tumor microenvironmental landscape and their therapeutic implications von Faisal, Syed M., Comba, Andrea, Varela, Maria L., Argento, Anna E., Brumley, Emily, Abel, Clifford, Castro, Maria G., Lowenstein, Pedro R.

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Generation of 3D ex vivo mouse- and patient-derived glioma explant slice model for integration of confocal time-lapse imaging and spatial analysis von Comba, Andrea, Varela, Maria Luisa, Faisal, Syed M., Abel, Clifford C., Argento, Anna E., Al-Holou, Wajd N., Hollon, Todd C., Perelman, Jacqueline D., Dunn, Patrick J., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.

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Fiber density and matrix stiffness modulate distinct cell migration modes in a 3D stroma mimetic composite hydrogel von Hiraki, Harrison L., Matera, Daniel L., Wang, William Y., Prabhu, Eashan S., Zhang, Zane, Midekssa, Firaol, Argento, Anna E., Buschhaus, Johanna M., Humphries, Brock A., Luker, Gary D., Pena-Francesch, Abdon, Baker, Brendon M.

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Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses von Comba, Andrea, Dunn, Patrick J, Argento, Anna E, Kadiyala, Padma, Ventosa, Maria, Patel, Priti, Zamler, Daniel B, Núñez, Felipe J, Zhao, Lili, Castro, Maria G, Lowenstein, Pedro R

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Erratum: Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses von Comba, Andrea, Dunn, Patrick J, Argento, Anna E, Kadiyala, Padma, Ventosa, Maria, Patel, Priti, Zamler, Daniel B, Nunez, Felipe J, Zhao, Lili, Castro, Maria G, Lowenstein, Pedro R

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3131 ONCOSTREAMS: NOVEL DYNAMICS PATHOLOGICAL MULTICELLULAR STRUCTURES INVOLVED IN GLIOBLATOMA GROWTH AND INVASION von Comba, Andrea, Dunn, Patrick, Argento, Anna E, Kadiyala, Padma, Motsch, Sebastien, Kish, Phillip, Kahana, Alon, Zamler, Daniel, Muraszko, Karin, Castro, Maria G, Lowenstein, Pedro R

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Abstract 3950: Spatiotemporal analysis of gliomas: Dynamics of mesenchymal multicellular structures as novel target for tumor treatment von Comba, Andrea, Dunn, Patrick, Argento, Anna E., Kadiyala, Padma, Motsch, Sebastien, Zamler, Daniel, Kahana, Alon, Kish, Phillips E., Castro, Maria G., Lowenstein, Pedro R.

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Fyn tyrosine kinase, a downstream target of receptor tyrosine kinases, modulates antiglioma immune responses (vol 33, pg 561, 2020) von Comba, Andrea, Dunn, Patrick J., Argento, Anna E., Kadiyala, Padma, Ventosa, Maria, Patel, Priti, Zamler, Daniel B., Nunez, Felipe J., Zhao, Lili, Castro, Maria G., Lowenstein, Pedro R.

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TMIC-58. THE CELLULAR AND MOLECULAR BASIS FOR MESENCHYMAL TRANSFORMATION IN GLIOMAS von Comba, Andrea, J Dunn, Patrick, E Argento, Anna, Kadiyala, Padma, Motsch, Sebastien, Kahana, Alon, E Kish, Phillip, Castro, Maria, Lowenstein, Pedro

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TMIC-62. FYN, AN EFFECTOR OF ONCOGENIC RECEPTOR TYROSINE KINASES SIGNALING IN GLIOBLASTOMA, INHIBITS ANTI-GLIOMA IMMUNE RESPONSES: IMPLICATIONS FOR IMMUNOTHERAPY von Comba, Andrea, J Dunn, Patrick, E Argento, Anna, Kadiyala, Padma, Ventosa, Maria, Patel, Priti, Zamler, Daniel, Nunez, Felipe, Zhao, Lili, Castro, Maria, Lowenstein, Pedro

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CSIG-39. Fyn, AN ONCOGENE THAT REDUCES GLIOBLASTOMA SURVIVAL YET SENSITIZES TO CHEMO-RADIOTHERAPY von Comba, Andrea, Kadiyala, Padma, Argento, Anna E, Patel, Priti, Nunez, Felipe J, Saxena, Meghna, Castro, Maria G, Lowenstein, Pedro R

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Abstract 5835: Targeting discoidin domain receptor 1 (DDR1) reverses glioma immune suppression by remodeling collagen fiber architecture von Faisal, Syed M., Comba, Andrea, Varela, Maria L., Argento, Anna E., Brumley, Emily, West, Molly E., Haase, Santiago, Mujeeb, Anzar A., Abel, Clifford, Barissi, Marcus N., Clewner, Jarred E., Stack, Brooklyn, Abbud, Grace A., Castro, Maria G., Lowenstein, Pedro R.

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CSIG-11. ONCOSTREAMS: NOVEL STRUCTURES THAT SPECIFY GLIOMAS’ SELF-ORGANIZATION, ARE ANATOMICALLY DISCRETE, FUNCTIONALLY UNIQUE, AND MOLECULARLY DISTINCT von Comba, Andrea, Zamler, Dan, Argento, Anna E, Koschmann, Carl, Nunez, Felipe J, Edwards, Marta, Kadiyala, Padma, Kamran, Neha, Yadav, Viveka Nand, Motsch, Sebastien, Castro, Maria G, Lowenstein, Pedro R

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Abstract 2476: S patiotemporal analyses of preclinical glioma models reveal ‘oncostreams’ as dynamic fascicles regulating tumor mesenchymal transformation, invasion, and malignancy... von Comba, Andrea, Faisal, Syed, Dunn, Patrick J., Argento, Anna E., Hollon, Todd C., Al-Holou, Wajd N., Varela, Maria L., Zamler, Daniel B., Quass, Gunnar L., Apostolides, Pierre F., Brown, Christine E., Kish, Phillip E. E., Kahana, Alon, Kleer, Celina G., Motsch, Sebastien, Castro, Maria G., Lowenstein, Pedro R.

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Mortality among patients with pleural effusion undergoing thoracentesis von DeBiasi, Erin M, Pisani, Margaret A, Murphy, Terrence E, Araujo, Katy, Kookoolis, Anna, Argento, A Christine, Puchalski, Jonathan

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Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia von Grant, Rogan A., Morales-Nebreda, Luisa, Markov, Nikolay S., Swaminathan, Suchitra, Querrey, Melissa, Guzman, Estefany R., Abbott, Darryl A., Donnelly, Helen K., Donayre, Alvaro, Goldberg, Isaac A., Klug, Zasu M., Borkowski, Nicole, Lu, Ziyan, Kihshen, Hermon, Politanska, Yuliya, Sichizya, Lango, Kang, Mengjia, Shilatifard, Ali, Qi, Chao, Lomasney, Jon W., Argento, A. Christine, Kruser, Jacqueline M., Malsin, Elizabeth S., Pickens, Chiagozie O., Smith, Sean B., Walter, James M., Pawlowski, Anna E., Schneider, Daniel, Nannapaneni, Prasanth, Abdala-Valencia, Hiam, Bharat, Ankit, Gottardi, Cara J., Budinger, G. R. Scott, Misharin, Alexander V., Singer, Benjamin D., Wunderink, Richard G.

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Bacterial Superinfection Pneumonia in Patients Mechanically Ventilated for COVID-19 Pneumonia von Pickens, Chiagozie O., Gao, Catherine A., Cuttica, Michael J., Smith, Sean B., Pesce, Lorenzo L., Grant, Rogan A., Kang, Mengjia, Morales-Nebreda, Luisa, Bavishi, Avni A., Arnold, Jason M., Pawlowski, Anna, Qi, Chao, Budinger, G. R. Scott, Singer, Benjamin D., Wunderink, Richard G.

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Local and systemic responses to SARS-CoV-2 infection in children and adults von Yoshida, Masahiro, Worlock, Kaylee B, Huang, Ni, Lindeboom, Rik G.H, Butler, Colin R, Kumasaka, Natsuhiko, Conde, Cecilia Dominguez, Mamanova, Lira, Bolt, Liam, Richardson, Laura, Polanski, Krzysztof, Madissoon, Elo, Barnes, Josephine L, Allen-Hyttinen, Jessica, Kilich, Eliz, Jones, Brendan C, de Wilton, Angus, Wilbrey-Clark, Anna, Sungnak, Waradon, Pett, J. Patrick, Prigmore, Elena, Yung, Henry, Mehta, Puja, Saleh, Aarash, Saigal, Anita, Chu, Vivian, Cohen, Jonathan M, Cane, Clare, Iordanidou, Aikaterini, Shibuya, Soichi, Reuschl, Ann-Kathrin, Herczeg, Ivan T, Argento, A. Christine, Wunderink, Richard G, Smith, Sean B, Poor, Taylor A, Gao, Catherine A, Dematte, Jane E, Reynolds, Gary, Haniffa, Muzlifah, Bowyer, Georgina S, Coates, Matthew, Clatworthy, Menna R, Calero-Nieto, Fernando J, Goettgens, Berthold, O'Callaghan, Christopher, Sebire, Neil J, Jolly, Clare, de Coppi, Paolo, Smith, Claire M, Misharin, Alexander, Janes, Sam M, Teichmann, Sarah A, Nikolic, Marko Z, Meyer, Kerstin B

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Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia von Grant, Rogan A., Morales-Nebreda, Luisa, Markov, Nikolay S., Swaminathan, Suchitra, Querrey, Melissa, Guzman, Estefany R., Abbott, Darryl A., Donnelly, Helen K., Donayre, Alvaro, Goldberg, Isaac A., Klug, Zasu M., Borkowski, Nicole, Lu, Ziyan, Kihshen, Hermon, Politanska, Yuliya, Sichizya, Lango, Kang, Mengjia, Shilatifard, Ali, Qi, Chao, Lomasney, Jon W., Argento, A. Christine, Kruser, Jacqueline M., Malsin, Elizabeth S., Pickens, Chiagozie O., Smith, Sean B., Walter, James M., Pawlowski, Anna E., Schneider, Daniel, Nannapaneni, Prasanth, Abdala-Valencia, Hiam, Bharat, Ankit, Gottardi, Cara J., Budinger, G. R. Scott, Misharin, Alexander, Singer, Benjamin D., Wunderink, Richard G.

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