On the Pathogenesis of Alzheimer's Disease: The MAM Hypothesis von Area-Gomez, Estela, Schon, Eric A.

Volltext

Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging von Jiménez-Loygorri, Juan Ignacio, Villarejo-Zori, Beatriz, Viedma-Poyatos, Álvaro, Zapata-Muñoz, Juan, Benítez-Fernández, Rocío, Frutos-Lisón, María Dolores, Tomás-Barberán, Francisco A., Espín, Juan Carlos, Area-Gómez, Estela, Gomez-Duran, Aurora, Boya, Patricia

Volltext

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease von Area-Gomez, Estela, del Carmen Lara Castillo, Maria, Tambini, Marc D, Guardia-Laguarta, Cristina, de Groof, Ad J C, Madra, Moneek, Ikenouchi, Junichi, Umeda, Masato, Bird, Thomas D, Sturley, Stephen L, Schon, Eric A

Volltext

Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease von Pera, Marta, Larrea, Delfina, Guardia‐Laguarta, Cristina, Montesinos, Jorge, Velasco, Kevin R, Agrawal, Rishi R, Xu, Yimeng, Chan, Robin B, Di Paolo, Gilbert, Mehler, Mark F, Perumal, Geoffrey S, Macaluso, Frank P, Freyberg, Zachary Z, Acin‐Perez, Rebeca, Enriquez, Jose Antonio, Schon, Eric A, Area‐Gomez, Estela

Volltext

γ-Linolenic acid in maternal milk drives cardiac metabolic maturation von Paredes, Ana, Justo-Méndez, Raquel, Jiménez-Blasco, Daniel, Núñez, Vanessa, Calero, Irene, Villalba-Orero, María, Alegre-Martí, Andrea, Fischer, Thierry, Gradillas, Ana, Sant’Anna, Viviane Aparecida Rodrigues, Were, Felipe, Huang, Zhiqiang, Hernansanz-Agustín, Pablo, Contreras, Carmen, Martínez, Fernando, Camafeita, Emilio, Vázquez, Jesús, Ruiz-Cabello, Jesús, Area-Gómez, Estela, Sánchez-Cabo, Fátima, Treuter, Eckardt, Bolaños, Juan Pedro, Estébanez-Perpiñá, Eva, Rupérez, Francisco Javier, Barbas, Coral, Enríquez, José Antonio, Ricote, Mercedes

Volltext

ATAD3 controls mitochondrial cristae structure in mouse muscle, influencing mtDNA replication and cholesterol levels von Peralta, Susana, Goffart, Steffi, Williams, Sion L, Diaz, Francisca, Garcia, Sofia, Nissanka, Nadee, Area-Gomez, Estela, Pohjoismäki, Jaakko, Moraes, Carlos T

Volltext

Author Correction: Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging von Jiménez-Loygorri, Juan Ignacio, Villarejo-Zori, Beatriz, Viedma-Poyatos, Álvaro, Zapata-Muñoz, Juan, Benítez-Fernández, Rocío, Frutos-Lisón, María Dolores, Tomás-Barberán, Francisco A., Espín, Juan Carlos, Area-Gómez, Estela, Gomez-Duran, Aurora, Boya, Patricia

Volltext

RINT1 deficiency disrupts lipid metabolism and underlies a complex hereditary spastic paraplegia von Launay, Nathalie, Ruiz, Montserrat, Planas-Serra, Laura, Verdura, Edgard, Rodríguez-Palmero, Agustí, Schlüter, Agatha, Goicoechea, Leire, Guilera, Cristina, Casas, Josefina, Campelo, Felix, Jouanguy, Emmanuelle, Casanova, Jean-Laurent, Boespflug-Tanguy, Odile, Vazquez Cancela, Maria, Gutiérrez-Solana, Luis González, Casasnovas, Carlos, Area-Gomez, Estela, Pujol, Aurora

Volltext

Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice von Miranda, André Miguel, Ashok, Archana, Chan, Robin Barry, Zhou, Bowen, Xu, Yimeng, McIntire, Laura Beth, Area-Gomez, Estela, Di Paolo, Gilbert, Duff, Karen E., Oliveira, Tiago Gil, Nuriel, Tal

Volltext

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease von Area-Gomez, Estela, de Groof, Ad, Bonilla, Eduardo, Montesinos, Jorge, Tanji, Kurenai, Boldogh, Istvan, Pon, Liza, Schon, Eric A.

Volltext

Lipidome changes due to accumulation of cholesterol via APP‐C99 alters neuronal permeability von Montesinos, Jorge, Area‐Gomez, Estela

Volltext

Lipid level alteration in human and cellular models of alpha synuclein mutations von Avisar, Hila, Guardia-Laguarta, Cristina, Surface, Matthew, Papagiannakis, Nikos, Maniati, Matina, Antonellou, Roubina, Papadimitriou, Dimitra, Koros, Christos, Athanassiadou, Aglaia, Przedborski, Serge, Lerner, Boaz, Stefanis, Leonidas, Area-Gomez, Estela, Alcalay, Roy N.

Volltext

A POGLUT 1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss von Servián‐Morilla, Emilia, Takeuchi, Hideyuki, Lee, Tom V, Clarimon, Jordi, Mavillard, Fabiola, Area‐Gómez, Estela, Rivas, Eloy, Nieto‐González, Jose L, Rivero, Maria C, Cabrera‐Serrano, Macarena, Gómez‐Sánchez, Leonardo, Martínez‐López, Jose A, Estrada, Beatriz, Márquez, Celedonio, Morgado, Yolanda, Suárez‐Calvet, Xavier, Pita, Guillermo, Bigot, Anne, Gallardo, Eduard, Fernández‐Chacón, Rafael, Hirano, Michio, Haltiwanger, Robert S, Jafar‐Nejad, Hamed, Paradas, Carmen

Volltext

MECHANISMS OF MAM DYSFUNCTION IN ALZHEIMER’S DISEASE AND OTHER NEURODEGENERATIVE DISEASES von Area-Gomez, Estela

Volltext

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice von Area-Gomez, Estela, Larrea, Delfina, Pera, Marta, Agrawal, Rishi R., Guilfoyle, David N., Pirhaji, Leila, Shannon, Kathleen, Arain, Hirra A., Ashok, Archana, Chen, Qiuying, Dillman, Allissa A., Figueroa, Helen Y., Cookson, Mark R., Gross, Steven S., Fraenkel, Ernest, Duff, Karen E., Nuriel, Tal

Volltext

Alzheimer’s-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury von Agrawal, Rishi R., Larrea, Delfina, Xu, Yimeng, Shi, Lingyan, Zirpoli, Hylde, Cummins, Leslie G., Emmanuele, Valentina, Song, Donghui, Yun, Taekyung D., Macaluso, Frank P., Min, Wei, Kernie, Steven G., Deckelbaum, Richard J., Area-Gomez, Estela

Volltext

STIM1 Deficiency Leads to Specific Down-Regulation of ITPR3 in SH-SY5Y Cells von Pascual-Caro, Carlos, Orantos-Aguilera, Yolanda, Sanchez-Lopez, Irene, de Juan-Sanz, Jaime, Parys, Jan B., Area-Gomez, Estela, Pozo-Guisado, Eulalia, Martin-Romero, Francisco Javier

Volltext

Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression von Sol, Joaquim, Jové, Mariona, Povedano, Monica, Sproviero, William, Domínguez, Raul, Piñol-Ripoll, Gerard, Romero-Guevara, Ricardo, Hye, Abdul, Al-Chalabi, Ammar, Torres, Pascual, Andres-Benito, Pol, Area-Gómez, Estela, Pamplona, Reinald, Ferrer, Isidro, Ayala, Victòria, Portero-Otín, Manuel

Volltext

MFN2 coordinates mitochondria motility with α-tubulin acetylation and this regulation is disrupted in CMT2A von Kumar, Atul, Larrea, Delfina, Pero, Maria Elena, Infante, Paola, Conenna, Marilisa, Shin, Grace J., Van Elias, Vincent, Grueber, Wesley B., Di Marcotullio, Lucia, Area-Gomez, Estela, Bartolini, Francesca

Volltext

LIPIDS ALTERATION IN TDP-43 von Toledo, Irene García, Corchuelo, Juan Miguel Godoy, Ali, Zeinab, Jimenez-Rodriguez, Jesús, Jimenez-Coca, Irene, Fernández-Bernal, Anna, Jové, Mariona, Obis, Èlia, Matias-Guiu, Jorge, Cunningham, Thommas, Portero-Otin, Manuel, Pamplona, Reinald, Area-Gomez, Estela, Corrochano, Silvia

Volltext