2291. SARS-CoV-2 Viral Kinetics Among Immunologically Naïve Adults: Comparison by Variant and Reinfection Status von Doll, Margaret K, Shakoor, Brianna Levenson, Kimball, Louise E, Crukley, Jeffery, Ozbek, Nina, Blazevic, Rachel L, Mose, Larry, Boonyaratanakornkit, Jim, Stevens-Ayers, Terry L, Cornell, Kevin, Sheppard, Benjamin D, Hampson, Emma, Sharmin, Faria, Goodwin, Benjamin, Dan, Jennifer M, Archie, Tom, O’Connor, Terry, Boeckh, Michael J, Crotty, Shane, Waghmare, Alpana

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Acute and Postacute COVID-19 Outcomes Among Immunologically Naive Adults During Delta vs Omicron Waves von Doll, Margaret K, Waghmare, Alpana, Heit, Antje, Levenson Shakoor, Brianna, Kimball, Louise E, Ozbek, Nina, Blazevic, Rachel L, Mose, Larry, Boonyaratanakornkit, Jim, Stevens-Ayers, Terry L, Cornell, Kevin, Sheppard, Benjamin D, Hampson, Emma, Sharmin, Faria, Goodwin, Benjamin, Dan, Jennifer M, Archie, Tom, O'Connor, Terry, Heckerman, David, Schmitz, Frank, Boeckh, Michael, Crotty, Shane

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A meta-analysis of genome-wide association studies of epigenetic age acceleration von Gibson, Jude, Russ, Tom C, Clarke, Toni-Kim, Howard, David M, Hillary, Robert F, Evans, Kathryn L, Walker, Rosie M, Bermingham, Mairead L, Morris, Stewart W, Campbell, Archie, Hayward, Caroline, Murray, Alison D, Porteous, David J, Horvath, Steve, Lu, Ake T, McIntosh, Andrew M, Whalley, Heather C, Marioni, Riccardo E

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Accessing routinely collected health data to improve clinical trials: recent experience of access von Macnair, Archie, Love, Sharon B., Murray, Macey L., Gilbert, Duncan C., Parmar, Mahesh K. B., Denwood, Tom, Carpenter, James, Sydes, Matthew R., Langley, Ruth E., Cafferty, Fay H.

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DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain von Gadd, Danni A, Smith, Hannah M, Mullin, Donncha, Chybowska, Ola, Hillary, Robert F, Kimenai, Dorien M, Bernabeu, Elena, Cheng, Yipeng, Fawns-Ritchie, Chloe, Campbell, Archie, Page, Danielle, Taylor, Adele, Corley, Janie, Del C Valdés-Hernández, Maria, Maniega, Susana Muñoz, Bastin, Mark E, Wardlaw, Joanna M, Walker, Rosie M, Evans, Kathryn L, McIntosh, Andrew M, Hayward, Caroline, Russ, Tom C, Harris, Sarah E, Welsh, Paul, Sattar, Naveed, Cox, Simon R, McCartney, Daniel L, Marioni, Riccardo E

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Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease von Zhou, Wei, Tsuo, Kristin, Hirbo, Jibril B., Wang, Ying, Bhattacharya, Arjun, Zhao, Huiling, Surakka, Ida, Wolford, Brooke N., Lo Faro, Valeria, Lopera-Maya, Esteban A., Läll, Kristi, Favé, Marie-Julie, Chapman, Sinéad B., Karjalainen, Juha, Maasha, Mutaamba, Chavan, Sameer, Daya, Michelle, Ding, Yi, Feng, Yen-Chen A., Guare, Lindsay A., Gignoux, Christopher R., Graham, Sarah E., Ingold, Nathan, Ismail, Said I., Laisk, Triin, Lin, Kuang, Millwood, Iona Y., Moreno-Grau, Sonia, Nam, Kisung, Palta, Priit, Saad, Chadi, Setia-Verma, Shefali, Thorsteinsdottir, Unnur, Verma, Anurag, Zawistowski, Matthew, Afifi, Nahla, Al-Dabhani, Kawthar M., Campbell, Archie, Crooks, Kristy, Fritsche, Lars G., Fthenou, Eleni, Guo, Yu, Hunt, Karen A., Ioannidis, Alexander, Jansonius, Nomdo M., Konuma, Takahiro, Lee, Ming Ta Michael, Lopez-Pineda, Arturo, Matsuda, Yuta, Marioni, Riccardo E., Numakura, Kensuke, Patil, Snehal, Richmond, Anne, Rojas-Muñoz, Agustin, Shortt, Jonathan A., Tao, Ran, Vanderwerff, Brett, Vernekar, Manvi, Veturi, Yogasudha, Barnes, Kathleen C., Chen, Zhengming, Smith, George Davey, Finucane, Hilary K., Gamazon, Eric R., Gaunt, Tom R., Ge, Tian, Katsanis, Nicholas, Koskela, Jukka T., Law, Matthew H., Li, Liming, Loos, Ruth J.F., Matsuda, Koichi, Olsen, Catherine M., Shavit, Jordan A., Snieder, Harold, Takano, Tomohiro, Vonk, Judith M., Wicks, Stephen J., Wijmenga, Cisca, Wright, John, Zhou, Xiang, Awadalla, Philip, Boehnke, Michael, Bustamante, Carlos D., Fatumo, Segun, Hayward, Caroline, Hveem, Kristian, Kenny, Eimear E., Lee, Seunggeun, Mbarek, Hamdi, Mägi, Reedik, Martin, Hilary C., Medland, Sarah E., Palotie, Aarno V., Pasaniuc, Bogdan, Rader, Daniel J., Ritchie, Marylyn D., Smoller, Jordan W., Stefansson, Kari, Martin, Alicia R.

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Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health von Smith, Hannah M, Moodie, Joanna E, Monterrubio-Gómez, Karla, Gadd, Danni A, Hillary, Robert F, Chybowska, Aleksandra D, McCartney, Daniel L, Campbell, Archie, Redmond, Paul, Page, Danielle, Taylor, Adele, Corley, Janie, Harris, Sarah E, Valdés Hernández, Maria, Muñoz Maniega, Susana, Bastin, Mark E, Wardlaw, Joanna M, Deary, Ian J, Boardman, James P, Mullin, Donncha S, Russ, Tom C, Cox, Simon R, Marioni, Riccardo E

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Effect of Hemodynamics on Stroke Risk in Symptomatic Atherosclerotic Vertebrobasilar Occlusive Disease von Amin-Hanjani, Sepideh, Pandey, Dilip K, Rose-Finnell, Linda, Du, Xinjian, Richardson, DeJuran, Thulborn, Keith R, Elkind, Mitchell S. V, Zipfel, Gregory J, Liebeskind, David S, Silver, Frank L, Kasner, Scott E, Aletich, Victor A, Caplan, Louis R, Derdeyn, Colin P, Gorelick, Philip B, Charbel, Fady T

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Use of sildenafil in patients with severe COVID-19 pneumonitis von McFadyen, Charles, Garfield, Ben, Mancio, Jennifer, Ridge, Carole A., Semple, Tom, Keeling, Archie, Ledot, Stephane, Patel, Brijesh, Samaranayake, Chinthaka B., McCabe, Colm, Wort, S. John, Price, Susanna, Price, Laura C.

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Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts von Wang, Ying, Namba, Shinichi, Lopera, Esteban, Kerminen, Sini, Kanai, Masahiro, Zhou, Wei, Bhatta, Laxmi, Awadalla, Philip, Hveem, Kristian, Lo Faro, Valeria, Mägi, Reedik, Sanna, Serena, Smoller, Jordan W., Uzunovic, Jasmina, Zhou, Wei, Kanai, Masahiro, Rasheed, Humaira, Tsuo, Kristin, Hirbo, Jibril B., Bhattacharya, Arjun, Zhao, Huiling, Namba, Shinichi, Surakka, Ida, Wolford, Brooke N., Lo Faro, Valeria, Läll, Kristi, Favé, Marie-Julie, Chapman, Sinéad B., Karjalainen, Juha, Kurki, Mitja, Mutaamba, Maasha, Partanen, Juulia J., Chavan, Sameer, Chen, Tzu-Ting, Daya, Michelle, Ding, Yi, Graham, Sarah E., Ingold, Nathan, Johnson, Ruth, Laisk, Triin, Lin, Kuang, Lv, Jun, Millwood, Iona Y., Pandit, Anita, Preuss, Michael H., Thorsteinsdottir, Unnur, Uzunovic, Jasmina, Zawistowski, Matthew, Zhong, Xue, Campbell, Archie, Douville, Nicholas J., Finer, Sarah, Griffiths, Christopher J., Marioni, Riccardo E., Nomdo, Jansonius, Patil, Snehal, Richmond, Anne, Straub, Peter, Vanderwerff, Brett, Barnes, Kathleen C., Chen, Zhengming, Chen, Chia-Yen, Smith, George Davey, Finucane, Hilary K., Franke, Lude, Gamazon, Eric R., Ganna, Andrea, Gaunt, Tom R., Ge, Tian, Huffman, Jennifer, MacGregor, Stuart, Matsuda, Koichi, Olsen, Catherine M., Porteous, David J., Shavit, Jordan A., Trembath, Richard C., Vonk, Judith M., Whiteman, David, Wicks, Stephen J., Wijmenga, Cisca, Wright, John, Zhou, Xiang, Cox, Nancy J., Geschwind, Daniel H., Hayward, Caroline, Hveem, Kristian, Kenny, Eimear E., Lin, Yen-Feng, Mägi, Reedik, Martin, Hilary C., Walters, Robin G., Zöllner, Sebastian, Martin, Alicia R., Willer, Cristen J., Daly, Mark J., Neale, Benjamin M., Surakka, Ida, Okada, Yukinori, Martin, Alicia R., Hirbo, Jibril

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A teachable moment von Syson, Tom, Campbell, Archie

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Hemodynamic Features of Symptomatic Vertebrobasilar Disease von Amin-Hanjani, Sepideh, Du, Xinjian, Rose-Finnell, Linda, Pandey, Dilip K, Richardson, DeJuran, Thulborn, Keith R, Elkind, Mitchell S.V, Zipfel, Gregory J, Liebeskind, David S, Silver, Frank L, Kasner, Scott E, Aletich, Victor A, Caplan, Louis R, Derdeyn, Colin P, Gorelick, Philip B, Charbel, Fady T, Xie, Hui, Flannery, Michael P, Ganin, Hagai, Ruland, Sean, Grysiewicz, Rebecca, Khaja, Aslam, Pedelty, Laura, Testai, Fernando, Ong, Archie, Epstein, Noam, Muqtadar, Hurmina, Watson, Karriem, Mlinarevich, Nada, Hillmann, Maureen, Hirsch, Joy, Dashnaw, Stephen, Meyers, Philip M, Willey, Josh Z, McNeill-Simaan, Edwina, Perez, Veronica, Canaan, Alberto, Paulino-Hernandez, Wayna, Vo, Katie, Foster, Glenn, Ford, Andria, Nassief, Abdullah, Bradley, Abbie, Serna-Northway, Jannie, Kraus, Kristi, Shiwani, Lina, Hantler, Nancy, Alger, Jeffrey, Godinez, Sergio, Saver, Jeffrey L, Ali, Latisha, Kim, Doojin, Tenser, Matthew, Froehler, Michael, Raychev, Radoslav, Song, Sarah, Ovbiagele, Bruce, Abcede, Hermelinda, Adamczyk, Peter, Rao, Neal, Yallapragada, Anil, Modir, Royya, Hinman, Jason, Tansy, Aaron, Calderon-Arnulphi, Mateo, Sheth, Sunil, Noorian, Alireza, Ng, Kwan, Liang, Conrad, Gadhia, Jignesh, Smith, Hannah, Avila, Gilda, Avelar, Johanna, Mikulis, David, Fierstra, Jorn, Hlasny, Eugen, Casaubon, Leanne K, Vergouwen, Mervyn, del Campo, J.C Martin, Jaigobin, Cheryl S, Astorga, Cherissa, Kalman, Libby, Kramer, Jeffrey, Vaughan, Susan, Owens, Laura, Kissela, Brett, Turan, Tanya N, Jacobs, Tom P, Janis, Scott

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Changes in sick notes associated with COVID-19 from 2020 to 2022: a cohort study in 24 million primary care patients in OpenSAFELY-TPP von Bhaskaran, Krishnan, Denaxas, Spiros, Bacon, Sebastian C J, Mehrkar, Amir, Bates, Christopher, Greaves, Felix, Macleod, John, Davy, Simon, Ben Goldacre, Liam Hart, Hickman, George, Inglesby, Peter, Maude, Steven, Morley, Jessica, Ward, Tom, Massey, Jon, Wiedemann, Milan, Bates, Christopher, Cockburn, Jonathan, Harper, Sam, Chaturvedi, Nishi, Park, Chloe, Williams, Dylan, Boyd, Andy, Evans, Katharine M, McLachlan, Stela, Timpson, Nicholas, Kwong, Alex, Jones, Louise, Herbert, Annie, Palmer, Tom, Sterne, Jonathan, Fox, Laura, Denholm, Rachel, Kate, Northstone, Arun, Kanagaratnam, Horne, Elsie, Forbes, Harriet, North, Teri, Taylor, Kurt, Arab, Marwa AL, Karthikeyan, Arun S, Wielgoszewska, Bozena, Bridger-Staatz, Charis, Thompson, Ellen, Garcia, Paz, Cheetham, Nathan, Roberts, Amy, Fisher, Louis, MacKenna, Brian, Andrews, Colm, Curtis, Helen, Hopcroft, Lisa, Maddock, Jane, Patel, Kishan, Jacques, Wels, Tilling, Kate, Silverwood, Anoop Shah Richard, Campbell, Archie, Tomlinson, Laurie, Tazare, John, Zheng, Bang, Smeeth, Liam, Herrett, Emily, Cowling, Thomas, Costello, Ruth E, Wang, Kevin, Mahalingasivam, Viyaasan, Douglas, Ian, Parker, Michael, Kennedy, Jonathan, McEachan, Rosie, Badrick, Ellena, Hou, Bo, Steptoe, Andrew, Gessa, Giorgio Di, Zaninotto, Paola, Wood, Angela, Cezard, Genevieve, Ip, Samantha, Bolton, Tom, Sampri, Alexia, Rafeti, Elena, Katikireddi, Vittal, Shaw, Richard, Greaves, Felix, Wong, Andrew, Nigrelli, Lidia, McArdle, Fintan, Beckford, Chelsea, Folarin, Amos, Stewart, Callum, Carpentieri, Jd, Sheard, Laura, Fang, Chao, Gibson, Andy, Kellas, John, Jezzard, Peter, Green, Mark, Lemanska, Agnieszka, Piehlmaier, Dominik

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Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings von Vermunt, Lisa, Muniz-Terrera, Graciela, ter Meulen, Lea, Veal, Colin, Blennow, Kaj, Campbell, Archie, Carrie, Isabelle, Delrieu, Julien, Fauria, Karine, Huesa Rodriguez, Gema, Ingala, Silvia, Jenkins, Natalie, Luis Molinuevo, Jose, Ousset, Pierre-Jean, Porteous, David, Prins, Niels D., Solomon, Alina, Tom, Brian D., Zetterberg, Henrik, Zwan, Marissa, Ritchie, Craig W., Scheltens, Philip, Luscan, Gerald, Brookes, Anthony J., Visser, Pieter Jelle

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Accessing routinely collected health data to improve clinical trials: recent experience of access von Macnair, Archie, Love, Sharon B, Murray, Macey L, Gilbert, Duncan C, Parmar, Mahesh KB, Denwood, Tom, Carpenter, James, Sydes, Matthew R, Langley, Ruth E, Cafferty, Fay H

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Multi‐centre ethics and research governance review can impede non‐interventional clinical research von Duplancic, Christine, Crough, Tania, Bell, Scott C., Thomson, Rachel, Wainwright, Claire, Clements, Archie, Floto, Andres, Rogers, Geraint, Sly, Peter, Burr, Lucy, Feather, Iain, Moloney, Susan, Grimwood, Keith, Bye, Peter, Belessis, Yvonne, Selvadurai, Hiran, Schultz, Andre, Mulrennan, Siobhain, Stock, David, Beggs, Sean, Wark, Peter, Hilton, Jodi, Greville, Hugh, Bastian, Ivan, Tai, Andrew, Kotsimbos, Tom, Armstrongimj, David, Daley, Chris, Ranganathan, Sarath, Harrison, Joanne, Coulter, Chris

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Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer von Timofeeva, Maria N., Kinnersley, Ben, Farrington, Susan M., Whiffin, Nicola, Palles, Claire, Svinti, Victoria, Lloyd, Amy, Gorman, Maggie, Ooi, Li-Yin, Hosking, Fay, Barclay, Ella, Zgaga, Lina, Dobbins, Sara, Martin, Lynn, Theodoratou, Evropi, Broderick, Peter, Tenesa, Albert, Smillie, Claire, Grimes, Graeme, Hayward, Caroline, Campbell, Archie, Porteous, David, Deary, Ian J., Harris, Sarah E., Northwood, Emma L., Barrett, Jennifer H., Smith, Gillian, Wolf, Roland, Forman, David, Morreau, Hans, Ruano, Dina, Tops, Carli, Wijnen, Juul, Schrumpf, Melanie, Boot, Arnoud, Vasen, Hans F A, Hes, Frederik J., van Wezel, Tom, Franke, Andre, Lieb, Wolgang, Schafmayer, Clemens, Hampe, Jochen, Buch, Stephan, Propping, Peter, Hemminki, Kari, Försti, Asta, Westers, Helga, Hofstra, Robert, Pinheiro, Manuela, Pinto, Carla, Teixeira, Manuel, Ruiz-Ponte, Clara, Fernández-Rozadilla, Ceres, Carracedo, Angel, Castells, Antoni, Castellví-Bel, Sergi, Campbell, Harry, Bishop, D. Timothy, Tomlinson, Ian P M, Dunlop, Malcolm G., Houlston, Richard S.

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Optimized Hemodynamic Assessment to Predict Stroke Risk in Vertebrobasilar Disease: Analysis From the VERiTAS Study von See, Alfred P., Pandey, Dilip K., Du, Xinjian, Rose-Finnell, Linda, Charbel, Fady T., Derdeyn, Colin P., Amin-Hanjani, Sepideh

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A randomized trial of topical anesthesia comparing lidocaine versus lidocaine plus xylometazoline for unsedated transnasal upper gastrointestinal endoscopy von Cheung, Justin, Goodman, Karen, Bailey, Robert, Fedorak, Richard, Morse, John, Millan, Mario, Guzowski, Tom, van Zanten, Sander Veldhuyzen

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Jazz at the Villette. Archie Shepp, Melvin Van Peebles, The Heliocentrics von Melvin Van Peebles, Archie Shepp

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