A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity von Miller, Michael L, Fishkin, Nathan E, Li, Wei, Whiteman, Kathleen R, Kovtun, Yelena, Reid, Emily E, Archer, Katie E, Maloney, Erin K, Audette, Charlene A, Mayo, Michele F, Wilhelm, Alan, Modafferi, Holly A, Singh, Rajeeva, Pinkas, Jan, Goldmacher, Victor, Lambert, John M, Chari, Ravi V J

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Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody–Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation... von Bai, Chen, Reid, Emily E, Wilhelm, Alan, Shizuka, Manami, Maloney, Erin K, Laleau, Rassol, Harvey, Lauren, Archer, Katie E, Vitharana, Dilrukshi, Adams, Sharlene, Kovtun, Yelena, Miller, Michael L, Chari, Ravi, Keating, Thomas A, Yoder, Nicholas C

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Optimizing Lysosomal Activation of Antibody–Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers von Salomon, Paulin L, Reid, Emily E, Archer, Katie E, Harris, Luke, Maloney, Erin K, Wilhelm, Alan J, Miller, Michael L, Chari, Ravi V. J, Keating, Thomas A, Singh, Rajeeva

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A DNA-Interacting Payload Designed to Eliminate Cross-Linking Improves the Therapeutic Index of Antibody-Drug Conjugates (ADCs) von Miller, Michael L, Shizuka, Manami, Wilhelm, Alan, Salomon, Paulin, Reid, Emily E, Lanieri, Leanne, Sikka, Surina, Maloney, Erin K, Harvey, Lauren, Qiu, Qifeng, Archer, Katie E, Bai, Chen, Vitharana, Dilrukshi, Harris, Luke, Singh, Rajeeva, Ponte, Jose F, Yoder, Nicholas C, Kovtun, Yelena, Lai, Katharine C, Ab, Olga, Pinkas, Jan, Keating, Thomas A, Chari, Ravi V J

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Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs) von Reid, Emily E., Archer, Katie E., Shizuka, Manami, McShea, Molly A., Maloney, Erin K., Ab, Olga, Lanieri, Leanne, Wilhelm, Alan, Ponte, Jose F., Yoder, Nicholas C., Chari, Ravi V.J., Miller, Michael L.

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Effect of Linker Stereochemistry on the Activity of Indolinobenzodiazepine Containing Antibody–Drug Conjugates (ADCs) von Reid, Emily E, Archer, Katie E, Shizuka, Manami, Wilhelm, Alan, Yoder, Nicholas C, Bai, Chen, Fishkin, Nathan E, Harris, Luke, Maloney, Erin K, Salomon, Paulin, Hong, Erica, Wu, Rui, Ab, Olga, Jin, Shan, Lai, Katharine C, Sikka, Surina, Chari, Ravi V. J, Miller, Michael L

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Synthesis of Highly Potent N‑10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody–Drug Conjugates (ADCs) von Archer, Katie E, Reid, Emily E, Shizuka, Manami, Woods, James, Harris, Luke, Maloney, Erin K, Bartle, Laura M, Ab, Olga, Wilhelm, Alan, Setiady, Yulius, Ponte, Jose F, Singh, Rajeeva, Keating, Thomas A, Chari, Ravi V. J, Miller, Michael L

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Abstract 224: Antibody-drug conjugates (ADCs) of a new class of N-10 amino linked DNA alkylating indolino-benzodiazepines (IGNs) von Miller, Michael L., Reid, Emily E., Archer, Katie E., Harris, Luke, Maloney, Erin K., Bartle, Laura M., Ab, Olga, Wilhelm, Alan J., Ponte, Jose F., Singh, Rajeeva, Keating, Thomas A., Chari, Ravi V.

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Abstract 747: A new class of DNA alkylating indolino-benzodiazepine agents (BIAs) linked with a DNA binding moiety for use with antibody-drug conjugates (ADCs) von Miller, Michael L., Reid, Emily E., Archer, Katie E., Shizuka, Manami, McShea, Molly A., Maloney, Erin K., Ab, Olga, Lanieri, Leanne, Wilhelm, Alan J., Ponte, Jose F., Yoder, Nicholas C., Chari, Ravi V.

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Abstract 53: Antibody-drug conjugates (ADCs) of peptide-linked Indolino-Benzodiazepine (IGN) DNA-alkylator provides improved anti-tumor activity over that of a crosslinker von Miller, Michael L., Shizuka, Manami, Ponte, Jose F., Lanieri, Leanne, Vitharana, Dilrukshi, Qiu, Qifeng, Reid, Emily E., Archer, Katie E., Wu, Rui, Maloney, Erin K., Ab, Olga, Pinkas, Jan, Chari, Ravi V.

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Achieving global biodiversity goals by 2050 requires urgent and integrated actions von Leadley, Paul, Gonzalez, Andrew, Obura, David, Krug, Cornelia B., Londoño-Murcia, Maria Cecilia, Millette, Katie L., Radulovici, Adriana, Rankovic, Aleksandar, Shannon, Lynne J., Archer, Emma, Armah, Frederick Ato, Bax, Nic, Chaudhari, Kalpana, Costello, Mark John, Dávalos, Liliana M., Roque, Fabio de Oliveira, DeClerck, Fabrice, Dee, Laura E., Essl, Franz, Ferrier, Simon, Genovesi, Piero, Guariguata, Manuel R., Hashimoto, Shizuka, Ifejika Speranza, Chinwe, Isbell, Forest, Kok, Marcel, Lavery, Shane D., Leclère, David, Loyola, Rafael, Lwasa, Shuaib, McGeoch, Melodie, Mori, Akira S., Nicholson, Emily, Ochoa, Jose M., Öllerer, Kinga, Polasky, Stephen, Rondinini, Carlo, Schroer, Sibylle, Selomane, Odirilwe, Shen, Xiaoli, Strassburg, Bernardo, Sumaila, Ussif Rashid, Tittensor, Derek P., Turak, Eren, Urbina, Luis, Vallejos, Maria, Vázquez-Domínguez, Ella, Verburg, Peter H., Visconti, Piero, Woodley, Stephen, Xu, Jianchu

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Variants in myelin regulatory factor (MYRF) cause autosomal dominant and syndromic nanophthalmos in humans and retinal degeneration in mice von Garnai, Sarah J, Brinkmeier, Michelle L, Emery, Ben, Aleman, Tomas S, Pyle, Louise C, Veleva-Rotse, Biliana, Sisk, Robert A, Rozsa, Frank W, Ozel, Ayse Bilge, Li, Jun Z, Moroi, Sayoko E, Archer, Steven M, Lin, Cheng-Mao, Sheskey, Sarah, Wiinikka-Buesser, Laurel, Eadie, James, Urquhart, Jill E, Black, Graeme C M, Othman, Mohammad I, Boehnke, Michael, Sullivan, Scot A, Skuta, Gregory L, Pawar, Hemant S, Katz, Alexander E, Huryn, Laryssa A, Hufnagel, Robert B, Camper, Sally A, Richards, Julia E, Prasov, Lev

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Establishing a Sociodemographic Data Banking Study in Patients with Hematologic Disorders - a Feasibility Assessment von Oni, Morohuntodun O., Hawkins, Alexandria, Stein, Emily, Dubois, Steven G., Greenzang, Katie A., Aziz-Bose, Rahela, Duncan, Christine, O'Neill, Allison F., Place, Andrew E., Umaretiya, Puja J., Archer, Natasha, Bona, Kira

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Targeting thalamocortical circuits for closed-loop stimulation in Lennox-Gastaut syndrome von Warren, Aaron E L, Butson, Christopher R, Hook, Matthew P, Dalic, Linda J, Archer, John S, Macdonald-Laurs, Emma, Schaper, Frederic L W V J, Hart, Lauren A, Singh, Hargunbir, Johnson, Lise, Bullinger, Katie L, Gross, Robert E, Morrell, Martha J, Rolston, John D

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Conceptualizing the Civil–Military Gap: A Research Note von Rahbek-Clemmensen, Jon, Archer, Emerald M., Barr, John, Belkin, Aaron, Guerrero, Mario, Hall, Cameron, Swain, Katie E. O.

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Psychological distress and positive gain in mothers of children with autism, with or without other children with neurodevelopmental disorders von Stanford, Catherine E., Hastings, Richard P., Riby, Deborah M., Archer, Heather J., Page, Sarah E., Cebula, Katie

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Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height von Tatton-Brown, Katrina, Hanks, Sandra, Ruark, Elise, Zachariou, Anna, Duarte, Silvana Del Vecchio, Ramsay, Emma, Snape, Katie, Murray, Anne, Perdeaux, Elizabeth R, Seal, Sheila, Loveday, Chey, Banka, Siddharth, Clericuzio, Carol, Flinter, Frances, Magee, Alex, McConnell, Vivienne, Patton, Michael, Raith, Wolfgang, Rankin, Julia, Splitt, Miranda, Strenger, Volker, Taylor, Clare, Wheeler, Patricia, Temple, Karen I, Cole, Trevor, Douglas, Jenny, Rahman, Nazneen

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Myoclonus and hypercalcemia in a dog with poorly differentiated lymphoproliferative neoplasia von Hare, Cassia H. Z., Archer, Joy, Cloup, Emilie, Genain, Marie‐Aude, Hughes, Katherine, McCallum, Katie E., Alves, Lisa

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Adipose-Derived Stem Cells: Methods and Protocols von Bunnell, Bruce A, Gimble, Jeffrey M

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Spin-label scanning reveals conformational sensitivity of the bound helical interfaces of IA 3 von M. Dunleavy, Katie, Milshteyn, Eugene, Sorrentino, Zachary, L. Pirman, Natasha, Liu, Zhanglong, B. Chandler, Matthew, W. D’Amore, Peter, E. Fanucci, Gail

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