Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2 von Keysar, Stephen B, Le, Phuong N, Miller, Bettina, Jackson, Brian C, Eagles, Justin R, Nieto, Cera, Kim, Jihye, Tang, Binwu, Glogowska, Magdalena J, Morton, J Jason, Padilla-Just, Nuria, Gomez, Karina, Warnock, Emily, Reisinger, Julie, Arcaroli, John J, Messersmith, Wells A, Wakefield, Lalage M, Gao, Dexiang, Tan, Aik-Choon, Serracino, Hilary, Vasiliou, Vasilis, Roop, Dennis R, Wang, Xiao-Jing, Jimeno, Antonio

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Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL) von Hawkins, Hayley J, Yacob, Betelehem W, Brown, Monica E, Goldstein, Brandon R, Arcaroli, John J, Bagby, Stacey M, Hartman, Sarah J, Macbeth, Morgan, Goodspeed, Andrew, Danhorn, Thomas, Lentz, Robert W, Lieu, Christopher H, Leal, Alexis D, Messersmith, Wells A, Dempsey, Peter J, Pitts, Todd M

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Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade von Flaig, Thomas W, Salzmann-Sullivan, Maren, Su, Lih-Jen, Zhang, Zhiyong, Joshi, Molishree, Gijón, Miguel A, Kim, Jihye, Arcaroli, John J, Van Bokhoven, Adrie, Lucia, M Scott, La Rosa, Francisco G, Schlaepfer, Isabel R

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Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms von Scott, Aaron J, Arcaroli, John J, Bagby, Stacey M, Yahn, Rachel, Huber, Kendra M, Serkova, Natalie J, Nguyen, Anna, Kim, Jihye, Thorburn, Andrew, Vogel, Jon, Quackenbush, Kevin S, Capasso, Anna, Schreiber, Anna, Blatchford, Patrick, Klauck, Peter J, Pitts, Todd M, Eckhardt, S Gail, Messersmith, Wells A

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Acetaldehyde and Retinaldehyde-Metabolizing Enzymes in Colon and Pancreatic Cancers von Singh, S., Arcaroli, J., Thompson, D. C., Messersmith, W., Vasiliou, V.

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Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer von Pitts, Todd M, Newton, Timothy P, Bradshaw-Pierce, Erica L, Addison, Rebecca, Arcaroli, John J, Klauck, Peter J, Bagby, Stacey M, Hyatt, Stephanie L, Purkey, Alicia, Tentler, John J, Tan, Aik Choon, Messersmith, Wells A, Eckhardt, S Gail, Leong, Stephen

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Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer von SPREAFICO, Anna, TENTLER, John J, MICEL, Lindsey N, SELBY, Heather M, NEWTON, Timothy P, MCPHILLIPS, Kelly L, GUSTAFSON, Daniel L, DEGREGORI, James V, MESSERSMITH, Wells A, WINN, Robert A, ECKHARDT, S. Gail, PITTS, Todd M, AIK CHOON TAN, GREGORY, Mark A, ARCAROLI, John J, KLAUCK, Peter J, MCMANUS, Martine C, HANSEN, Ryan J, JIHYE KIM

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Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation von Abraham, Edward, Arcaroli, John, Carmody, Aaron, Wang, Haichao, Tracey, Kevin J

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Topoisomerase IIα mediates TCF-dependent epithelial–mesenchymal transition in colon cancer von Zhou, Q, Abraham, A D, Li, L, Babalmorad, A, Bagby, S, Arcaroli, J J, Hansen, R J, Valeriote, F A, Gustafson, D L, Schaack, J, Messersmith, W A, LaBarbera, D V

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Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ-secretase inhibitor, in a preclinical colorectal explant model von Arcaroli, J J, Quackenbush, K S, Purkey, A, Powell, R W, Pitts, T M, Bagby, S, Tan, A C, Cross, B, McPhillips, K, Song, E-K, Tai, W M, Winn, R A, Bikkavilli, K, VanScoyk, M, Eckhardt, S G, Messersmith, W A

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Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer von Bikkavilli, R K, Avasarala, S, Van Scoyk, M, Arcaroli, J, Brzezinski, C, Zhang, W, Edwards, M G, Rathinam, M K K, Zhou, T, Tauler, J, Borowicz, S, Lussier, Y A, Parr, B A, Cool, C D, Winn, R A

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Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer von Klauck, Peter J, Bagby, Stacey M, Capasso, Anna, Bradshaw-Pierce, Erica L, Selby, Heather M, Spreafico, Anna, Tentler, John J, Tan, Aik Choon, Kim, Jihye, Arcaroli, John J, Purkey, Alicia, Messersmith, Wells A, Kuida, Keisuke, Eckhardt, S Gail, Pitts, Todd M

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CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma von Ravindran Menon, Dinoop, Luo, Yuchun, Arcaroli, John J, Liu, Sucai, KrishnanKutty, Lekha Nair, Osborne, Douglas G, Li, Yang, Samson, Jenny Mae, Bagby, Stacey, Tan, Aik-Choon, Robinson, William A, Messersmith, Wells A, Fujita, Mayumi

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Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer von Pitts, Todd M, Bradshaw-Pierce, Erica L, Bagby, Stacey M, Hyatt, Stephanie L, Selby, Heather M, Spreafico, Anna, Tentler, John J, McPhillips, Kelly, Klauck, Peter J, Capasso, Anna, Diamond, Jennifer R, Davis, S Lindsey, Tan, Aik Choon, Arcaroli, John J, Purkey, Alicia, Messersmith, Wells A, Ecsedy, Jeffery A, Eckhardt, S Gail

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Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer von ARCAROLI, John J, TOUBAN, Basel M, CHOON TAN, Aik, VARELLA-GARCIA, Marileila, POWELL, Rebecca W, ECKHARDT, S. Gail, ELVIN, Paul, DEXIANG GAO, MESSERSMITH, Wells A

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A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins von Keysar, Stephen B., Astling, David P., Anderson, Ryan T., Vogler, Brian W., Bowles, Daniel W., Morton, J. Jason, Paylor, Jeramiah J., Glogowska, Magdalena J., Le, Phuong N., Eagles-Soukup, Justin R., Kako, Severine L., Takimoto, Sarah M., Sehrt, Daniel B., Umpierrez, Adrian, Pittman, Morgan A., Macfadden, Sarah M., Helber, Ryan M., Peterson, Scott, Hausman, Diana F., Said, Sherif, Leem, Ted H., Goddard, Julie A., Arcaroli, John J., Messersmith, Wells A., Robinson, William A., Hirsch, Fred R., Varella-Garcia, Marileila, Raben, David, Wang, Xiao-Jing, Song, John I., Tan, Aik-Choon, Jimeno, Antonio

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Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer von Bikkavilli, R K, Avasarala, S, Van Scoyk, M, Arcaroli, J, Brzezinski, C, Zhang, W, Edwards, M G, Rathinam, M K K, Zhou, T, Tauler, J, Borowicz, S, Lussier, Y A, Parr, B A, Cool, C D, Winn, R A

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Early Alterations in Neutrophil Activation Are Associated with Outcome in Acute Lung Injury von Yang, Kuang-Yao, Arcaroli, John J, Abraham, Edward

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An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent von Li, Linfeng, Abraham, Adedoyin D, Zhou, Qiong, Ali, Hadi, O'Brien, Jeremy V, Hamill, Brayden D, Arcaroli, John J, Messersmith, Wells A, LaBarbera, Daniel V

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Involvement of Phosphoinositide 3-Kinases in Neutrophil Activation and the Development of Acute Lung Injury von Yum, Ho-Kee, Arcaroli, John, Kupfner, John, Shenkar, Robert, Penninger, Josef M, Sasaki, Takehiko, Yang, Kuang-Yao, Park, Jong Sung, Abraham, Edward

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