Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma von Gonzalez-Meljem, Jose Mario, Haston, Scott, Carreno, Gabriela, Apps, John R., Pozzi, Sara, Stache, Christina, Kaushal, Grace, Virasami, Alex, Panousopoulos, Leonidas, Mousavy-Gharavy, Seyedeh Neda, Guerrero, Ana, Rashid, Mamunur, Jani, Nital, Goding, Colin R., Jacques, Thomas S., Adams, David J., Gil, Jesus, Andoniadou, Cynthia L., Martinez-Barbera, Juan Pedro

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Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors von Carreno, Gabriela, Apps, John R, Lodge, Emily J, Panousopoulos, Leonidas, Haston, Scott, Gonzalez-Meljem, Jose Mario, Hahn, Heidi, Andoniadou, Cynthia L, Martinez-Barbera, Juan Pedro

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PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice von Poulogiannis, George, McIntyre, Rebecca E., Dimitriadi, Maria, Apps, John R., Wilson, Catherine H., Ichimura, Koichi, Luo, Feijun, Cantley, Lewis C., Wyllie, Andrew H., Adams, David J., Arends, Mark J.

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Intra-Tumor Genetic Heterogeneity in Wilms Tumor: Clonal Evolution and Clinical Implications von Cresswell, George D., Apps, John R., Chagtai, Tasnim, Mifsud, Borbala, Bentley, Christopher C., Maschietto, Mariana, Popov, Sergey D., Weeks, Mark E., Olsen, Øystein E., Sebire, Neil J., Pritchard-Jones, Kathy, Luscombe, Nicholas M., Williams, Richard D., Mifsud, William

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Recurrent adamantinomatous craniopharyngiomas show MAPK pathway activation, clonal evolution and rare TP53-loss-mediated malignant progression von Apps, John R, Gonzalez-Meljem, Jose Mario, Guiho, Romain, Pickles, Jessica C, Prince, Eric, Schwalbe, Edward, Joshi, Nikhil, Stone, Thomas J, Ogunbiyi, Olumide, Chalker, Jane, Bassey, Akang, Otto, Georg, Davies, Rosalind, Hughes, Debbie, Brandner, Sebastian, Tan, Enrica, Lee, Victoria, Hayhurst, Caroline, Kline, Cassie, Castellano, Sergi, Hankinson, Todd, Deutschbein, Timo, Jacques, Thomas S, Martinez-Barbera, Juan Pedro

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MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma von Haston, Scott, Pozzi, Sara, Carreno, Gabriela, Manshaei, Saba, Panousopoulos, Leonidas, Gonzalez-Meljem, Jose Mario, Apps, John R, Virasami, Alex, Thavaraj, Selvam, Gutteridge, Alice, Forshew, Tim, Marais, Richard, Brandner, Sebastian, Jacques, Thomas S, Andoniadou, Cynthia L, Martinez-Barbera, Juan Pedro

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Tumour compartment transcriptomics demonstrates the activation of inflammatory and odontogenic programmes in human adamantinomatous craniopharyngioma and identifies the MAPK/ERK pa... von Apps, John R., Carreno, Gabriela, Gonzalez-Meljem, Jose Mario, Haston, Scott, Guiho, Romain, Cooper, Julie E., Manshaei, Saba, Jani, Nital, Hölsken, Annett, Pettorini, Benedetta, Beynon, Robert J., Simpson, Deborah M., Fraser, Helen C., Hong, Ying, Hallang, Shirleen, Stone, Thomas J., Virasami, Alex, Donson, Andrew M., Jones, David, Aquilina, Kristian, Spoudeas, Helen, Joshi, Abhijit R., Grundy, Richard, Storer, Lisa C. D., Korbonits, Márta, Hilton, David A., Tossell, Kyoko, Thavaraj, Selvam, Ungless, Mark A., Gil, Jesus, Buslei, Rolf, Hankinson, Todd, Hargrave, Darren, Goding, Colin, Andoniadou, Cynthia L., Brogan, Paul, Jacques, Thomas S., Williams, Hywel J., Martinez-Barbera, Juan Pedro

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Nephrogenic rests in Wilms tumors treated with preoperative chemotherapy: The UK SIOP Wilms Tumor 2001 Trial experience von Vujanić, Gordan M., Apps, John R., Moroz, Veronica, Ceroni, Federica, Williams, Richard D., Sebire, Neil J., Pritchard‐Jones, Kathy

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Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis von Prince, Eric W, Apps, John R, Jeang, John, Chee, Keanu, Medlin, Stephen, Jackson, Eric M, Dudley, Roy, Limbrick, David, Naftel, Robert, Johnston, James, Feldstein, Neil, Prolo, Laura M, Ginn, Kevin, Niazi, Toba, Smith, Amy, Kilburn, Lindsay, Chern, Joshua, Leonard, Jeffrey, Lam, Sandi, Hersh, David S, Gonzalez-Meljem, Jose Mario, Amani, Vladimir, Donson, Andrew M, Mitra, Siddhartha S, Bandopadhayay, Pratiti, Martinez-Barbera, Juan Pedro, Hankinson, Todd C

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Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ von Xekouki, Paraskevi, Lodge, Emily J, Matschke, Jakob, Santambrogio, Alice, Apps, John R, Sharif, Ariane, Jacques, Thomas S, Aylwin, Simon, Prevot, Vincent, Li, Ran, Flitsch, Jörg, Bornstein, Stefan R, Theodoropoulou, Marily, Andoniadou, Cynthia L

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Preclinical transgenic and patient‐derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma von Boult, Jessica K. R., Apps, John R., Hölsken, Annett, Hutchinson, J. Ciaran, Carreno, Gabriela, Danielson, Laura S., Smith, Laura M., Bäuerle, Tobias, Buslei, Rolf, Buchfelder, Michael, Virasami, Alex K., Koers, Alexander, Arthurs, Owen J., Jacques, Thomas S., Chesler, Louis, Martinez‐Barbera, Juan Pedro, Robinson, Simon P.

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EASILY MISSED? Cow's milk allergy in children von Apps, John R, Beattie, R Mark

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A new generation of academic paediatricians von Brown, Chrysothemis C, Apps, John R, Winyard, Paul J

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Imaging Invasion: Micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion von Apps, John R, Hutchinson, J Ciaran, Arthurs, Owen J, Virasami, Alex, Joshi, Abhijit, Zeller-Plumhoff, Berit, Moulding, Dale, Jacques, Thomas S, Sebire, Neil J, Martinez-Barbera, Juan Pedro

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Abstract 1804: Expression analysis of adamantinomatous craniopharyngioma suggests two subtypes associated with CTNNB1 mutational frequency and highlights potential therapeutic targ... von Apps, John R., Jani, Nital, Carreno, Gabriela, Gonzalez-Meljem, Jose M., Tossell, Kyoko, Stone, Thomas J., Ungless, Mark A., Williams, Hywel J., Jacques, Thomas S., Martinez-Barbera, Juan-Pedro

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Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04) von Apps, John R, Maycock, Shanna, Ellison, David W, Jaspan, Timothy, Ritzmann, Timothy A, Macarthur, Donald, Mallucci, Conor, Wheatley, Keith, Veal, Gareth J, Grundy, Richard G, Picton, Susan

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Learning from cases: Analysis of two cases of craniopharyngioma from the 19th to the 21st centuries von Apps, John R., Hutchinson, J. Ciaran, Shelmerdine, Susan, Virasami, Alex, Winter, Eduard, Jacques, Thomas S., Martinez-Barbera, Juan-Pedro, Arthurs, Owen, Czech, Thomas

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Learning from cases: Analysis of two cases of craniopharyngioma from the 19 th to the 21 st centuries. [version 1; peer review: 2 approved] von Apps, John R, Hutchinson, J. Ciaran, Shelmerdine, Susan, Virasami, Alex, Winter, Eduard, Jacques, Thomas S, Martinez-Barbera, Juan-Pedro, Arthurs, Owen, Czech, Thomas

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An overview of drug therapies used in the treatment of dystonia and spasticity in children von Tickner, Neil, Apps, John R, Keady, Simon, Sutcliffe, Alastair G

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Making your way as an academic paediatric trainee in the UK von Brown, Chrysothemis C, Apps, John R, Davies, Gwyneth, Ware, Nicholas, Fisher, John, Winyard, Paul J D

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