Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition von Reich, Siegfried H, Sprengeler, Paul A, Chiang, Gary G, Appleman, James R, Chen, Joan, Clarine, Jeff, Eam, Boreth, Ernst, Justin T, Han, Qing, Goel, Vikas K, Han, Edward Z. R, Huang, Vera, Hung, Ivy N. J, Jemison, Adrianna, Jessen, Katti A, Molter, Jolene, Murphy, Douglas, Neal, Melissa, Parker, Gregory S, Shaghafi, Michael, Sperry, Samuel, Staunton, Jocelyn, Stumpf, Craig R, Thompson, Peggy A, Tran, Chinh, Webber, Stephen E, Wegerski, Christopher J, Zheng, Hong, Webster, Kevin R

Volltext

Transcription inactivation through local refolding of the RNA polymerase structure von Belogurov, Georgiy A., Vassylyeva, Marina N., Sevostyanova, Anastasiya, Appleman, James R., Xiang, Alan X., Lira, Ricardo, Webber, Stephen E., Klyuyev, Sergiy, Nudler, Evgeny, Artsimovitch, Irina, Vassylyev, Dmitry G.

Volltext

Pharmacokinetics and Pharmacodynamics of Setrobuvir, an Orally Administered Hepatitis C Virus Non-Nucleoside Analogue Inhibitor von Mallalieu, Navita L., PhD, Rahimy, Mohamad H., PhD, Crowley, Constance A., BSc, Appleman, James R., PhD, Smith, Patrick F., PharmD, Freddo, James L., MD

Volltext

Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase von Lira, Ricardo, Xiang, Alan X., Doundoulakis, Thomas, Biller, William T., Agrios, Konstantinos A., Simonsen, Klaus B., Webber, Stephen E., Sisson, Wes, Aust, Robert M., Shah, Amit M., Showalter, Richard E., Banh, Virginia N., Steffy, Kevin R., Appleman, James R.

Volltext

New point of care test is highly specific but less sensitive for influenza virus A and B in children and adults von Rawlinson, William D., Waliuzzaman, Zubair M., Fennell, Michael, Appleman, James R., Shimasaki, Craig D., Carter, Ian W.

Volltext

Clinical Evaluation of the ZstatFlu-II Test: a Chemiluminescent Rapid Diagnostic Test for Influenza Virus von HAMILTON, Marilyn S, ABEL, David M, BALLAM, Yolanda J, OTTO, Mary K, NICKELL, Angela F, PENCE, Lisa M, APPLEMAN, James R, SHIMASAKI, Craig D, ACHYUTHAN, Komandoor E

Volltext

Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7 von BOONSTRA, Andre, LIU, Bi-Sheng, BAUMAN, Lisa A, RAHIMY, Mohamad, APPLEMAN, James R, FREDDO, James L, REESINK, Hendrik W, DE KNEGT, Robert J, JANSSEN, Harry La, GROOTHUISMINK, Zwier Ma, BERGMANN, Jilling F, DE BRUIJNE, Joep, HOTHO, Daphne M, HANSEN, Bettina E, VLIET, Andre A.van, DE WETERING DE ROOIJ, Jeroen Van, FLETCHER, Simon P

Volltext

Abstract 3262: Discovery of a series of novel toll-like receptor 7 agonists for systemic immunotherapy of cancer von Appleman, James R., Webber, Stephen E.

Volltext

ZstatFlu®-II test: a chemiluminescent neuraminidase assay for influenza viral diagnostics von Achyuthan, Komandoor E., Pence, Lisa M., Appleman, James R., Shimasaki, Craig D.

Volltext

SCAN™—A High-Throughput Assay for Detecting Small Molecule Binding to RNA Targets von Baugh, Chris, Wang, Shaohui, Li, Bin, Appleman, James R., Thompson, Peggy A.

Volltext

A novel inhibitor of respiratory syncytial virus isolated from ethnobotanicals von Ojwang, Joshua O., Wang, Yan-Hong, Wyde, Philip R., Fischer, Nikolaus H., Schuehly, Wolfgang, Appleman, James R., Hinds, Soreeta, Shimasaki, Craig D.

Volltext

Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation von DOUNDOULAKIS, Thomas, XIANG, Alan X, SIMONSEN, Klaus B, LIRA, Ricardo, AGRIOS, Konstantinos A, WEBBER, Stephen E, SISSON, Wes, AUST, Robert M, SHAH, Amit M, SHOWALTER, Richard E, APPLEMAN, James R

Volltext

Kinetic Scheme for Thymidylate Synthase from Escherichia coli:  Determination from Measurements of Ligand Binding, Primary and Secondary Isotope Effects, and Pre-Steady-State Catal... von Spencer, H. Trent, Villafranca, J. Ernest, Appleman, James R

Volltext

Identification of ligand binding by protein stabilization: comparison of ATLAS with biophysical and enzymatic methods von Thompson, Peggy A, Wang, Shaohui, Howett, Lindsay J, Wang, Mei-Mei, Patel, Rupal, Averill, April, Showalter, Richard E, Li, Bin, Appleman, James R

Volltext

Abstract CT180: Activation of innate and adaptive immune response with a clinical stage TLR7 agonist prodrug PRTX007 von Lemech, Charlotte R., Argent, Christopher, Scribner, Curtis L., Sharabi, Andrew, Daniels, Richard, Appleman, James R.

Volltext

ATLAS--a high-throughput affinity-based screening technology for soluble proteins: technology application using p38 MAP kinase von Patel, Rupal, Lebrun, Laurie A, Wang, Shaohui, Howett, Lindsay J, Thompson, Peggy A, Appleman, James R, Li, Bin

Volltext

AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series von Bookser, Brett C, Kasibhatla, Srinivas Rao, Appleman, James R, Erion, Mark D

Volltext

AMP Deaminase Inhibitors. 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues von Kasibhatla, Srinivas Rao, Bookser, Brett C, Probst, Gary, Appleman, James R, Erion, Mark D

Volltext

Discovery of AMP Mimetics that Exhibit High Inhibitory Potency and Specificity for AMP Deaminase von Erion, Mark D, Kasibhatla, Srinivas Rao, Bookser, Brett C, van Poelje, Paul D, Reddy, M. Rami, Gruber, Harry E, Appleman, James R

Volltext

eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (D... von Webster, Kevin R., Goel, Vikas K, Hung, Ivy NJ, Parker, Gregory S, Staunton, Jocelyn, Neal, Melissa, Molter, Jolene, Chiang, Gary G, Jessen, Katti A., Wegerski, Christopher J, Sperry, Samuel, Huang, Vera, Chen, Joan, Thompson, Peggy A, Appleman, James R, Webber, Stephen E, Sprengeler, Paul A, Reich, Siegfried H

Volltext