Crystal structure of the human PRMT5:MEP50 complex von Antonysamy, Stephen, Bonday, Zahid, Campbell, Robert M, Doyle, Brandon, Druzina, Zhanna, Gheyi, Tarun, Han, Bomie, Jungheim, Louis N, Qian, Yuewei, Rauch, Charles, Russell, Marijane, Sauder, J. Michael, Wasserman, Stephen R, Weichert, Kenneth, Willard, Francis S, Zhang, Aiping, Emtage, Spencer

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Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing von Lieu, Ricky, Antonysamy, Stephen, Druzina, Zhanna, Ho, Carolyn, Kang, N. Rebecca, Pustilnik, Anna, Wang, Jing, Atwell, Shane

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LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2 von Nguyen, Hannah, Allali-Hassani, Abdellah, Antonysamy, Stephen, Chang, Shawn, Chen, Lisa Hong, Curtis, Carmen, Emtage, Spencer, Fan, Li, Gheyi, Tarun, Li, Fengling, Liu, Shichong, Martin, Joseph R., Mendel, David, Olsen, Jonathan B., Pelletier, Laura, Shatseva, Tatiana, Wu, Song, Zhang, Feiyu Fred, Arrowsmith, Cheryl H., Brown, Peter J., Campbell, Robert M., Garcia, Benjamin A., Barsyte-Lovejoy, Dalia, Mader, Mary, Vedadi, Masoud

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Structural context of disease-associated mutations and putative mechanism of autoinhibition revealed by X-ray crystallographic analysis of the EZH2-SET domain von Antonysamy, Stephen, Condon, Bradley, Druzina, Zhanna, Bonanno, Jeffrey B, Gheyi, Tarun, Zhang, Feiyu, MacEwan, Iain, Zhang, Aiping, Ashok, Sheela, Rodgers, Logan, Russell, Marijane, Gately Luz, John

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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy von McCue, Amelia C, Demarest, Stephen J, Froning, Karen J, Hickey, Michael J, Antonysamy, Stephen, Kuhlman, Brian

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Utilization of peptide phage display to investigate hotspots on IL-17A and what it means for drug discovery von Ting, Joey P, Tung, Frances, Antonysamy, Stephen, Wasserman, Stephen, Jones, Spencer B, Zhang, Feiyu F, Espada, Alfonso, Broughton, Howard, Chalmers, Michael J, Woodman, Michael E, Bina, Holly A, Dodge, Jeffrey A, Benach, Jordi, Zhang, Aiping, Groshong, Christopher, Manglicmot, Danalyn, Russell, Marijane, Afshar, Sepideh

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Structural Bases of PAS Domain-regulated Kinase (PASK) Activation in the Absence of Activation Loop Phosphorylation von Kikani, Chintan K., Antonysamy, Stephen A., Bonanno, Jeffrey B., Romero, Rich, Zhang, Feiyu Fred, Russell, Marijane, Gheyi, Tarun, Iizuka, Miyo, Emtage, Spencer, Sauder, J. Michael, Turk, Benjamin E., Burley, Stephen K., Rutter, Jared

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Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors von Antonysamy, Stephen S., Aubol, Brandon, Blaney, Jeff, Browner, Michelle F., Giannetti, Anthony M., Harris, Seth F., Hébert, Normand, Hendle, Jörg, Hopkins, Stephanie, Jefferson, Elizabeth, Kissinger, Charles, Leveque, Vincent, Marciano, David, McGee, Ethel, Nájera, Isabel, Nolan, Brian, Tomimoto, Masaki, Torres, Eduardo, Wright, Tobi

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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene von Gong, Xueqian, Du, Jian, Parsons, Stephen H, Merzoug, Farhana F, Webster, Yue, Iversen, Philip W, Chio, Li-Chun, Van Horn, Robert D, Lin, Xi, Blosser, Wayne, Han, Bomie, Jin, Shaoling, Yao, Sufang, Bian, Huimin, Ficklin, Chris, Fan, Li, Kapoor, Avnish, Antonysamy, Stephen, Mc Nulty, Ann M, Froning, Karen, Manglicmot, Danalyn, Pustilnik, Anna, Weichert, Kenneth, Wasserman, Stephen R, Dowless, Michele, Marugán, Carlos, Baquero, Carmen, Lallena, María José, Eastman, Scott W, Hui, Yu-Hua, Dieter, Matthew Z, Doman, Thompson, Chu, Shaoyou, Qian, Hui-Rong, Ye, Xiang S, Barda, David A, Plowman, Gregory D, Reinhard, Christoph, Campbell, Robert M, Henry, James R, Buchanan, Sean G

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LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity von Bonday, Zahid Q., Cortez, Guillermo S., Grogan, Michael J., Antonysamy, Stephen, Weichert, Ken, Bocchinfuso, Wayne P., Li, Fengling, Kennedy, Steven, Li, Binghui, Mader, Mary M., Arrowsmith, Cheryl H., Brown, Peter J., Eram, Mohammad S., Szewczyk, Magdalena M., Barsyte-Lovejoy, Dalia, Vedadi, Masoud, Guccione, Ernesto, Campbell, Robert M.

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Crystal Structures of mPGES‑1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics von Luz, John Gately, Antonysamy, Stephen, Kuklish, Steven L, Condon, Bradley, Lee, Matthew R, Allison, Dagart, Yu, Xiao-Peng, Chandrasekhar, Srinivasan, Backer, Ryan, Zhang, Aiping, Russell, Marijane, Chang, Shawn S, Harvey, Anita, Sloan, Ashley V, Fisher, Matthew J

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Abstract 2753: The molecular basis of blocking the TIM-3 checkpoint with the LY3321367 mAb in cancer immunotherapy von Haidar, Jaafar N., Antonysamy, Stephen, Mathew, Sneha, Wu, Lan, Zhang, Yi, Kearins, Margaret C., Shen, Leyi, Sauder, J. Michael, Schaer, David, Driscoll, Kyla E., Kalos, Michael

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Fragment-based discovery of JAK-2 inhibitors von Antonysamy, Stephen, Hirst, Gavin, Park, Frances, Sprengeler, Paul, Stappenbeck, Frank, Steensma, Ruo, Wilson, Mark, Wong, Melissa

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Structure-based, multi-targeted drug discovery approach to eicosanoid inhibition: Dual inhibitors of mPGES-1 and 5-lipoxygenase activating protein (FLAP) von Ho, Joseph D., Lee, Matthew R., Rauch, Charles T., Aznavour, Kristen, Park, Jonathan S., Luz, John G., Antonysamy, Stephen, Condon, Bradley, Maletic, Milan, Zhang, Aiping, Hickey, Michael J., Hughes, Norman E., Chandrasekhar, Srinivasan, Sloan, Ashley V., Gooding, Karen, Harvey, Anita, Yu, Xiao-Peng, Kahl, Steven D., Norman, Bryan H.

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Abstract LB-274: Identification and characterization of LY3410738, a novel covalent inhibitor of cancer-associated mutant Isocitrate Dehydrogenase 1 (IDH1) von Brooks, Nathan, DeWalt, Robin, Boulet, Serge, Lu, ZhaoHai, Kays, Lisa, cavitt, Rachel, Gomez, Sandra, Strelow, John, Milligan, Paul, Roth, Kenneth, Bauer, Renato, Antonysamy, Stephen, Hahn, Patric, Rankovic, Zoran, McCann, Denis, Mo, Gary, Tiu, Ramon, Burkholder, Timothy, Geeganage, Sandaruwan, Gilmour, Raymond

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Discovery and Characterization of 2‑Acylaminoimidazole Microsomal Prostaglandin E Synthase‑1 Inhibitors von Schiffler, Matthew A, Antonysamy, Stephen, Bhattachar, Shobha N, Campanale, Kristina M, Chandrasekhar, Srinivasan, Condon, Bradley, Desai, Prashant V, Fisher, Matthew J, Groshong, Christopher, Harvey, Anita, Hickey, Michael J, Hughes, Norman E, Jones, Scott A, Kim, Euibong J, Kuklish, Steven L, Luz, John G, Norman, Bryan H, Rathmell, Richard E, Rizzo, John R, Seng, Thomas W, Thibodeaux, Stefan J, Woods, Timothy A, York, Jeremy S, Yu, Xiao-Peng

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Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabo... von Chappell, Mark D, Li, Renhua, Smith, Stephon C, Dressman, Bruce A, Tromiczak, Eric G, Tripp, Allie E, Blanco, Maria-Jesus, Vetman, Tatiana, Quimby, Steven J, Matt, James, Britton, Thomas C, Fivush, Adam M, Schkeryantz, Jeffrey M, Mayhugh, Daniel, Erickson, Jon A, Bures, Mark G, Jaramillo, Carlos, Carpintero, Mercedes, Diego, José Eugenio de, Barberis, Mario, Garcia-Cerrada, Susana, Soriano, José F, Antonysamy, Stephen, Atwell, Shane, MacEwan, Iain, Condon, Bradley, Sougias, Christine, Wang, Jing, Zhang, Aiping, Conners, Kris, Groshong, Chris, Wasserman, Stephen R, Koss, John W, Witkin, Jeffrey M, Li, Xia, Overshiner, Carl, Wafford, Keith A, Seidel, Wesley, Wang, Xu-Shan, Heinz, Beverly A, Swanson, Steven, Catlow, John T, Bedwell, David W, Monn, James A, Mitch, Charles H, Ornstein, Paul L

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Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1 von Partridge, Katherine M., Antonysamy, Stephen, Bhattachar, Shobha N., Chandrasekhar, Srinivasan, Fisher, Matthew J., Fretland, Adrian, Gooding, Karen, Harvey, Anita, Hughes, Norman E., Kuklish, Steven L., Luz, John G., Manninen, Peter R., McGee, James E., Mudra, Daniel R., Navarro, Antonio, Norman, Bryan H., Quimby, Steven J., Schiffler, Matthew A., Sloan, Ashley V., Warshawsky, Alan M., Weller, Jennifer M., York, Jeremy S., Yu, Xiao-Peng

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Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors von Kuklish, Steven L., Antonysamy, Stephen, Bhattachar, Shobha N., Chandrasekhar, Srinivasan, Fisher, Matthew J., Fretland, Adrian J., Gooding, Karen, Harvey, Anita, Hughes, Norman E., Luz, John G., Manninen, Peter R., McGee, James E., Navarro, Antonio, Norman, Bryan H., Partridge, Katherine M., Quimby, Steven J., Schiffler, Matthew A., Sloan, Ashley V., Warshawsky, Alan M., York, Jeremy S., Yu, Xiao-Peng

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Rapid and robust antibody Fab fragment crystallization utilizing edge-to-edge beta-sheet packing von Ricky Lieu, Stephen Antonysamy, Zhanna Druzina, Carolyn Ho, N Rebecca Kang, Anna Pustilnik, Jing Wang, Shane Atwell

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