Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas von Newman, Scott, Fan, Liying, Pribnow, Allison, Silkov, Antonina, Rice, Stephen V., Lee, Seungjae, Shao, Ying, Shaner, Bridget, Mulder, Heather, Nakitandwe, Joy, Shurtleff, Sheila, Azzato, Elizabeth M., Wu, Gang, Zhou, Xin, Barnhill, Raymond, Easton, John, Nichols, Kim E., Ellison, David W., Downing, James R., Pappo, Alberto, Potter, Philip M., Zhang, Jinghui, Bahrami, Armita

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SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins von Park, Mi-Jeong, Sheng, Ren, Silkov, Antonina, Jung, Da-Jung, Wang, Zhi-Gang, Xin, Yao, Kim, Hyunjin, Thiagarajan-Rosenkranz, Pallavi, Song, Seohyeon, Yoon, Youngdae, Nam, Wonhee, Kim, Ilshin, Kim, Eui, Lee, Dong-Gyu, Chen, Yong, Singaram, Indira, Wang, Li, Jang, Myoung Ho, Hwang, Cheol-Sang, Honig, Barry, Ryu, Sungho, Lorieau, Justin, Kim, You-Me, Cho, Wonhwa

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An Ankyrin Repeat Domain of AKR2 Drives Chloroplast Targeting through Coincident Binding of Two Chloroplast Lipids von Kim, Dae Heon, Park, Mi-Jeong, Gwon, Gwang Hyeon, Silkov, Antonina, Xu, Zheng-Yi, Yang, Eun Chan, Song, Seohyeon, Song, Kyungyoung, Kim, Younghyun, Yoon, Hwan Su, Honig, Barry, Cho, Wonhwa, Cho, Yunje, Hwang, Inhwan

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p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase von Barrows, Douglas, Schoenfeld, Sarah M., Hodakoski, Cindy, Silkov, Antonina, Honig, Barry, Couvillon, Anthony, Shymanets, Aliaksei, Nürnberg, Bernd, Asara, John M., Parsons, Ramon

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Genome-wide Structural Analysis Reveals Novel Membrane Binding Properties of AP180 N-terminal Homology (ANTH) Domains von Silkov, Antonina, Yoon, Youngdae, Lee, Hunjoong, Gokhale, Nikhil, Adu-Gyamfi, Emmanuel, Stahelin, Robert V., Cho, Wonhwa, Murray, Diana

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Resolving medulloblastoma cellular architecture by single-cell genomics von Hovestadt, Volker, Smith, Kyle S., Bihannic, Laure, Filbin, Mariella G., Shaw, McKenzie L., Baumgartner, Alicia, DeWitt, John C., Groves, Andrew, Mayr, Lisa, Weisman, Hannah R., Richman, Alyssa R., Shore, Marni E., Goumnerova, Liliana, Rosencrance, Celeste, Carter, Robert A., Phoenix, Timothy N., Hadley, Jennifer L., Tong, Yiai, Houston, Jim, Ashmun, Richard A., DeCuypere, Michael, Sharma, Tanvi, Flasch, Diane, Silkov, Antonina, Ligon, Keith L., Pomeroy, Scott L., Rivera, Miguel N., Rozenblatt-Rosen, Orit, Rusert, Jessica M., Wechsler-Reya, Robert J., Li, Xiao-Nan, Peyrl, Andreas, Gojo, Johannes, Kirchhofer, Dominik, Lötsch, Daniela, Czech, Thomas, Dorfer, Christian, Haberler, Christine, Geyeregger, Rene, Halfmann, Angela, Gawad, Charles, Easton, John, Pfister, Stefan M., Regev, Aviv, Gajjar, Amar, Orr, Brent A., Slavc, Irene, Robinson, Giles W., Bernstein, Bradley E., Suvà, Mario L., Northcott, Paul A.

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Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing von Newman, Scott, Nakitandwe, Joy, Kesserwan, Chimene A, Azzato, Elizabeth M, Wheeler, David A, Rusch, Michael, Shurtleff, Sheila, Hedges, Dale J, Hamilton, Kayla V, Foy, Scott G, Edmonson, Michael N, Thrasher, Andrew, Bahrami, Armita, Orr, Brent A, Klco, Jeffery M, Gu, Jiali, Harrison, Lynn W, Wang, Lu, Clay, Michael R, Ouma, Annastasia, Silkov, Antonina, Liu, Yanling, Zhang, Zhaojie, Liu, Yu, Brady, Samuel W, Zhou, Xin, Chang, Ti-Cheng, Pande, Manjusha, Davis, Eric, Becksfort, Jared, Patel, Aman, Wilkinson, Mark R, Rahbarinia, Delaram, Kubal, Manish, Maciaszek, Jamie L, Pastor, Victor, Knight, Jay, Gout, Alexander M, Wang, Jian, Gu, Zhaohui, Mullighan, Charles G, McGee, Rose B, Quinn, Emily A, Nuccio, Regina, Mostafavi, Roya, Gerhardt, Elsie L, Taylor, Leslie M, Valdez, Jessica M, Hines-Dowell, Stacy J, Pappo, Alberto S, Robinson, Giles, Johnson, Liza-Marie, Pui, Ching-Hon, Ellison, David W, Downing, James R, Zhang, Jinghui, Nichols, Kim E

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69. Efficient clinical review of complex NGS tumor copy number profiles using ACMG/CGC guidelines and an interactive web app von Chen, Ellen, Wang, Jinlian, Kueffner, Robert, Al-Kateb, Hussam, Silkov, Antonina, Uzilov, Andrew, Lochovsky, Lucas, Li, Hui, Newman, Scott

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Template-based prediction of protein function von Petrey, Donald, Chen, T Scott, Deng, Lei, Garzon, Jose Ignacio, Hwang, Howook, Lasso, Gorka, Lee, Hunjoong, Silkov, Antonina, Honig, Barry

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Lipids Regulate Lck Protein Activity through Their Interactions with the Lck Src Homology 2 Domain von Sheng, Ren, Jung, Da-Jung, Silkov, Antonina, Kim, Hyunjin, Singaram, Indira, Wang, Zhi-Gang, Xin, Yao, Kim, Eui, Park, Mi-Jeong, Thiagarajan-Rosenkranz, Pallavi, Smrt, Sean, Honig, Barry, Baek, Kwanghee, Ryu, Sungho, Lorieau, Justin, Kim, You-Me, Cho, Wonhwa

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Specific Interaction of TAFII105 with OCA-B Is Involved in Activation of Octamer-dependent Transcription von Wolstein, Orit, Silkov, Antonina, Revach, Merav, Dikstein, Rivka

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Genome-wide Functional Annotation of Dual-Specificity Protein- and Lipid-Binding Modules that Regulate Protein Interactions von Chen, Yong, Sheng, Ren, Källberg, Morten, Silkov, Antonina, Tun, Moe P., Bhardwaj, Nitin, Kurilova, Svetlana, Hall, Randy A., Honig, Barry, Lu, Hui, Cho, Wonhwa

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Abstract 731: Clinical genome sequencing uncovers potentially targetable truncations and fusions of MAP3K8 in spitzoid and other melanomas von Newman, Scott, Fan, Liying, Pribnow, Allison, Silkov, Antonina, Rice, Stephen V., Lee, Seungjae, Shao, Ying, Shaner, Bridget, Mulder, Heather, Nakitandwe, Joy, Shurtleff, Sheila, Azzato, Elizabeth, Wu, Gang, Zhou, Xin, Barnhill, Raymond, Easton, John, Nichols, Kim E., Ellison, David W., James, Downing R., Pappo, Alberto, Potter, Philip M., Zhang, Jinghui, Bahrami, Armita

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Abstract 642: Genomes for Kids: Comprehensive DNA and RNA sequencing defining the scope of actionable mutations in pediatric cancer von Wheeler, David A., Newman, Scott, Nakitandwe, Joy, Kesserwan, Chimene A., Azzato, Elizabeth M., Rusch, Michael C., Shurtleff, Sheila, Bahrami, Armita, Orr, Brent, Klco, Jeffery M., Hedges, Dale J., Hamilton, Kayla V., Foy, Scott G., Edmonson, Michael N., Thrasher, Andrew, Gu, Jiali, Harrison, Lynn W., Wang, Lu, Mostafavi, Roya, Kubal, Manish, Maciaszek, Jamie, Clay, Michael, Ouma, Annastasia, Silkov, Antonina, Liu, Yanling, Zhang, Zhaojie, Liu, Yu, Brady, Samuel W., Zhou, Xin, Wilkinson, Mark, Rahbarinia, Delaram, Knight, Jay, Wang, Jian, Mullighan, Charles G., McGee, Rose B., Quinn, Emily A., Gerhardt, Elsie L., Taylor, Leslie M., Nuccio, Regina, Valdez, Jessica M., Hines-Dowell, Stacy J., Pappo, Alberto, Robinson, Giles, Johnson, Liza-Marie, Pui, Ching-Hon, Ellison, David W., Downing, James R., Zhang, Jinghui, Nichols, Kim E.

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Real-time sharing of comprehensive clinical genomics sequencing data in St. Jude Cloud von Newman, Scott, McLeod, Clay, Macias, Michael, Birch, Kirby, Gout, Alexander, Foy, Scott, Silkov, Antonina, Kesserwan, Chimene, Nakitandwe, Joy, Shurtleff, Sheila, Azzato, Elizabeth M., Wang, Lu, Rusch, Michael C, Nichols, Kim, Gajjar, Amar J., Pappo, Alberto S., Mullighan, Charles Grenfell, Ellison, David W., Zhang, Jinghui, Downing, James

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A Composite Nuclear Export Signal in the TBP-associated Factor TAFII105 von Anna Rashevsky-Finkel, Antonina Silkov, Rivka Dikstein

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Abstract PR13: Systems and structural biology approaches to elucidate new effectors in KRAS mutant tumors von Broyde, Joshua, Simpson, David, Wah, David A., Giorgi, Federico M., Petrey, Donald, Alvarez, Mariano J., Silkov, Antonina, Lachmann, Alexander, Hill, David E., Vidal, Marc, Jackson, Peter, Honig, Barry, Sweet-Cordero, Alejandro, Califano, Andrea

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Structural Alignment of Protein–DNA Interfaces: Insights into the Determinants of Binding Specificity von Siggers, Trevor W., Silkov, Antonina, Honig, Barry

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Chloroplast targeting factor AKR2 evolved from an ankyrin repeat domain coincidentally binds two chloroplast lipids von Kim, Dae Heon, Park, Mi-Jeong, Gwon, Gwang Hyeon, Silkov, Antonina, Xu, Zheng-Yi, Yang, Eun Chan, Song, Seohyeon, Song, Kyungyoung, Kim, Younghyun, Yoon, Hwan Su, Honig, Barry, Cho, Wonhwa, Cho, Yunje, Hwang, Inhwan

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Genome-Wide Identification and Functional Annotation of Dual Specificity Protein- and Lipid-Binding Modules That Modulate Protein Interactions at the Membrane von Chen, Yong, Sheng, Ren, Kallberg, Morten, Silkov, Antonina, Tun, Moe P., Bhardwaj, Nitin, Kurilova, Svetlana, Hall, Randy A., Honig, Barry, Lu, Hui, Cho, Wonhwa

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