A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles von Butler, Marcus O., Ansén, Sascha, Tanaka, Makito, Imataki, Osamu, Berezovskaya, Alla, Mooney, Mary M., Metzler, Genita, Milstein, Matthew I., Nadler, Lee M., Hirano, Naoto

Volltext

Efficient Presentation of Naturally Processed HLA Class I Peptides by Artificial Antigen-Presenting Cells for the Generation of Effective Antitumor Responses von HIRANO, Naoto, BUTLER, Marcus O, ZHINAN XIA, BEREZOVSKAYA, Alla, MURRAY, Andrew P, ANSEN, Sascha, NADLER, Lee M

Volltext

Phase I/II Combined Chemoimmunotherapy with Carcinoembryonic Antigen–Derived HLA-A2–Restricted CAP-1 Peptide and Irinotecan, 5-Fluorouracil, and Leucovorin in Patients with Primary... von WEIHRAUCH, Martin R, ANSEN, Sascha, WOLF, Juergen, BOHLEN, Heribert, NADLER, Lee M, JURKIEWICZ, Elke, GEISEN, Caroline, ZHINAN XIA, ANDERSEN, Karen S, GRACIEN, Edith, SCHMIDT, Manuel, WITTIG, Burghardt, DIEHL, Volker

Volltext

Comprehensive genomic profiles of small cell lung cancer von George, Julie, Lim, Jing Shan, Jang, Se Jin, Cun, Yupeng, Ozretić, Luka, Kong, Gu, Leenders, Frauke, Lu, Xin, Fernández-Cuesta, Lynnette, Bosco, Graziella, Müller, Christian, Dahmen, Ilona, Jahchan, Nadine S., Park, Kwon-Sik, Yang, Dian, Karnezis, Anthony N., Vaka, Dedeepya, Torres, Angela, Wang, Maia Segura, Korbel, Jan O., Menon, Roopika, Chun, Sung-Min, Kim, Deokhoon, Wilkerson, Matt, Hayes, Neil, Engelmann, David, Pützer, Brigitte, Bos, Marc, Michels, Sebastian, Vlasic, Ignacija, Seidel, Danila, Pinther, Berit, Schaub, Philipp, Becker, Christian, Altmüller, Janine, Yokota, Jun, Kohno, Takashi, Iwakawa, Reika, Tsuta, Koji, Noguchi, Masayuki, Muley, Thomas, Hoffmann, Hans, Schnabel, Philipp A., Petersen, Iver, Chen, Yuan, Soltermann, Alex, Tischler, Verena, Choi, Chang-min, Kim, Yong-Hee, Massion, Pierre P., Zou, Yong, Jovanovic, Dragana, Kontic, Milica, Wright, Gavin M., Russell, Prudence A., Solomon, Benjamin, Koch, Ina, Lindner, Michael, Muscarella, Lucia A., la Torre, Annamaria, Field, John K., Jakopovic, Marko, Knezevic, Jelena, Castaños-Vélez, Esmeralda, Roz, Luca, Pastorino, Ugo, Brustugun, Odd-Terje, Lund-Iversen, Marius, Thunnissen, Erik, Köhler, Jens, Schuler, Martin, Botling, Johan, Sandelin, Martin, Sanchez-Cespedes, Montserrat, Salvesen, Helga B., Achter, Viktor, Lang, Ulrich, Bogus, Magdalena, Schneider, Peter M., Zander, Thomas, Ansén, Sascha, Hallek, Michael, Wolf, Jürgen, Vingron, Martin, Yatabe, Yasushi, Travis, William D., Nürnberg, Peter, Reinhardt, Christian, Perner, Sven, Heukamp, Lukas, Büttner, Reinhard, Haas, Stefan A., Brambilla, Elisabeth, Peifer, Martin, Sage, Julien, Thomas, Roman K.

Volltext

Mechanisms of Primary Drug Resistance in FGFR1 -Amplified Lung Cancer von Malchers, Florian, Ercanoglu, Meryem, Schütte, Daniel, Castiglione, Roberta, Tischler, Verena, Michels, Sebastian, Dahmen, Ilona, Brägelmann, Johannes, Menon, Roopika, Heuckmann, Johannes M, George, Julie, Ansén, Sascha, Sos, Martin L, Soltermann, Alex, Peifer, Martin, Wolf, Jürgen, Büttner, Reinhard, Thomas, Roman K

Volltext

Long-Lived Antitumor CD8+ Lymphocytes for Adoptive Therapy Generated Using an Artificial Antigen-Presenting Cell von BUTLER, Marcus O, LEE, Jeng-Shin, HIRANO, Naoto, ANSEN, Sascha, NEUBERG, Donna, HODI, F. Stephen, MURRAY, Andrew P, DRURY, Linda, BEREZOVSKAYA, Alla, MULLIGAN, Richard C, NADLER, Lee M

Volltext

Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors von Ortiz-Cuaran, Sandra, Scheffler, Matthias, Plenker, Dennis, Dahmen, Llona, Scheel, Andreas H, Fernandez-Cuesta, Lynnette, Meder, Lydia, Lovly, Christine M, Persigehl, Thorsten, Merkelbach-Bruse, Sabine, Bos, Marc, Michels, Sebastian, Fischer, Rieke, Albus, Kerstin, König, Katharina, Schildhaus, Hans-Ulrich, Fassunke, Jana, Ihle, Michaela A, Pasternack, Helen, Heydt, Carina, Becker, Christian, Altmüller, Janine, Ji, Hongbin, Müller, Christian, Florin, Alexandra, Heuckmann, Johannes M, Nuernberg, Peter, Ansén, Sascha, Heukamp, Lukas C, Berg, Johannes, Pao, William, Peifer, Martin, Buettner, Reinhard, Wolf, Jürgen, Thomas, Roman K, Sos, Martin L

Volltext

CD74-NRG1 fusions in lung adenocarcinoma von Fernandez-Cuesta, Lynnette, Plenker, Dennis, Osada, Hirotaka, Sun, Ruping, Menon, Roopika, Leenders, Frauke, Ortiz-Cuaran, Sandra, Peifer, Martin, Bos, Marc, Daßler, Juliane, Malchers, Florian, Schöttle, Jakob, Vogel, Wenzel, Dahmen, Ilona, Koker, Mirjam, Ullrich, Roland T, Wright, Gavin M, Russell, Prudence A, Wainer, Zoe, Solomon, Benjamin, Brambilla, Elisabeth, Nagy-Mignotte, Hélène, Moro-Sibilot, Denis, Brambilla, Christian G, Lantuejoul, Sylvie, Altmüller, Janine, Becker, Christian, Nürnberg, Peter, Heuckmann, Johannes M, Stoelben, Erich, Petersen, Iver, Clement, Joachim H, Sänger, Jörg, Muscarella, Lucia A, la Torre, Annamaria, Fazio, Vito M, Lahortiga, Idoya, Perera, Timothy, Ogata, Souichi, Parade, Marc, Brehmer, Dirk, Vingron, Martin, Heukamp, Lukas C, Buettner, Reinhard, Zander, Thomas, Wolf, Jürgen, Perner, Sven, Ansén, Sascha, Haas, Stefan A, Yatabe, Yasushi, Thomas, Roman K

Volltext

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer von Schildhaus, Hans-Ulrich, Heukamp, Lukas C, Merkelbach-Bruse, Sabine, Riesner, Katharina, Schmitz, Katja, Binot, Elke, Paggen, Ellen, Albus, Kerstin, Schulte, Wolfgang, Ko, Yon-Dschun, Schlesinger, Andreas, Ansén, Sascha, Engel-Riedel, Walburga, Brockmann, Michael, Serke, Monika, Gerigk, Ulrich, Huss, Sebastian, Göke, Friederike, Perner, Sven, Hekmat, Khosro, Frank, Konrad F, Reiser, Marcel, Schnell, Roland, Bos, Marc, Mattonet, Christian, Sos, Martin, Stoelben, Erich, Wolf, Jürgen, Zander, Thomas, Buettner, Reinhard

Volltext

Benchmarking of mutation diagnostics in clinical lung cancer specimens von Querings, Silvia, Altmüller, Janine, Ansén, Sascha, Zander, Thomas, Seidel, Danila, Gabler, Franziska, Peifer, Martin, Markert, Eva, Stemshorn, Kathryn, Timmermann, Bernd, Saal, Beate, Klose, Stefan, Ernestus, Karen, Scheffler, Matthias, Engel-Riedel, Walburga, Stoelben, Erich, Brambilla, Elisabeth, Wolf, Jürgen, Nürnberg, Peter, Thomas, Roman K

Volltext

Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer von Lovly, Christine M, McDonald, Nerina T, Chen, Heidi, Ortiz-Cuaran, Sandra, Heukamp, Lukas C, Yan, Yingjun, Florin, Alexandra, Ozretić, Luka, Lim, Diana, Wang, Lu, Chen, Zhao, Chen, Xi, Lu, Pengcheng, Paik, Paul K, Shen, Ronglai, Jin, Hailing, Buettner, Reinhard, Ansén, Sascha, Perner, Sven, Brockmann, Michael, Bos, Marc, Wolf, Jürgen, Gardizi, Masyar, Wright, Gavin M, Solomon, Benjamin, Russell, Prudence A, Rogers, Toni-Maree, Suehara, Yoshiyuki, Red-Brewer, Monica, Tieu, Rudy, de Stanchina, Elisa, Wang, Qingguo, Zhao, Zhongming, Johnson, David H, Horn, Leora, Wong, Kwok-Kin, Thomas, Roman K, Ladanyi, Marc, Pao, William

Volltext

PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations von Scheel, Andreas H., Ansén, Sascha, Schultheis, Anne M., Scheffler, Matthias, Fischer, Rieke N., Michels, Sebastian, Hellmich, Martin, George, Julie, Zander, Thomas, Brockmann, Michael, Stoelben, Erich, Groen, Harry, Timens, Wim, Perner, Sven, von Bergwelt-Baildon, Michael, Büttner, Reinhard, Wolf, Jürgen

Volltext

Immunoglobulin gene segment usage, location and immunogenicity in mutated and unmutated chronic lymphocytic leukaemia von Mauerer, Katja, Zahrieh, David, Gorgun, Gullu, Li, Aihong, Zhou, Jianbiao, Ansén, Sascha, Rassenti, Laura Z., Gribben, John G.

Volltext

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer von Sos, Martin L, Fischer, Stefanie, Ullrich, Roland, Peifer, Martin, Heuckmann, Johannes M, Koker, Mirjam, Heynck, Stefanie, Stückrath, Isabel, Weiss, Jonathan, Fischer, Florian, Michel, Kathrin, Goel, Aviva, Regales, Lucia, Politi, Katerina A, Perera, Samanthi, Getlik, Matthäus, Heukamp, Lukas C, Ansén, Sascha, Zander, Thomas, Beroukhim, Rameen, Kashkar, Hamid, Shokat, Kevan M, Sellers, William R, Rauh, Daniel, Orr, Christine, Hoeflich, Klaus P, Friedman, Lori, Wong, Kwok-Kin, Pao, William, Thomas, Roman K

Volltext

Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help von Butler, Marcus O, Imataki, Osamu, Yamashita, Yoshihiro, Tanaka, Makito, Ansén, Sascha, Berezovskaya, Alla, Metzler, Genita, Milstein, Matthew I, Mooney, Mary M, Murray, Andrew P, Mano, Hiroyuki, Nadler, Lee M, Hirano, Naoto

Volltext

Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity von Hirano, Naoto, Butler, Marcus O., Xia, Zhinan, Ansén, Sascha, von Bergwelt-Baildon, Michael S., Neuberg, Donna, Freeman, Gordon J., Nadler, Lee M.

Volltext

Blood-Based Gene Expression Signatures in Non―Small Cell Lung Cancer von ZANDER, Thomas, HOFMANN, Andrea, GATHOF, Birgit, MAUCH, Cornelia, DELANK, Karl-Stefan, ENGEL-RIEDEL, Walburga, WICHMANN, H.-Erich, STOELBEN, Erich, SCHULTZE, Joachim L, WOLF, Jürgen, STARATSCHEK-JOX, Andrea, CLASSEN, Sabine, DEBEY-PASCHER, Svenja, MAISEL, Daniela, ANSEN, Sascha, HAHN, Moritz, BEYER, Marc, THOMAS, Roman K

Volltext

Induction of HLA-DP4-Restricted Anti-Survivin Th1 and Th2 Responses Using an Artificial Antigen-Presenting Cell von TANAKA, Makito, BUTLER, Marcus O, ANSEN, Sascha, IMATAKI, Osamu, BEREZOVSKAYA, Alla, NADLER, Lee M, HIRANO, Naoto

Volltext

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma von Brägelmann, Johannes, Dammert, Marcel A., Dietlein, Felix, Heuckmann, Johannes M., Choidas, Axel, Böhm, Stefanie, Richters, André, Basu, Debjit, Tischler, Verena, Lorenz, Carina, Habenberger, Peter, Fang, Zhizhou, Ortiz-Cuaran, Sandra, Leenders, Frauke, Eickhoff, Jan, Koch, Uwe, Getlik, Matthäus, Termathe, Martin, Sallouh, Muhammad, Greff, Zoltán, Varga, Zoltán, Balke-Want, Hyatt, French, Christopher A., Peifer, Martin, Reinhardt, H. Christian, Örfi, László, Kéri, György, Ansén, Sascha, Heukamp, Lukas C., Büttner, Reinhard, Rauh, Daniel, Klebl, Bert M., Thomas, Roman K., Sos, Martin L.

Volltext

Dissociation of Its Opposing Immunologic Effects Is Critical for the Optimization of Antitumor CD8+ T-Cell Responses Induced by Interleukin 21 von Ansén, Sascha, Butler, Marcus O, Berezovskaya, Alla, Murray, Andrew P, Stevenson, Kristen, Nadler, Lee M, Hirano, Naoto

Volltext