A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies von Rasco, Drew W, Papadopoulos, Kyriakos P, Pourdehnad, Michael, Gandhi, Anita K, Hagner, Patrick R, Li, Yan, Wei, Xin, Chopra, Rajesh, Hege, Kristen, DiMartino, Jorge, Shih, Kent

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Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase... von Gandhi, Anita K, Kang, Jian, Havens, Courtney G, Conklin, Thomas, Ning, Yuhong, Wu, Lei, Ito, Takumi, Ando, Hideki, Waldman, Michelle F, Thakurta, Anjan, Klippel, Anke, Handa, Hiroshi, Daniel, Thomas O, Schafer, Peter H, Chopra, Rajesh

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Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS von Krönke, Jan, Fink, Emma C., Hollenbach, Paul W., MacBeth, Kyle J., Hurst, Slater N., Udeshi, Namrata D., Chamberlain, Philip P., Mani, D. R., Man, Hon Wah, Gandhi, Anita K., Svinkina, Tanya, Schneider, Rebekka K., McConkey, Marie, Järås, Marcus, Griffiths, Elizabeth, Wetzler, Meir, Bullinger, Lars, Cathers, Brian E., Carr, Steven A., Chopra, Rajesh, Ebert, Benjamin L.

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Avadomide monotherapy in relapsed/refractory DLBCL: safety, efficacy, and a predictive gene classifier von Carpio, Cecilia, Bouabdallah, Reda, Ysebaert, Loïc, Sancho, Juan-Manuel, Salles, Gilles, Cordoba, Raul, Pinto, Antonio, Gharibo, Mecide, Rasco, Drew, Panizo, Carlos, Lopez-Martin, Jose A., Santoro, Armando, Salar, Antonio, Damian, Silvia, Martin, Alejandro, Verhoef, Gregor, Van den Neste, Eric, Wang, Maria, Couto, Suzana, Carrancio, Soraya, Weng, Andrew, Wang, Xuehai, Schmitz, Frank, Wei, Xin, Hege, Kristen, Trotter, Matthew W.B., Risueño, Alberto, Buchholz, Tonia J., Hagner, Patrick R., Gandhi, Anita K., Pourdehnad, Michael, Ribrag, Vincent

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CC-122, a pleiotropic pathway modifier, mimics an interferon response and has antitumor activity in DLBCL von Hagner, Patrick R., Man, Hon-Wah, Fontanillo, Celia, Wang, Maria, Couto, Suzana, Breider, Mike, Bjorklund, Chad, Havens, Courtney G., Lu, Gang, Rychak, Emily, Raymon, Heather, Narla, Rama Krishna, Barnes, Leo, Khambatta, Gody, Chiu, Hsiling, Kosek, Jolanta, Kang, Jian, Amantangelo, Michael D., Waldman, Michelle, Lopez-Girona, Antonia, Cai, Ti, Pourdehnad, Michael, Trotter, Matthew, Daniel, Thomas O., Schafer, Peter H., Klippel, Anke, Thakurta, Anjan, Chopra, Rajesh, Gandhi, Anita K.

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SpatialSort: a Bayesian model for clustering and cell population annotation of spatial proteomics data von Lee, Eric, Chern, Kevin, Nissen, Michael, Wang, Xuehai, Huang, Chris, Gandhi, Anita K, Bouchard-Côté, Alexandre, Weng, Andrew P, Roth, Andrew

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Triggering interferon signaling in T cells with avadomide sensitizes CLL to anti-PD-L1/PD-1 immunotherapy von Ioannou, Nikolaos, Hagner, Patrick R., Stokes, Matt, Gandhi, Anita K., Apollonio, Benedetta, Fanous, Mariam, Papazoglou, Despoina, Sutton, Lesley-Ann, Rosenquist, Richard, Amini, Rose-Marie, Chiu, Hsiling, Lopez-Girona, Antonia, Janardhanan, Preethi, Awan, Farrukh T., Jones, Jeffrey, Kay, Neil E., Shanafelt, Tait D., Tallman, Martin S., Stamatopoulos, Kostas, Patten, Piers E.M., Vardi, Anna, Ramsay, Alan G.

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Measuring cereblon as a biomarker of response or resistance to lenalidomide and pomalidomide requires use of standardized reagents and understanding of gene complexity von Gandhi, Anita K., Mendy, Derek, Waldman, Michelle, Chen, Gengxin, Rychak, Emily, Miller, Karen, Gaidarova, Svetlana, Ren, Yan, Wang, Maria, Breider, Michael, Carmel, Gilles, Mahmoudi, Afshin, Jackson, Pilgrim, Abbasian, Mahan, Cathers, Brian E., Schafer, Peter H., Daniel, Tom O., Lopez‐Girona, Antonia, Thakurta, Anjan, Chopra, Rajesh

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Interactome of Aiolos/Ikaros Reveals Combination Rationale of Cereblon Modulators with HDAC Inhibitors in DLBCL von Hagner, Patrick R, Chiu, Hsiling, Chopra, Vivek S, Colombo, Martino, Patel, Nisha, Estevez, Maria Ortiz, Waldman, Michelle F, Loos, Remco, Towfic, Fadi, Gandhi, Anita K

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Transcriptomic classification of diffuse large B-cell lymphoma identifies a high-risk activated B-cell-like subpopulation with targetable MYC dysregulation von Stokes, Matthew E., Wenzl, Kerstin, Huang, C. Chris, Ortiz, María, Hsu, Chih-Chao, Maurer, Matthew J., Stong, Nicholas, Nakayama, Yumi, Wu, Lei, Chiu, Hsiling, Polonskaia, Ann, Danziger, Samuel A., Towfic, Fadi, Parker, Joel, King, Rebecca L., Link, Brian K., Slager, Susan L., Sarangi, Vivekananda, Asmann, Yan W., Novak, Joseph P., Sudhindra, Akshay, Ansell, Stephen M., Habermann, Thomas M., Hagner, Patrick R., Nowakowski, Grzegorz S., Cerhan, James R., Novak, Anne J., Gandhi, Anita K.

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Immunomodulatory effects in a phase II study of lenalidomide combined with cetuximab in refractory KRAS-mutant metastatic colorectal cancer patients von Gandhi, Anita K, Shi, Tao, Li, Mingyu, Jungnelius, Ulf, Romano, Alfredo, Tabernero, Josep, Siena, Salvatore, Schafer, Peter H, Chopra, Rajesh

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Targeting of inflammatory pathways with R2CHOP in high-risk DLBCL von Hartert, Keenan T., Wenzl, Kerstin, Krull, Jordan E., Manske, Michelle, Sarangi, Vivekananda, Asmann, Yan, Larson, Melissa C., Maurer, Matthew J., Slager, Susan, Macon, William R., King, Rebecca L., Feldman, Andrew L., Gandhi, Anita K., Link, Brian K., Habermann, Thomas M., Yang, Zhi-Zhang, Ansell, Stephen M., Cerhan, James R., Witzig, Thomas E., Nowakowski, Grzegorz S., Novak, Anne J.

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High-plex imaging and cellular neighborhood spatial analysis reveals multiple immune escape and suppression patterns in diffuse large B-cell lymphoma von Reiss, David J., Nakayama, Yumi, Weng, Andrew P., Stokes, Matthew E., Sehn, Laurie, Steidl, Christian, Scott, David W., Huang, C. Chris, Gandhi, Anita K.

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Combination lenalidomide‐rituximab immunotherapy activates anti‐tumour immunity and induces tumour cell death by complementary mechanisms of action in follicular lymphoma von Chiu, Hsiling, Trisal, Preeti, Bjorklund, Chad, Carrancio, Soraya, Toraño, Estela G., Guarinos, Carla, Papazoglou, Despoina, Hagner, Patrick R., Beldi‐Ferchiou, Asma, Tarte, Karin, Delfau‐Larue, Marie‐Hélène, Morschhauser, Franck, Ramsay, Alan G., Gandhi, Anita K.

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Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell‐mediated cytotoxicity von Hagner, Patrick R., Chiu, Hsiling, Ortiz, Maria, Apollonio, Benedetta, Wang, Maria, Couto, Suzana, Waldman, Michelle F., Flynt, Erin, Ramsay, Alan G., Trotter, Matthew, Gandhi, Anita K., Chopra, Rajesh, Thakurta, Anjan

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A Single Cell Atlas of Diffuse Large B Cell Lymphomas Reveals Distinct Cellular States Predictive of Outcomes von Baaklini, Sabrina, Sarrabay, Alexandre, Barthelemy, Camille, Dahbi, Laila, Gil, Laurine, Mossadegh-Keller, Noushin, Navarro, Jean-Marc, Huber, Caroline, Fenouil, Romain, Escaliere, Bertrand, Trombetta, Romane, Pujol, Marine, Gaulard, Philippe, Riviere, Benjamin, Dartigues, Peggy, Llamas Gutierrez, Francesco, Pangault, Celine, Jardin, Fabrice, Lemonnier, Francois, Brisou, Gabriel, Haioun, Corinne, Gravelle, Pauline, Laurent, Camille, Spinelli, Lionel, Huang, C Chris, Stokes, Matthew E, Seth, Sahil, Ortiz, Maria, Gandhi, Anita K., Nadel, Bertrand, Milpied, Pierre, Roulland, Sandrine

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Leveraging gene expression subgroups to classify DLBCL patients and select for clinical benefit from a novel agent von Risueño, Alberto, Hagner, Patrick R., Towfic, Fadi, Fontanillo, Celia, Djebbari, Amira, Parker, Joel S., Drew, Clifton P., Nowakowski, Grzegorz S., Maurer, Matthew J., Cerhan, James R., Wei, Xin, Ren, Yan, Lee, Chung-Wein, Couto, Suzana, Wang, Maria, Pourdehnad, Michael, Gandhi, Anita K., Trotter, Matthew W.B.

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Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase von Jeyaraju, Danny V, Alapa, Maryam, Polonskaia, Ann, Risueño, Alberto, Subramanyam, Prakash, Anand, Amit, Ghosh, Kaushik, Kyriakopoulos, Charalampos, Hemerich, Daiane, Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, Ahsan, Aarif, Chiu, Hsiling, Thomas, Geethu, Lind, Evan F, Menezes, Daniel L, Schimmer, Aaron D, Hagner, Patrick R, Gandhi, Anita, Thakurta, Anjan G

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Pomalidomide in combination with dexamethasone results in synergistic anti‐tumour responses in pre‐clinical models of lenalidomide‐resistant multiple myeloma von Rychak, Emily, Mendy, Derek, Shi, Tao, Ning, Yuhong, Leisten, Jim, Lu, Ling, Miller, Karen, Narla, Rama K., Orlowski, Robert Z., Raymon, Heather K., Bjorklund, Chad C., Thakurta, Anjan, Gandhi, Anita K., Cathers, Brian E., Chopra, Rajesh, Daniel, Thomas O., Lopez‐Girona, Antonia

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Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma von Apollonio, Benedetta, Spada, Filomena, Petrov, Nedyalko, Cozzetto, Domenico, Papazoglou, Despoina, Jarvis, Peter, Kannambath, Shichina, Terranova-Barberio, Manuela, Amini, Rose-Marie, Enblad, Gunilla, Graham, Charlotte, Benjamin, Reuben, Phillips, Elisabeth, Ellis, Richard, Nuamah, Rosamond, Saqi, Mansoor, Calado, Dinis P, Rosenquist, Richard, Sutton, Lesley A, Salisbury, Jon, Zacharioudakis, Georgios, Vardi, Anna, Hagner, Patrick R, Gandhi, Anita K, Bacac, Marina, Claus, Christina, Umana, Pablo, Jarrett, Ruth F, Klein, Christian, Deutsch, Alexander, Ramsay, Alan G

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