Inhibition of Lapatinib-induced Kinome Reprogramming in ERBB2-positive Breast Cancer by Targeting BET Family Bromodomains von Stuhlmiller, Timothy J., Miller, Samantha M., Zawistowski, Jon S., Nakamura, Kazuhiro, Beltran, Adriana S., Duncan, James S., Angus, Steven P., Collins, Kyla A.L, Granger, Deborah A., Reuther, Rachel A., Graves, Lee M., Gomez, Shawn M., Kuan, Pei-Fen, Parker, Joel S., Chen, Xin, Sciaky, Noah, Carey, Lisa A., Earp, H. Shelton, Jin, Jian, Johnson, Gary L.

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Molecular Pathways: Adaptive Kinome Reprogramming in Response to Targeted Inhibition of the BRAF―MEK―ERK Pathway in Cancer von JOHNSON, Gary L, STUHLMILLER, Timothy J, ANGUS, Steven P, ZAWISTOWSKI, Jon S, GRAVES, Lee M

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Epigenetic Mechanisms Regulating Adaptive Responses to Targeted Kinase Inhibitors in Cancer von Angus, Steven P, Zawistowski, Jon S, Johnson, Gary L

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New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging von Brighton, Hailey E, Angus, Steven P, Bo, Tao, Roques, Jose, Tagliatela, Alicia C, Darr, David B, Karagoz, Kubra, Sciaky, Noah, Gatza, Michael L, Sharpless, Norman E, Johnson, Gary L, Bear, James E

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Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex von Zawistowski, Jon S, Bevill, Samantha M, Goulet, Daniel R, Stuhlmiller, Timothy J, Beltran, Adriana S, Olivares-Quintero, Jose F, Singh, Darshan, Sciaky, Noah, Parker, Joel S, Rashid, Naim U, Chen, Xin, Duncan, James S, Whittle, Martin C, Angus, Steven P, Velarde, Sara Hanna, Golitz, Brian T, He, Xiaping, Santos, Charlene, Darr, David B, Gallagher, Kristalyn, Graves, Lee M, Perou, Charles M, Carey, Lisa A, Earp, H Shelton, Johnson, Gary L

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FOXO Transcription Factors Control E2F1 Transcriptional Specificity and Apoptotic Function von SHATS, Igor, GATZA, Michael L, BEIYU LIU, ANGUS, Steven P, LINGCHONG YOU, NEVINS, Joseph R

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Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN -null, BRAFV600E melanoma to BRAF/MEK inhibition von DuBose, Evan, Bevill, Samantha M, Mitchell, Dana K, Sciaky, Noah, Golitz, Brian T, Dixon, Shelley A H, Rhodes, Steven D, Bear, James E, Johnson, Gary L, Angus, Steven P

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High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy von Cheng, Chialin, Reis, Surya A., Adams, Emily T., Fass, Daniel M., Angus, Steven P., Stuhlmiller, Timothy J., Richardson, Jared, Olafson, Hailey, Wang, Eric T., Patnaik, Debasis, Beauchamp, Roberta L., Feldman, Danielle A., Silva, M. Catarina, Sur, Mriganka, Johnson, Gary L., Ramesh, Vijaya, Miller, Bruce L., Temple, Sally, Kosik, Kenneth S., Dickerson, Bradford C., Haggarty, Stephen J.

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Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies von Adebayo, Adedeji K., Bhat-Nakshatri, Poornima, Davis, Christopher, Angus, Steven P., Erdogan, Cihat, Gao, Hongyu, Green, Nick, Kumar, Brijesh, Liu, Yunlong, Nakshatri, Harikrishna

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Kinome and Transcriptome Profiling Reveal Broad and Distinct Activities of Erlotinib, Sunitinib, and Sorafenib in the Mouse Heart and Suggest Cardiotoxicity From Combined Signal Tr... von Stuhlmiller, Timothy J., Zawistowski, Jon S., Chen, Xin, Sciaky, Noah, Angus, Steven P., Hicks, Sean T., Parry, Traci L., Huang, Wei, Beak, Ju Youn, Willis, Monte S., Johnson, Gary L., Jensen, Brian C.

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Engineering a Protein Binder Specific for p38α with Interface Expansion von Hussain, Mahmud, Angus, Steven P, Kuhlman, Brian

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SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2 von Mehta, Gaurav A., Angus, Steven P., Khella, Christen A., Tong, Kevin, Khanna, Pooja, Dixon, Shelley A. H., Verzi, Michael P., Johnson, Gary L., Gatza, Michael L.

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Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial von Fisher, Michael J., Shih, Chie-Schin, Rhodes, Steven D., Armstrong, Amy E., Wolters, Pamela L., Dombi, Eva, Zhang, Chi, Angus, Steven P., Johnson, Gary L., Packer, Roger J., Allen, Jeffrey C., Ullrich, Nicole J., Goldman, Stewart, Gutmann, David H., Plotkin, Scott R., Rosser, Tena, Robertson, Kent A., Widemann, Brigitte C., Smith, Abbi E., Bessler, Waylan K., He, Yongzheng, Park, Su-Jung, Mund, Julie A., Jiang, Li, Bijangi-Vishehsaraei, Khadijeh, Robinson, Coretta Thomas, Cutter, Gary R., Korf, Bruce R., Blakeley, Jaishri O., Clapp, D. Wade

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GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer von Bevill, Samantha M, Olivares-Quintero, Jose F, Sciaky, Noah, Golitz, Brian T, Singh, Darshan, Beltran, Adriana S, Rashid, Naim U, Stuhlmiller, Timothy J, Hale, Andrew, Moorman, Nathaniel J, Santos, Charlene M, Angus, Steven P, Zawistowski, Jon S, Johnson, Gary L

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Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma von Flint, Alyssa C, Mitchell, Dana K, Angus, Steven P, Smith, Abbi E, Bessler, Waylan, Jiang, Li, Mang, Henry, Li, Xiaohong, Lu, Qingbo, Rodriguez, Brooke, Sandusky, George E, Masters, Andi R, Zhang, Chi, Dang, Pengtao, Koenig, Jenna, Johnson, Gary L, Shen, Weihua, Liu, Jiangang, Aggarwal, Amit, Donoho, Gregory P, Willard, Melinda D, Bhagwat, Shripad V, Clapp, D Wade, Rhodes, Steven D

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A molecular basis for neurofibroma-associated skeletal manifestations in NF1 von Ma, Yun, Gross, Andrea M., Dombi, Eva, Pemov, Alexander, Choi, Kwangmin, Chaney, Katherine, Rhodes, Steven D., Angus, Steven P., Sciaky, Noah, Clapp, D. Wade, Ratner, Nancy, Widemann, Brigitte C., Rios, Jonathan J., Elefteriou, Florent

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Ravidomycin Analogs from Streptomyces sp. Exhibit Altered Antimicrobial and Cytotoxic Selectivity von Park, Kyoung Jin, Maier, Sarah, Zhang, Chengqian, Dixon, Shelley A. H., Rusch, Douglas B., Pupo, Monica T., Angus, Steven P., Gerdt, Joseph P.

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MAP3K1: Genomic Alterations in Cancer and Function in Promoting Cell Survival or Apoptosis von Pham, Trang T, Angus, Steven P, Johnson, Gary L

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Retinoblastoma Tumor Suppressor Targets dNTP Metabolism to Regulate DNA Replication von Angus, Steven P, Wheeler, Linda J, Ranmal, Sejal A, Zhang, Xiaoping, Markey, Michael P, Mathews, Christopher K, Knudsen, Erik S

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Interaction of E2F7 Transcription Factor with E2F1 and C-terminal-binding Protein (CtBP) Provides a Mechanism for E2F7-dependent Transcription Repression von Liu, Beiyu, Shats, Igor, Angus, Steven P., Gatza, Michael L., Nevins, Joseph R.

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