R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies von ARTS, J, ANGIBAUD, P, JOHNSON, D. L, ANDRIES, L, JUNG, M, JANICOT, M, VAN EMELEN, K, MARIËN, A, FLOREN, W, JANSSENS, B, KING, P, VAN DUN, J, JANSSEN, L, GEERTS, T, TUMAN, R. W

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356 Discovery of novel pyrido[2,3-b]pyrazine as fibroblast growth factor receptor (FGFR-1, 2, 3 & 4) kinase inhibitors with nanomolar affinity von Angibaud, P, Querolle, O, Berdini, V, Saxty, G, Cleasby, A, Colombel, H, Csoka, I, Gilissen, R, King, P, Meerpoel, L, Paulussen, C, Pilatte, I, Poncelet, V, Rees, D.C, Roux, B, Tronel, V, Verhulst, T, Wroblowski, B, Murray, C.W, Vialard, J

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400 Optimization of novel pyrido[2,3-b]pyrazine based small molecule fibroblast growth factor receptor 1, 2, 3 & 4 (FGFR) inhibitors into a potential clinical candidate von Angibaud, P, Querolle, O, Berdini, V, Saxty, G, Cleasby, A, Colombel, H, Csoka, I, Esser, N, Gilissen, R, Meerpoel, L, Paulussen, C, Pilatte, I, Poncelet, V, Rees, D.C, Roux, B, Verhulst, T, Tronel, V, Wroblowski, B, Murray, C.W, Vialard, J

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Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro von END, David W, SMETS, Gerda, DEVINE, Ann, WOUTERS, Walter, BOWDEN, Charles, TODD, Alison V, APPLEGATE, Tanya L, FUERY, Caroline J, ANGIBAUD, Patrick, VENET, Marc, SANZ, Gerard, POIGNET, Herve, SKRZAT, Stacy

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On the use of boronates in the Petasis reaction von Jourdan, Hélène, Gouhier, Géraldine, Van Hijfte, Luc, Angibaud, Patrick, Piettre, Serge R.

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Abstract 1361: Fragment based drug discovery of selective inhibitors of Fibroblast Growth Factor Receptor (FGFR) von Saxty, Gordon, Akkari, R, Angibaud, P, Arts, J, Benderitter, P, Berdini, V, Bonnet, P, Cleasby, A, Embrechts, W, Freyne, E, Gilissen, R, King, P, Lacrampe, J, Ligny, Y, Madin, A, Mcclue, S, Mevellec, L, Murray, C W., Newell, H, Page, M, Papanikos, A, Perera, T, Querolle, O, Rees, D C., Rich, S J., Saalau-Bethell, S M., Sement, E, Simmonet, Y, Squires, M, Tronel, V, Ward, G A., Willems, M, B, Wroblowski, Thompson, N T.

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New Chiral Brominating and Chlorinating Agents von Duhamel, L., Plé, G., Angibaud, P., Desmurs, J. R.

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Abstract 5778: Fragment-based drug discovery of selective inhibitors of fibroblast growth factor receptor (FGFr) von Saxty, Gordon, Squires, M S., Murray, C W., Berdini, V, Ward, G A., Miller, D, Rich, S J., Cleasby, A, Saalau-Bethell, S M., Coyle, J, Madin, A, Carr, M G., O'Brien, M A., Jones, C Griffiths, Vickerstaff, E, Nijjar, R K., Graham, B, Pike, A, Lewis, E J., Perera, T, Angibaud, P, Newell, H

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Asymmetric Synthesis of 2-chloro- and 2-bromo-alkanoic acids by halogenation of α-D-glucofuranose-derived silyl ketene acetals von Angibaud, P, Chaumette, J.L, Desmurs, J.R, Duhamel, L, Plé, G, Valnot, J.Y, Duhamel, P

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5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors von Angibaud, Patrick, Bourdrez, Xavier, Devine, Ann, End, David W, Freyne, Eddy, Ligny, Yannick, Muller, Philippe, Mannens, Geert, Pilatte, Isabelle, Poncelet, Virginie, Skrzat, Stacy, Smets, Gerda, Van Dun, Jacky, Van Remoortere, Pieter, Venet, Marc, Wouters, Walter

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Asymmetric Synthesis of (S)-2-Chloroalkanoic Acids with High Enantiomeric Excess by Diastereoselective Halogenation of α-D-Glucofuranose-Derived Silyl Ketene Acetals von Duhamel, L., Angibaud, P., Desmurs, J. R., Valnot, J. Y.

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Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors von Angibaud, Patrick, Arts, Janine, Van Emelen, Kristof, Poncelet, Virginie, Pilatte, Isabelle, Roux, Bruno, Van Brandt, Sven, Verdonck, Marc, De Winter, Hans, Ten Holte, Peter, Marien, Ann, Floren, Wim, Janssens, Boudewijn, Van Dun, Jacky, Aerts, An, Van Gompel, Jacky, Gaurrand, Sandrine, Queguiner, Laurence, Argoullon, Jean-Michel, Van Hijfte, Luc, Freyne, Eddy, Janicot, Michel

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Substituted azoloquinolines and -quinazolines as new potent Farnesyl Protein Transferase inhibitors von ANGIBAUD, Patrick, BOURDREZ, Xavier, MEYER, Christophe, MULLER, Philippe, PILATTE, Isabelle, PONCELET, Virginie, ROUX, Bruno, SMETS, Gerda, VAN DUN, Jacky, VAN REMOORTERE, Pieter, VENET, Marc, WOUTERS, Walter, END, David W, FREYNE, Eddy, JANICOT, Michel, LEZOURET, Patricia, LIGNY, Yannick, MANNENS, Geert, DAMSCH, Siegrid, MEVELLEC, Laurence

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An Easy Access to (3R,4R)-O,O-Diacyltartrimides von Duhamel, L., Herman, T., Angibaud, P.

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Glass-forming tendency and stability of the amorphous state in the aqueous solutions of linear polyalcohols with four carbons: I. Binary systems water-polyalcohol von Boutron, P., Mehl, P., Kaufmann, A., Angibaud, P.

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4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA von ANGIBAUD, Patrick, SAHA, Ashis K, PONCELET, Virginie, ROUX, Bruno, SMETS, Gerda, VAN DUN, Jacky, VENET, Marc, WOUTERS, Walter, BOURDREZ, Xavier, END, David W, FREYNE, Eddy, LEZOURET, Patricia, MANNENS, Geert, MEVELLEC, Laurence, MEYER, Christophe, PILATTE, Isabelle

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125 Synthesis, biological evaluation and structure activity relationships of a novel servies of aromatic hydroxamic acids as potent HDAC inhibitors von Van Emelen, K., Arts, J., Angibaud, P., De Winter, H., Van Brandt, S., Verdonck, M., Van Dun, J., Geerts, T., Floren, W., Van Gompel, J.

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Farnesyl Protein Transferase Inhibitors: Medicinal Chemistry, Molecular Mechanisms, and Progress in the Clinic von End, D. W., Mevellec, L., Angibaud, P.

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FARNESYL TRANSFERASE INHIBITING BENZOHETEROCYCLIC DERIVATIVES von PONCELET, V, ANGIBAUD, P, VENET, MARC

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Glass-forming tendency and stability of the amorphous state in the aqueous solutions of linear polyalcohols with four carbons von Boutron, P., Mehl, P., Kaufmann, A., Angibaud, P.

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