Drug Development and Medicinal Chemistry Efforts toward SARS‐Coronavirus and Covid‐19 Therapeutics von Ghosh, Arun K., Brindisi, Margherita, Shahabi, Dana, Chapman, Mackenzie E., Mesecar, Andrew D.

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The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds von Báez-Santos, Yahira M., St. John, Sarah E., Mesecar, Andrew D.

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Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing von Riva, Laura, Yuan, Shuofeng, Yin, Xin, Martin-Sancho, Laura, Matsunaga, Naoko, Pache, Lars, Burgstaller-Muehlbacher, Sebastian, De Jesus, Paul D., Teriete, Peter, Hull, Mitchell V., Chang, Max W., Chan, Jasper Fuk-Woo, Cao, Jianli, Poon, Vincent Kwok-Man, Herbert, Kristina M., Cheng, Kuoyuan, Nguyen, Tu-Trinh H., Rubanov, Andrey, Pu, Yuan, Nguyen, Courtney, Choi, Angela, Rathnasinghe, Raveen, Schotsaert, Michael, Miorin, Lisa, Dejosez, Marion, Zwaka, Thomas P., Sit, Ko-Yung, Martinez-Sobrido, Luis, Liu, Wen-Chun, White, Kris M., Chapman, Mackenzie E., Lendy, Emma K., Glynne, Richard J., Albrecht, Randy, Ruppin, Eytan, Mesecar, Andrew D., Johnson, Jeffrey R., Benner, Christopher, Sun, Ren, Schultz, Peter G., Su, Andrew I., García-Sastre, Adolfo, Chatterjee, Arnab K., Yuen, Kwok-Yung, Chanda, Sumit K.

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A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication von Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Hayashi, Hironori, Allu, Srinivasa Rao, Raghavaiah, Jakka, Bulut, Haydar, Das, Debananda, Anson, Brandon J., Lendy, Emma K., Takamatsu, Yuki, Takamune, Nobutoki, Kishimoto, Naoki, Murayama, Kazutaka, Hasegawa, Kazuya, Li, Mi, Davis, David A., Kodama, Eiichi N., Yarchoan, Robert, Wlodawer, Alexander, Misumi, Shogo, Mesecar, Andrew D., Ghosh, Arun K., Mitsuya, Hiroaki

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Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins von Zhang, Heng, Li, Zhuang, Daczkowski, Courtney M., Gabel, Clinton, Mesecar, Andrew D., Chang, Leifu

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Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities von Mielech, Anna M., Chen, Yafang, Mesecar, Andrew D., Baker, Susan C.

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Indole Chloropyridinyl Ester-Derived SARS-CoV‑2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X‑ray Structural Studies von Ghosh, Arun K, Raghavaiah, Jakka, Shahabi, Dana, Yadav, Monika, Anson, Brandon J, Lendy, Emma K, Hattori, Shin-ichiro, Higashi-Kuwata, Nobuyo, Mitsuya, Hiroaki, Mesecar, Andrew D

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MERS-CoV papain-like protease has deISGylating and deubiquitinating activities von Mielech, Anna M, Kilianski, Andy, Baez-Santos, Yahira M, Mesecar, Andrew D, Baker, Susan C

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Pleiotropic mechanisms facilitated by resveratrol and its metabolites von Calamini, Barbara, Ratia, Kiira, Malkowski, Michael G, Cuendet, Muriel, Pezzuto, John M, Santarsiero, Bernard D, Mesecar, Andrew D

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Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1 von Eggler, Aimee L, Small, Evan, Hannink, Mark, Mesecar, Andrew D

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Modification of Keap1 Cysteine Residues by Sulforaphane von Hu, Chenqi, Eggler, Aimee L, Mesecar, Andrew D, van Breemen, Richard B

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Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease von Clasman, Jozlyn R., Everett, Renata K., Srinivasan, Karthik, Mesecar, Andrew D.

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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19 von Boras, Britton, Jones, Rhys M., Anson, Brandon J., Arenson, Dan, Aschenbrenner, Lisa, Bakowski, Malina A., Beutler, Nathan, Binder, Joseph, Chen, Emily, Eng, Heather, Hammond, Holly, Hammond, Jennifer, Haupt, Robert E., Hoffman, Robert, Kadar, Eugene P., Kania, Rob, Kimoto, Emi, Kirkpatrick, Melanie G., Lanyon, Lorraine, Lendy, Emma K., Lillis, Jonathan R., Logue, James, Luthra, Suman A., Ma, Chunlong, Mason, Stephen W., McGrath, Marisa E., Noell, Stephen, Obach, R. Scott, O’ Brien, Matthew N., O’Connor, Rebecca, Ogilvie, Kevin, Owen, Dafydd, Pettersson, Martin, Reese, Matthew R., Rogers, Thomas F., Rosales, Romel, Rossulek, Michelle I., Sathish, Jean G., Shirai, Norimitsu, Steppan, Claire, Ticehurst, Martyn, Updyke, Lawrence W., Weston, Stuart, Zhu, Yuao, White, Kris M., García-Sastre, Adolfo, Wang, Jun, Chatterjee, Arnab K., Mesecar, Andrew D., Frieman, Matthew B., Anderson, Annaliesa S., Allerton, Charlotte

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Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus von Báez-Santos, Yahira M, Mielech, Anna M, Deng, Xufang, Baker, Susan, Mesecar, Andrew D

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Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species von Daczkowski, Courtney M., Dzimianski, John V., Clasman, Jozlyn R., Goodwin, Octavia, Mesecar, Andrew D., Pegan, Scott D.

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Molecular mechanisms of natural products in chemoprevention: Induction of cytoprotective enzymes by Nrf2 von Eggler, Aimee L, Gay, Kelly A, Mesecar, Andrew D

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Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of... von Turlington, Mark, Chun, Aspen, Tomar, Sakshi, Eggler, Aimee, Grum-Tokars, Valerie, Jacobs, Jon, Daniels, J. Scott, Dawson, Eric, Saldanha, Adrian, Chase, Peter, Baez-Santos, Yahira M., Lindsley, Craig W., Hodder, Peter, Mesecar, Andrew D., Stauffer, Shaun R.

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noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication von Ratia, Kiira, Pegan, Scott, Takayama, Jun, Sleeman, Katrina, Coughlin, Melissa, Baliji, Surendranath, Chaudhuri, Rima, Fu, Wentao, Prabhakar, Bellur S, Johnson, Michael E, Baker, Susan C, Ghosh, Arun K, Mesecar, Andrew D

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The Papain-Like Protease of Severe Acute Respiratory Syndrome Coronavirus Has Deubiquitinating Activity von BARRETTO, Naina, JUKNELIENE, Dalia, RATIA, Kiira, ZHONGBIN CHEN, MESECAR, Andrew D, BAKER, Susan C

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Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity von Stobart, Christopher C, Sexton, Nicole R, Munjal, Havisha, Lu, Xiaotao, Molland, Katrina L, Tomar, Sakshi, Mesecar, Andrew D, Denison, Mark R

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