RNP-Granule Assembly via Ataxin-2 Disordered Domains Is Required for Long-Term Memory and Neurodegeneration von Bakthavachalu, Baskar, Huelsmeier, Joern, Sudhakaran, Indulekha P., Hillebrand, Jens, Singh, Amanjot, Petrauskas, Arnas, Thiagarajan, Devasena, Sankaranarayanan, M., Mizoue, Laura, Anderson, Eric N., Pandey, Udai Bhan, Ross, Eric, VijayRaghavan, K., Parker, Roy, Ramaswami, Mani

Volltext

RNA-recognition motif in Matrin-3 mediates neurodegeneration through interaction with hnRNPM von Ramesh, Nandini, Kour, Sukhleen, Anderson, Eric N, Rajasundaram, Dhivyaa, Pandey, Udai Bhan

Volltext

LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice von Prakasam, Ramachandran, Bonadiman, Angela, Andreotti, Roberta, Zuccaro, Emanuela, Dalfovo, Davide, Marchioretti, Caterina, Tripathy, Debasmita, Petris, Gianluca, Anderson, Eric N., Migazzi, Alice, Tosatto, Laura, Cereseto, Anna, Battaglioli, Elena, Sorarù, Gianni, Lim, Wooi Fang, Rinaldi, Carlo, Sambataro, Fabio, Pourshafie, Naemeh, Grunseich, Christopher, Romanel, Alessandro, Pandey, Udai Bhan, Contestabile, Andrea, Ronzitti, Giuseppe, Basso, Manuela, Pennuto, Maria

Volltext

SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration von Fortuna, Tyler R., Kour, Sukhleen, Chimata, Anuradha Venkatakrishnan, Muiños-Bühl, Anixa, Anderson, Eric N., Nelson IV, Charlie H., Ward, Caroline, Chauhan, Om, O’Brien, Casey, Rajasundaram, Dhivyaa, Rajan, Deepa S., Wirth, Brunhilde, Singh, Amit, Pandey, Udai Bhan

Volltext

NUP62 localizes to ALS/FTLD pathological assemblies and contributes to TDP-43 insolubility von Gleixner, Amanda M., Verdone, Brandie Morris, Otte, Charlton G., Anderson, Eric N., Ramesh, Nandini, Shapiro, Olivia R., Gale, Jenna R., Mauna, Jocelyn C., Mann, Jacob R., Copley, Katie E., Daley, Elizabeth L., Ortega, Juan A., Cicardi, Maria Elena, Kiskinis, Evangelos, Kofler, Julia, Pandey, Udai B., Trotti, Davide, Donnelly, Christopher J.

Volltext

The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons von Anderson, Eric N, Hirpa, Delnessaw, Zheng, Kan Hong, Banerjee, Rupkatha, Gunawardena, Shermali

Volltext

Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology von Anderson, Eric N, Morera, Andrés A, Kour, Sukhleen, Cherry, Jonathan D, Ramesh, Nandini, Gleixner, Amanda, Schwartz, Jacob C, Ebmeier, Christopher, Old, William, Donnelly, Christopher J, Cheng, Jeffrey P, Kline, Anthony E, Kofler, Julia, Stein, Thor D, Pandey, Udai Bhan

Volltext

Huntingtin-mediated axonal transport requires arginine methylation by PRMT6 von Migazzi, Alice, Scaramuzzino, Chiara, Anderson, Eric N., Tripathy, Debasmita, Hernández, Ivó H., Grant, Rogan A., Roccuzzo, Michela, Tosatto, Laura, Virlogeux, Amandine, Zuccato, Chiara, Caricasole, Andrea, Ratovitski, Tamara, Ross, Christopher A., Pandey, Udai B., Lucas, José J., Saudou, Frédéric, Pennuto, Maria, Basso, Manuela

Volltext

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization von Casci, Ian, Krishnamurthy, Karthik, Kour, Sukhleen, Tripathy, Vadreenath, Ramesh, Nandini, Anderson, Eric N., Marrone, Lara, Grant, Rogan A., Oliver, Stacie, Gochenaur, Lauren, Patel, Krishani, Sterneckert, Jared, Gleixner, Amanda M., Donnelly, Christopher J., Ruepp, Marc-David, Sini, Antonella M., Zuccaro, Emanuela, Pennuto, Maria, Pasinelli, Piera, Pandey, Udai Bhan

Volltext

Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2 von Kim, Sang Hwa, Nichols, Kye D, Anderson, Eric N, Liu, Yining, Ramesh, Nandini, Jia, Weiyan, Kuerbis, Connor J, Scalf, Mark, Smith, Lloyd M, Pandey, Udai Bhan, Tibbetts, Randal S

Volltext

Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo von Reinhardt, Lydia, Kordes, Susanne, Reinhardt, Peter, Glatza, Michael, Baumann, Matthias, Drexler, Hannes C.A., Menninger, Sascha, Zischinsky, Gunther, Eickhoff, Jan, Fröb, Claudia, Bhattarai, Prabesh, Arulmozhivarman, Guruchandar, Marrone, Lara, Janosch, Antje, Adachi, Kenjiro, Stehling, Martin, Anderson, Eric N., Abo-Rady, Masin, Bickle, Marc, Pandey, Udai Bhan, Reimer, Michell M., Kizil, Caghan, Schöler, Hans R., Nussbaumer, Peter, Klebl, Bert, Sterneckert, Jared L.

Volltext

RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3 von Ramesh, Nandini, Daley, Elizabeth L, Gleixner, Amanda M, Mann, Jacob R, Kour, Sukhleen, Mawrie, Darilang, Anderson, Eric N, Kofler, Julia, Donnelly, Christopher J, Kiskinis, Evangelos, Pandey, Udai Bhan

Volltext

Traumatic injury induces stress granule formation and enhances motor dysfunctions in ALS/FTD models von Anderson, Eric N, Gochenaur, Lauren, Singh, Aditi, Grant, Rogan, Patel, Krishani, Watkins, Simon, Wu, Jane Y, Pandey, Udai Bhan

Volltext

WNK kinases sense molecular crowding and rescue cell volume via phase separation von Boyd-Shiwarski, Cary R., Shiwarski, Daniel J., Griffiths, Shawn E., Beacham, Rebecca T., Norrell, Logan, Morrison, Daryl E., Wang, Jun, Mann, Jacob, Tennant, William, Anderson, Eric N., Franks, Jonathan, Calderon, Michael, Connolly, Kelly A., Cheema, Muhammad Umar, Weaver, Claire J., Nkashama, Lubika J., Weckerly, Claire C., Querry, Katherine E., Pandey, Udai Bhan, Donnelly, Christopher J., Sun, Dandan, Rodan, Aylin R., Subramanya, Arohan R.

Volltext

Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway von Lin, Yen-Chen, Kumar, Meenakshi Sundaram, Ramesh, Nandini, Anderson, Eric N., Nguyen, Aivi T., Kim, Boram, Cheung, Simon, McDonough, Justin A., Skarnes, William C., Lopez-Gonzalez, Rodrigo, Landers, John E., Fawzi, Nicolas L., Mackenzie, Ian R. A., Lee, Edward B., Nickerson, Jeffrey A., Grunwald, David, Pandey, Udai B., Bosco, Daryl A.

Volltext

Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo von Kour, Sukhleen, Fortuna, Tyler, Anderson, Eric N, Mawrie, Darilang, Bilstein, Jessica, Sivasubramanian, Ramakrishnan, Ward, Caroline, Roy, Rishit, Rajasundaram, Dhivyaa, Sterneckert, Jared, Pandey, Udai Bhan

Volltext

DDX17 is involved in DNA damage repair and modifies FUS toxicity in an RGG-domain dependent manner von Fortuna, Tyler R., Kour, Sukhleen, Anderson, Eric N., Ward, Caroline, Rajasundaram, Dhivyaa, Donnelly, Christopher J., Hermann, Andreas, Wyne, Hala, Shewmaker, Frank, Pandey, Udai Bhan

Volltext

Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome von García-Cazorla, Àngels, Verdura, Edgard, Juliá-Palacios, Natalia, Anderson, Eric N., Goicoechea, Leire, Planas-Serra, Laura, Tsogtbaatar, Enkhtuul, Dsouza, Nikita R., Schlüter, Agatha, Urreizti, Roser, Tarnowski, Jessica M., Gavrilova, Ralitza H., Ruiz, Montserrat, Rodríguez-Palmero, Agustí, Fourcade, Stéphane, Cogné, Benjamin, Besnard, Thomas, Vincent, Marie, Bézieau, Stéphane, Folmes, Clifford D., Zimmermann, Michael T., Klee, Eric W., Pandey, Udai Bhan, Artuch, Rafael, Cousin, Margot A., Pujol, Aurora

Volltext

Further delineation of GEMIN4 related neurodevelopmental disorder with microcephaly, cataract, and renal abnormalities syndrome von Altassan, Ruqaiah, Qudair, Ahmad, Alokaili, Riyadh, Alhasan, Khalid, Faqeih, Eissa A., Alhashem, Amal, Alowain, Muhammed, Alsayed, Moeanaldeen, Rahbeeni, Zuhair, Albadi, Lama, Alkuraya, Fowzan S., Anderson, Eric N., Rajan, Deepa, Pandey, Udai Bhan

Volltext

Loss of function of the ALS-associated NEK1 kinase disrupts microtubule homeostasis and nuclear import von Mann, Jacob R, McKenna, Elizabeth D, Mawrie, Darilang, Papakis, Vasileios, Alessandrini, Francesco, Anderson, Eric N, Mayers, Ryan, Ball, Hannah E, Kaspi, Evan, Lubinski, Katherine, Baron, Desiree M, Tellez, Liana, Landers, John E, Pandey, Udai B, Kiskinis, Evangelos

Volltext