Case report: Novel variants in RELA associated with familial Behcet's-like disease von An, Jason W, Pimpale-Chavan, Pallavi, Stone, Deborah L, Bandeira, Marcia, Dedeoglu, Fatma, Lo, Jeffrey, Bohnsack, John, Rosenzweig, Sofia, Schnappauf, Oskar, Dissanayake, Dilan, Hiraki, Linda T, Kastner, Daniel L, Pelajo, Christina, Laxer, Ronald M, Aksentijevich, Ivona

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Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation von Richardson, Tom G, Leyden, Genevieve M, Wang, Qin, Bell, Joshua A, Elsworth, Benjamin, Davey Smith, George, Holmes, Michael V

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Human sperm displays rapid responses to diet von Nätt, Daniel, Kugelberg, Unn, Casas, Eduard, Nedstrand, Elizabeth, Zalavary, Stefan, Henriksson, Pontus, Nijm, Carola, Jäderquist, Julia, Sandborg, Johanna, Flinke, Eva, Ramesh, Rashmi, Örkenby, Lovisa, Appelkvist, Filip, Lingg, Thomas, Guzzi, Nicola, Bellodi, Cristian, Löf, Marie, Vavouri, Tanya, Öst, Anita

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High-coverage plasma lipidomics reveals novel sex-specific lipidomic fingerprints of age and BMI: Evidence from two large population cohort studies von Beyene, Habtamu B, Olshansky, Gavriel, T Smith, Adam Alexander, Giles, Corey, Huynh, Kevin, Cinel, Michelle, Mellett, Natalie A, Cadby, Gemma, Hung, Joseph, Hui, Jennie, Beilby, John, Watts, Gerald F, Shaw, Jonathan E, Moses, Eric K, Magliano, Dianna J, Meikle, Peter J

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Deep learning allows genome-scale prediction of Michaelis constants from structural features von Kroll, Alexander, Engqvist, Martin K M, Heckmann, David, Lercher, Martin J

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Machine learning of human plasma lipidomes for obesity estimation in a large population cohort von Gerl, Mathias J, Klose, Christian, Surma, Michal A, Fernandez, Celine, Melander, Olle, Männistö, Satu, Borodulin, Katja, Havulinna, Aki S, Salomaa, Veikko, Ikonen, Elina, Cannistraci, Carlo V, Simons, Kai

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Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort von Lauber, Chris, Gerl, Mathias J, Klose, Christian, Ottosson, Filip, Melander, Olle, Simons, Kai

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Plasma metabolome predicts trained immunity responses after antituberculosis BCG vaccination von Koeken, Valerie A. C. M, Qi, Cancan, Mourits, Vera P, de Bree, L. Charlotte J, Moorlag, Simone J. C. F. M, Sonawane, Vidhisha, Lemmers, Heidi, Dijkstra, Helga, Joosten, Leo A. B, van Laarhoven, Arjan, Xu, Cheng-Jian, van Crevel, Reinout, Netea, Mihai G, Li, Yang

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Histone methyltransferase activity affects metabolism in human cells independently of transcriptional regulation von Perez, Marcos Francisco, Sarkies, Peter

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On the optimality of the enzyme-substrate relationship in bacteria von Dourado, Hugo, Mori, Matteo, Hwa, Terence, Lercher, Martin J

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A lifecourse mendelian randomization study highlights the long-term influence of childhood body size on later life heart structure von O'Nunain, Katie, Park, Chloe, Urquijo, Helena, Leyden, Genevieve M, Hughes, Alun D, Davey Smith, George, Richardson, Tom G

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Rab2A regulates the progression of nonalcoholic fatty liver disease downstream of AMPK-TBC1D1 axis by stabilizing PPARγ von Chen, Zi-Yue, Sun, Ya-Ting, Wang, Zi-Ming, Hong, Jie, Xu, Min, Zhang, Fu-Ting, Zhou, Xian-Qing, Rong, Ping, Wang, Qi, Wang, Hong Yu, Wang, Hua, Chen, Shuai, Chen, Liang

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Polygenic scores for complex traits are associated with changes in concentration of circulating lipid species von Tabassum, Rubina, Mars, Nina, Parolo, Pietro Della Briotta, Gerl, Mathias J, Klose, Christian, Pirinen, Matti, Simons, Kai, Widén, Elisabeth, Ripatti, Samuli

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Comparative time-series multi-omics analyses suggest H1.2 involvement in anoxic adaptation and cancer resistance von Du, Juan, Liu, Weiqiang, Li, Meng, Li, Zihao, Li, Xuanjing, Dai, Yichen, Liu, Gaoming, Wang, Xiao, Zhu, Pingfen, Gladyshev, Vadim N, Zhou, Xuming

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Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer von Gutiérrez-Salmerón, María, García-Martínez, José Manuel, Martínez-Useros, Javier, Fernández-Aceñero, María Jesús, Viollet, Benoit, Olivier, Severine, Chauhan, Jagat, Lucena, Silvia R, De la Vieja, Antonio, Goding, Colin R, Chocarro-Calvo, Ana, García-Jiménez, Custodia

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The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures von Mori, Hiroyuki, Dugan, Colleen E, Nishii, Akira, Benchamana, Ameena, Li, Ziru, Cadenhead, 4th, Thomas S, Das, Arun K, Evans, Charles R, Overmyer, Katherine A, Romanelli, Steven M, Peterson, Sydney K, Bagchi, Devika P, Corsa, Callie A, Hardij, Julie, Learman, Brian S, El Azzouny, Mahmoud, Coon, Joshua J, Inoki, Ken, MacDougald, Ormond A

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EMF1 and PRC2 cooperate to repress key regulators of Arabidopsis development von Kim, Sang Yeol, Lee, Jungeun, Eshed-Williams, Leor, Zilberman, Daniel, Sung, Z Renee

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The landscape of metabolic pathway dependencies in cancer cell lines von Joly, James H, Chew, Brandon T L, Graham, Nicholas A

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Towards precision medicine in diabetes? A critical review of glucotypes von Hulman, Adam, Foreman, Yuri D, Brouwers, Martijn C G J, Kroon, Abraham A, Reesink, Koen D, Dagnelie, Pieter C, van der Kallen, Carla J H, Greevenbroek, Marleen M J van, Færch, Kristine, Vistisen, Dorte, Jørgensen, Marit E, Stehouwer, Coen D A, Witte, Daniel R

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Response to Hulman and colleagues regarding "Glucotypes reveal new patterns of glucose dysregulation" von Breschi, Alessandra, Perelman, Dalia, Snyder, Michael Paul

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