Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924 von Milhollen, Michael A., Thomas, Michael P., Narayanan, Usha, Traore, Tary, Riceberg, Jessica, Amidon, Benjamin S., Bence, Neil F., Bolen, Joseph B., Brownell, James, Dick, Lawrence R., Loke, Huay-Keng, McDonald, Alice A., Ma, Jingya, Manfredi, Mark G., Sells, Todd B., Sintchak, Mike D., Yang, Xiaofeng, Xu, Qing, Koenig, Erik M., Gavin, James M., Smith, Peter G.

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Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6 von Gavin, James M., Chen, Jesse J., Liao, Hua, Rollins, Neil, Yang, Xiaofeng, Xu, Qing, Ma, Jingya, Loke, Huay-Keng, Lingaraj, Trupti, Brownell, James E., Mallender, William D., Gould, Alexandra E., Amidon, Benjamin S., Dick, Lawrence R.

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment von Hyer, Marc L, Milhollen, Michael A, Ciavarri, Jeff, Fleming, Paul, Traore, Tary, Sappal, Darshan, Huck, Jessica, Shi, Judy, Gavin, James, Brownell, Jim, Yang, Yu, Stringer, Bradley, Griffin, Robert, Bruzzese, Frank, Soucy, Teresa, Duffy, Jennifer, Rabino, Claudia, Riceberg, Jessica, Hoar, Kara, Lublinsky, Anya, Menon, Saurabh, Sintchak, Michael, Bump, Nancy, Pulukuri, Sai M, Langston, Steve, Tirrell, Stephen, Kuranda, Mike, Veiby, Petter, Newcomb, John, Li, Ping, Wu, Jing Tao, Powe, Josh, Dick, Lawrence R, Greenspan, Paul, Galvin, Katherine, Manfredi, Mark, Claiborne, Chris, Amidon, Benjamin S, Bence, Neil F

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MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma von Shi, Judy Quiju, Lasky, Kerri, Shinde, Vaishali, Stringer, Bradley, Qian, Mark G, Liao, Debra, Liu, Ray, Driscoll, Denise, Nestor, Michelle Tighe, Amidon, Benjamin S, Rao, Youlan, Duffey, Matt O, Manfredi, Mark G, Vos, Tricia J, D' Amore, Natalie, Hyer, Marc L

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Microarray approach for cloned library quality assessment and the comprehensive identification of positives from library screens von Blackman, Ronald K, Amidon, Benjamin S

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Abstract 1493: LonP1 is required for tumor maintenance and growth von Amidon, Benjamin S., Wu, Dongyun, Bradley, John, Ma, Jingya, Tsu, Christopher, Carideo-Cunniff, Elizabeth, Kolev, Vihren, Garnsey, James, Shah, Pooja, Koenig, Erik, Liao, Hua, Cullis, Courtney

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Abstract 2156: IK-930 is a novel TEAD inhibitor for the treatment of cancers harboring mutations in the Hippo signal transduction pathway von Amidon, Benjamin S., Sanchez-Martin, Marta, Bartolini, Wilmin, Syed, Sakeena, McGovern, Karen, Xu, Lan, Ecsedy, Jeffrey, Zhang, X. Michelle, Constan, Alex, Castro, Alfredo C.

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INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6 von CARDIN, DAVID, P, AMIDON, BENJAMIN, S, GOULD, ALEXANDRA, E, HARRISON, SEAN, J, GREENSPAN, PAUL, D

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INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6 von CARDIN, DAVID, P, AMIDON, BENJAMIN, S, GOULD, ALEXANDRA, E, HARRISON, SEAN, J, GREENSPAN, PAUL, D

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Indole-substituted pyrrolopyrimidinyl inhibitors of Uba6 von GOULD ALEXANDRA E, GREENSPAN PAUL D, HARRISON SEAN J, CARDIN DAVID P, AMIDON BENJAMIN S

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INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6 von CARDIN, DAVID, P, AMIDON, BENJAMIN, S, GOULD, ALEXANDRA, E, HARRISON, SEAN, J, GREENSPAN, PAUL, D

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INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF UBA6 von GREENSPAN, PAUL D, AMIDON, BENJAMIN S, CARDIN, DAVID P, HARRISON, SEAN J, GOULD, ALEXANDRA E

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Screen for CDC7 inhibitors von BULAWA CHRISTINE E, AMIDON BENJAMIN S

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Modelling climate constraints on the formation of pluvial Lake Bonneville in the Great Basin, United States von Belanger, Bryce K., Amidon, William H., Laabs, Benjamin J. C., Munroe, Jeffrey S., Quirk, Brendon J.

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Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell lines von Driscoll, Denise L, Chakravarty, Arijit, Bowman, Doug, Shinde, Vaishali, Lasky, Kerri, Shi, Judy, Vos, Tricia, Stringer, Bradley, Amidon, Ben, D'Amore, Natalie, Hyer, Marc L

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Abstract P216: IK-930 mediated TEAD inhibition decreases and delays tumor growth and enhances targeted apoptosis in lung and colon cancer xenografts when combined with MEK or EGFR... von Amidon, Benjamin, Frosch, Hyejin, Syed, Sakeena, Cavanaugh, Jill, Turcotte, Chelsea, O'Callaghan, Katie, Natarajan, Prabitha, Ecsedy, Jeffrey, McGovern, Karen, Castro, Alfredo

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Abstract P212: Systems biology-guided indication selection to inform the clinical development of a novel TEAD inhibitor von Sanchez-Martin, Marta, Syed, Sakeena, Frosch, Hyejin, Turcotte, Chelsea, Amidon, Benjamin, McGovern, Karen, Ecsedy, Jeffrey, Zhang, Michelle X.

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Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover von Milhollen, Michael A, Narayanan, Usha, Soucy, Teresa A, Veiby, Petter O, Smith, Peter G, Amidon, Benjamin

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Combination of 3-(imidazol-4-yl)-4-(amino)-benzenesulfonamide TEAD inhibitors with EGFR inhibitors and/or MEK inhibitors for treatment of lung cancer von BURK MARK, AMIDON BENJAMIN, CASTRO ALFREDO C, FROSCH HOLGER

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Inhibition of NEDDB-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT1 Turnover von MILHOLLEN, Michael A, NARAYANAN, Usha, SOUCY, Teresa A, VEIBY, Petter O, SMITH, Peter G, AMIDON, Benjamin

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