Decade-long leukaemia remissions with persistence of CD4+ CAR T cells von Melenhorst, J. Joseph, Chen, Gregory M., Wang, Meng, Porter, David L., Chen, Changya, Collins, McKensie A., Gao, Peng, Bandyopadhyay, Shovik, Sun, Hongxing, Zhao, Ziran, Lundh, Stefan, Pruteanu-Malinici, Iulian, Nobles, Christopher L., Maji, Sayantan, Frey, Noelle V., Gill, Saar I., Loren, Alison W., Tian, Lifeng, Kulikovskaya, Irina, Gupta, Minnal, Ambrose, David E., Davis, Megan M., Fraietta, Joseph A., Brogdon, Jennifer L., Young, Regina M., Chew, Anne, Levine, Bruce L., Siegel, Donald L., Alanio, Cécile, Wherry, E. John, Bushman, Frederic D., Lacey, Simon F., Tan, Kai, June, Carl H.

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PD-1 blockade modulates chimeric antigen receptor (CAR)–modified T cells: refueling the CAR von Chong, Elise A., Melenhorst, J.Joseph, Lacey, Simon F., Ambrose, David E., Gonzalez, Vanessa, Levine, Bruce L., June, Carl H., Schuster, Stephen J.

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Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell von Ruella, Marco, Xu, Jun, Barrett, David M., Fraietta, Joseph A., Reich, Tyler J., Ambrose, David E., Klichinsky, Michael, Shestova, Olga, Patel, Prachi R., Kulikovskaya, Irina, Nazimuddin, Farzana, Bhoj, Vijay G., Orlando, Elena J., Fry, Terry J., Bitter, Hans, Maude, Shannon L., Levine, Bruce L., Nobles, Christopher L., Bushman, Frederic D., Young, Regina M., Scholler, John, Gill, Saar I., June, Carl H., Grupp, Stephan A., Lacey, Simon F., Melenhorst, J. Joseph

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Author Correction: Decade-long leukaemia remissions with persistence of CD4+ CAR T cells von Melenhorst, J. Joseph, Chen, Gregory M., Wang, Meng, Porter, David L., Chen, Changya, Collins, McKensie A., Gao, Peng, Bandyopadhyay, Shovik, Sun, Hongxing, Zhao, Ziran, Lundh, Stefan, Pruteanu-Malinici, Iulian, Nobles, Christopher L., Maji, Sayantan, Frey, Noelle V., Gill, Saar I., Loren, Alison W., Tian, Lifeng, Kulikovskaya, Irina, Gupta, Minnal, Ambrose, David E., Davis, Megan M., Fraietta, Joseph A., Brogdon, Jennifer L., Young, Regina M., Chew, Anne, Levine, Bruce L., Siegel, Donald L., Alanio, Cécile, Wherry, E. John, Bushman, Frederic D., Lacey, Simon F., Tan, Kai, June, Carl H.

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Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia von Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph

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Decade-Long Remissions of Leukemia Sustained By the Persistence of Activated CD4+ CAR T-Cells von Melenhorst, J. Joseph, Chen, Gregory M, Wang, Meng, Porter, David L., Gao, Peng, Bandyopadhyay, Shovik, Pruteanu-Malinici, Iulian, Nobles, Christopher L, Maji, Sayantan, Frey, Noelle V, Gill, Saar, Tian, Lifeng, Kulikovskaya, Irina, Davis, Megan M, Fraietta, Joseph A, Brogdon, Jennifer L, Young, Regina, Ambrose, David E, Chew, Anne, Levine, Bruce L, Siegel, Don L., Alanio, Cécile, Wherry, E. John, Bushman, Frederic D., Lacey, Simon F, Tan, Kai, June, Carl H

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Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia von Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph

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Long-Term Remission of CLL Sustained By Pauciclonal Anti-CD19 Chimeric Antigen Receptor T (CTL019) Cell Clones von Melenhorst, J. Joseph, Porter, David L., Tian, Lifeng, Lacey, Simon F, Nobles, Christopher L, Fraietta, Joseph A, Frey, Noelle V., Kulikovskaya, Irina, Gupta, Minnal, Young, Regina M, Ambrose, David E, Siegel, Don L., Bushman, Frederic D, June, Carl H

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Abstract LB-053: Next-generation sequencing of T-cell receptor-beta gene rearrangements reveals dramatic expansion of T-cell clonotypes after CART-EGFRvIII therapy for glioblastoma von O'Rourke, Donald M., Chen, Fang, Binder, Zev A., Kulikovskaya, Irina, Gupta, Minnal, Finklestein, Jeffrey, Ambrose, David E., Nasrallah, MacLean P., June, Carl H., Lacey, Simon F., Melenhorst, J. Joseph

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Safety and Efficacy of B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) with Cyclophosphamide Conditioning for Refractory Multiple Myeloma (M... von Cohen, Adam D., Garfall, Alfred L., Stadtmauer, Edward A., Lacey, Simon F, Lancaster, Eric, Vogl, Dan T., Weiss, Brendan M, Ambrose, David E, Nelson, Anne Marie, Chen, Fang, Plesa, Gabriela, Kulikovskaya, Irina, Gonzalez, Vanessa, Gupta, Minnal, Young, Regina M, Dengel, Karen, O'keefe, Laura, Le, Samantha, Richardson, Celeste, Isaacs, Randi E., Melenhorst, J. Joseph, Levine, Bruce L, June, Carl H, Milone, Michael C.

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Clinical Evidence That Deficiency of the Methylcytosine Dioxygenase TET2 Gene Promotes the Clonal Expansion and Therapeutic Efficacy of CD19-Directed T Cells von Fraietta, Joseph A, Nobles, Christopher L, Sammons, Morgan A, Carty, Shannon A., Lundh, Stefan M, Reich, Tyler, Cogdill, Alexandria P, Gohil, Mercy, Morrissette, Jennifer J.D., Kulikovskaya, Irina, Nazimuddin, Farzana, Gupta, Minnal, Wang, Yan, Liu, Xiaojun, Young, Regina M, Ambrose, David E, Jordan, Martha S, Marcucci, Katherine T, Levine, Bruce L, Zhao, Yangbing, Kalos, Michael, Porter, David L, Lacey, Simon F, Berger, Shelley L, Bushman, Frederic D, June, Carl H, Melenhorst, J. Joseph

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B-Cell Maturation Antigen (BCMA)-Specific Chimeric Antigen Receptor T Cells (CART-BCMA) for Multiple Myeloma (MM): Initial Safety and Efficacy from a Phase I Study von Cohen, Adam D., Garfall, Alfred L., Stadtmauer, Edward A, Lacey, Simon Francis, Lancaster, Eric, Vogl, Dan T., Dengel, Karen, Ambrose, David E, Chen, Fang, Plesa, Gabriela, Kulikovskaya, Irina, Gonzalez, Vanessa E, Gupta, Minnal, Young, Regina M, Carey, Tenesia, Ferthio, Regina, Weiss, Brendan M., Richardson, Celeste, Isaacs, Randi E., Melenhorst, J. Joseph, Levine, Bruce L., June, Carl H, Milone, Michael C.

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Identification of Functional Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy of Chronic Lymphocytic Leukemia von Fraietta, Joseph A, Lacey, Simon F, Orlando, Elena, Pruteanu, Julian, Gohil, Mercy, Wang, Yan, Boesteanu, Alina, OConnor, Roddy, Ambrose, David E, Hwang, Wei-Ting, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Parakandi, Harit, Gupta, Minnal, Pequignot, Edward, Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Lundh, Stefan M, Xu, Jun, Davis, Megan M, Young, Regina M, Levine, Bruce L, Siegel, Don L., Huang, Alexander, Wherry, E. John, Zhou, Jing, Paczkowski, Patrick, Mackay, Sean, Brogdon, Jennifer, Bitter, Hans, Porter, David L, June, Carl H, Melenhorst, J. Joseph

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Biomarkers of Response to Anti-CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy in Patients with Chronic Lymphocytic Leukemia von Fraietta, Joseph A., Lacey, Simon F., Wilcox, Nicholas S, Bedoya, Felipe, Chen, Fang, Orlando, Elena, Brogdon, Jennifer L, Hwang, Wei-Ting, Frey, Noelle, Young, Regina M, Pequignot, Edward, Ambrose, David E, Levine, Bruce L, Bitter, Hans, Porter, David L, Xu, Jun, June, Carl H, Melenhorst, Jan Joseph

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Cars in Leukemia: Relapse with Antigen-Negative Leukemia Originating from a Single B Cell Expressing the Leukemia-Targeting CAR von Lacey, Simon Francis, Xu, Jun, Ruella, Marco, Barrett, David M., Kulikovskaya, Irina, Ambrose, David E, Patel, Prachi R., Reich, Tyler, Scholler, John, Nazimuddin, Farzana, Fraietta, Joseph A., Maude, Shannon L, Gill, Saar I., Levine, Bruce L, Nobles, Christopher L, Bushman, Frederic D, Orlando, Elena, Grupp, Stephan A., June, Carl H, Melenhorst, Jan Joseph

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Pilot Study of Anti-CD19 Chimeric Antigen Receptor T Cells (CTL019) in Conjunction with Salvage Autologous Stem Cell Transplantation for Advanced Multiple Myeloma von Garfall, Alfred L., Stadtmauer, Edward A, Maus, Marcela V., Hwang, Wei-Ting, Vogl, Dan T., Cohen, Adam D., Weiss, Brendan M, Porter, David L, Frey, Noelle, Milone, Michael, Mangan, Patricia, Krevvata, Maria, Ayers, Emily, Dengel, Karen, Kerr, Naseem DS, Lacey, Simon F., Melenhorst, Jan Joseph, Ambrose, David E, Chen, Fang, Gonzalez, Vanessa E, Kulikovskaya, Irina, Gupta, Minnal, Finklestein, Jeffrey, Lamontagne, Anne, O'Rourke, Matthew, Suhoski Davis, Megan, Malykhin, Alexander, Levine, Bruce L, June, Carl H

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Posterior Reversible Encephalopathy Syndrome (PRES) after Infusion of Anti-Bcma CAR T Cells (CART-BCMA) for Multiple Myeloma: Successful Treatment with Cyclophosphamide von Garfall, Alfred L., Lancaster, Eric, Stadtmauer, Edward A, Lacey, Simon F., Dengel, Karen, Ambrose, David E, Chen, Fang, Gupta, Minnal, Kulikovskaya, Irina, Vogl, Dan T., Plesa, Gabriela, Weiss, Brendan M, Ferthio, Regina, Richardson, Celeste, Melenhorst, Jan Joseph, Levine, Bruce L, June, Carl H, Milone, Michael, Cohen, Adam D.

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Efficacy and Safety of Humanized Chimeric Antigen Receptor (CAR)-Modified T Cells Targeting CD19 in Children with Relapsed/Refractory ALL von Maude, Shannon L, Barrett, David M., Ambrose, David E, Rheingold, Susan R., Aplenc, Richard, Teachey, David T, Callahan, Colleen, Barker, Christine S, Mudambi, Maya, Shaw, Pamela A, Brogdon, Jennifer, Young, Regina M, Scholler, John, Loew, Andreas, Marcucci, Katherine T., Finklestein, Jeffrey, Kulikovskaya, Irina, Nazimuddin, Farzana, Zheng, Zhaohui, Levine, Bruce L., Porter, David L, Lacey, Simon F., Melenhorst, Jan J., June, Carl H., Grupp, Stephan A.

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Long-Term Functional Persistence, B Cell Aplasia and Anti-Leukemia Efficacy In Refractory B Cell Malignancies Following T Cell Immunotherapy Using CAR-Redirected T Cells Targeting... von Kalos, Michael, Nazimuddin, Farzana, Finklestein, Jeffrey M., Gupta, Minnal, Kulikovskaya, Irina, Ambrose, David E., Gill, Saar, Lacey, Simon F., Zheng, Zhaohui, Melenhorst, J. Joseph, Levine, Bruce L., Frey, Noelle V., Grupp, Stephan A., Porter, David L., June, Carl H.

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Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell von Ruella, Marco, Xu, Jun, Barrett, David M, Fraietta, Joseph A, Reich, Tyler J, Ambrose, David E, Klichinsky, Michael

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