A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II von Liu, Yanli, Iqbal, Aman, Li, Weiguo, Ni, Zuyao, Wang, Yalong, Ramprasad, Jurupula, Abraham, Karan Joshua, Zhang, Mengmeng, Zhao, Dorothy Yanling, Qin, Su, Loppnau, Peter, Jiang, Honglv, Guo, Xinghua, Brown, Peter J., Zhen, Xuechu, Xu, Guoqiang, Mekhail, Karim, Ji, Xingyue, Bedford, Mark T., Greenblatt, Jack F., Min, Jinrong

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Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability von Houliston, R. Scott, Lemak, Alexander, Iqbal, Aman, Ivanochko, Danton, Duan, Shili, Kaustov, Lilia, Ong, Michelle S., Fan, Lixin, Senisterra, Guillermo, Brown, Peter J., Wang, Yun-Xing, Arrowsmith, Cheryl H.

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Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2‑Oxoglutarate Dependent Oxygenases von Tarhonskaya, Hanna, Szöllössi, Andrea, Leung, Ivanhoe K. H, Bush, Jacob T, Henry, Luc, Chowdhury, Rasheduzzaman, Iqbal, Aman, Claridge, Timothy D. W, Schofield, Christopher J, Flashman, Emily

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The trend of measles in Afghanistan von Nishat, Homeira, Aman, Mohammad Iqbal, Ibrahimi, Farahnaz, Zahed, Ajmal, Khader, Yousef, Shaheen, Malak A

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Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X‑Linked Inhibitor of Apoptosis Protein (XIAP) von Tamanini, Emiliano, Buck, Ildiko M, Chessari, Gianni, Chiarparin, Elisabetta, Day, James E. H, Frederickson, Martyn, Griffiths-Jones, Charlotte M, Hearn, Keisha, Heightman, Tom D, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Peakman, Torren, Reader, Michael, Rich, Sharna J, Ward, George A, Williams, Pamela A, Wilsher, Nicola E

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Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP von Chessari, Gianni, Buck, Ildiko M, Day, James E. H, Day, Philip J, Iqbal, Aman, Johnson, Christopher N, Lewis, Edward J, Martins, Vanessa, Miller, Darcey, Reader, Michael, Rees, David C, Rich, Sharna J, Tamanini, Emiliano, Vitorino, Marc, Ward, George A, Williams, Pamela A, Williams, Glyn, Wilsher, Nicola E, Woolford, Alison J.-A

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Identification and characterization of the first fragment hits for SETDB1 Tudor domain von Mader, Pavel, Mendoza-Sanchez, Rodrigo, Iqbal, Aman, Dong, Aiping, Dobrovetsky, Elena, Corless, Victoria B., Liew, Sean K., Houliston, Scott R., De Freitas, Renato Ferreira, Smil, David, Sena, Carlo C. Dela, Kennedy, Steven, Diaz, Diego B., Wu, Hong, Dombrovski, Ludmila, Allali-Hassani, Abdellah, Min, Jinrong, Schapira, Matthieu, Vedadi, Masoud, Brown, Peter J., Santhakumar, Vijayaratnam, Yudin, Andrei K., Arrowsmith, Cheryl H.

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Removing user fees for basic health services: a pilot study and national roll-out in Afghanistan von Steinhardt, Laura C, Aman, Iqbal, Pakzad, Iqbalshah, Kumar, Binay, Singh, Lakhwinder P, Peters, David

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Early warning systems for identifying severe maternal outcomes: findings from the WHO global maternal sepsis studyResearch in context von Yamikani Chimwaza, Alexandra Hunt, Livia Oliveira-Ciabati, Laura Bonnett, Edgardo Abalos, Cristina Cuesta, João Paulo Souza, Mercedes Bonet, Vanessa Brizuela, David Lissauer, Yamikani Chimwaza, Alexandra Hunt, Livia Oliveira-Ciabati, Laura Bonnett, Edgardo Abalos, Cristina Cuesta, João Paulo Souza, Mercedes Bonet, Vanessa Brizuela, David Lissauer, Mohammad Iqbal Aman, Bashir Noormal, Marisa Espinoza, Julia Pasquale, Charlotte Leroy, Kristien Roelens, Griet Vandenberghe, M. Christian Urlyss Agossou, Sourou Goufodji Keke, Christiane Tshabu Aguemon, Patricia Soledad Apaza Peralta, Víctor Conde Altamirano, Rosalinda Hernández Muñoz, José Guilherme Cecatti, Carolina Ribeiro do Valle, Vincent Batiene, Kadari Cisse, Henri Gautier Ouedraogo, Kannitha Cheang, Phirun Lam, Tung Rathavy, Elie Simo, Pierre-Marie Tebeu, Emah Irene Yakana, Javier Carvajal, María Fernanda Escobar, Paula Fernández, Lotte Berdiin Colmorn, Jens Langhoff-Roos, Wilson Mereci, Paola Vélez, Yasser Salah Eldin, Alaa Sultan, Alula M. Teklu, Dawit Worku, Richard Adanu, Philip Govule, Charles Noora Lwanga, William Enrique Arriaga Romero, María Guadalupe Flores Aceituno, Carolina Bustillo, Bredy Lara, Vijay Kumar, Vanita Suri, Sonia Trikha, Irene Cetin, Serena Donati, Carlo Personeni, Guldana Baimussanova, Saule Kabylova, Balgyn Sagyndykova, George Gwako, Alfred Osoti, Zahida Qureshi, Raisa Asylbasheva, Aigul Boobekova, Damira Seksenbaeva, Saad Eddine Itani, Meilė Minkauskienė, Diana Ramašauskaitė, Owen Chikhwaza, Luis Gadama, Eddie Malunga, Haoua Dembele, Hamadoun Sangho, Fanta Eliane Zerbo, Filiberto Dávila Serapio, Nazarea Herrera Maldonado, Juan I. Islas Castañeda, Tatiana Cauaus, Ala Curteanu, Victor Petrov, Yadamsuren Buyanjargal, Seded Khishgee, Bat-Erdene Lkhagvasuren, Amina Essolbi, Rachid Moulki, Zara Jaze, Arlete Mariano, Nafissa Bique Osman

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Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors von Murray, Christopher W, Berdini, Valerio, Buck, Ildiko M, Carr, Maria E, Cleasby, Anne, Coyle, Joseph E, Curry, Jayne E, Day, James E. H, Day, Phillip J, Hearn, Keisha, Iqbal, Aman, Lee, Lydia Y. W, Martins, Vanessa, Mortenson, Paul N, Munck, Joanne M, Page, Lee W, Patel, Sahil, Roomans, Susan, Smith, Kirsten, Tamanini, Emiliano, Saxty, Gordon

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Structural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathway von Valegård, Karin, Iqbal, Aman, Kershaw, Nadia J., Ivison, David, Généreux, Catherine, Dubus, Alain, Blikstad, Cecilia, Demetriades, Marina, Hopkinson, Richard J., Lloyd, Adrian J., Roper, David I., Schofield, Christopher J., Andersson, Inger, McDonough, Michael A.

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Epidemiological profile of Crimean Congo Hemorrhagic Fever (CCHF) in Afghanistan: a teaching-case study von Amini, Wahida, Aman, Mohammad Iqbal, Khader, Yousef, Shaheen, Malik

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Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates von Iqbal, Aman, Clifton, Ian J, Chowdhury, Rasheduzzaman, Ivison, David, Domene, Carmen, Schofield, Christopher J

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Abstract 2944: AT-IAP, a dual cIAP1 and XIAP antagonist with oral antitumor activity in melanoma models von Chessari, Gianni, Maria, Ahn, Buck, Ildiko, Chiarparin, Elisabetta, Coyle, Joe, Day, James, Frederickson, Martyn, Griffiths-Jones, Charlotte, Hearn, Keisha, Howard, Steven, Heightman, Tom, Hillmann, Petra, Iqbal, Aman, Johnson, Christopher N., Lewis, Jon, Martins, Vanessa, Munck, Joanne, Reader, Mike, Page, Lee, Hopkins, Anna, Millemaggi, Alessia, Richardson, Caroline, Saxty, Gordon, Smyth, Tomoko, Tamanini, Emiliano, Thompson, Neil, Ward, George, Williams, Glyn, Williams, Pamela, Wilsher, Nicola, Woolford, Alison

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Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway von Iqbal, Aman, Arunlanantham, Haren, Brown Jr, Tom, Chowdhury, Rasheduzzaman, Clifton, Ian J., Kershaw, Nadia J., Hewitson, Kirsty S., McDonough, Michael A., Schofield, Christopher J.

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Abstract 2018: Discovery of potent dual inhibitors of both XIAP and cIAP1 using fragment based drug discovery von Chessari, Gianni, Buck, Ildiko, Chiarparin, Elisabetta, Day, James, Frederickson, Martyn, Hearn, Keisha, Heightman, Tom, Hillmann, Petra, Iqbal, Aman, Johnson, Chris, Lewis, Jon, Martins, Vanessa, Richardson, Caroline, Smyth, Tomoko, Tamanini, Emiliano, Thompson, Neil, Ward, George, Williams, Glyn, Williams, Pamela, Wilsher, Nicola, Woolford, Alison

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Crystal Structures of an Oligopeptide-Binding Protein from the Biosynthetic Pathway of the β-Lactamase Inhibitor Clavulanic Acid von Mackenzie, Alasdair K., Valegård, Karin, Iqbal, Aman, Caines, Matthew E.C., Kershaw, Nadia J., Jensen, Susan E., Schofield, Christopher J., Andersson, Inger

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METHOD OF DEVELOPING SMALL MOLECULE PEPTIDE CONJUGATES FOR BIOMEDICAL APPLICATIONS von Iqbal, Aman

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Method of developing small molecule peptide conjugates for biomedical applications von Iqbal, Aman

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Anatomy of a Simple Acyl Intermediate in Enzyme Catalysis: Combined Biophysical and Modeling Studies on Ornithine Acetyl Transferase von Iqbal, Aman, Clifton, Ian J, Bagonis, Maria, Kershaw, Nadia J, Domene, Carmen, Claridge, Timothy D. W, Wharton, Christopher W, Schofield, Christopher J

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