Unraveling the therapeutic potential of the Hedgehog pathway in cancer von Amakye, Dereck, Jagani, Zainab, Dorsch, Marion

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A Phase I, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Smoothened Inhibitor Sonidegib (LDE225) in Patients with Advanced Solid Tumors von RODON, Jordi, TAWBI, Hussein A, LIN YANG, GRANVIL, Camille, EUNJU HURH, ROSE, Kristine L, AMAKYE, Dereck D, DUMMER, Reinhard, MITA, Alain C, THOMAS, Anne L, STOLLER, Ronald G, TURTSCHI, Christian P, BASELGA, Jose, SARANTOPOULOS, John, MAHALINGAM, Devalingam, YAPING SHOU, MOLES, Melissa A

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A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma von Shou, Yaping, Robinson, Douglas M, Amakye, Dereck D, Rose, Kristine L, Cho, Yoon-Jae, Ligon, Keith L, Sharp, Thad, Haider, Asifa S, Bandaru, Raj, Ando, Yuichi, Geoerger, Birgit, Doz, François, Ashley, David M, Hargrave, Darren R, Casanova, Michela, Tawbi, Hussein A, Rodon, Jordi, Thomas, Anne L, Mita, Alain C, MacDonald, Tobey J, Kieran, Mark W

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Clinical perspectives on the utility of aromatase inhibitors for the adjuvant treatment of breast cancer von Chlebowski, Rowan, Cuzick, Jack, Amakye, Dereck, Bauerfeind, Ingo, Buzdar, Aman, Chia, Stephen, Cutuli, Bruno, Linforth, Rick, Maass, Nicolaì, Noguchi, Shinzaburo, Robidoux, André, Verma, Sunil, Hadji, Peyman

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Biomarkers in oncology drug development von Hodgson, Darren R., Whittaker, Robin D., Herath, Athula, Amakye, Dereck, Clack, Glen

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A phase I pharmacodynamic study of the effects of the cyclin-dependent kinase-inhibitor AZD5438 on cell cycle markers within the buccal mucosa, plucked scalp hairs and peripheral b... von CAMIDGE, D. Ross, PEMBERTON, Mike, GROWCOTT, Jim, AMAKYE, Dereck, WILSON, David, SWAISLAND, Helen, FORDER, Cheryl, WILKINSON, Robert, BYTH, Kate, HUGHES, Andrew

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Tenofovir alafenamide does not inhibit mitochondrial function and cholesterol biosynthesis in human T lymphoblastoid cell line von Li, Min, Zhou, Lei, Dorsey, Harold G., Musoff, Charles, Jnr, Dereck Amakye, Schoen, Natalie, Djan, Kweku, Paintsil, Elijah

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Improved Efficacy Of Combination Of JAK2 and Hedgehog Inhibitors In Myelofibrosis von Bhagwat, Neha, Keller, Matthew D, Rampal, Raajit K., Shank, Kaitlyn, de Stanchina, Elisa, Rose, Kristine, Amakye, Dereck, Levine, Ross L.

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A Phase 1, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Hedgehog Inhibitor Sonidegib (LDE225) in Patients With Advanced Solid Tumors von Rodon, Jordi, Tawbi, Hussein A, Thomas, Anne L, Stoller, Ronald, Turtschi, Christian P, Baselga, Jose, Sarantopoulos, John, Mahalingam, Devalingam, Shou, Yaping, Moles, Melissa A, Yang, Lin, Granvil, Camille, Hurh, Eunju, Rose, Kristine L, Amakye, Dereck D, Dummer, Reinhard, Mita, Alain C

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Mitigating smoothened inhibitor-induced growth plate closure with parathyroid hormone von Timsit, Yoav E, Gunson, Diane E, Krucker, Thomas, Markovits, Judit E, Buonamici, Silvia, Boral, Anthony, Amakye, Dereck Dokyi, Nelson, Aaron L, Pognan, Francois, Chibout, Salah-Dine, Turner, Nancy A

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A phase I/II study of LDE225, a smoothened (Smo) antagonist, in pediatric patients with recurrent medulloblastoma (MB) or other solid tumors von Geoerger, Birgit, Aerts, Isabelle, Casanova, Michela, Chisholm, Julia C., Hargrave, Darren R, Leary, Sarah, Ashley, David M, Bouffet, Eric, MacDonald, Tobey, Hurh, Eunju, Dey, Jyotirmoy, Kalambakas, Stacey, Amakye, Dereck Dokyi, Kieran, Mark W.

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Abstract 4818: The predictive value of a 5-gene signature as a patient pre-selection tool in medulloblastoma for Hedgehog pathway inhibitor therapy von Amakye, Dereck, Robinson, Douglas, Rose, Kristine, Cho, Jae, Ligon, Keith L., Sharp, Thad, Haider, Asifa, Bandaru, Raj, Ando, Yuichi, Geoerger, Birgit, Doz, Francois, Ashley, David, Hargrave, Darren, Casanova, Michela, Rodon, Jordi, Thomas, Anne, Mita, Alain, MacDonald, Tobey, Kieran, Mark W.

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Abstract 1288: A Phase I evaluation of safety, pharmacokinetics (PK) and pharmacodynamics (PD) of LDE225, a smoothened (Smo) antagonist, in patients with advanced solid tumors von Mita, Alain, Rodon, Jordi, Dummer, Reinhard, Baselga, Jose, Shou, Yaping, Feng, Wentao, Mahalingam, Devalingam, Thomas, Anne, Granvil, Camille, Amakye, Dereck, Tawbi, Hussein

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Interaction Trial between Artemether-Lumefantrine (Riamet®) and Quinine in Healthy Subjects von Lefèvre, G., Carpenter, P., Souppart, C., Schmidli, H., Martin, J.M., Lane, A., Ward, C., Amakye, D.

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Interaction Trial between Artemether-Lumefantrine (Riamet®) and Quinine in Healthy Subjects von Lefèvre, Gilbert, Carpenter, Polly, Souppart, Claire, Schmidli, Heinz, Martin, John M., Lane, Andrew, Ward, Chris, Amakye, Dereck

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