A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors von Yang, Kai S., Ma, Xinyu R., Ma, Yuying, Alugubelli, Yugendar R., Scott, Danielle A., Vatansever, Erol C., Drelich, Aleksandra K., Sankaran, Banumathi, Geng, Zhi Z., Blankenship, Lauren R., Ward, Hannah E., Sheng, Yan J., Hsu, Jason C., Kratch, Kaci C., Zhao, Baoyu, Hayatshahi, Hamed S., Liu, Jin, Li, Pingwei, Fierke, Carol A., Tseng, Chien‐Te K., Xu, Shiqing, Liu, Wenshe Ray

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Evaluation of SARS-CoV‐2 Main Protease Inhibitors Using a Novel Cell-Based Assay von Cao, Wenyue, Cho, Chia-Chuan Dean, Geng, Zhi Zachary, Shaabani, Namir, Ma, Xinyu R, Vatansever, Erol C, Alugubelli, Yugendar R, Ma, Yuying, Chaki, Sankar P, Ellenburg, William H, Yang, Kai S, Qiao, Yuchen, Allen, Robert, Neuman, Benjamin W, Ji, Henry, Xu, Shiqing, Liu, Wenshe Ray

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Accurate Mass Identification of an Interfering Water Adduct and Strategies in Development and Validation of an LC-MS/MS Method for Quantification of MPI8, a Potent SARS-CoV-2 Main... von Wang, Yang, Xie, Huan, Alugubelli, Yugendar R, Ma, Yuying, Xu, Shiqing, Ma, Jing, Liu, Wenshe R, Liang, Dong

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MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L von Ma, Xinyu R., Alugubelli, Yugendar R., Ma, Yuying, Vatansever, Erol C., Scott, Danielle A., Qiao, Yuchen, Yu, Ge, Xu, Shiqing, Liu, Wenshe Ray

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Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Orally Available Drug Candidates for Acute Myeloid Leukemia von Guo, Xuejiao Shirley, Atla, Sandeep, Nyalata, Satyanarayana, Alugubelli, Yugendar R., Chen, Peng-Hsun Chase, Xu, Shiqing, Liu, Wenshe Ray

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A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals von Alugubelli, Yugendar R., Geng, Zhi Zachary, Yang, Kai S., Shaabani, Namir, Khatua, Kaustav, Ma, Xinyu R., Vatansever, Erol C., Cho, Chia-Chuan, Ma, Yuying, Xiao, Jing, Blankenship, Lauren R., Yu, Ge, Sankaran, Banumathi, Li, Pingwei, Allen, Robert, Ji, Henry, Xu, Shiqing, Liu, Wenshe Ray

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Discovery of First-in-Class PROTAC Degraders of SARS-CoV‐2 Main Protease von Alugubelli, Yugendar R., Xiao, Jing, Khatua, Kaustav, Kumar, Sathish, Sun, Long, Ma, Yuying, Ma, Xinyu R., Vulupala, Veerabhadra R., Atla, Sandeep, Blankenship, Lauren R., Coleman, Demonta, Xie, Xuping, Neuman, Benjamin W., Liu, Wenshe Ray, Xu, Shiqing

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A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals von Ma, Yuying, Yang, Kai S., Geng, Zhi Zachary, Alugubelli, Yugendar R., Shaabani, Namir, Vatansever, Erol C., Ma, Xinyu R., Cho, Chia-Chuan, Khatua, Kaustav, Xiao, Jing, Blankenship, Lauren R., Yu, Ge, Sankaran, Banumathi, Li, Pingwei, Allen, Robert, Ji, Henry, Xu, Shiqing, Liu, Wenshe Ray

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A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV‐2 Main Protease von Geng, Zhi Zachary, Atla, Sandeep, Shaabani, Namir, Vulupala, Veerabhadra, Yang, Kai S., Alugubelli, Yugendar R., Khatua, Kaustav, Chen, Peng-Hsun, Xiao, Jing, Blankenship, Lauren R., Ma, Xinyu R., Vatansever, Erol C., Cho, Chia-Chuan D., Ma, Yuying, Allen, Robert, Ji, Henry, Xu, Shiqing, Liu, Wenshe Ray

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Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV‐... von Hampton, J. Trae, Lalonde, Tyler J., Tharp, Jeffery M., Kurra, Yadagiri, Alugubelli, Yugendar R., Roundy, Christopher M., Hamer, Gabriel L., Xu, Shiqing, Liu, Wenshe Ray

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Phage‐assisted, active site‐directed ligand evolution of a potent and selective histone deacetylase 8 inhibitor von Morse, Jared S., Sheng, Yan J., Hampton, Joshua Trae, Sylvain, Lauralee D., Das, Sukant, Alugubelli, Yugendar R., Chen, Peng‐Hsun Chase, Yang, Kai S., Xu, Shiqing, Fierke, Carol A., Liu, Wenshe Ray

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Azapeptides with unique covalent warheads as SARS-CoV-2 main protease inhibitors von Khatua, Kaustav, Alugubelli, Yugendar R., Yang, Kai S., Vulupala, Veerabhadra R., Blankenship, Lauren R., Coleman, Demonta, Atla, Sandeep, Chaki, Sankar P., Geng, Zhi Zachary, Ma, Xinyu R., Xiao, Jing, Chen, Peng-Hsun, Cho, Chia-Chuan D., Sharma, Shivangi, Vatansever, Erol C., Ma, Yuying, Yu, Ge, Neuman, Benjamin W., Xu, Shiqing, Liu, Wenshe Ray

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SARS-CoV‐2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme von Blankenship, Lauren R., Yang, Kai S., Vulupala, Veerabhadra R., Alugubelli, Yugendar R., Khatua, Kaustav, Coleman, Demonta, Ma, Xinyu R., Sankaran, Banumathi, Cho, Chia-Chuan D., Ma, Yuying, Neuman, Benjamin W., Xu, Shiqing, Liu, Wenshe Ray

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Front Cover: MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L (ChemMedChem 1/2022) von Ma, Xinyu R., Alugubelli, Yugendar R., Ma, Yuying, Vatansever, Erol C., Scott, Danielle A., Qiao, Yuchen, Yu, Ge, Xu, Shiqing, Liu, Wenshe Ray

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A systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals von Alugubelli, Yugendar R., Geng, Zhi Zachary, Yang, Kai S., Shaabani, Namir, Khatua, Kaustav, Ma, Xinyu R., Vatansever, Erol C., Cho, Chia-Chuan, Ma, Yuying, Xiao, Jing, Blankenship, Lauren R., Yu, Ge, Sankaran, Banumathi, Li, Pingwei, Allen, Robert, Ji, Henry, Xu, Shiqing, Liu, Wenshe Ray

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A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals von Ma, Yuying, Yang, Kai S., Geng, Zhi Zachary, Alugubelli, Yugendar R., Shaabani, Namir, Vatansever, Erol C., Ma, Xinyu R., Cho, Chia-Chuan, Khatua, Kaustav, Xiao, Jing, Blankenship, Lauren R., Yu, Ge, Sankaran, Banumathi, Li, Pingwei, Allen, Robert, Ji, Henry, Xu, Shiqing, Liu, Wenshe Ray

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