Targeting OGG1 arrests cancer cell proliferation by inducing replication stress von Visnes, Torkild, Benítez-Buelga, Carlos, Cázares-Körner, Armando, Sanjiv, Kumar, Hanna, Bishoy M F, Mortusewicz, Oliver, Rajagopal, Varshni, Albers, Julian J, Hagey, Daniel W, Bekkhus, Tove, Eshtad, Saeed, Baquero, Juan Miguel, Masuyer, Geoffrey, Wallner, Olov, Müller, Sarah, Pham, Therese, Göktürk, Camilla, Rasti, Azita, Suman, Sharda, Torres-Ruiz, Raúl, Sarno, Antonio, Wiita, Elisée, Homan, Evert J, Karsten, Stella, Marimuthu, Karthick, Michel, Maurice, Koolmeister, Tobias, Scobie, Martin, Loseva, Olga, Almlöf, Ingrid, Unterlass, Judith Edda, Pettke, Aleksandra, Boström, Johan, Pandey, Monica, Gad, Helge, Herr, Patrick, Jemth, Ann-Sofie, El Andaloussi, Samir, Kalderén, Christina, Rodriguez-Perales, Sandra, Benítez, Javier, Krokan, Hans E, Altun, Mikael, Stenmark, Pål, Berglund, Ulrika Warpman, Helleday, Thomas

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Development of a chemical probe against NUDT15 von Zhang, Si Min, Desroses, Matthieu, Hagenkort, Anna, Valerie, Nicholas C. K., Rehling, Daniel, Carter, Megan, Wallner, Olov, Koolmeister, Tobias, Throup, Adam, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Lundbäck, Thomas, Axelsson, Hanna, Regmi, Shruti, Sarno, Antonio, Krämer, Andreas, Pudelko, Linda, Bräutigam, Lars, Rasti, Azita, Göttmann, Mona, Wiita, Elisée, Kutzner, Juliane, Schaller, Torsten, Kalderén, Christina, Cázares-Körner, Armando, Page, Brent D. G., Krimpenfort, Rosa, Eshtad, Saeed, Altun, Mikael, Rudd, Sean G., Knapp, Stefan, Scobie, Martin, Homan, Evert J., Berglund, Ulrika Warpman, Stenmark, Pål, Helleday, Thomas

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Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space von Rudling, Axel, Gustafsson, Robert, Almlöf, Ingrid, Homan, Evert, Scobie, Martin, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål, Carlsson, Jens

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AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma von Das, Ishani, Gad, Helge, Bräutigam, Lars, Pudelko, Linda, Tuominen, Rainer, Höiom, Veronica, Almlöf, Ingrid, Rajagopal, Varshni, Hansson, Johan, Helleday, Thomas, Egyházi Brage, Suzanne, Warpman Berglund, Ulrika

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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells von Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas

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Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel von Zhang, Si Min, Paulin, Cynthia B.J., Shu, Huazhang, Yagüe-Capilla, Miriam, Michel, Maurice, Marttila, Petra, Ortis, Florian, Bwanika, Henri Colyn, Dirks, Christopher, Venkatram, Rajagopal Papagudi, Wiita, Elisée, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Hormann, Femke M., Koolmeister, Tobias, Linde, Erika, Lee, Sun, Llona-Minguez, Sabin, Haraldsson, Martin, Axelsson, Hanna, Strömberg, Kia, Homan, Evert J., Scobie, Martin, Lundbäck, Thomas, Helleday, Thomas, Rudd, Sean G.

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MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells von Karsten, Stella, Fiskesund, Roland, Zhang, Xing-Mei, Marttila, Petra, Sanjiv, Kumar, Pham, Therese, Rasti, Azita, Bräutigam, Lars, Almlöf, Ingrid, Marcusson-Ståhl, Maritha, Sandman, Carolina, Platzack, Björn, Harris, Robert A., Kalderén, Christina, Cederbrant, Karin, Helleday, Thomas, Warpman Berglund, Ulrika

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Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis von Scaletti, Emma R., Unterlass, Judith E., Almlöf, Ingrid, Koolmeister, Tobias, Vallin, Karl S., Kapsitidou, Despina, Tsuber, Viktoriia, Helleday, Thomas, Stenmark, Pål, Jemth, Ann‐Sofie

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An orthotopic glioblastoma animal model suitable for high-throughput screenings von Pudelko, Linda, Edwards, Steven, Balan, Mirela, Nyqvist, Daniel, Al-Saadi, Jonathan, Dittmer, Johannes, Almlöf, Ingrid, Helleday, Thomas, Bräutigam, Lars

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Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity von Narwal, Mohit, Jemth, Ann-Sofie, Gustafsson, Robert, Almlöf, Ingrid, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål

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MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP von Jemth, Ann-Sofie, Gustafsson, Robert, Bräutigam, Lars, Henriksson, Linda, Vallin, Karl S A, Sarno, Antonio, Almlöf, Ingrid, Homan, Evert, Rasti, Azita, Warpman Berglund, Ulrika, Stenmark, Pål, Helleday, Thomas

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MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia von Sanjiv, Kumar, Calderon-Montano, Jose Manuel, Pham, Therese M., Erkers, Tom, Tsuber, Viktoriia, Almlof, Ingrid, Hoglund, Andreas, Heshmati, Yaser, Seashore-Ludlow, Brinton, Danda, Akhilesh Nagesh, Gad, Helge, Wiita, Elisee, Gokturk, Camilla, Rasti, Azita, Friedrich, Stefanie, Centio, Anders, Estruch, Montserrat, Vatsveen, Thea Kristin, Struyf, Nona, Visnes, Torkild, Scobie, Martin, Koolmeister, Tobias, Henriksson, Martin, Wallner, Olov, Sandvall, Teresa, Lehmann, Soren, Theilgaard-Monch, Kim, Garnett, Mathew J., Ostling, Paivi, Walfridsson, Julian, Helleday, Thomas, Berglund, Ulrika Warpman

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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir von Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas

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Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1 von Llona-Minguez, Sabin, Höglund, Andreas, Wiita, Elisee, Almlöf, Ingrid, Mateus, André, Calderón-Montaño, José Manuel, Cazares-Körner, Cindy, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Jemth, Ann-Sofie, Häggblad, Maria, Martens, Ulf, Lundgren, Bo, Artursson, Per, Lundbäck, Thomas, Jenmalm Jensen, Annika, Warpman Berglund, Ulrika, Scobie, Martin, Helleday, Thomas

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dUTPase inhibition augments replication defects of 5-Fluorouracil von Hagenkort, Anna, Paulin, Cynthia B J, Desroses, Matthieu, Sarno, Antonio, Wiita, Elisée, Mortusewicz, Oliver, Koolmeister, Tobias, Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Homan, Evert, Lundbäck, Thomas, Gustavsson, Anna-Lena, Scobie, Martin, Helleday, Thomas

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Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1 von Llona-Minguez, Sabin, Höglund, Andreas, Jacques, Sylvain A, Johansson, Lars, Calderón-Montaño, José Manuel, Claesson, Magnus, Loseva, Olga, Valerie, Nicholas C. K, Lundbäck, Thomas, Piedrafita, Javier, Maga, Giovanni, Crespan, Emmanuele, Meijer, Laurent, Burgos Morón, Estefanía, Baranczewski, Pawel, Hagbjörk, Ann-Louise, Svensson, Richard, Wiita, Elisee, Almlöf, Ingrid, Visnes, Torkild, Jeppsson, Fredrik, Sigmundsson, Kristmundur, Jensen, Annika Jenmalm, Artursson, Per, Jemth, Ann-Sofie, Stenmark, Pål, Warpman Berglund, Ulrika, Scobie, Martin, Helleday, Thomas

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Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors von Llona-Minguez, Sabin, Höglund, Andreas, Ghassemian, Artin, Desroses, Matthieu, Calderón-Montaño, José Manuel, Burgos Morón, Estefanía, Valerie, Nicholas C. K, Wiita, Elisee, Almlöf, Ingrid, Koolmeister, Tobias, Mateus, André, Cazares-Körner, Cindy, Sanjiv, Kumar, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Darabi, Masoud, Mehdizadeh, Amir, Fayezi, Shabnam, Jemth, Ann-Sofie, Warpman Berglund, Ulrika, Sigmundsson, Kristmundur, Lundbäck, Thomas, Jenmalm Jensen, Annika, Artursson, Per, Scobie, Martin, Helleday, Thomas

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In silico Druggability Assessment of the NUDIX Hydrolase Protein Family as a Workflow for Target Prioritization von Michel, Maurice, Homan, Evert J., Wiita, Elisée, Pedersen, Kia, Almlöf, Ingrid, Gustavsson, Anna-Lena, Lundbäck, Thomas, Helleday, Thomas, Warpman Berglund, Ulrika

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Fluorescence-Based Screening Assays for the NAD+-Dependent Histone Deacetylase smSirt2 from Schistosoma mansoni von Schiedel, Matthias, Marek, Martin, Lancelot, Julien, Karaman, Berin, Almlöf, Ingrid, Schultz, Johan, Sippl, Wolfgang, Pierce, Raymond J., Romier, Christophe, Jung, Manfred

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Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells von Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas

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