MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells von Karsten, Stella, Fiskesund, Roland, Zhang, Xing-Mei, Marttila, Petra, Sanjiv, Kumar, Pham, Therese, Rasti, Azita, Bräutigam, Lars, Almlöf, Ingrid, Marcusson-Ståhl, Maritha, Sandman, Carolina, Platzack, Björn, Harris, Robert A., Kalderén, Christina, Cederbrant, Karin, Helleday, Thomas, Warpman Berglund, Ulrika

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Therapeutic implications of MTH1 inhibitor TH1579 in cutaneous malignant melanoma von Das, I., Gad, H., Bräutigam, L., Pudelko, L., Tuominen, R., Höiom, V., Almlöf, I., Hansson, J., Helleday, T., Brage, S.E., Berglund, U.W.

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Validation and development of MTH1 inhibitors for treatment of cancer von Warpman Berglund, U., Sanjiv, K., Gad, H., Kalderén, C., Koolmeister, T., Pham, T., Gokturk, C., Jafari, R., Maddalo, G., Seashore-Ludlow, B., Chernobrovkin, A., Manoilov, A., Pateras, I.S., Rasti, A., Jemth, A.-S., Almlöf, I., Loseva, O., Visnes, T., Einarsdottir, B.O., Gaugaz, F.Z., Saleh, A., Platzack, B., Wallner, O.A., Vallin, K.S.A., Henriksson, M., Wakchaure, P., Borhade, S., Herr, P., Kallberg, Y., Baranczewski, P., Homan, E.J., Wiita, E., Nagpal, V., Meijer, T., Schipper, N., Rudd, S.G., Bräutigam, L., Lindqvist, A., Filppula, A., Lee, T.-C., Artursson, P., Nilsson, J.A., Gorgoulis, V.G., Lehtiö, J., Zubarev, R.A., Scobie, M., Helleday, T.

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Fluorescence-Based Screening Assays for the NAD+-Dependent Histone Deacetylase smSirt2 from Schistosoma mansoni von Schiedel, Matthias, Marek, Martin, Lancelot, Julien, Karaman, Berin, Almlöf, Ingrid, Schultz, Johan, Sippl, Wolfgang, Pierce, Raymond J., Romier, Christophe, Jung, Manfred

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24PTherapeutic implications of MTH1 inhibitor TH1579 in cutaneous malignant melanoma von Das, I, Gad, H, Bräutigam, L, Pudelko, L, Tuominen, R, Höiom, V, Almlöf, I, Hansson, J, Helleday, T, Brage, S E, Berglund, U W

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Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories von 't Hoen, Peter A C, Friedländer, Marc R, Almlöf, Jonas, Sammeth, Michael, Pulyakhina, Irina, Anvar, Seyed Yahya, Laros, Jeroen F J, Buermans, Henk P J, Karlberg, Olof, Brännvall, Mathias, den Dunnen, Johan T, van Ommen, Gert-Jan B, Gut, Ivo G, Guigó, Roderic, Estivill, Xavier, Syvänen, Ann-Christine, Dermitzakis, Emmanouil T, Lappalainen, Tuuli

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Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases von Lundtoft, Christian, Martin, Myriam, Bianchi, Matteo, Lundström, Emeli, Eloranta, Maija‐Leena, Sjöwall, Christopher, Gunnarsson, Iva, Rantapää‐Dahlqvist, Solbritt, Leonard, Dag, Jonsson, Roland, Hammenfors, Daniel, Forsblad‐d'Elia, Helena, Mandl, Thomas, Magnusson Bucher, Sara, Norheim, Katrine B., Auglænd Johnsen, Svein Joar, Omdal, Roald, Kvarnström, Marika, Wahren‐Herlenius, Marie, Notarnicola, Antonella, Andersson, Helena, Molberg, Øyvind, Diederichsen, Louise Pyndt, Almlöf, Jonas, Syvänen, Ann‐Christine, Kozyrev, Sergey V., Lindblad‐Toh, Kerstin, Rönnblom, Lars, Nordmark, Gunnel, Sandling, Johanna K., Pucholt, Pascal, Kozyrev, Sergey V., Eloranta, Maija‐Leena, Alexsson, Andrei, Bianchi, Matteo, Jonsson, Roland, Omdal, Roald, Molberg, Øyvind, Syvänen, Ann‐Christine, Jönsen, Andreas, Gunnarsson, Iva, Svenungsson, Elisabet, Rantapää‐Dahlqvist, Solbritt, Bengtsson, Anders A., Sjöwall, Christopher, Lindblad‐Toh, Kerstin, Almlöf, Jonas Carlsson, Hagberg, Niklas, Meadows, Jennifer R. S., Nordin, Jessika, Wahren‐Herlenius, Marie, Tjärnlund, Anna, Hammenfors, Daniel, Theander, Elke, Baecklund, Eva, Thorlacius, Guðný Ella, Chinoy, Hector, Enocsson, Helena, Forsblad‐d'Elia, Helena, Lamb, Janine, Brun, Johan G., Wetterö, Jonas, Ramírez Sepúlveda, Jorge I., Imgenberg‐Kreuz, Juliana, Hjorton, Karin, Skarstein, Kathrine, Norheim, Katrine Brække, Vasaitis, Lilian, Diederichsen, Louise Pyndt, Jonsson, Malin V., Kvarnström, Marika, Eriksson, Per, Cooper, Robert G., Appel, Silke, Rothwell, Simon, Johnsen, Svein Joar, Mandl, Thomas, Jensen, Janicke Liaaen, Palm, Øyvind, Liden, Maria, Skogh, Thomas, Hanna, Balsam, Hallengren, Christina Ståhl, Hellström, Helena, Häggström, Åsa, Mohammad, Aladdin, Lindblad‐Toh, Kerstin, Pielberg, Gerli Rosengren, Lobell, Anna, Karlsson, Åsa, Murén, Eva, Andersson, Göran, Ahlgren, Kerstin M., Kämpe, Olle, Nilsson, Bo, Blom, Anna M., Lundberg, Ingrid E., Nordmark, Gunnel, Diaz‐Gallo, Lina Marcela, Svenungsson, Elisabet

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Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel von Zhang, Si Min, Paulin, Cynthia B.J., Shu, Huazhang, Yagüe-Capilla, Miriam, Michel, Maurice, Marttila, Petra, Ortis, Florian, Bwanika, Henri Colyn, Dirks, Christopher, Venkatram, Rajagopal Papagudi, Wiita, Elisée, Jemth, Ann-Sofie, Almlöf, Ingrid, Loseva, Olga, Hormann, Femke M., Koolmeister, Tobias, Linde, Erika, Lee, Sun, Llona-Minguez, Sabin, Haraldsson, Martin, Axelsson, Hanna, Strömberg, Kia, Homan, Evert J., Scobie, Martin, Lundbäck, Thomas, Helleday, Thomas, Rudd, Sean G.

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Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space von Rudling, Axel, Gustafsson, Robert, Almlöf, Ingrid, Homan, Evert, Scobie, Martin, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål, Carlsson, Jens

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AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma von Das, Ishani, Gad, Helge, Bräutigam, Lars, Pudelko, Linda, Tuominen, Rainer, Höiom, Veronica, Almlöf, Ingrid, Rajagopal, Varshni, Hansson, Johan, Helleday, Thomas, Egyházi Brage, Suzanne, Warpman Berglund, Ulrika

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Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells von Page, Brent D. G., Valerie, Nicholas C. K., Wright, Roni H. G., Wallner, Olov, Isaksson, Rebecka, Carter, Megan, Rudd, Sean G., Loseva, Olga, Jemth, Ann-Sofie, Almlöf, Ingrid, Font-Mateu, Jofre, Llona-Minguez, Sabin, Baranczewski, Pawel, Jeppsson, Fredrik, Homan, Evert, Almqvist, Helena, Axelsson, Hanna, Regmi, Shruti, Gustavsson, Anna-Lena, Lundbäck, Thomas, Scobie, Martin, Strömberg, Kia, Stenmark, Pål, Beato, Miguel, Helleday, Thomas

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Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients von Ramírez Sepúlveda, Jorge I, Kvarnström, Marika, Eriksson, Per, Mandl, Thomas, Norheim, Katrine Brække, Johnsen, Svein Joar, Hammenfors, Daniel, Jonsson, Malin V, Skarstein, Kathrine, Brun, Johan G, Rönnblom, Lars, Forsblad-d'Elia, Helena, Magnusson Bucher, Sara, Baecklund, Eva, Theander, Elke, Omdal, Roald, Jonsson, Roland, Nordmark, Gunnel, Wahren-Herlenius, Marie

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Tandem RNA chimeras contribute to transcriptome diversity in human population and are associated with intronic genetic variants von Greger, Liliana, Su, Jing, Rung, Johan, Ferreira, Pedro G, Lappalainen, Tuuli, Dermitzakis, Emmanouil T, Brazma, Alvis

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Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis von Scaletti, Emma R., Unterlass, Judith E., Almlöf, Ingrid, Koolmeister, Tobias, Vallin, Karl S., Kapsitidou, Despina, Tsuber, Viktoriia, Helleday, Thomas, Stenmark, Pål, Jemth, Ann‐Sofie

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An orthotopic glioblastoma animal model suitable for high-throughput screenings von Pudelko, Linda, Edwards, Steven, Balan, Mirela, Nyqvist, Daniel, Al-Saadi, Jonathan, Dittmer, Johannes, Almlöf, Ingrid, Helleday, Thomas, Bräutigam, Lars

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Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity von Narwal, Mohit, Jemth, Ann-Sofie, Gustafsson, Robert, Almlöf, Ingrid, Warpman Berglund, Ulrika, Helleday, Thomas, Stenmark, Pål

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MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP von Jemth, Ann-Sofie, Gustafsson, Robert, Bräutigam, Lars, Henriksson, Linda, Vallin, Karl S A, Sarno, Antonio, Almlöf, Ingrid, Homan, Evert, Rasti, Azita, Warpman Berglund, Ulrika, Stenmark, Pål, Helleday, Thomas

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MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia von Sanjiv, Kumar, Calderon-Montano, Jose Manuel, Pham, Therese M., Erkers, Tom, Tsuber, Viktoriia, Almlof, Ingrid, Hoglund, Andreas, Heshmati, Yaser, Seashore-Ludlow, Brinton, Danda, Akhilesh Nagesh, Gad, Helge, Wiita, Elisee, Gokturk, Camilla, Rasti, Azita, Friedrich, Stefanie, Centio, Anders, Estruch, Montserrat, Vatsveen, Thea Kristin, Struyf, Nona, Visnes, Torkild, Scobie, Martin, Koolmeister, Tobias, Henriksson, Martin, Wallner, Olov, Sandvall, Teresa, Lehmann, Soren, Theilgaard-Monch, Kim, Garnett, Mathew J., Ostling, Paivi, Walfridsson, Julian, Helleday, Thomas, Berglund, Ulrika Warpman

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NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir von Zhang, Si Min, Rehling, Daniel, Jemth, Ann-Sofie, Throup, Adam, Landázuri, Natalia, Almlöf, Ingrid, Göttmann, Mona, Valerie, Nicholas C.K., Borhade, Sanjay R., Wakchaure, Prasad, Page, Brent D.G., Desroses, Matthieu, Homan, Evert J., Scobie, Martin, Rudd, Sean G., Berglund, Ulrika Warpman, Söderberg-Nauclér, Cecilia, Stenmark, Pål, Helleday, Thomas

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Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1 von Llona-Minguez, Sabin, Höglund, Andreas, Wiita, Elisee, Almlöf, Ingrid, Mateus, André, Calderón-Montaño, José Manuel, Cazares-Körner, Cindy, Homan, Evert, Loseva, Olga, Baranczewski, Pawel, Jemth, Ann-Sofie, Häggblad, Maria, Martens, Ulf, Lundgren, Bo, Artursson, Per, Lundbäck, Thomas, Jenmalm Jensen, Annika, Warpman Berglund, Ulrika, Scobie, Martin, Helleday, Thomas

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