Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway von Chen, Zhiguo, Mo, Juan, Brosseau, Jean-Philippe, Shipman, Tracey, Wang, Yong, Liao, Chung-Ping, Cooper, Jonathan M, Allaway, Robert J, Gosline, Sara J C, Guinney, Justin, Carroll, Thomas J, Le, Lu Q

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Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: The Multi-Targeting Drug DREAM Challenge von Xiong, Zhaoping, Jeon, Minji, Allaway, Robert J., Kang, Jaewoo, Park, Donghyeon, Lee, Jinhyuk, Jeon, Hwisang, Ko, Miyoung, Jiang, Hualiang, Zheng, Mingyue K., Tan, Aik Choon, Guo, Xindi, Dang, Kristen K. K., Tropsha, Alex A., Hecht, Chana, Das, Tirtha K., Carlson, Heather A., Abagyan, Ruben, Guinney, Justin, Schlessinger, Avner, Cagan, Ross

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Probing the chemical–biological relationship space with the Drug Target Explorer von Allaway, Robert J., La Rosa, Salvatore, Guinney, Justin, Gosline, Sara J. C.

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Machine learning in rare disease von Banerjee, Jineta, Taroni, Jaclyn N., Allaway, Robert J., Prasad, Deepashree Venkatesh, Guinney, Justin, Greene, Casey

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Cutaneous neurofibromas in the genomics era: current understanding and open questions von Allaway, Robert J., Gosline, Sara J. C., La Rosa, Salvatore, Knight, Pamela, Bakker, Annette, Guinney, Justin, Le, Lu Q.

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Chemical genetic screens reveal defective lysosomal trafficking as synthetic lethal with NF1 loss von Bouley, Stephanie J, Grassetti, Andrew V, Allaway, Robert J, Wood, Matthew D, Hou, Helen W, Burdon Dasbach, India R, Seibel, William, Wu, Jimmy, Gerber, Scott A, Dragnev, Konstantin H, Walker, James A, Sanchez, Yolanda

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A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma von Way, Gregory P, Allaway, Robert J, Bouley, Stephanie J, Fadul, Camilo E, Sanchez, Yolanda, Greene, Casey S

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COVID-19 in people with neurofibromatosis 1, neurofibromatosis 2, or schwannomatosis von Banerjee, Jineta, Friedman, Jan M., Klesse, Laura J., Yohay, Kaleb H., Jordan, Justin T., Plotkin, Scott R., Allaway, Robert J., Blakeley, Jaishri O.

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A community challenge for a pancancer drug mechanism of action inference from perturbational profile data von Douglass, Eugene F., Allaway, Robert J., Szalai, Bence, Wang, Wenyu, Tian, Tingzhong, Fernández-Torras, Adrià, Realubit, Ron, Karan, Charles, Zheng, Shuyu, Pessia, Alberto, Tanoli, Ziaurrehman, Jafari, Mohieddin, Wan, Fangping, Li, Shuya, Xiong, Yuanpeng, Duran-Frigola, Miquel, Bertoni, Martino, Badia-i-Mompel, Pau, Mateo, Lídia, Guitart-Pla, Oriol, Chung, Verena, Tang, Jing, Zeng, Jianyang, Aloy, Patrick, Saez-Rodriguez, Julio, Guinney, Justin, Gerhard, Daniela S., Califano, Andrea

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Centralizing neurofibromatosis experimental tool knowledge with the NF Research Tools Database von Clayton, Ashley, DeFelice, Mialy, Zalmanek, Brynn, Hodgson, Jay, Morin, Caroline, Simon, Stockard, Bletz, Julie A, Eddy, James A, Nikolov, Milen, Banerjee, Jineta, Vinnakota, Kalyan, Marasca, Marco, Boske, Kevin J, Hoff, Bruce, Bradic, Ljubomir, Kim, YooRi, Goss, James R, Allaway, Robert J

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Genomic characterization of patient-derived xenograft models established from fine needle aspirate biopsies of a primary pancreatic ductal adenocarcinoma and from patient-matched m... von Allaway, Robert J, Fischer, Dawn A, de Abreu, Francine B, Gardner, Timothy B, Gordon, Stuart R, Barth, Richard J, Colacchio, Thomas A, Wood, Matthew, Kacsoh, Balint Z, Bouley, Stephanie J, Cui, Jingxuan, Hamilton, Joanna, Choi, Jungbin A, Lange, Joshua T, Peterson, Jason D, Padmanabhan, Vijayalakshmi, Tomlinson, Craig R, Tsongalis, Gregory J, Suriawinata, Arief A, Greene, Casey S, Sanchez, Yolanda, Smith, Kerrington D

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Engaging a community to enable disease-centric data sharing with the NF Data Portal von Allaway, Robert J., La Rosa, Salvatore, Verma, Sharad, Mangravite, Lara, Guinney, Justin, Blakeley, Jaishri, Bakker, Annette, Gosline, Sara J. C.

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Integrative Analysis Identifies Candidate Tumor Microenvironment and Intracellular Signaling Pathways that Define Tumor Heterogeneity in NF1 von Banerjee, Jineta, Allaway, Robert J., Taroni, Jaclyn N., Baker, Aaron, Zhang, Xiaochun, Moon, Chang In, Pratilas, Christine A., Blakeley, Jaishri O., Guinney, Justin, Hirbe, Angela, Greene, Casey S., Gosline, Sara J. C.

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Exploiting mitochondrial and metabolic homeostasis as a vulnerability in NF1 deficient cells von Allaway, Robert J, Wood, Matthew D, Downey, Sondra L, Bouley, Stephanie J, Traphagen, Nicole A, Wells, Jason D, Batra, Jaya, Melancon, Sir Norman, Ringelberg, Carol, Seibel, William, Ratner, Nancy, Sanchez, Yolanda

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A Crowdsourcing Approach to Develop Machine Learning Models to Quantify Radiographic Joint Damage in Rheumatoid Arthritis von Sun, Dongmei, Nguyen, Thanh M, Allaway, Robert J, Wang, Jelai, Chung, Verena, Yu, Thomas V, Mason, Michael, Dimitrovsky, Isaac, Ericson, Lars, Li, Hongyang, Guan, Yuanfang, Israel, Ariel, Olar, Alex, Pataki, Balint Armin, Stolovitzky, Gustavo, Guinney, Justin, Gulko, Percio S, Frazier, Mason B, Chen, Jake Y, Costello, James C, Bridges, Jr, S Louis

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Crowdsourced mapping of unexplored target space of kinase inhibitors von Cichońska, Anna, Ravikumar, Balaguru, Allaway, Robert J., Wan, Fangping, Park, Sungjoon, Isayev, Olexandr, Li, Shuya, Mason, Michael, Lamb, Andrew, Tanoli, Ziaurrehman, Jeon, Minji, Kim, Sunkyu, Popova, Mariya, Capuzzi, Stephen, Zeng, Jianyang, Dang, Kristen, Koytiger, Gregory, Kang, Jaewoo, Wells, Carrow I., Willson, Timothy M., Oprea, Tudor I., Schlessinger, Avner, Drewry, David H., Stolovitzky, Gustavo, Wennerberg, Krister, Guinney, Justin, Aittokallio, Tero

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Abstract 4643: Drug-Target Explorer: An interactive tool for examining chemical-biological interactions von Allaway, Robert J., Gosline, Sara J., Nievo, Marco, Rosa, Salvatore La, Bakker, Annette, Guinney, Justin

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Abstract B23: A novel model of neurofibroma that deciphers its developmental origin and susceptibility to modification by the Hippo pathway von Chen, Zhiguo, Mo, Juan, Brosseau, Jean-Philippe, Shipman, Tracey, Wang, Yong, Liao, Chung-Ping, Cooper, Jonathan M., Allaway, Robert J., Gosline, Sara J.C., Guinney, Justin, Carroll, Thomas J., Le, Lu Q.

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Crowdsourced mapping of unexplored target space of kinase inhibitors von Cichonska, Anna, Ravikumar, Balaguru, Allaway, Robert J, Wan, Fangping, Park, Sungjoon, Isayev, Olexandr, Li, Shuya, Mason, Michael, Lamb, Andrew, Tanoli, Ziaurrehman, Jeon, Minji, Kim, Sunkyu, Popova, Mariya, Capuzzi, Stephen, Zeng, Jianyang, Dang, Kristen, Koytiger, Gregory, Kang, Jaewoo, Wells, Carrow I, Willson, Timothy M, Oprea, Tudor I, Schlessinger, Avner, Drewry, David H, Stolovitzky, Gustavo, Wennerberg, Krister, Guinney, Justin, Aittokallio, Tero, Boeckaerts, Dimitri, Stock, Michiel, De Baets, Bernard, Briers, Yves, IDG-DREAM Drug-Kinase Binding, on behalf of

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Abstract LB056: Crowdsourcing rare cancer research in the Hack4NF GENIE-NF tumor identification and classification challenge von Allaway, Robert J., Scott, Sasha, Altay, Gabriel, Donthi, Hariprasad, R, Karthika, Alwattar, Muhammad Alaa, Romay, Lucas Pastur, Parsha, Ayesha, Banerjee, Jineta, Nayan, Chelsea, Bletz, Julie, La Rosa, Salvatore

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