Differentiation stage of myeloma plasma cells: biological and clinical significance von Paiva, B, Puig, N, Cedena, M T, de Jong, B G, Ruiz, Y, Rapado, I, Martinez-Lopez, J, Cordon, L, Alignani, D, Delgado, J A, van Zelm, M C, Van Dongen, J J M, Pascual, M, Agirre, X, Prosper, F, Martín-Subero, J I, Vidriales, M-B, Gutierrez, N C, Hernandez, M T, Oriol, A, Echeveste, M A, Gonzalez, Y, Johnson, S K, Epstein, J, Barlogie, B, Morgan, G J, Orfao, A, Blade, J, Mateos, M V, Lahuerta, J J, San-Miguel, J F

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P1593: IMMUNE BIOMARKERS TO PREDICT SARS‐COV‐2 VACCINE EFFECTIVENESS IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES von Tamariz‐Amador, L.‐E., Battaglia, A. M., Maia, C., Zherniakova, A., Guerrero, C., Zabaleta, A., Burgos, L., Botta, C., Fortuño, M.‐A., Alignani, D., Blanco, L., Grande, C., Manubens, A., Arguiñano, J.‐M., Gomez, C., Perez‐Persona, E., Olazabal, I., Oiartzabal, I., Panizo, C., Prosper, F., San Miguel, J. F., Rodriguez‐Otero, P., Martín‐Sánchez, E., Paiva, B., ASOVASNA, A. V.‐N. H.‐H.

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Use of human pharyngeal and palatine tonsils as a reservoir for the analysis of B-cell ontogeny in 10 paired samples von Pascual, M., Alignani, D., Vilas-Zornoza, A., Delgado, J.A., Vázquez, I., Malumbres, R., Rodriguez, I., Barriuso, R., Calasanz, M.J., Paiva, B., Agirre, X., Prósper, F., Cervera-Paz, F.J.

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Uncovering the Cis-Regulatory Program of Early Human B-Cell Commitment and Its Implications in the Pathogenesis of B-Cell Acute Lymphoblastic Leukemia von Planell, Nuria, Martínez-de-Morentin, Xabier, Mouzo, Daniel, Lara-Astiaso, David, Vilas-Zornoza, Amaia, San-Martin, Patxi, Alignani, Diego, Paiva, Bruno, Maillo, Alberto, Kurowska, Aleksandra, Urdangarin, Arantxa, Noori, Peri, Ortega-Legarreta, Asier, Hernaez, Mikel, Lagani, Vincenzo, Kiani, Narsis, Martin Subero, Iñaki I., Ramírez, Ricardo N., Tegner, Jesper, Prosper, Felipe, Gomez-Cabrero, David

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Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation von Ye, Jin, Calvo, Isabel A., Cenzano, Itziar, Vilas, Amaia, Martinez-de-Morentin, Xabier, Lasaga, Miren, Alignani, Diego, Paiva, Bruno, Viñado, Ana C., San Martin-Uriz, Patxi, Romero, Juan P., Quilez Agreda, Delia, Miñana Barrios, Marta, Sancho-González, Ignacio, Todisco, Gabriele, Malcovati, Luca, Planell, Nuria, Saez, Borja, Tegner, Jesper N., Prosper, Felipe, Gomez-Cabrero, David

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Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice von Alignani, D, Maletto, B, Liscovsky, M, Ropolo, A, Moron, G, Pistoresi-Palencia, M C

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Chronic exposure to IFN  drives medullar lymphopoiesis towards T cell differentiation in mice von Di Scala, M., Gil-Farina, I., Vanrell, L., Sanchez-Bayona, R., Alignani, D., Olague, C., Vales, A., Berraondo, P., Prieto, J., Gonzalez-Aseguinolaza, G.

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PS1348 DETAILED PHENOTYPIC, MOLECULAR AND FUNCTIONAL PROFILING OF MYELOID DERIVED SUPPRESSOR CELLS (MDSCS) IN THE TUMOR IMMUNE MICRO‐ENVIRONMENT (TIME) OF MULTIPLE MYELOMA (MM) von Pérez, C., Botta, C., Zabaleta, A., Puig, N., Cedena, M.T., Merino, J., Alignani, D., Garate, S., Goicoechea, I., Lara‐Astiaso, D., Sarvide, S., Martínez‐López, J., Oriol, A., Ríos, R., Rosiñol, L., Mateos, M.‐V., Lahuerta, J.‐J., Bladé, J., San‐Miguel, J.F., Paiva, B.

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PF583 COMPREHENSIVE ANALYSIS OF THE COMPLEXITY AND HETEROGENEITY OF THE LNCRNAS TRANSCRIPTOME IN MULTIPLE MYELOMA von Carrasco‐Leon, A., Ezponda, T., Meydan, C., Valcárcel, L.V., Ordoñez, R., Kulis, M., Garate, L., Miranda, E., Segura, V., Guruceaga, E., Vilas‐Zornoza, A., Alignani, D., Castro‐Labrador, L., Pascual, M., Amundarain, A., El‐Omri, H., Taha, R. Y, Calasanz, M.J., Planes, F.J., Mason, C., Miguel, J. San, Subero, J.I. Martin, Melnick, A., Prosper, F., Agirre, X.

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S121 SINGLE‐CELL CHARACTERIZATION OF THE MULTIPLE MYELOMA (MM) IMMUNE MICROENVIRONMENT IDENTIFIES CD27‐ T CELLS AS POTENTIAL SOURCE OF TUMOR‐REACTIVE LYMPHOCYTES von Botta, C., Perez, C., Puig, N., Cedena, M.T., Cordon, L., Zabaleta, A., Burgos, L., Maia, C., Goicoechea, I., Rodriguez, S., Rodriguez, I., Sarvide, S., Alignani, D., Vilas‐Zornoza, A., Lorenzo‐Vivas, E., Rosiñol, L., Oriol, A., Blanchard, M.‐J., Rios, R., Sureda, A., Martinez, R., Martin, J., Bargay, J., Rubia, J., Rossi, M., Tagliaferri, P., Tassone, P., Merino, J., Prosper, F., Orfao, A., Mateos, M.‐V., Lahuerta, J.‐J., Bladé, J., San Miguel, J., Paiva, B.

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CpG oligodeoxinucleotides functions as an effective adjuvant in aged BALB/c mice von Maletto, Belkys Angélica, Rópolo, Andrea Silvana, Liscovsky, Miriam Verónica, Alignani, Diego Oscar, Glocker, Mónica, Pistoresi-Palencia, María Cristina

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Whole-genome fingerprint of the DNA methylome during human B cell differentiation von Kulis, M, Merkel, A, Heath, S, Queirós, AC, Schuyler, RP, Castellano, G, Beekman, R, Raineri, E, Esteve, A, Clot, G, Verdaguer-Dot, N, Duran-Ferrer, M, Russiñol, N, Vilarrasa-Blasi, R, Ecker, S, Pancaldi, V, Rico, D, Agueda, L, Blanc, J, Richardson, D, Clarke, L, Datta, A, Pascual, M, Agirre, X, Prosper, F, Alignani, D, Paiva, B, Caron, G, Fest, T, Muench, MO, Fomin, ME, Lee, S-T, Wiemels, JL, Valencia, A, Gut, M, Flicek, P, Stunnenberg, HG, Siebert, R, Küppers, R, Gut, IG, Campo, E, Martín-Subero, JI

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Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia von Lasaga, Miren, Río, Paula, Vilas-Zornoza, Amaia, Planell, Nuria, Navarro, Susana, Alignani, Diego, Fernández-Varas, Beatriz, Mouzo, Daniel, Zubicaray, Josune, Pujol, Roser M, Nicoletti, Eileen, Schwartz, Jonathan D, Sevilla, Julián, Ainciburi, Marina, Ullate-Agote, Asier, Surrallés, Jordi, Perona, Rosario, Sastre, Leandro, Prosper, Felipe, Gomez-Cabrero, David, Bueren, Juan A

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Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis von Ortiz-Espinosa, Sergio, Morales, Xabier, Senent, Yaiza, Alignani, Diego, Tavira, Beatriz, Macaya, Irati, Ruiz, Borja, Moreno, Haritz, Remírez, Ana, Sainz, Cristina, Rodriguez-Pena, Alejandro, Oyarbide, Alvaro, Ariz, Mikel, Andueza, Maria P., Valencia, Karmele, Teijeira, Alvaro, Hoehlig, Kai, Vater, Axel, Rolfe, Barbara, Woodruff, Trent M., Lopez-Picazo, Jose Maria, Vicent, Silvestre, Kochan, Grazyna, Escors, David, Gil-Bazo, Ignacio, Perez-Gracia, Jose Luis, Montuenga, Luis M., Lambris, John D., Ortiz de Solorzano, Carlos, Lecanda, Fernando, Ajona, Daniel, Pio, Ruben

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A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia von Arriazu, Elena, Vicente, Carmen, Pippa, Raffaella, Peris, Irene, Martínez-Balsalobre, Elena, García-Ramírez, Patricia, Marcotegui, Nerea, Igea, Ana, Alignani, Diego, Rifón, José, Mateos, María C., Cayuela, María L., Nebreda, Angel R., Odero, María D.

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Single-Cell Techniques Using Chromosomally Tagged Fluorescent Bacteria To Study Listeria monocytogenes Infection Processes von Balestrino, Damien, Hamon, Mélanie Anne, Dortet, Laurent, Nahori, Marie-Anne, Pizarro-Cerda, Javier, Alignani, Diego, Dussurget, Olivier, Cossart, Pascale, Toledo-Arana, Alejandro

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Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia von Lasaga, Miren, Río, Paula, Vilas-Zornoza, Amaia, Planell, Núria, Navarro, Susanna, Alignani, Diego, Fernández-Varas, Beatriz, Mouzo, Daniel, Zubicaray, Josune, Pujol, Roser, Nicoletti, Eileen, Schwartz, Jonathan D, Sevilla, Julián, Ainciburi, Marina, Ullate-Agote, Asier, Surrallés i Calonge, Jordi, Perona, Rosario, Sastre, Leandro, Prosper, Felipe, Gomez-Cabrero, David, Bueren, Juan A, Universitat Autònoma de Barcelona

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