Enhancing anti-EGFRvIII CAR T cell therapy against glioblastoma with a paracrine SIRPγ-derived CD47 blocker von Martins, Tomás A., Kaymak, Deniz, Tatari, Nazanin, Gerster, Fiona, Hogan, Sabrina, Ritz, Marie-Françoise, Sabatino, Valerio, Wieboldt, Ronja, Bartoszek, Ewelina M., McDaid, Marta, Gerber, Alexandra, Buck, Alicia, Beshirova, Aisha, Heider, Anja, Shekarian, Tala, Mohamed, Hayget, Etter, Manina M., Schmassmann, Philip, Abel, Ines, Boulay, Jean-Louis, Saito, Yasuyuki, Mariani, Luigi, Guzman, Raphael, Snijder, Berend, Weiss, Tobias, Läubli, Heinz, Hutter, Gregor

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Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects von Wang, Yufei, Buck, Alicia, Piel, Brandon, Zerefa, Luann, Murugan, Nithyassree, Coherd, Christian D, Miklosi, Andras G, Johal, Haraman, Bastos, Ricardo Nunes, Huang, Kun, Ficial, Miriam, Laimon, Yasmin Nabil, Signoretti, Sabina, Zhong, Zhou, Hoang, Song-My, Kastrunes, Gabriella M, Grimaud, Marion, Fayed, Atef, Yuan, Hsien-Chi, Nguyen, Quang-De, Thai, Tran, Ivanova, Elena V, Paweletz, Cloud P, Wu, Ming-Ru, Choueiri, Toni K, Wee, Jon O, Freeman, Gordon J, Barbie, David A, Marasco, Wayne A

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Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model von Wang, Yufei, Buck, Alicia, Grimaud, Marion, Culhane, Aedin C., Kodangattil, Sreekumar, Razimbaud, Cecile, Bonal, Dennis M., Nguyen, Quang-De, Zhu, Zhu, Wei, Kevin, O'Donnell, Madison L., Huang, Ying, Signoretti, Sabina, Choueiri, Toni K., Freeman, Gordon J., Zhu, Quan, Marasco, Wayne A.

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Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model von Wang, Yufei, Cho, Jae-Won, Kastrunes, Gabriella, Buck, Alicia, Razimbaud, Cecile, Culhane, Aedin C., Sun, Jiusong, Braun, David A., Choueiri, Toni K., Wu, Catherine J., Jones, Kristen, Nguyen, Quang-De, Zhu, Zhu, Wei, Kevin, Zhu, Quan, Signoretti, Sabina, Freeman, Gordon J., Hemberg, Martin, Marasco, Wayne A.

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442 CAIX targeted CAR-T cells exhibited antitumor efficacy on renal cell carcinoma (RCC) patient derived organotypic tumor spheroids (PDOTS) von Wang, Yufei, Buck, Alicia, Piel, Brandon, Zerefa, Luann, Miklosi, Andras-Gabor, Huang, Kun, Kastrunes, Gabriella, Grimaud, Marion, Fayed, Atef, Ficial, Miriam, Signoretti, Sabina, Thai, Tran, Ivanova, Elena, Paweletz, Cloud, Wu, Ming-Ru, Wee, Jon, Choueiri, Toni K, Freeman, Gordon, Barbie, David, Marasco, Wayne

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An Unusual Case of Bowel Evisceration after Sneezing von Jones, Jason, Buck, Alicia, Adams, Jeffrey, Meyer, Anthony

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1355: MEDICATION-FACILITATED ADVANCED AIRWAY MANAGEMENT WITH FIRST-LINE USE OF A SUPRAGLOTTIC DEVICE von Johnston, Bethany, Leung, Alison, Jones, Jason, Chowdhury, Muhammad Abdul Baker, Hwang, Charles, Fitzpatrick, Desmond, Meurer, David, Buck, Alicia, Becker, Torben

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DDDR-19. PHARMACOSCOPY FOR BRAIN METASTASES FROM NON-SMALL CELL LUNG CANCER (NSCLC) von Le Rhun, Emilie, Mena, Julien, Lee, Sohyon, Festl, Yasmin, Buck, Alicia, Voglis, Stefanos, Zeitlberger, Anna Maria, Weiss, Tobias, Serra, Carlo, Neidert, Marian, Regli, Luca, Weller, Michael, Snijder, Berend

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Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis von Schoenhacker-Alte, Beatrix, Mohr, Thomas, Pirker, Christine, Kryeziu, Kushtrim, Kuhn, Paul-Steffen, Buck, Alicia, Hofmann, Thilo, Gerner, Christopher, Hermann, Gerrit, Koellensperger, Gunda, Keppler, Bernhard K., Berger, Walter, Heffeter, Petra

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DDDR-05. SPATIALLY RESOLVED DRUG SENSITIVITY PROFILING IN GLIOBLASTOMA von Buck, Alicia, Lee, Sohyon, Wegmann, Rebekka, Mena, Julien, Vasella, Flavio, Friesen, Julia, Regli, Luca, Le Rhun, Emilie, Zeitlberger, Anna Maria, Neidert, Marian Christoph, Tatari, Nazanin, Hutter, Gregor, Weller, Michael, Snijder, Berend, Weiss, Tobias

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High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity von Lee, Sohyon, Weiss, Tobias, Bühler, Marcel, Mena, Julien, Lottenbach, Zuzanna, Wegmann, Rebekka, Sun, Miaomiao, Bihl, Michel, Augustynek, Bartłomiej, Baumann, Sven P, Goetze, Sandra, van Drogen, Audrey, Pedrioli, Patrick G A, Penton, David, Festl, Yasmin, Buck, Alicia, Kirschenbaum, Daniel, Zeitlberger, Anna M, Neidert, Marian C, Vasella, Flavio, Rushing, Elisabeth J, Wollscheid, Bernd, Hediger, Matthias A, Weller, Michael, Snijder, Berend

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In Vivo Transmigrated Human Neutrophils Are Highly Primed for Intracellular Radical Production Induced by Monosodium Urate Crystals von Davidsson, Lisa, Dahlstrand Rudin, Agnes, Sanchez Klose, Felix Peter, Buck, Alicia, Björkman, Lena, Christenson, Karin, Bylund, Johan

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A prognostic neural epigenetic signature in high-grade glioma von Drexler, Richard, Khatri, Robin, Sauvigny, Thomas, Mohme, Malte, Maire, Cecile L, Ryba, Alice, Zghaibeh, Yahya, Dührsen, Lasse, Salviano-Silva, Amanda, Lamszus, Katrin, Westphal, Manfred, Gempt, Jens, Wefers, Annika K, Neumann, Julia E, Bode, Helena, Hausmann, Fabian, Huber, Tobias B, Bonn, Stefan, Jütten, Kerstin, Delev, Daniel, Weber, Katharina J, Harter, Patrick N, Onken, Julia, Vajkoczy, Peter, Capper, David, Wiestler, Benedikt, Weller, Michael, Snijder, Berend, Buck, Alicia, Weiss, Tobias

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Targeting the Siglec-sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma von Schmassmann, Philip, Roux, Julien, Buck, Alicia, Tatari, Nazanin, Hogan, Sabrina, Wang, Jinyu, Rodrigues Mantuano, Natalia, Wieboldt, Ronja, Lee, Sohyon, Snijder, Berend, Kaymak, Deniz, Martins, Tomás A, Ritz, Marie-Françoise, Shekarian, Tala, McDaid, Marta, Weller, Michael, Weiss, Tobias, Läubli, Heinz, Hutter, Gregor

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EXTH-44. ENHANCING GLIOBLASTOMA CLEARANCE: EMPOWERING ANTI-EGFRVIII CAR T CELLS WITH A PARACRINE SIRPΓ-DERIVED CD47 BLOCKER von Martins, Tomas, Tatari, Nazanin, Kaymak, Deniz, Bartoszek, Ewelina M, Hogan, Sabrina, Buck, Alicia, Ritz, Marie-Françoise, Wieboldt, Ronja, McDaid, Marta, Gerber, Alexandra, Shekarian, Tala, Hedad, Hayget Mohamed Seid, Schmassmann, Philip, Weiss, Tobias, Laeubli, Heinz, Hutter, Gregor

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Abstract 6606: Develop dual-targeted CAR-T cells to achieve RCC cures von Wang, Yufei, Grimaud, Marion, Buck, Alicia, Fayed, Atef, Chang, Matthew, Jennings, Rebecca, Sticco-Ivins, Maura, Ficial, Miriam, Chan, Leo L., Signoretti, Sabina, Zhu, Quan, Marasco, Wayne A.

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High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity von Lee, Sohyon, Weiss, Tobias, Bühler, Marcel, Mena, Julien, Lottenbach, Zuzanna, Wegmann, Rebekka, Sun, Miaomiao, Bihl, Michel, Augustynek, Bartłomiej, Baumann, Sven P., Goetze, Sandra, van Drogen, Audrey, Pedrioli, Patrick G. A., Penton, David, Festl, Yasmin, Buck, Alicia, Kirschenbaum, Daniel, Zeitlberger, Anna M., Neidert, Marian C., Vasella, Flavio, Rushing, Elisabeth J., Wollscheid, Bernd, Hediger, Matthias A., Weller, Michael, Snijder, Berend

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A prognostic neural epigenetic signature in high-grade glioma von Drexler, Richard, Khatri, Robin, Sauvigny, Thomas, Mohme, Malte, Maire, Cecile L., Ryba, Alice, Zghaibeh, Yahya, Dührsen, Lasse, Salviano-Silva, Amanda, Lamszus, Katrin, Westphal, Manfred, Gempt, Jens, Wefers, Annika K., Neumann, Julia E., Bode, Helena, Hausmann, Fabian, Huber, Tobias B., Bonn, Stefan, Jütten, Kerstin, Delev, Daniel, Weber, Katharina J., Harter, Patrick N., Onken, Julia, Vajkoczy, Peter, Capper, David, Wiestler, Benedikt, Weller, Michael, Snijder, Berend, Buck, Alicia, Weiss, Tobias, Göller, Pauline C., Sahm, Felix, Menstel, Joelle Aline, Zimmer, David Niklas, Keough, Michael B., Ni, Lijun, Monje, Michelle, Silverbush, Dana, Hovestadt, Volker, Suvà, Mario L., Krishna, Saritha, Hervey-Jumper, Shawn L., Schüller, Ulrich, Heiland, Dieter H., Hänzelmann, Sonja, Ricklefs, Franz L.

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Abstract 62: Development of dual-targeted fine-tuned immune restoring (DFIR) CAR T cell therapy for clear cell renal cell carcinoma (ccRCC) von Wang, Yufei, Buck, Alicia, Grimaud, Marion, Kodangattil, Sreekumar, Razimbaud, Cecile, Fayed, Atef, Chang, Matthew, Culhane, Aedin, Braun, David A., Choueiri, Toni K., Wu, Catherine J., Wei, Kevin S., Chan, Leo L., Piel, Brandon P., Ivanova, Elena V., Paweletz, Cloud P., Barbie, David A., Jennings, Rebecca, Ficial, Miriam, Sticco-Ivins, Maura Aliezah, Signoretti, Sabina, Freeman, Gordon J., Zhu, Quan K., Marasco, Wayne A.

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DPI Selectively Inhibits Intracellular NADPH Oxidase Activity in Human Neutrophils von Buck, Alicia, Sanchez Klose, Felix P, Venkatakrishnan, Vignesh, Khamzeh, Arsham, Dahlgren, Claes, Christenson, Karin, Bylund, Johan

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