Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer von Henneman, Linda, van Miltenburg, Martine H., Michalak, Ewa M., Braumuller, Tanya M., Jaspers, Janneke E., Drenth, Anne Paulien, de Korte-Grimmerink, Renske, Gogola, Ewa, Szuhai, Karoly, Schlicker, Andreas, Ali, Rahmen Bin, Pritchard, Colin, Huijbers, Ivo J., Berns, Anton, Rottenberg, Sven, Jonkers, Jos

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Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland von Annunziato, Stefano, Kas, Sjors M, Nethe, Micha, Yücel, Hatice, Del Bravo, Jessica, Pritchard, Colin, Bin Ali, Rahmen, van Gerwen, Bas, Siteur, Bjørn, Drenth, Anne Paulien, Schut, Eva, van de Ven, Marieke, Boelens, Mirjam C, Klarenbeek, Sjoerd, Huijbers, Ivo J, van Miltenburg, Martine H, Jonkers, Jos

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Using the GEMM-ESC strategy to study gene function in mouse models von Huijbers, Ivo J, Del Bravo, Jessica, Bin Ali, Rahmen, Pritchard, Colin, Braumuller, Tanya M, van Miltenburg, Martine H, Henneman, Linda, Michalak, Ewa M, Berns, Anton, Jonkers, Jos

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Effective CRISPR/Cas9-mediated correction of a Fanconi anemia defect by error-prone end joining or templated repair von van de Vrugt, Henri J., Harmsen, Tim, Riepsaame, Joey, Alexantya, Georgina, van Mil, Saskia E., de Vries, Yne, Bin Ali, Rahmen, Huijbers, Ivo J., Dorsman, Josephine C., Wolthuis, Rob M. F., te Riele, Hein

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Colorectal carcinoma progression is not influenced by the pseudokinase PEAK1 von Zuidema, Alba, Atherton, Paul, van der Poel, Sabine, Kreft, Maaike, Song, Ji-Ying, Bierbooms, Martine, Verhoeven, Sophie, Papagianni, Chrysoula, Kroese, Lona, Ali, Rahmen Bin, Huijbers, Ivo, Carvalho, Beatriz, Sonnenberg, Arnoud

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Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells von Huijbers, Ivo J, Bin Ali, Rahmen, Pritchard, Colin, Cozijnsen, Miranda, Kwon, Min‐Chul, Proost, Natalie, Song, Ji‐Ying, de Vries, Hilda, Badhai, Jitendra, Sutherland, Kate, Krimpenfort, Paul, Michalak, Ewa M, Jonkers, Jos, Berns, Anton

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Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism von Gan, Changpei, Wang, Jing, Martínez-Chávez, Alejandra, Hillebrand, Michel, de Vries, Niels, Beukers, Joke, Wagenaar, Els, Wang, Yaogeng, Lebre, Maria C., Rosing, Hilde, Klarenbeek, Sjoerd, Ali, Rahmen Bin, Pritchard, Colin, Huijbers, Ivo, Beijnen, Jos H., Schinkel, Alfred H.

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Identification of an alternative triglyceride biosynthesis pathway von McLelland, Gian-Luca, Lopez-Osias, Marta, Verzijl, Cristy R. C., Ellenbroek, Brecht D., Oliveira, Rafaela A., Boon, Nicolaas J., Dekker, Marleen, van den Hengel, Lisa G., Ali, Rahmen, Janssen, Hans, Song, Ji-Ying, Krimpenfort, Paul, van Zutphen, Tim, Jonker, Johan W., Brummelkamp, Thijn R.

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Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice von Wang, Yao-Geng, Gan, Chang-Pei, Beukers-Korver, Joke, Rosing, Hilde, Li, Wen-Long, Wagenaar, Els, Lebre, Maria C, Song, Ji-Ying, Pritchard, Colin, Bin Ali, Rahmen, Huijbers, Ivo, Beijnen, Jos H, Schinkel, Alfred H

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Improved pregnancy and birth rates with routine application of nonsurgical embryo transfer von Bin Ali, Rahmen, van der Ahé, Fina, Braumuller, Tanya M, Pritchard, Colin, Krimpenfort, Paul, Berns, Anton, Huijbers, Ivo J

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Abstract 2687: Rapid in vivo testing of tumor suppressors in ILC by CRISPR-Cas9 mediated somatic gene editing of the mammary gland von Annunziato, Stefano, Kas, Sjors, Nethe, Micha, Yucel, Hatice, del Bravo, Jessica, Pritchard, Colin, Bin Ali, Rahmen, van Gerwen, Bas, Siteur, Bjorn, Drenth, Anne Paulien, Schut-Kregel, Eva, Klarenbeek, Sjoerd, Huijbers, Ivo, van Miltenburg, Martine, Jonkers, Jos

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Abstract 3295: Systematic in vivo analysis of PI3K pathway aberrations in a mouse model for invasive lobular carcinoma von van Miltenburg, Martine H., Klarenbeek, Sjoerd, Braumuller, Tanya, Henneman, Linda, Ali, Rahmen Bin, Huijbers, Ivo, Krimpenfort, Paul, Berns, Anton, Jonkers, Jos

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Conformational Change in Human DNA Repair Enzyme O 6-Methylguanine-DNA Methyltransferase upon Alkylation of Its Active Site by SN1 (Indirect-Acting) and SN2 (Direct-Acting) Alkylat... von Oh, Hue-Kian, Teo, Alvin K.-C, Ali, Rahmen B, Lim, Allan, Ayi, Teck-Choon, Yarosh, D. B, Li, Benjamin F.-L

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Implication of Localization of Human DNA Repair Enzyme O 6-Methylguanine-DNA Methyltransferase at Active Transcription Sites in Transcription-Repair Coupling of the Mutagenic O 6-M... von Ali, Rahmen B., Teo, Alvin K.-C., Oh, Hue-Kian, Chuang, Linda S.-H., Ayi, Teck-Choon, Li, Benjamin F. L.

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The Modified Human DNA Repair EnzymeO 6-Methylguanine-DNA Methyltransferase Is a Negative Regulator of Estrogen Receptor-Mediated Transcription upon Alkylation DNA Damage von Teo, Alvin K. C., Oh, Hue Kian, Ali, Rahmen B., Li, Benjamin F. L.

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The Modified Human DNA Repair Enzyme O 6 -Methylguanine-DNA Methyltransferase Is a Negative Regulator of Estrogen Receptor-Mediated Transcription upon Alkylation DNA Damage von Teo, Alvin K. C., Oh, Hue Kian, Ali, Rahmen B., Li, Benjamin F. L.

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Conformational Change in Human DNA Repair Enzyme O6-Methylguanine-DNA Methyltransferase upon Alkylation of Its Active Site by SN1 (Indirect-Acting) and SN2 (Direct-Acting) Alkylati... von OH, Hue-Kian, TEO, Alvin K.-C., ALI, Rahmen B., LIM, Allan, AYI, Teck-Choon, YAROSH, D. B., LI, Benjamin F.-L.

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The Modified Human DNA Repair Enzyme O6-Methylguanine-DNA Methyltransferase Is a Negative Regulator of Estrogen Receptor-Mediated Transcription upon Alkylation DNA Damage von Teo, Alvin K. C., Oh, Hue Kian, Ali, Rahmen B., Li, Benjamin F. L.

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INTRACELLULAR-LOCALIZATION OF HUMAN DNA-REPAIR ENZYME METHYLGUANINE-DNA METHYLTRANSFERASE BY ANTIBODIES AND ITS IMPORTANCE von AYI, TC, LOH, KC, ALI, RB, LI, BFL

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Implication of localization of human DNA repair enzyme O6-methylguanine-DNA methyltransferase at active transcription sites in transcription-repair coupling of the mutagenic O6-met... von Ali, R B, Teo, A K, Oh, H K, Chuang, L S, Ayi, T C, Li, B F

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