Targeting DNA‐Dependent Protein Kinase for Cancer Therapy von Harnor, Suzannah J., Brennan, Alfie, Cano, Céline

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Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge von Ford, Brian E., Chachra, Shruti S., Alshawi, Ahmed, Brennan, Alfie, Harnor, Suzannah, Cano, Celine, Baker, David J., Smith, David M., Fairclough, Rebecca J., Agius, Loranne

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Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyteATPhomeostasis during substrate challenge von Ford, Brian E., Chachra, Shruti S., Alshawi, Ahmed, Brennan, Alfie, Harnor, Suzannah, Cano, Celine, Baker, David J., Smith, David M., Fairclough, Rebecca J., Agius, Loranne

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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death von Mannion, Jonathan, Gifford, Valentina, Bellenie, Benjamin, Fernando, Winnie, Ramos Garcia, Laura, Wilson, Rebecca, John, Sidonie Wicky, Udainiya, Savita, Patin, Emmanuel C., Tiu, Crescens, Smith, Angel, Goicoechea, Maria, Craxton, Andrew, Moraes de Vasconcelos, Nathalia, Guppy, Naomi, Cheung, Kwai-Ming J., Cundy, Nicholas J., Pierrat, Olivier, Brennan, Alfie, Roumeliotis, Theodoros I., Benstead-Hume, Graeme, Alexander, John, Muirhead, Gareth, Layzell, Scott, Lyu, Wenxin, Roulstone, Victoria, Allen, Mark, Baldock, Holly, Legrand, Arnaud, Gabel, Florian, Serrano-Aparicio, Natalia, Starling, Chris, Guo, Hongyan, Upton, Jason, Gyrd-Hansen, Mads, MacFarlane, Marion, Seddon, Benedict, Raynaud, Florence, Roxanis, Ioannis, Harrington, Kevin, Haider, Syed, Choudhary, Jyoti S., Hoelder, Swen, Tenev, Tencho, Meier, Pascal

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Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors von Davis, Owen A., Cheung, Kwai-Ming J., Brennan, Alfie, Lloyd, Matthew G., Rodrigues, Matthew J., Pierrat, Olivier A., Collie, Gavin W., Le Bihan, Yann-Vaï, Huckvale, Rosemary, Harnden, Alice C., Varela, Ana, Bright, Michael D., Eve, Paul, Hayes, Angela, Henley, Alan T., Carter, Michael D., McAndrew, P. Craig, Talbot, Rachel, Burke, Rosemary, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Meniconi, Mirco, Bellenie, Benjamin R., Hoelder, Swen

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Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones von Harnden, Alice C., Davis, Owen A., Box, Gary M., Hayes, Angela, Johnson, Louise D., Henley, Alan T., de Haven Brandon, Alexis K., Valenti, Melanie, Cheung, Kwai-Ming J., Brennan, Alfie, Huckvale, Rosemary, Pierrat, Olivier A., Talbot, Rachel, Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, de Klerk, Selby, McAndrew, Peter Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen

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Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo von Huckvale, Rosemary, Harnden, Alice C., Cheung, Kwai-Ming J., Pierrat, Olivier A., Talbot, Rachel, Box, Gary M., Henley, Alan T., de Haven Brandon, Alexis K., Hallsworth, Albert E., Bright, Michael D., Akpinar, Hafize Aysin, Miller, Daniel S. J., Tarantino, Dalia, Gowan, Sharon, Hayes, Angela, Gunnell, Emma A., Brennan, Alfie, Davis, Owen A., Johnson, Louise D., de Klerk, Selby, McAndrew, Craig, Le Bihan, Yann-Vaï, Meniconi, Mirco, Burke, Rosemary, Kirkin, Vladimir, van Montfort, Rob L. M., Raynaud, Florence I., Rossanese, Olivia W., Bellenie, Benjamin R., Hoelder, Swen

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Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach von Miller, Duncan C, Martin, Mathew P, Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A, Golding, Bernard T, Hardcastle, Ian R, Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R, Noble, Martin E M, Cano, Celine

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Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approachElectronic supplementary information (ESI) available. See D... von Miller, Duncan C, Martin, Mathew P, Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A, Golding, Bernard T, Hardcastle, Ian R, Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R, Noble, Martin E. M, Cano, Celine

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Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach† †Electronic supplementary information (ESI) available. Se... von Miller, Duncan C., Martin, Mathew P., Adhikari, Santosh, Brennan, Alfie, Endicott, Jane A., Golding, Bernard T., Hardcastle, Ian R., Heptinstall, Amy, Hobson, Stephen, Jennings, Claire, Molyneux, Lauren, Ng, Yvonne, Wedge, Stephen R., Noble, Martin E. M., Cano, Celine

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Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatasesElectronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03612g von Reuillon, Tristan, Alhasan, Sari F, Beale, Gary S, Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L, Newell, David R, Golding, Bernard T, Miller, Duncan C, Griffin, Roger J

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Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases von Reuillon, Tristan, Alhasan, Sari F, Beale, Gary S, Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L, Newell, David R, Golding, Bernard T, Miller, Duncan C, Griffin, Roger J

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Design and synthesis of biphenyl and biphenyl ether inhibitors of sulfatases† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03612g von Reuillon, Tristan, Alhasan, Sari F., Beale, Gary S., Bertoli, Annalisa, Brennan, Alfie, Cano, Celine, Reeves, Helen L., Newell, David R., Golding, Bernard T., Miller, Duncan C., Griffin, Roger J.

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INHIBITOR COMPOUNDS von HOELDER, Swen, HARNDEN, Alice Claire, HUCKVALE, Rosemary, BELLENIE, Benjamin Richard, BRENNAN, Alfie, DAVIS, Owen Alexander, CHEUNG, Ming Jack

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BCL6 inhibitors von Rosemary Huckvale, Mirco Meniconi, Matthew Garth Lloyd, Swen Hoelder, Gavin Collie, Kwai Ming Jack Cheung, Alfie Brennan, Benjamin Richard Bellenie, Owen Alexander Davis

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BCL6 INHIBITORS von Davis, Owen Alexander, Lloyd, Matthew Garth, Collie, Gavin, Hoelder, Swen, Bellenie, Benjamin Richard, Huckvale, Rosemary, Meniconi, Mirco, Cheung, Kwai Ming Jack, Brennan, Alfie

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BCL6 inhibitors von CHEUNG, Kwai Ming Jack, HOELDER, Swen, MENICONI, Mirco, HUCKVALE, Rosemary, BELLENIE, Benjamin Richard, COLLIE, Gavin, DAVIS, Owen Alexander, BRENNAN, Alfie, LLOYD, Matthew Garth

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[1,4]OXAZEPINO[2,3-C]QUINOLINONE DERIVATIVES AS BCL6 INHIBITORS von CHEUNG, Kwai Ming Jack, HOELDER, Swen, HARNDEN, Alice Claire, HUCKVALE, Rosemary, BELLENIE, Benjamin Richard, BRENNAN, Alfie, DAVIS, Owen Alexander

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BCL6 INHIBITORS von CHEUNG, Kwai Ming Jack, HOELDER, Swen, MENICONI, Mirco, HUCKVALE, Rosemary, BELLENIE, Benjamin Richard, COLLIE, Gavin, DAVIS, Owen Alexander, BRENNAN, Alfie, LLOYD, Matthew Garth

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BCL6 INHIBITORS von Davis, Owen Alexander, Lloyd, Matthew Garth, Collie, Gavin, Hoelder, Swen, Bellenie, Benjamin Richard, Huckvale, Rosemary, Meniconi, Mirco, Cheung, Kwai Ming Jack, Brennan, Alfie

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