A Deep Learning Framework for Predicting Response to Therapy in Cancer von Sakellaropoulos, Theodore, Vougas, Konstantinos, Narang, Sonali, Koinis, Filippos, Kotsinas, Athanassios, Polyzos, Alexander, Moss, Tyler J., Piha-Paul, Sarina, Zhou, Hua, Kardala, Eleni, Damianidou, Eleni, Alexopoulos, Leonidas G., Aifantis, Iannis, Townsend, Paul A., Panayiotidis, Mihalis I., Sfikakis, Petros, Bartek, Jiri, Fitzgerald, Rebecca C., Thanos, Dimitris, Mills Shaw, Kenna R., Petty, Russell, Tsirigos, Aristotelis, Gorgoulis, Vassilis G.

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Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells von Kalli, Maria, Minia, Angeliki, Pliaka, Vaia, Fotis, Christos, Alexopoulos, Leonidas G., Stylianopoulos, Triantafyllos

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Towards a rigorous assessment of systems biology models: the DREAM3 challenges von Prill, Robert J, Marbach, Daniel, Saez-Rodriguez, Julio, Sorger, Peter K, Alexopoulos, Leonidas G, Xue, Xiaowei, Clarke, Neil D, Altan-Bonnet, Gregoire, Stolovitzky, Gustavo

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The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data von Samaga, Regina, Saez-Rodriguez, Julio, Alexopoulos, Leonidas G, Sorger, Peter K, Klamt, Steffen

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Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction von Sorger, Peter K, Saez-Rodriguez, Julio, Alexopoulos, Leonidas G, Epperlein, Jonathan, Samaga, Regina, Lauffenburger, Douglas A, Klamt, Steffen

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An ex vivo tissue model of cartilage degradation suggests that cartilage state can be determined from secreted key protein patterns von Neidlin, Michael, Chantzi, Efthymia, Macheras, George, Gustafsson, Mats G, Alexopoulos, Leonidas G

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Multiscale Regulation of the Intervertebral Disc: Achievements in Experimental, In Silico, and Regenerative Research von Baumgartner, Laura, Wuertz-Kozak, Karin, Le Maitre, Christine L., Wignall, Francis, Richardson, Stephen M., Hoyland, Judith, Ruiz Wills, Carlos, Gonzalez Ballester, Miguel A., Neidlin, Michael, Alexopoulos, Leonidas G., Noailly, Jerome

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Lysophosphatidic Acid Is a Proinflammatory Stimulus of Renal Tubular Epithelial Cells von Magkrioti, Christiana, Antonopoulou, Georgia, Fanidis, Dionysios, Pliaka, Vaia, Sakellaropoulos, Theodore, Alexopoulos, Leonidas G., Ullmer, Christoph, Aidinis, Vassilis

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Accurate SARS-CoV-2 seroprevalence surveys require robust multi-antigen assays von Fotis, Christos, Meimetis, Nikolaos, Tsolakos, Nikos, Politou, Marianna, Akinosoglou, Karolina, Pliaka, Vaia, Minia, Angeliki, Terpos, Evangelos, Trougakos, Ioannis P., Mentis, Andreas, Marangos, Markos, Panayiotakopoulos, George, Dimopoulos, Meletios A., Gogos, Charalampos, Spyridonidis, Alexandros, Alexopoulos, Leonidas G.

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Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models von SAEZ-RODRIGUEZ, Julio, ALEXOPOULOS, Leonidas G, MINGSHENG ZHANG, MORRIS, Melody K, LAUFFENBURGER, Douglas A, SORGER, Peter K

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Dynamics and heterogeneity of brain damage in multiple sclerosis von Kotelnikova, Ekaterina, Kiani, Narsis A, Abad, Elena, Martinez-Lapiscina, Elena H, Andorra, Magi, Zubizarreta, Irati, Pulido-Valdeolivas, Irene, Pertsovskaya, Inna, Alexopoulos, Leonidas G, Olsson, Tomas, Martin, Roland, Paul, Friedemann, Tegnér, Jesper, Garcia-Ojalvo, Jordi, Villoslada, Pablo

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Mechanical Compression Regulates Brain Cancer Cell Migration Through MEK1/Erk1 Pathway Activation and GDF15 Expression von Kalli, Maria, Voutouri, Chrysovalantis, Minia, Angeliki, Pliaka, Vaia, Fotis, Christos, Alexopoulos, Leonidas G., Stylianopoulos, Triantafyllos

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Regulatory network-based model to simulate the biochemical regulation of chondrocytes in healthy and osteoarthritic environments von Segarra-Queralt, Maria, Neidlin, Michael, Tio, Laura, Monfort, Jordi, Monllau, Joan Carles, González Ballester, Miguel Á., Alexopoulos, Leonidas G., Piella, Gemma, Noailly, Jérôme

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COMBSecretomics: A pragmatic methodological framework for higher-order drug combination analysis using secretomics von Chantzi, Efthymia, Neidlin, Michael, Macheras, George A., Alexopoulos, Leonidas G., Gustafsson, Mats G.

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The Pericellular Matrix as a Transducer of Biomechanical and Biochemical Signals in Articular Cartilage von GUILAK, FARSHID, ALEXOPOULOS, LEONIDAS G., UPTON, MAUREEN L., YOUN, INCHAN, CHOI, JAE BONG, CAO, LI, SETTON, LORI A., HAIDER, MANSOOR A.

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Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data von Mitsos, Alexander, Melas, Ioannis N, Siminelakis, Paraskeuas, Chairakaki, Aikaterini D, Saez-Rodriguez, Julio, Alexopoulos, Leonidas G

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Immuno-Modulatory Effects of Intervertebral Disc Cells von Bermudez-Lekerika, Paola, Crump, Katherine B., Tseranidou, Sofia, Nüesch, Andrea, Kanelis, Exarchos, Alminnawi, Ahmad, Baumgartner, Laura, Muñoz-Moya, Estefano, Compte, Roger, Gualdi, Francesco, Alexopoulos, Leonidas G., Geris, Liesbet, Wuertz-Kozak, Karin, Le Maitre, Christine L., Noailly, Jérôme, Gantenbein, Benjamin

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Networks Inferred from Biochemical Data Reveal Profound Differences in Toll-like Receptor and Inflammatory Signaling between Normal and Transformed Hepatocytes von Alexopoulos, Leonidas G., Saez-Rodriguez, Julio, Cosgrove, Benjamin D., Lauffenburger, Douglas A., Sorger, Peter K.

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Detecting and removing inconsistencies between experimental data and signaling network topologies using integer linear programming on interaction graphs von Melas, Ioannis N, Samaga, Regina, Alexopoulos, Leonidas G, Klamt, Steffen

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Determination of the Poisson's ratio of the cell: recovery properties of chondrocytes after release from complete micropipette aspiration von Trickey, Wendy R., Baaijens, Frank P.T., Laursen, Tod A., Alexopoulos, Leonidas G., Guilak, Farshid

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