Identification of RIP1 kinase as a specific cellular target of necrostatins von Degterev, Alexei, Yuan, Junying, Hitomi, Junichi, Germscheid, Megan, Ch'en, Irene L, Korkina, Olga, Teng, Xin, Abbott, Derek, Cuny, Gregory D, Yuan, Chengye, Wagner, Gerhard, Hedrick, Stephen M, Gerber, Scott A, Lugovskoy, Alexey

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MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM von Casaletto, Jessica B., Geddie, Melissa L., Abu-Yousif, Adnan O., Masson, Kristina, Fulgham, Aaron, Boudot, Antoine, Maiwald, Tim, Kearns, Jeffrey D., Kohli, Neeraj, Su, Stephen, Razlog, Maja, Raue, Andreas, Kalra, Ashish, Håkansson, Maria, Logan, Derek T., Welin, Martin, Chattopadhyay, Shrikanta, Harms, Brian D., Nielsen, Ulrik B., Schoeberl, Birgit, Lugovskoy, Alexey A., MacBeath, Gavin

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A novel screening method to assess developability of antibody-like molecules von Kohli, Neeraj, Jain, Nidhi, Geddie, Melissa L, Razlog, Maja, Xu, Lihui, Lugovskoy, Alexey A

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Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism von Marcotte, Douglas, Zeng, Weike, Hus, Jean-Christophe, McKenzie, Andres, Hession, Cathy, Jin, Ping, Bergeron, Chris, Lugovskoy, Alexey, Enyedy, Istvan, Cuervo, Hernan, Wang, Deping, Atmanene, Cédric, Roecklin, Dominique, Vecchi, Malgorzata, Vivat, Valérie, Kraemer, Joachim, Winkler, Dirk, Hong, Victor, Chao, Jianhua, Lukashev, Matvey, Silvian, Laura

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Understanding the role of cross-arm binding efficiency in the activity of monoclonal and multispecific therapeutic antibodies von Harms, Brian D., Kearns, Jeffrey D., Iadevaia, Sergio, Lugovskoy, Alexey A.

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MM-141, an IGF-IR- and ErbB3-directed bispecific antibody, overcomes network adaptations that limit activity of IGF-IR inhibitors von Fitzgerald, Jonathan B, Johnson, Bryan W, Baum, Jason, Adams, Sharlene, Iadevaia, Sergio, Tang, Jian, Rimkunas, Victoria, Xu, Lihui, Kohli, Neeraj, Rennard, Rachel, Razlog, Maja, Jiao, Yang, Harms, Brian D, Olivier, Jr, Kenneth J, Schoeberl, Birgit, Nielsen, Ulrik B, Lugovskoy, Alexey A

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Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer von Camblin, Adam J, Pace, Emily A, Adams, Sharlene, Curley, Michael D, Rimkunas, Victoria, Nie, Lin, Tan, Gege, Bloom, Troy, Iadevaia, Sergio, Baum, Jason, Minx, Charlene, Czibere, Akos, Louis, Chrystal U, Drummond, Daryl C, Nielsen, Ulrik B, Schoeberl, Birgit, Pipas, J Marc, Straubinger, Robert M, Askoxylakis, Vasileios, Lugovskoy, Alexey A

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Development of disulfide-stabilized Fabs for targeting of antibody-directed nanotherapeutics von Geddie, Melissa L, Kirpotin, Dmitri B, Kohli, Neeraj, Kornaga, Tad, Boll, Bjoern, Razlog, Maja, Drummond, Daryl C, Lugovskoy, Alexey A

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Identification and Characterization of Mefloquine Efficacy against JC Virus In Vitro von BRICKELMAIER, Margot, LUGOVSKOY, Alexey, KARTIKEYAN, Ramya, REVIRIEGO-MENDOZA, Marta M, ALLAIRE, Norm, SIMON, Kenneth, FRISQUE, Richard J, GORELIK, Leonid

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Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E von Gross, John D., Moerke, Nathan J., von der Haar, Tobias, Lugovskoy, Alexey A., Sachs, Alan B., McCarthy, John E.G., Wagner, Gerhard

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Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML) von Sunyaev, Shamil R, Lugovskoy, Alexey, Simon, Kenneth, Gorelik, Leonid

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Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma von Eavarone, David A, Al-Alem, Linah, Lugovskoy, Alexey, Prendergast, Jillian M, Nazer, Rawan I, Stein, Jenna N, Dransfield, Daniel T, Behrens, Jeff, Rueda, Bo R

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Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer von Camblin, Adam J., Tan, Gege, Curley, Michael D., Yannatos, Isabel, Iadevaia, Sergio, Rimkunas, Victoria, Mino-Kenudson, Mari, Bloom, Troy, Schoeberl, Birgit, Drummond, Daryl C., Lugovskoy, Alexey A., Louis, Chrystal U., Askoxylakis, Vasileios

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Proteome-wide Analysis in Saccharomyces cerevisiae Identifies Several PHD Fingers as Novel Direct and Selective Binding Modules of Histone H3 Methylated at Either Lysine 4 or Lysin... von Shi, Xiaobing, Kachirskaia, Ioulia, Walter, Kay L., Kuo, Jen-Hao A., Lake, Aimee, Davrazou, Foteini, Chan, Steve M., Martin, David G.E., Fingerman, Ian M., Briggs, Scott D., Howe, LeAnn, Utz, Paul J., Kutateladze, Tatiana G., Lugovskoy, Alexey A., Bedford, Mark T., Gozani, Or

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Fast screening of protein surfaces using geometric invariant fingerprints von Yin, Shuangye, Proctor, Elizabeth A, Lugovskoy, Alexey A, Dokholyan, Nikolay V

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De novo discovery of antibody drugs - great promise demands scrutiny von Finlay, William J.J., Lugovskoy, Alexey A.

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Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains von Miao, Benchun, Skidan, Igor, Yang, Jinsheng, Lugovskoy, Alexey, Reibarkh, Mikhail, Long, Kai, Brazell, Tres, Durugkar, Kulbhushan A., Maki, Jenny, Ramana, C. V., Schaffhausen, Brian, Wagner, Gerhard, Torchilin, Vladimir, Yuan, Junying, Degterev, Alexei, Tsichlis, Philip N.

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Small-Molecule Inhibition of TNF-α von He, Molly M., Smith, Annemarie Stroustrup, Oslob, Johan D., Flanagan, William M., Braisted, Andrew C., Whitty, Adrian, Cancilla, Mark T., Wang, Jun, Lugovskoy, Alexey A., Yoburn, Josh C., Fung, Amy D., Farrington, Graham, Eldredge, John K., Day, Eric S., Cruz, Leslie A., Cachero, Teresa G., Miller, Stephan K., Friedman, Jessica E., Choong, Ingrid C., Cunningham, Brian C.

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Rational engineering of antibody therapeutics targeting multiple oncogene pathways von Fitzgerald, Jonathan, Lugovskoy, Alexey A.

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Improving the solubility of anti‐LINGO‐1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis von Pepinsky, R. Blake, Silvian, Laura, Berkowitz, Steven A., Farrington, Graham, Lugovskoy, Alexey, Walus, Lee, Eldredge, John, Capili, Allan, Mi, Sha, Graff, Christilyn, Garber, Ellen

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