Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo von Saenz, Steven A, Local, Andrea, Carr, Tiffany, Shakya, Arvind, Koul, Shivsmriti, Hu, Haiqing, Chourb, Lisa, Stedman, Justin, Malley, Jenna, D'Agostino, Laura Akullian, Shanmugasundaram, Veerabahu, Malona, John, Schwartz, C Eric, Beebe, Lisa, Clements, Meghan, Rajaraman, Ganesh, Cho, John, Jiang, Lan, Dubrovskiy, Alex, Kreilein, Matt, Shimanovich, Roman, Hamann, Lawrence G, Escoubet, Laure, Ellis, J Michael

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Inhibition of Btk with CC-292 Provides Early Pharmacodynamic Assessment of Activity in Mice and Humans von Evans, Erica K., Tester, Richland, Aslanian, Sharon, Karp, Russell, Sheets, Michael, Labenski, Matthew T., Witowski, Steven R., Lounsbury, Heather, Chaturvedi, Prasoon, Mazdiyasni, Hormoz, Zhu, Zhendong, Nacht, Mariana, Freed, Martin I., Petter, Russell C., Dubrovskiy, Alex, Singh, Juswinder, Westlin, William F.

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Small molecule allosteric inhibitors of ROR[gamma]t block Th17-dependent inflammation and associated gene expression in vivo von Saenz, Steven A, Local, Andrea, Carr, Tiffany, Shakya, Arvind, Koul, Shivsmriti, Hu, Haiqing, Chourb, Lisa, Stedman, Justin, Malley, Jenna, D'Agostino, Laura Akullian, Shanmugasundaram, Veerabahu, Malona, John, Schwartz, C. Eric, Beebe, Lisa, Clements, Meghan, Rajaraman, Ganesh, Cho, John, Jiang, Lan, Dubrovskiy, Alex, Kreilein, Matt, Shimanovich, Roman, Hamann, Lawrence G, Escoubet, Laure, Ellis, J. Michael

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Discovery of Selective, Covalent FGFR4 Inhibitors with Antitumor Activity in Models of Hepatocellular Carcinoma von Liu, Haibo, Niu, Deqiang, Tham Sjin, Robert Tjin, Dubrovskiy, Alex, Zhu, Zhendong, McDonald, Joseph J, Fahnoe, Kelly, Wang, Zhigang, Munson, Mark, Scholte, Andrew, Barrague, Matthieu, Fitzgerald, Maria, Liu, Jinyu, Kothe, Michael, Sun, Fangxian, Murtie, Joshua, Ge, Jie, Rocnik, Jennifer, Harvey, Darren, Ospina, Beatriz, Perron, Keli, Zheng, Gang, Shehu, Elvis, D’Agostino, Laura Akullian

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Abstract 2101A: CNX-2006, a novel irreversible epidermal growth factor receptor (EGFR) inhibitor, selectively inhibits EGFR T790M and fails to induce T790M-mediated resistance in v... von Ohashi, Kadoaki, Suda, Kenichi, Sun, Jing, Pan, Yumei, Walter, Annette O., Dubrovskiy, Alex, Tjin, Robert, Mitsudomi, Tetsuya, Pao, William

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Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo von Steven A. Saenz, Andrea Local, Tiffany Carr, Arvind Shakya, Shivsmriti Koul, Haiqing Hu, Lisa Chourb, Justin Stedman, Jenna Malley, Laura Akullian D’Agostino, Veerabahu Shanmugasundaram, John Malona, C. Eric Schwartz, Lisa Beebe, Meghan Clements, Ganesh Rajaraman, John Cho, Lan Jiang, Alex Dubrovskiy, Matt Kreilein, Roman Shimanovich, Lawrence G. Hamann, Laure Escoubet, J. Michael Ellis

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Abstract 1791: CO-1686, a novel mutant-selective EGFR inhibitor, overcomes T790M mediated resistance in Non-Small Cell Lung Cancer (NSCLC) von Walter, Annette O., Tjin, Robert, Haringsma, Henry, Lin, Kevin, Dubrovskiy, Alex, Lee, Kwangho, Martin, Thia St, Karp, Russell, Zhu, Zhendong, Nu, Deqiang, Nacht, Mariana, Suda, Kenichi, Mitsudomi, Tetsuya, Petter, Russell C., Westlin, William F., Singh, Juswinder, Raponi, Mitch, Allen, Andrew

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Superiority of a novel EGFR targeted covalent inhibitor over its reversible counterpart in overcoming drug resistance von Singh, Juswinder, Evans, Erica, Hagel, Margit, Labinski, Matthew, Dubrovskiy, Alex, Nacht, Mariana, Petter, Russell C., Prasad, Aravind, Sheets, Michael, St Martin, Thia, Tjin Tham Sjin, Robert, Westlin, William, Zhu, Zhendong

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Abstract C189: CO-1686, an orally available, mutant-selective inhibitor of the epidermal growth factor receptor (EGFR), causes tumor shrinkage in non-small cell lung cancer (NSCLC)... von Walter, Annette O., Tjin, Robert, Haringsma, Henry, Lin, Kevin, Dubrovskiy, Alex, Lee, Kwangho, St. Martin, Thia, Karp, Russell, Zhu, Zhendong, Niu, Deqiang, Nacht, Mariana, Petter, Russell C., Westlin, William F., Singh, Juswinder, Raponi, Mitch, Allen, Andrew

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Superiority of a novel EGFR targeted covalent inhibitor over its reversible counterpart in overcoming drug resistanceThis article is part of the MedChemComm drug residence web them... von Singh, Juswinder, Evans, Erica, Hagel, Margit, Labinski, Matthew, Dubrovskiy, Alex, Nacht, Mariana, Petter, Russell C, Prasad, Aravind, Sheets, Michael, St Martin, Thia, Tjin Tham Sjin, Robert, Westlin, William, Zhu, Zhendong

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