Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation von Bulatov, Emil, Ciulli, Alessio

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Biophysical Screening for the Discovery of Small-Molecule Ligands von Ciulli, Alessio

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Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory von Cowan, Angus D, Ciulli, Alessio

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Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies von Lucas, Xavier, Ciulli, Alessio

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Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and T... von Chan, Kwok-Ho, Zengerle, Michael, Testa, Andrea, Ciulli, Alessio

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Structure‐Based Design of a Macrocyclic PROTAC von Testa, Andrea, Hughes, Scott J., Lucas, Xavier, Wright, Jane E., Ciulli, Alessio

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DUB be good to me von Liu, Xingui, Ciulli, Alessio

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Structural basis of PROTAC cooperative recognition for selective protein degradation von Gadd, Morgan S, Testa, Andrea, Lucas, Xavier, Chan, Kwok-Ho, Chen, Wenzhang, Lamont, Douglas J, Zengerle, Michael, Ciulli, Alessio

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Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity von Klein, Victoria G, Bond, Adam G, Craigon, Conner, Lokey, R. Scott, Ciulli, Alessio

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Iterative Design and Optimization of Initially Inactive Proteolysis Targeting Chimeras (PROTACs) Identify VZ185 as a Potent, Fast, and Selective von Hippel–Lindau (VHL) Based Dual... von Zoppi, Vittoria, Hughes, Scott J, Maniaci, Chiara, Testa, Andrea, Gmaschitz, Teresa, Wieshofer, Corinna, Koegl, Manfred, Riching, Kristin M, Daniels, Danette L, Spallarossa, Andrea, Ciulli, Alessio

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Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase von Lucas, Xavier, Van Molle, Inge, Ciulli, Alessio

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Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex von Cardote, Teresa A.F., Gadd, Morgan S., Ciulli, Alessio

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Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase von Kung, Wei-Wei, Ramachandran, Sarath, Makukhin, Nikolai, Bruno, Elvira, Ciulli, Alessio

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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity von Imaide, Satomi, Riching, Kristin M., Makukhin, Nikolai, Vetma, Vesna, Whitworth, Claire, Hughes, Scott J., Trainor, Nicole, Mahan, Sarah D., Murphy, Nancy, Cowan, Angus D., Chan, Kwok-Ho, Craigon, Conner, Testa, Andrea, Maniaci, Chiara, Urh, Marjeta, Daniels, Danette L., Ciulli, Alessio

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation von Maniaci, Chiara, Hughes, Scott J., Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J., Rocha, Sonia, Alessi, Dario R., Romeo, Roberto, Ciulli, Alessio

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SPR-Measured Dissociation Kinetics of PROTAC Ternary Complexes Influence Target Degradation Rate von Roy, Michael J, Winkler, Sandra, Hughes, Scott J, Whitworth, Claire, Galant, Michael, Farnaby, William, Rumpel, Klaus, Ciulli, Alessio

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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design von Farnaby, William, Koegl, Manfred, Roy, Michael J., Whitworth, Claire, Diers, Emelyne, Trainor, Nicole, Zollman, David, Steurer, Steffen, Karolyi-Oezguer, Jale, Riedmueller, Carina, Gmaschitz, Teresa, Wachter, Johannes, Dank, Christian, Galant, Michael, Sharps, Bernadette, Rumpel, Klaus, Traxler, Elisabeth, Gerstberger, Thomas, Schnitzer, Renate, Petermann, Oliver, Greb, Peter, Weinstabl, Harald, Bader, Gerd, Zoephel, Andreas, Weiss-Puxbaum, Alexander, Ehrenhöfer-Wölfer, Katharina, Wöhrle, Simon, Boehmelt, Guido, Rinnenthal, Joerg, Arnhof, Heribert, Wiechens, Nicola, Wu, Meng-Ying, Owen-Hughes, Tom, Ettmayer, Peter, Pearson, Mark, McConnell, Darryl B., Ciulli, Alessio

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Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins von Bond, Adam G, Craigon, Conner, Chan, Kwok-Ho, Testa, Andrea, Karapetsas, Athanasios, Fasimoye, Rotimi, Macartney, Thomas, Blow, J. Julian, Alessi, Dario R, Ciulli, Alessio

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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo von Kofink, Christiane, Trainor, Nicole, Mair, Barbara, Wöhrle, Simon, Wurm, Melanie, Mischerikow, Nikolai, Roy, Michael J., Bader, Gerd, Greb, Peter, Garavel, Géraldine, Diers, Emelyne, McLennan, Ross, Whitworth, Claire, Vetma, Vesna, Rumpel, Klaus, Scharnweber, Maximilian, Fuchs, Julian E., Gerstberger, Thomas, Cui, Yunhai, Gremel, Gabriela, Chetta, Paolo, Hopf, Stefan, Budano, Nicole, Rinnenthal, Joerg, Gmaschitz, Gerhard, Mayer, Moriz, Koegl, Manfred, Ciulli, Alessio, Weinstabl, Harald, Farnaby, William

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Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition von Frost, Julianty, Galdeano, Carles, Soares, Pedro, Gadd, Morgan S., Grzes, Katarzyna M., Ellis, Lucy, Epemolu, Ola, Shimamura, Satoko, Bantscheff, Marcus, Grandi, Paola, Read, Kevin D., Cantrell, Doreen A., Rocha, Sonia, Ciulli, Alessio

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