Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection von Drelich, Aleksandra K, Rayavara, Kempaiah, Hsu, Jason, Saenkham-Huntsinger, Panatda, Judy, Barbara M, Tat, Vivian, Ksiazek, Thomas G, Peng, Bi-Hung, Tseng, Chien-Te K

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A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2 von Tai, Wanbo, Zhang, Xiujuan, Drelich, Aleksandra, Shi, Juan, Hsu, Jason C., Luchsinger, Larry, Hillyer, Christopher D., Tseng, Chien-Te K., Jiang, Shibo, Du, Lanying

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Bepridil is potent against SARS-CoV-2 in vitro von Vatansever, Erol C., Yang, Kai S., Drelich, Aleksandra K., Kratch, Kaci C., Cho, Chia-Chuan, Kempaiah, Kempaiah Rayavara, Hsu, Jason C., Mellott, Drake M., Xu, Shiqing, Tseng, Chien-Te K., Liu, Wenshe Ray

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A Quick Route to Multiple Highly Potent SARS‐CoV‐2 Main Protease Inhibitors von Yang, Kai S., Ma, Xinyu R., Ma, Yuying, Alugubelli, Yugendar R., Scott, Danielle A., Vatansever, Erol C., Drelich, Aleksandra K., Sankaran, Banumathi, Geng, Zhi Z., Blankenship, Lauren R., Ward, Hannah E., Sheng, Yan J., Hsu, Jason C., Kratch, Kaci C., Zhao, Baoyu, Hayatshahi, Hamed S., Liu, Jin, Li, Pingwei, Fierke, Carol A., Tseng, Chien‐Te K., Xu, Shiqing, Liu, Wenshe Ray

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BALB/c mice challenged with SARS-CoV-2 B.1.351 β variant cause pathophysiological and neurological changes within the lungs and brains von Saenkham-Huntsinger, Panatda, Drelich, Aleksandra K, Huang, Pinghan, Peng, Bi-Hung, Tseng, Chien-Te K

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Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice von Hsu, Jason C, Saenkham-Huntsinger, Panatda, Huang, Pinghan, Octaviani, Cassio Pontes, Drelich, Aleksandra K, Peng, Bi-Hung, Tseng, Chien-Te K

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Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection von Geng, Qibin, Tai, Wanbo, Baxter, Victoria K., Shi, Juan, Wan, Yushun, Zhang, Xiujuan, Montgomery, Stephanie A., Taft-Benz, Sharon A., Anderson, Elizabeth J., Knight, Audrey C., Dinnon, Kenneth H., Leist, Sarah R., Baric, Ralph S., Shang, Jian, Hong, Sung-Wook, Drelich, Aleksandra, Tseng, Chien-Te K., Jenkins, Marc, Heise, Mark, Du, Lanying, Li, Fang

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Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold von Sun, Zehua, Chen, Chuan, Li, Wei, Martinez, David R., Drelich, Aleksandra, Baek, Du-San, Liu, Xianglei, Mellors, John W., Tseng, Chien-Te, Baric, Ralph S., Dimitrov, Dimiter S.

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Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases von Calvier, Laurent, Drelich, Aleksandra, Hsu, Jason, Tseng, Chien-Te, Mina, Yair, Nath, Avindra, Kounnas, Maria Z, Herz, Joachim

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A Bacteriophage-Based, Highly Efficacious, Needle- and Adjuvant-Free, Mucosal COVID-19 Vaccine von Zhu, Jingen, Jain, Swati, Sha, Jian, Batra, Himanshu, Ananthaswamy, Neeti, Kilgore, Paul B, Hendrix, Emily K, Hosakote, Yashoda M, Wu, Xiaorong, Olano, Juan P, Kayode, Adeyemi, Galindo, Cristi L, Banga, Simran, Drelich, Aleksandra, Tat, Vivian, Tseng, Chien-Te K, Chopra, Ashok K, Rao, Venigalla B

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Increased talin–vinculin spatial proximities in livers in response to spotted fever group rickettsial and Ebola virus infections von Liu, Yakun, Xiao, Jie, Zhang, Ben, Shelite, Thomas R., Su, Zhengchen, Chang, Qing, Judy, Barbara, Li, Xiang, Drelich, Aleksandra, Bei, Jiani, Zhou, Yixuan, Zheng, Junying, Jin, Yang, Rossi, Shannan L., Tang, Shao-Jun, Wakamiya, Maki, Saito, Tais, Ksiazek, Thomas, Kaphalia, Bhupendra, Gong, Bin

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Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections von Su, Zhengchen, Chang, Qing, Drelich, Aleksandra, Shelite, Thomas, Judy, Barbara, Liu, Yakun, Xiao, Jie, Zhou, Changchen, He, Xi, Jin, Yang, Saito, Tais, Tang, Shaojun, Soong, Lynn, Wakamiya, Maki, Fang, Xiang, Bukreyev, Alexander, Ksiazek, Thomas, Russell, William K., Gong, Bin

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Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays von Curreli, Francesca, Ahmed, Shahad, Victor, Sofia M B, Drelich, Aleksandra, Panda, Siva S, Altieri, Andrea, Kurkin, Alexander V, Tseng, Chien-Te K, Hillyer, Christopher D, Debnath, Asim K

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Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents von Zhu, Jiyun, Li, Linfeng, Drelich, Aleksandra, Chenna, Bala C., Mellott, Drake M., Taylor, Zane W., Tat, Vivian, Garcia, Christopher Z., Katzfuss, Ardala, Tseng, Chien-Te K., Meek, Thomas D.

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Exchange Protein Directly Activated by cAMP Modulates Ebola Virus Uptake into Vascular Endothelial Cells von Drelich, Aleksandra, Judy, Barbara, He, Xi, Chang, Qing, Yu, Shangyi, Li, Xiang, Lu, Fanglin, Wakamiya, Maki, Popov, Vsevolod, Zhou, Jia, Ksiazek, Thomas, Gong, Bin

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Deciphering COVID-19 host transcriptomic complexity and variations for therapeutic discovery against new variants von Xing, Jing, Shankar, Rama, Ko, Meehyun, Zhang, Keke, Zhang, Sulin, Drelich, Aleksandra, Paithankar, Shreya, Chekalin, Eugene, Chua, Mei-Sze, Rajasekaran, Surender, Kent Tseng, Chien-Te, Zheng, Mingyue, Kim, Seungtaek, Chen, Bin

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Comparison of replicating and nonreplicating vaccines against SARS-CoV-2 von Mudrick, Haley E, Massey, Shane, McGlinch, Erin B, Parrett, Brian J, Hemsath, Jack R, Barry, Mary E, Rubin, Jeffrey D, Uzendu, Chisom, Hansen, Michael J, Erskine, Courtney L, Van Keulen, Virginia P, Drelich, Aleksandra, Panos, Joseph A, Fida, Madiha, Suh, Gina A, Peikert, Tobias, Block, Matthew S, Tseng, Chien-Te Kent, Olivier, Gloria R, Barry, Michael A

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Endogenous Type I interferon signaling plays a pivotal role in restricted SARS-CoV-2 infection in human ACE2 transgenic mice von Kempaiah, Kempaiah Rayavara, Drelich, Aleksandra, Hsu, Jason C, Tat, Vivian, Tseng, Chien-Te K

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High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models von Li, Wei, Schäfer, Alexandra, Kulkarni, Swarali S., Liu, Xianglei, Martinez, David R., Chen, Chuan, Sun, Zehua, Leist, Sarah R., Drelich, Aleksandra, Zhang, Liyong, Ura, Marcin L., Berezuk, Alison, Chittori, Sagar, Leopold, Karoline, Mannar, Dhiraj, Srivastava, Shanti S., Zhu, Xing, Peterson, Eric C., Tseng, Chien-Te, Mellors, John W., Falzarano, Darryl, Subramaniam, Sriram, Baric, Ralph S., Dimitrov, Dimiter S.

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High Potency of a Bivalent Human V-H Domain in SARS-CoV-2 Animal Models von Li, Wei, Schafer, Alexandra, Kulkarni, Swarali S., Liu, Xianglei, Martinez, David R., Chen, Chuan, Sun, Zehua, Leist, Sarah R., Drelich, Aleksandra, Zhang, Liyong, Ura, Marcin L., Berezuk, Alison, Chittori, Sagar, Leopold, Karoline, Mannar, Dhiraj, Srivastava, Shanti S., Zhu, Xing, Peterson, Eric C., Tseng, Chien-Te, Mellors, John W., Falzarano, Darryl, Subramaniam, Sriram, Baric, Ralph S., Dimitrov, Dimiter S.

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