Transplantation of bioengineered liver capable of extended function in a preclinical liver failure model von Higashi, Hisanobu, Yagi, Hiroshi, Kuroda, Kohei, Tajima, Kazuki, Kojima, Hideaki, Nishi, Kotaro, Morisaku, Toshinori, Hirukawa, Kazuya, Fukuda, Kazumasa, Matsubara, Kentaro, Kitago, Minoru, Shinoda, Masahiro, Obara, Hideaki, Adachi, Shungo, Nishimura, Kumiko, Natsume, Tohru, Tomi, Masatoshi, Soto‐Gutierrez, Alejandro, Kitagawa, Yuko

Volltext

Human-Scale Whole-Organ Bioengineering for Liver Transplantation: A Regenerative Medicine Approach von Yagi, Hiroshi, Fukumitsu, Ken, Fukuda, Kazumasa, Kitago, Minoru, Shinoda, Masahiro, Obara, Hideaki, Itano, Osamu, Kawachi, Shigeyuki, Tanabe, Minoru, Coudriet, Gina M., Piganelli, Jon D., Gilbert, Thomas W., Soto-Gutierrez, Alejandro, Kitagawa, Yuko

Volltext

Induced pluripotent stem cells model personalized variations in liver disease resulting from α1‐antitrypsin deficiency von Tafaleng, Edgar N., Chakraborty, Souvik, Han, Bing, Hale, Pamela, Wu, Wanquan, Soto‐Gutierrez, Alejandro, Feghali‐Bostwick, Carol A., Wilson, Andrew A., Kotton, Darrell N., Nagaya, Masaki, Strom, Stephen C., Roy‐Chowdhury, Jayanta, Stolz, Donna B., Perlmutter, David H., Fox, Ira J.

Volltext

Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells von Chen, Chen, Soto-Gutierrez, Alejandro, Baptista, Pedro M., Spee, Bart

Volltext

Future Economics of Liver Transplantation: A 20-Year Cost Modeling Forecast and the Prospect of Bioengineering Autologous Liver Grafts von Habka, Dany, Mann, David, Landes, Ronald, Soto-Gutierrez, Alejandro

Volltext

Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix von Uygun, Korkut, Uygun, Basak E, Soto-Gutierrez, Alejandro, Yagi, Hiroshi, Izamis, Maria-Louisa, Guzzardi, Maria A, Shulman, Carley, Milwid, Jack, Kobayashi, Naoya, Tilles, Arno, Berthiaume, Francois, Hertl, Martin, Nahmias, Yaakov, Yarmush, Martin L

Volltext

Hepatocyte Nuclear Factor 4 alpha 2 Messenger RNA Reprograms Liver‐Enriched Transcription Factors and Functional Proteins in End‐Stage Cirrhotic Human Hepatocytes von Tafaleng, Edgar N., Mukherjee, Amitava, Bell, Aaron, Morita, Kazutoyo, Guzman‐Lepe, Jorge, Haep, Nils, Florentino, Rodrigo M., Diaz‐Aragon, Ricardo, Frau, Carla, Ostrowska, Alina, Schultz, Joshua R., Martini, Paolo G. V., Soto‐Gutierrez, Alejandro, Fox, Ira J.

Volltext

Liver‐enriched transcription factor expression relates to chronic hepatic failure in humans von Guzman‐Lepe, Jorge, Cervantes‐Alvarez, Eduardo, Collin de l'Hortet, Alexandra, Wang, Yang, Mars, Wendy M., Oda, Yoshinao, Bekki, Yuki, Shimokawa, Masahiro, Wang, Huanlin, Yoshizumi, Tomoharu, Maehara, Yoshihiko, Bell, Aaron, Fox, Ira J., Takeishi, Kazuki, Soto‐Gutierrez, Alejandro

Volltext

Transmembrane channel activity in human hepatocytes and cholangiocytes derived from induced pluripotent stem cells von Florentino, Rodrigo M., Li, Qin, Coard, Michael C., Haep, Nils, Motomura, Takashi, Diaz‐Aragon, Ricardo, Faccioli, Lanuza A. P., Amirneni, Sriram, Kocas‐Kilicarslan, Zehra N., Ostrowska, Alina, Squires, James E., Feranchak, Andrew P., Soto‐Gutierrez, Alejandro

Volltext

Engineering of an Hepatic Organoid to Develop Liver Assist Devices von Soto-Gutierrez, Alejandro, Navarro-Alvarez, Nalú, Yagi, Hiroshi, Nahmias, Yakoov, Yarmush, Martin L., Kobayashi, Naoya

Volltext

Mesenchymal Stem Cells: Mechanisms of Immunomodulation and Homing von Yagi, Hiroshi, Soto-Gutierrez, Alejandro, Parekkadan, Biju, Kitagawa, Yuko, Tompkins, Ronald G., Kobayashi, Naoya, Yarmush, Martin L.

Volltext

Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells von Takeishi, Kazuki, Collin de l’Hortet, Alexandra, Wang, Yang, Handa, Kan, Guzman-Lepe, Jorge, Matsubara, Kentaro, Morita, Kazutoyo, Jang, Sae, Haep, Nils, Florentino, Rodrigo M., Yuan, Fangchao, Fukumitsu, Ken, Tobita, Kimimasa, Sun, Wendell, Franks, Jonathan, Delgado, Evan R., Shapiro, Erik M., Fraunhoffer, Nicolas A., Duncan, Andrew W., Yagi, Hiroshi, Mashimo, Tomoji, Fox, Ira J., Soto-Gutierrez, Alejandro

Volltext

Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans von Florentino, Rodrigo M., Fraunhoffer, Nicolas A., Morita, Kazutoyo, Takeishi, Kazuki, Ostrowska, Alina, Achreja, Abhinav, Animasahun, Olamide, Haep, Nils, Arazov, Shohrat, Agarwal, Nandini, Collin de l'Hortet, Alexandra, Guzman‐Lepe, Jorge, Tafaleng, Edgar N., Mukherjee, Amitava, Troy, Kris, Banerjee, Swati, Paranjpe, Shirish, Michalopoulos, George K., Bell, Aaron, Nagrath, Deepak, Hainer, Sarah J., Fox, Ira J., Soto‐Gutierrez, Alejandro

Volltext

Perspectives on whole-organ assembly: moving toward transplantation on demand von Soto-Gutierrez, Alejandro, Wertheim, Jason A, Ott, Harald C, Gilbert, Thomas W

Volltext

Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis von Lee, Sojin, Usman, Taofeek O, Yamauchi, Jun, Chhetri, Goma, Wang, Xingchun, Coudriet, Gina M, Zhu, Cuiling, Gao, Jingyang, McConnell, Riley, Krantz, Kyler, Rajasundaram, Dhivyaa, Singh, Sucha, Piganelli, Jon, Ostrowska, Alina, Soto-Gutierrez, Alejandro, Monga, Satdarshan P, Singhi, Aatur D, Muzumdar, Radhika H, Tsung, Allan, Dong, H Henry

Volltext

Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging von Wang, Rui-Hong, Zhao, Tingrui, Cui, Kairong, Hu, Gangqing, Chen, Qiang, Chen, Weiping, Wang, Xin-Wei, Soto-Gutierrez, Alejandro, Zhao, Keji, Deng, Chu-Xia

Volltext

Guide to the Assessment of Mature Liver Gene Expression in Stem Cell-Derived Hepatocytes von Zabulica, Mihaela, Srinivasan, Raghuraman C., Vosough, Massoud, Hammarstedt, Christina, Wu, Tingting, Gramignoli, Roberto, Ellis, Ewa, Kannisto, Kristina, Collin de l'Hortet, Alexandra, Takeishi, Kazuki, Soto-Gutierrez, Alejandro, Strom, Stephen C.

Volltext

Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication von Giugliano, Silvia, Kriss, Michael, Golden-Mason, Lucy, Dobrinskikh, Evgenia, Stone, Amy E.L, Soto-Gutierrez, Alejandro, Mitchell, Angela, Khetani, Salman R, Yamane, Daisuke, Stoddard, Mark, Li, Hui, Shaw, George M, Edwards, Michael G, Lemon, Stanley M, Gale, Michael, Shah, Vijay H, Rosen, Hugo R

Volltext

A switch in the source of ATP production and a loss in capacity to perform glycolysis are hallmarks of hepatocyte failure in advance liver disease von Nishikawa, Taichiro, Bellance, Nadège, Damm, Aaron, Bing, Han, Zhu, Zhen, Handa, Kan, Yovchev, Mladen I, Sehgal, Vasudha, Moss, Tyler J, Oertel, Michael, Ram, Prahlad T, Pipinos, Iraklis I, Soto-Gutierrez, Alejandro, Fox, Ira J, Nagrath, Deepak

Volltext

Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix-A Comparative Analysis of Bioartificial Liver Microenvironments von Wang, Bo, Jakus, Adam E, Baptista, Pedro M, Soker, Shay, Soto-Gutierrez, Alejandro, Abecassis, Michael M, Shah, Ramille N, Wertheim, Jason A

Volltext